Pleistocene reptile swim traces confirmed from South Africa’s Cape south coast

Large Pleistocene reptile tracks and traces were described from the Cape south coast of South Africa in 2020, including ‘probable swim traces’. These trace fossils were found on loose slabs and blocks of the Klein Brak Formation. Subsequently, another surface has become exposed on this coastline, also on a loose slab. It exhibits more definitive evidence of swim traces in epirelief, probably made by the Nile crocodile (Crocodylus niloticus) or water monitor (Varanus niloticus), although a chelonian origin cannot be excluded. Length of a possible crocodylian trackmaker was estimated from measurements of interdigital distance in the swim traces. These provide a compelling example of reptile swim traces from Africa.Significance: Pleistocene reptile swim traces have now been confidently confirmed from the Cape south coast of South Africa. The findings complement the suite of recently identified large reptile tracks. Trackmaker size can be estimated from the dimensions of reptile swim traces. These are the first compelling non-dinosaurian reptile swim traces to be described from Africa

A smart sewer asset information model to enable an ‘Internet of Things’ for operational wastewater management

Real-time prediction of flooding is vital for the successful future operational management of the UK sewerage network. Recent advances in smart infrastructure and the emergence of the Internet of Things (IoT), presents an opportunity within the wastewater sector to harness and report in real-time sewer condition data for operation management. This study presents the design and development of a prototype Smart Sewer Asset Information Model (SSAIM) for an existing sewerage network. The SSAIM, developed using Industry Foundation Class version 4 (IFC4) an open neutral data format for BIM, incorporates distributed smart sensors to enable real-time monitoring and reporting of sewer asset performance. Results describe an approach for sensor data analysis to facilitate the real-time prediction of flooding

New pterosaur tracks (Pteraichnidae) from the Late Cretaceous Uhangri Formation, southwestern Korea

This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.Numerous footprints of dinosaurs, pterosaurs and birds, together with arthropod tracks, have been discovered in the upper Cretaceous Uhangri Formation which crops out along the south-western coastline of South Korea. This ichnofauna contains the first pterosaur tracks reported from Asia. The digitigrade tridactyl manus impressions exhibit features of a typical pterosaur hand print. The pes impressions, however, show features that are different from pterosaur footprints reported previously: there is no visible trace of impressions of individual digits, and the toes are triangular or rounded in shape distally without distinct claw impressions. As these features clearly distinguish the Uhangri tracks from Pteraichnus and Purbeckopus, we assign them to a new genus, Haenamichnus which accommodates the new ichnospecies, Haenamichnus uhangriensis. The prints are five to six times larger than those of Pteraichnus, and are currently the largest pterosaur ichnites known. They show virtually no trace of the 5th phalange of the pes, indicating that they were made by pterodactyloids; moreover, features of the tracks suggest that they can be attributed to azhdarchids, the commonest pterosaur of the Late Cretaceous. The longest pterosaur trackway yet known from any track site (length 7.3 m) and consisting of 14 pairs of foot impressions, was also found in the Uhangri Formation and suggests that azhdarchids, at least, were competent terrestrial locomotors. The fossil track site at Uhangri represents the first occurrence of the tracks of pterosaurs, dinosaurs and web-footed birds all on the same level. This demonstrates that pterosaurs and birds visited the same habitat, but the large size disparity suggests that they occupied different ecological niches.Peer Reviewe

A Diverse Mammal-Dominated, Footprint Assemblage from Wetland Deposits in the Lower Cretaceous of Maryland

A newly discovered assemblage of predominantly small tracks from the Cretaceous Patuxent Formation at NASAs Goddard Space Flight Center, Maryland, reveals one of the highest track densities and diversities ever reported (~70 tracks, representing at least eight morphotypes from an area of only ~2m(exp 2)). The assemblage is dominated by small mammal tracks including the new ichnotxon Sederipes goddardensis, indicating sitting postures. Small crow-sized theropod trackways, the first from this unit, indicate social trackmakers and suggest slow-paced foraging behavior. Tracks of pterosaurs, and other small vertebrates suggest activity on an organic-rich substrate. Large well-preserved sauropod and nodosaurs tracks indicate the presence of large dinosaurs. The Patuxent Formation together with the recently reported Angolan assemblage comprise the worlds two largest Mesozoic mammal footprint assemblages. The high density of footprint registration at the NASA site indicates special preservational and taphonomic conditions. These include early, penecontemporaneous deposition of siderite in organic rich, reducing wetland settings where even the flesh of body fossils can be mummified. Thus, the track-rich ironstone substrates of the Patuxent Formation, appear to preserve a unique vertebrate ichnofacies, with associated, exceptionally-preserved body fossil remains for which there are currently no other similar examples preserved in the fossil record

FIRST REPORT ON DINOSAUR TRACKS FROM THE BURRO CAN YON FORMATION, SAN JUAN COUNTY, UTAH, USA – EVIDENCE OF A DIVERSE, HITHERTO UN KNOWN LOWER CRETACEOUS DINOSAUR FAUNA

The newly discovered White Mesa tracksite in the Burro Canyon Formation represents a snap shot of a diverse, Lower Cretaceous dinosaur fauna from south-eastern Utah. The tracks were found at a construction site where the sand stone had been bull dozed and broken up. All tracks were found as deep, well-preserved natural casts on the under side of the sand stone slabs. Individual theropod tracks are 19–57 cm in length; one peculiar track shows evidence of a possible pathological swelling in the middle of digit III and an apparently didactyl track is tentatively as signed to a dromaeosaurid. Individual sauropod tracks are found with pes lengths of 36–72 cm, and interestingly, three distinct shapes of manus tracks, ranging from wide banana shaped to rounded and hoof-like. Ornithopods are represented with individual tracks 18–37 cm in length; a single track can possibly be attributed to the thyreophoran ichnogenus Deltapodus. Zircon U-Pb dating places the track-bearing layer in the Barremian, contemporary to the lower Yellow Cat Member of the Cedar Mountain Formation, which has a similar faunal composition based on both tracks and body fossils. This new track-fauna demonstrates the existence of a diverse dinosaurian assemblage in the lower part of the Burro Canyon Formation, which hitherto is not known to yield skeletal remains

Hominin tracks in southern Africa: a review and an approach to identification

Three Late Pleistocene hominin tracksites have been reported from coastal aelioanites in South Africa. Two have been dated to 124 ka and 117 ka , and the third is inferred to be 90 ka. There are no other globally reported sites for probable Homo sapiens tracks older than 46 ka. Given this documented record, a search for further hominin tracksites in southern Africa may well yield additional positive results. However, this is a field that demands scientific rigour, as false positive tracksites (pseudotracks) may occur. Criteria have been developed for the identification of fossil vertebrate tracks and hominin tracks, but these are specific neither to southern Africa nor to aeolianites.An important caveat is that the tracks of shod humans would not fulfil these criteria. Preservation of tracks varies with facies and is known to be suboptimal in aeolianites. An analysis of the tracks from the three documented South African sites, along with pseudotracks and tracks of questionable provenance, allows for the proposal and development of guidelines for fossil hominin track identification that are of specific relevance to southern Africa. Such guidelines have broader implications for understanding the constraints that track preservation and substrate have on identifying diagnostic morphological features.Palaeontological Scientific Trust (PAST)JNC201

Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer

High-grade serous cancer (HGSC) accounts for ~67% of all ovarian cancer deaths. Although initially sensitive to platinum chemotherapy, resistance is inevitable and there is an unmet clinical need for novel therapies that can circumvent this event. We performed a drug screen with 1177 FDA-approved drugs and identified the hydroxyquinoline drug, chloroxine. In extensive validation experiments, chloroxine restored sensitivity to both cisplatin and carboplatin, demonstrating broad synergy in our range of experimental models of platinum-resistant HGSC. Synergy was independent of chloroxine’s predicted ionophore activity and did not relate to platinum uptake as measured by atomic absorption spectroscopy. Further mechanistic investigation revealed that chloroxine overrides DNA damage tolerance in platinum-resistant HGSC. Co-treatment with carboplatin and chloroxine (but not either drug alone) caused an increase in γH2AX expression, followed by a reduction in platinum-induced RAD51 foci. Moreover, this unrepaired DNA damage was associated with p53 stabilisation, cell cycle re-entry and triggering of caspase 3/7- mediated cell death. Finally, in our platinum-resistant, intraperitoneal in vivo model, treatment with carboplatin alone resulted in a transient tumour response followed by tumour regrowth. In contrast, treatment with chloroxine and carboplatin combined, was able to maintain tumour volume at baseline for over 4 months. In conclusion, our novel results show that chloroxine facilitates platinum-induced DNA damage to restore platinum sensitivity in HGSC. Since chloroxine is already licensed, this exciting combination therapy could now be rapidly translated for patient benefit