2,192 research outputs found
T. M. Lockhart to James Meredith (Undated)
https://egrove.olemiss.edu/mercorr_pro/1629/thumbnail.jp
Deformations of calibrated subbundles of Euclidean spaces via twisting by special sections
We extend the "bundle constructions" of calibrated submanifolds, due to
Harvey--Lawson in the special Lagrangian case, and to
Ionel--Karigiannis--Min-Oo in the cases of exceptional calibrations, by
"twisting" the bundles by a special (harmonic, holomorphic, parallel) section
of a complementary bundle. The existence of such deformations shows that the
moduli space of calibrated deformations of these "calibrated subbundles"
includes deformations which destroy the linear structure of the fibre.Comment: 16 pages, no figures. Version 2: Only minor cosmetic and
typographical revisions. To appear in "Annals of Global Analysis and
Geometry.
Mobile radio interferometric geodetic systems
Operation of the Astronomical Radio Interferometric Earth Surveying (ARIES) in a proof of concept mode is discussed. Accuracy demonstrations over a short baseline, a 180 km baseline, and a 380 km baseline are documented. Use of ARIES in the Sea Slope Experiment of the National Geodetic Survey to study the apparent differences between oceanographic and geodetic leveling determinations of the sea surface along the Pacific Coast is described. Intergration of the NAVSTAR Global Positioning System and a concept called SERIES (Satellite Emission Radio Interferometric Earth Surveying) is briefly reviewed
Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
We have assessed the impact of α-synuclein overexpression on the differentiation potential and phenotypic signatures of two neural-committed induced pluripotent stem cell lines derived from a Parkinson´s disease patient with a triplication of the human SNCA genomic locus. In parallel, comparative studies were performed on two control lines derived from healthy individuals and lines generated from the patient iPS-derived neuroprogenitor lines infected with a lentivirus incorporating a small hairpin RNA to knock down the SNCA mRNA. The SNCA triplication lines exhibited a reduced capacity to differentiate into dopaminergic or GABAergic neurons and decreased neurite outgrowth and lower neuronal activity compared with control cultures. This delayed maturation phenotype was confirmed by gene expression profiling, which revealed a significant reduction in mRNA for genes implicated in neuronal differentiation such as delta-like homolog 1 (DLK1), gamma-aminobutyric acid type B receptor subunit 2 (GABABR2), nuclear receptor related 1 protein (NURR1), G-protein-regulated inward-rectifier potassium channel 2 (GIRK-2) and tyrosine hydroxylase (TH). The differentiated patient cells also demonstrated increased autophagic flux when stressed with chloroquine. We conclude that a two-fold overexpression of α-synuclein caused by a triplication of the SNCA gene is sufficient to impair the differentiation of neuronal progenitor cells, a finding with implications for adult neurogenesis and Parkinson´s disease progression, particularly in the context of bioenergetic dysfunction.Fil: Oliveira, L. M. A.. Max-Planck-Institut fĂĽr biophysikalische Chemie; AlemaniaFil: Falomir Lockhart, Lisandro Jorge. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de Investigaciones BioquĂmicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias MĂ©dicas. Instituto de Investigaciones BioquĂmicas de La Plata ; Argentina. Max-Planck-Institut fĂĽr biophysikalische Chemie; AlemaniaFil: Botelho, M. G.. Max-Planck-Institut fĂĽr biophysikalische Chemie; Alemania. Universidade Federal do Rio de Janeiro; BrasilFil: Lin, K. H.. Max-Planck-Institut fĂĽr biophysikalische Chemie; AlemaniaFil: Wales, P.. Universität Göttingen; AlemaniaFil: Koch, J. C.. Universität Göttingen; AlemaniaFil: Gerhardt, Elizabeth. Universität Göttingen; AlemaniaFil: Taschenberger, H.. Max-Planck-Institut fĂĽr biophysikalische Chemie; AlemaniaFil: Outeiro, T. F.. Universität Göttingen; AlemaniaFil: Lingor, P.. Universität Göttingen; AlemaniaFil: SchĂĽele, B.. The Parkinson’s Institute; Estados UnidosFil: Arndt Jovin, D. J.. Max-Planck-Institut fĂĽr biophysikalische Chemie; AlemaniaFil: Jovin, T. M.. Max-Planck-Institut fĂĽr biophysikalische Chemie; Alemani
A Systematic Review on the Biomechanics of Breakfall Technique (Ukemi) in Relation to Injury in Judo within the Adult Judoka Population
Asymptotically cylindrical 7-manifolds of holonomy G_2 with applications to compact irreducible G_2-manifolds
We construct examples of exponentially asymptotically cylindrical Riemannian
7-manifolds with holonomy group equal to G_2. To our knowledge, these are the
first such examples. We also obtain exponentially asymptotically cylindrical
coassociative calibrated submanifolds. Finally, we apply our results to show
that one of the compact G_2-manifolds constructed by Joyce by desingularisation
of a flat orbifold T^7/\Gamma can be deformed to one of the compact
G_2-manifolds obtainable as a generalized connected sum of two exponentially
asymptotically cylindrical SU(3)-manifolds via the method given by the first
author (math.DG/0012189).Comment: 36 pages; v2: corrected trivial typos; v3: some arguments corrected
and improved; v4: a number of improvements on presentation, paritularly in
sections 4 and 6, including an added picture
Fivebranes and 4-manifolds
We describe rules for building 2d theories labeled by 4-manifolds. Using the
proposed dictionary between building blocks of 4-manifolds and 2d N=(0,2)
theories, we obtain a number of results, which include new 3d N=2 theories
T[M_3] associated with rational homology spheres and new results for
Vafa-Witten partition functions on 4-manifolds. In particular, we point out
that the gluing measure for the latter is precisely the superconformal index of
2d (0,2) vector multiplet and relate the basic building blocks with coset
branching functions. We also offer a new look at the fusion of defect lines /
walls, and a physical interpretation of the 4d and 3d Kirby calculus as
dualities of 2d N=(0,2) theories and 3d N=2 theories, respectivelyComment: 81 pages, 18 figures. v2: misprints corrected, clarifications and
references added. v3: additions and corrections about lens space theory,
4-manifold gluing, smooth structure
Electrostatic Patch Effect in Cylindrical Geometry. I. Potential and Energy between Slightly Non-Coaxial Cylinders
We study the effect of any uneven voltage distribution on two close
cylindrical conductors with parallel axes that are slightly shifted in the
radial and by any length in the axial direction. The investigation is
especially motivated by certain precision measurements, such as the Satellite
Test of the Equivalence Principle (STEP). By energy conservation, the force can
be found as the energy gradient in the vector of the shift, which requires
determining potential distribution and energy in the gap. The boundary value
problem for the potential is solved, and energy is thus found to the second
order in the small transverse shift, and to lowest order in the gap to cylinder
radius ratio. The energy consists of three parts: the usual capacitor part due
to the uniform potential difference, the one coming from the interaction
between the voltage patches and the uniform voltage difference, and the energy
of patch interaction, entirely independent of the uniform voltage. Patch effect
forces and torques in the cylindrical configuration are derived and analyzed in
the next two parts of this work.Comment: 26 pages, 1 Figure. Submitted to Classical and Quantum Gravit
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