Political trials and the suppression of popular radicalism in England, 1799-1820

This chapter examines the decision-making process between the Home Office and the government’s law officers in prosecuting individuals for sedition and treason in the period 1799–1820. The term state trial suggests a more centralised and government-led repression of popular radicalism than the process was in practice. Provincial reformers also faced the complex layers of their local justice system, which was more loyalist, committed to stamping out political radicalism. The trial of the “Thirty Eight” Manchester radicals in June 1812 demonstrates the mutable definitions of treason, sedition and processes of justice in the theatre of the court.Peer reviewe

X-ray variability analysis of a large series of XMM-Newton + NuSTAR observations of NGC 3227

We present a series of X-ray variability results from a long XMM-Newton + NuSTAR campaign on the bright, variable AGN NGC 3227. We present an analysis of the lightcurves, showing that the source displays typically softer-when-brighter behaviour, although also undergoes significant spectral hardening during one observation which we interpret as due to an occultation event by a cloud of absorbing gas. We spectrally decompose the data and show that the bulk of the variability is continuum-driven and, through rms variability analysis, strongly enhanced in the soft band. We show that the source largely conforms to linear rms-flux behaviour and we compute X-ray power spectra, detecting moderate evidence for a bend in the power spectrum, consistent with existing scaling relations. Additionally, we compute X-ray Fourier time lags using both the XMM-Newton and - through maximum-likelihood methods - NuSTAR data, revealing a strong low-frequency hard lag and evidence for a soft lag at higher frequencies, which we discuss in terms of reverberation models.Comment: Accepted for publication in MNRAS; 19 pages, 13 figures, 4 tables; minor typographical errors corrected and reference list update

Evidence for a Truncated Accretion Disc in the Low Luminosity Seyfert Galaxy, NGC 7213?

We present the broad-band 0.6-150 keV Suzaku and Swift BAT spectra of the low luminosity Seyfert galaxy, NGC 7213. The time-averaged continuum emission is well fitted by a single powerlaw of photon index Gamma = 1.75 and from consideration of the Fermi flux limit we constrain the high energy cutoff to be 350 keV < E < 25 MeV. Line emission from both near-neutral iron K_alpha at 6.39 keV and highly ionised iron, from Fe_(xxv) and Fe_(xxvi), is strongly detected in the Suzaku spectrum, further confirming the results of previous observations with Chandra and XMM-Newton. We find the centroid energies for the Fe_(xxv) and Fe_(xxvi) emission to be 6.60 keV and 6.95 keV respectively, with the latter appearing to be resolved in the Suzaku spectrum. We show that the Fe_(xxv) and Fe_(xxvi) emission can result from a highly photo-ionised plasma of column density N_(H) ~ 3 x 10^(23) cm^(-2). A Compton reflection component, e.g., originating from an optically-thick accretion disc or a Compton-thick torus, appears either very weak or absent in this AGN, subtending < 1 sr to the X-ray source, consistent with previous findings. Indeed the absence of either neutral or ionised Compton reflection coupled with the lack of any relativistic Fe K signatures in the spectrum suggests that an inner, optically-thick accretion disc is absent in this source. Instead, the accretion disc could be truncated with the inner regions perhaps replaced by a Compton-thin Radiatively Inefficient Accretion Flow. Thus, the Fe_(xxv) and Fe_(xxvi) emission could both originate in ionised material perhaps at the transition region between the hot, inner flow and the cold, truncated accretion disc on the order of 10^(3) - 10^(4) gravitational radii from the black hole. The origin for the unresolved neutral Fe K_alpha emission is then likely to be further out, perhaps originating in the optical BLR or a Compton-thin pc-scale torus.Comment: 15 pages, 11 figures, accepted for publication by MNRA

OBSERVATIONS ON NAVICULA THALLODES (BACILLARIOPHYCEAE), A BLADE-FORMING DIATOM FROM THE BERING SEA 1

A thallus-forming diatom, Navicula thallodes Proschkina-Lavrenko, previously known only from the original collection at Bering Island (U.S.S.R.), has been found at Amchitka Island in the Aleutians, Alaska. The most remarkable observation of the present report is that N. thallodes may form blades up to 50 cm long, which to our knowledge is the greatest length reported for a colonial diatom. SEM observations of this diatom are presented for the first time.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65176/1/j.1529-8817.1988.tb04487.x.pd

Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation

The cyclic AMP-specific phosphodiesterase PDE8 has been shown to play a pivotal role in important processes such as steroidogenesis, T cell adhesion, regulation of heart beat and chemotaxis. However, no information exists on how the activity of this enzyme is regulated. We show that under elevated cAMP conditions, PKA acts to phosphorylate PDE8A on serine 359 and this action serves to enhance the activity of the enzyme. This is the first indication that PDE8 activity can be modulated by a kinase, and we propose that this mechanism forms a feedback loop that results in the restoration of basal cAMP levels. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserve

The Hot and Energetic Universe: Astrophysics of feedback in local AGN

Understanding the astrophysics of feedback in active galactic nuclei (AGN) is key to understanding the growth and co-evolution of supermassive black holes and galaxies. AGN-driven winds/outflows are potentially the most effective way of transporting energy and momentum from the nuclear scales to the host galaxy, quenching star formation by sweeping away the gas reservoir. Key questions in this field are: 1) how do accretion disks around black holes launch winds/outflows, and how much energy do these carry? 2) How are the energy and metals accelerated in winds/outflows transferred and deposited into the circumgalactic medium? X-ray observations are a unique way to address these questions because they probe the phase of the outflows which carries most of the kinetic energy. We show how a high throughput, high spectral resolution instrument like the X-ray Integral Field Unit (X-IFU) on Athena+ will allow us to address these questions by determining the physical parameters (ionization state, density, temperature, abundances, velocities, geometry, etc.) of the outflows on a dynamical time-scale, in a broad sample of nearby bright AGN. The X-IFU will also allow direct spectral imaging of the impact of these winds on the host galaxy for local AGN, forming a template for understanding AGN at higher redshifts where wind shocks cannot be resolved.Comment: Supporting paper for the science theme "The Hot and Energetic Universe" to be implemented by the Athena+ X-ray observatory (http://www.the-athena-x-ray-observatory.eu). 10 pages, 6 figure

Recovery-focused cognitive-behavioural therapy for recent-onset bipolar disorder:randomised controlled pilot trial

Background Despite evidence for the effectiveness of structured psychological therapies for bipolar disorder no psychological interventions have been specifically designed to enhance personal recovery for individuals with recent-onset bipolar disorder. Aims A pilot study to assess the feasibility and effectiveness of a new intervention, recovery-focused cognitive-behavioural therapy (CBT), designed in collaboration with individuals with recent-onset bipolar disorder intended to improve clinical and personal recovery outcomes. Method A single, blind randomised controlled trial compared treatment as usual (TAU) with recovery-focused CBT plus TAU (n = 67). Results Recruitment and follow-up rates within 10% of pre-planned targets to 12-month follow-up were achieved. An average of 14.15 h (s.d. = 4.21) of recovery-focused CBT were attended out of a potential maximum of 18 h. Compared with TAU, recovery-focused CBT significantly improved personal recovery up to 12-month follow-up (Bipolar Recovery Questionnaire mean score 310.87, 95% CI 75.00-546.74 (s.e. = 120.34), P = 0.010, d = 0.62) and increased time to any mood relapse during up to 15 months follow-up (χ(2) = 7.64, P<0.006, estimated hazard ratio (HR) = 0.38, 95% CI 0.18-0.78). Groups did not differ with respect to medication adherence. Conclusions Recovery-focused CBT seems promising with respect to feasibility and potential clinical effectiveness. Clinical- and cost-effectiveness now need to be reliably estimated in a definitive trial

The broad-band X-ray spectrum of the Seyfert 1 galaxy, MCG+8-11-11

We present a long (100 ks) Suzaku observation of one of the X-ray brightest AGN, MCG+8-11-11. These data were complemented with the 54-month Swift BAT spectrum, allowing us to perform a broad-band fit in the 0.6-150 keV range. The fits performed in the 0.6-10 keV band give consistent results with respect to a previous XMM-Newton observation, i.e. the lack of a soft excess, warm absorption along the line of sight, a large Compton reflection component (R~1) and the absence of a relativistic component of the neutral iron K$\alpha$ emission line. However, when the PIN and Swift BAT data are included, the reflection amount drops significantly (R~0.2-0.3), and a relativistic iron line is required, the latter confirmed by a phenomenological analysis in a restricted energy band (3-10 keV). When a self-consistent model is applied to the whole broadband data, the observed reflection component appears to be all associated to the relativistic component of the iron K$\alpha$ line. The resulting scenario, though strongly model-dependent, requires that all the reprocessing spectral components from Compton-thick material must be associated to the accretion disc, and no evidence for the classical pc-scale torus is found. The narrow core of the neutral iron K$\alpha$ line is therefore produced in a Compton-thin material, like the BLR, similarly to what found in another Seyfert galaxy, NGC7213, but with the notable difference that MCG+8-11-11 presents spectral signatures from an accretion disc. The very low accretion rate of NGC7213 could explain the lack of relativistic signatures in its spectrum, but the absence of the torus in both sources is more difficult to explain, since their luminosities are comparable, and their accretion rates are completely different.Comment: 8 pages, 6 figure, accepted for publication in Astronomy and Astrophysic

Ice XII in its second regime of metastability

We present neutron powder diffraction results which give unambiguous evidence for the formation of the recently identified new crystalline ice phase[Lobban et al.,Nature, 391, 268, (1998)], labeled ice XII, at completely different conditions. Ice XII is produced here by compressing hexagonal ice I_h at T = 77, 100, 140 and 160 K up to 1.8 GPa. It can be maintained at ambient pressure in the temperature range 1.5 < T < 135 K. High resolution diffraction is carried out at T = 1.5 K and ambient pressure on ice XII and accurate structural properties are obtained from Rietveld refinement. At T = 140 and 160 K additionally ice III/IX is formed. The increasing amount of ice III/IX with increasing temperature gives an upper limit of T ~ 150 K for the successful formation of ice XII with the presented procedure.Comment: 3 Pages of RevTeX, 3 tables, 3 figures (submitted to Physical Review Letters

NGC454: unveiling a new "changing look" AGN

We present a detailed analysis of the X-ray spectrum of the Seyfert 2 galaxy NGC454E, belonging to the interacting system NGC454. Observations performed with Suzaku, XMM-Newton and Swift allowed us to detect a dramatic change in the curvature of the 2-10 keV spectrum, revealing a significant variation of the absorbing column density along the line of sight (from ~ 1 x10^{24}cm^{-2} to ~ 1x10^{23}cm^{-2}). Consequently, we propose this source as a new member of the class of "changing look" AGN, i.e. AGN that have been observed both in Compton-thin (NH =10^{23 cm^{-2}) and reflection dominated states (Compton-thick, NH >10^{24} cm^{-2}). Due to the quite long time lag (6 months) between the Suzaku and XMM-Newton observations we cannot infer the possible location of the obscuring material causing the observed variability. In the 6-7 keV range the XMM-Newton observation also shows a clear signature of the presence of an ionized absorber. Since this feature is not detected during the Suzaku observation (despite its detectability), the simplest interpretation is that the ionized absorber is also variable; its location is estimated to be within ~10^{-3} pc from the central black hole, probably much closer in than the rather neutral absorber.Comment: 10 page