201 research outputs found
Intercalation events visualized in single microcrystals of graphite.
The electrochemical intercalation of layered materials, particularly graphite, is fundamental to the operation of rechargeable energy-storage devices such as the lithium-ion battery and the carbon-enhanced lead-acid battery. Intercalation is thought to proceed in discrete stages, where each stage represents a specific structure and stoichiometry of the intercalant relative to the host. However, the three-dimensional structures of the stages between unintercalated and fully intercalated are not known, and the dynamics of the transitions between stages are not understood. Using optical and scanning transmission electron microscopy, we video the intercalation of single microcrystals of graphite in concentrated sulfuric acid. Here we find that intercalation charge transfer proceeds through highly variable current pulses that, although directly associated with structural changes, do not match the expectations of the classical theories. Evidently random nanoscopic defects dominate the dynamics of intercalation
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Electron beam-induced current imaging with two-angstrom resolution.
An electron microscope's primary beam simultaneously ejects secondary electrons (SEs) from the sample and generates electron beam-induced currents (EBICs) in the sample. Both signals can be captured and digitized to produce images. The off-sample Everhart-Thornley detectors that are common in scanning electron microscopes (SEMs) can detect SEs with low noise and high bandwidth. However, the transimpedance amplifiers appropriate for detecting EBICs do not have such good performance, which makes accessing the benefits of EBIC imaging at high-resolution relatively more challenging. Here we report lattice-resolution imaging via detection of the EBIC produced by SE emission (SEEBIC). We use an aberration-corrected scanning transmission electron microscope (STEM), and image both microfabricated devices and standard calibration grids
A SQL front-end semantic data model
SQLSDM is a front end semantic data model to a SQL relational database management system (RDBMS). SQLSDM provides a more semantically complete RDBMS through the implementation of a Domain and Relational Integrity scheme. SQLSDM provides integrity definition functions and a sub-system to interpret SQL commands . Integrity system tables are created through the use of SQLSDM \u27 s domain definition command and SQL \u27 s CREATE TABLE command. As SQL database update commands are interpreted, SQLSDM uses these integrity tables to enforce domain and referential integrity. SQLSDM operates virtually transparent to the user and provides for greater database consistency and semantic control. Furthermore, SQLSDM is designed and engineered to be a portable front-end that may be implemented on any SQL relational database management system
Trait anxiety: a hidden variable in physiological and pathological processes
Nell\u2019uomo esiste una differenza nella risposta agli stimoli stressogeni, che dipende dalla personale predisposizione all\u2019ansia, detta specificatamente \u201ctratto d\u2019ansia\u201d. La differente suscettibilit\ue0 all\u2019ansia \ue8 stata studiata nei roditori creando ceppi selezionati per tratti di elevata e bassa ansia; inoltre \ue8 stato dimostrato, sia nell\u2019uomo che nei ceppi selezionati di roditori, che differenti livelli di ansia basale influenzano la capacit\ue0 dei soggetti di attuare un determinato compito, anche cognitivo. Tuttavia la suscettibilit\ue0 individuale, all\u2019interno di uno stesso ceppo di ratti na\uefve, \ue8 ancora poco studiata. Lo scopo di questo studio quindi \ue8 stato quello di valutare le possibili differenze interindividuali nel livello d\u2019ansia, all\u2019interno di una popolazione di ratti appartenenti al ceppo Wistar, e di fornire indicazioni su come uno specifico tratto d\u2019ansia possa influenzare una successiva performance cognitiva, valutata mediante un test cognitivo ampiamente utilizzato, il Novel Object Recognition (NOR) test.
Seguendo questa linea di ricerca poi, abbiamo voluto indagare se il tratto di ansia potesse influenzare la suscettibilit\ue0 del ceppo di topo C57Bl/6J all\u2019insorgenza dell\u2019 epilessia, e se l\u2019esposizione ad un fattore fortemente stressogeno per il topo, l\u2019odore di un suo predatore, potesse provocare un aggravamento della malattia durante la fase cronica.
Questo lavoro di tesi mostra come esista una variabilit\ue0 interindividuale all\u2019interno di una popolazione di roditori per quanto riguarda l\u2019ansia di tratto, cio\ue8 la componente basale di ansia insita in ogni individuo. Questo fattore pu\uf2 influenzare la risposta ad alcuni compiti a cui l\u2019animale deve rispondere, come ad esempio quelli cognitivi. Il tratto d\u2019ansia basale potrebbe anche influenzare la predisposizione all\u2019insorgenza di una determinata malattia, oppure il decorso della malattia stessa. E\u2019 perci\uf2 molto importante considerare il tratto d\u2019ansia basale di ciascun soggetto sperimentale in tutti gli studi che prevedano una componente comportamentale, includendo tale dato come fattore covariato nelle analisi statistiche, cos\uec da evitare errori dovuti a questa variabile nascosta.Human subjects display a great variability in the predisposition to respond anxiogenically to stimuli, i.e. trait anxiety. This susceptibility has been studied in rodents through the creation of selected strains for anxiety-like behaviour, to obtain extreme anxiety traits. Moreover, anxiety has been shown to variously affect physiological processes, such as a cognitive task performance, both in humans and selected rodents strains. However, interindividual differences in basal anxiety level in na\uefve rats and how they may affect cognitive functioning have been poorly investigated. Therefore, the aim of this study is to provide an evidence of the huge interindividual differences in anxiety levels in a population of na\uefve Wistar rats and demonstrate how they can affect a widely used cognitive test, the Novel Object Recognition (NOR) test.
Following this line of research, in this study we also investigate if trait anxiety could affect pathological processes, such as the susceptibility on the onset of a neurological disease, the temporal lobe epilepsy, in a population of C57Bl/6J mice. Finally, we evaluate if the exposure to a strong stressful factor for mice, such as a predator odor, could induce an increase of the pathological process in chronic phase of the illness, for example in the number of seizures, in the same epileptic animals.
These results could show the relevance to consider trait anxiety, the propension to response in a manner more or less anxious to a specific stimulus, of each subject, in order to avoid interpretative errors during the evaluation of a specific behaviour shown by the subject.
Therefore we claim the need to consider interindividual differences in emotionality (e.g. anxiety) in general, and the need to assess anxiety level while studying rats cognitive abilities. It will be possible to include it as a covariate in the statistical analysis, in studies that schedule behavioural factors, in order to avoid interpretative errors dued to this hidden variable
Publisher Correction: Intercalation events visualized in single microcrystals of graphite.
The Peer Review File associated with this Article was updated shortly after publication to redact confidential comments to the editor
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Irreversibility at macromolecular scales in the flake graphite of the lithium-ion battery anode.
Charging a commercial lithium-ion battery intercalates lithium into the graphite-based anode, creating various lithium carbide structures. Despite their economic importance, these structures and the dynamics of their charging-discharging transitions are not well-understood. We have videoed single microcrystals of high-quality, natural graphite undergoing multiple lithiation-delithiation cycles. Because the equilibrium lithium-carbide compounds corresponding to full, half, and one-third charge are gold, red, and blue respectively, video observations give direct insight into both the macromolecular structures and the kinematics of charging and discharging. We find that the transport during the first lithiation is slow and orderly, and follows the core-shell or shrinking annuli model with phase boundaries moving at constant velocities (i.e. non-diffusively). Subsequent lithiations are markedly different, showing transport that is both faster and disorderly, which indicates that the initially pristine graphite is irreversibly and considerably altered during the first cycle. In all cases deintercalation is not the time-reverse of intercalation. These findings both illustrate how lithium enters nearly defect-free host material, and highlight the differences between the idealized case and an actual, cycling graphite anode
Differential electron yield imaging with STXM
Total electron yield (TEY) imaging is an established scanning transmission
X-ray microscopy (STXM) technique that gives varying contrast based on a
sample's geometry, elemental composition, and electrical conductivity. However,
the TEY-STXM signal is determined solely by the electrons that the beam ejects
from the sample. A related technique, X-ray beam-induced current (XBIC)
imaging, is sensitive to electrons and holes independently, but requires
electric fields in the sample. Here we report that multi-electrode devices can
be wired to produce differential electron yield (DEY) contrast, which is also
independently sensitive to electrons and holes, but does not require an
electric field. Depending on whether the region illuminated by the focused STXM
beam is better connected to one electrode or another, the DEY-STXM contrast
changes sign. DEY-STXM images thus provide a vivid map of a device's
connectivity landscape, which can be key to understanding device function and
failure. To demonstrate an application in the area of failure analysis, we
image a 100~nm, lithographically-defined aluminum nanowire that has failed
after being stressed with a large current density.Comment: 8 pages, 6 figure
In situ coherent diffractive imaging
Coherent diffractive imaging (CDI) has been widely applied in the physical
and biological sciences using synchrotron radiation, XFELs, high harmonic
generation, electrons and optical lasers. One of CDI's important applications
is to probe dynamic phenomena with high spatio-temporal resolution. Here, we
report the development of a general in situ CDI method for real-time imaging of
dynamic processes in solution. By introducing a time-invariant overlapping
region as a real-space constraint, we show that in situ CDI can simultaneously
reconstruct a time series of the complex exit wave of dynamic processes with
robust and fast convergence. We validate this method using numerical
simulations with coherent X-rays and performing experiments on a materials
science and a biological specimen in solution with an optical laser. Our
numerical simulations further indicate that in situ CDI can potentially reduce
the radiation dose by more than an order of magnitude relative to conventional
CDI. As coherent X-rays are under rapid development worldwide, we expect in
situ CDI could be applied to probe dynamic phenomena ranging from
electrochemistry, structural phase transitions, charge transfer, transport,
crystal nucleation, melting and fluid dynamics to biological imaging.Comment: 19 pages, 5 figure
Enterprise placements: factors which support learning and prolonged attainment in students
This article investigates the learning and academic attainment of undergraduate education students on enterprise placement projects in a longitudinal mixed methods study. By observing the placement learning and analysing previous and subsequent attainment of a second and third year group it adds to the ontology of purpose for enterprise in education and concurs with the growing body of work identifying placements with sustained academic improvement. The qualitative investigation identifies five key learning factors from the placements which support improved academic attainment. These are: pressure to learn; critical personal learning events; seeing the setting as a learning environment; professional attachments, and having space to learn. These factors support the transfer of learning from one context or situation to another and using concepts of transformative learning (Mezirow 2000; Jones, Matlay, and Harris 2012) or transitional learning (Illeris 2007) contributes to a cycle of increasing self-esteem and motivation and a sustained improvement in academic attainment. It concludes that a praxis curriculum, using self-assessments, continuous short (micro) reflections and taught awareness of the placement as a place to look for and recognise learning, would underpin these five factors and contribute to the academic processes underpinning attainment
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