763 research outputs found
Urinary Citrate, Bone Resorption and Intestinal Alkali Absorption in Stone Formers with Fasting Hypercalciuria
Reduced citrate in urine and increased fasting excretion of calcium are abnormalities frequently reported in stone forming (SF) patients. Increased dietary acid (or reduced alkali) introduction or absorption may be a potential cause of both these pathological findings. To test this hypothesis, we studied 64 SF patients {32 with fasting hypercalciuria (FH) and 32 without FH (NFH)}. After a basal evaluation for nephrolithiasis, while on a 500 mg calcium diet, they were evaluated for: (1) daily intestinal alkali absorption (IAA), by urinary electrolyte excretion; (2) basal concentrations of PTH, calcitonin (CT) and 1,25(OH)2-VitD; (3) oral calcium load for evaluation of changes in calcium and hydroxyproline urinary excretions; (4) intestinal calcium absorption (18 patients), with double curve analysis (stable Sr as tracer); and (S) changes in citrate excretion after an alkali load (50 mEq of a mixture of calcium gluconate, lactate and carbonate) in 10 patients.
The results demonstrated: (1) FH stone formers had reduced citrate excretion and lower mean IAA levels than NFH stone formers; (2) FH stone formers also had higher bone resorption levels with lower PTH and higher CT levels; (3) IAA levels were related to both citrate excretion and bone turnover indices; and (4) the increases in citrate excretion after oral alkali load were strictly related to basal IAA values (index of alkali absorption and/or generation after oral load), demonstrating that a different absorptive capacity of alkali rather than a different dietary content may underlie these metabolic abnormalities
Josephson Traveling Wave Parametric Amplifiers as non-classical light source for Microwave Quantum Illumination
Detection of low-reflectivity objects can be enriched via the so-called quantum illumination procedure. In order that this quantum procedure outperforms classical detection protocols, entangled states of microwave radiation are initially required. In this paper, we discuss the role of Josephson Traveling Wave Parametric Amplifiers (JTWPAs), based on circuit-QED components, as suitable sources of a two-mode squeezed vacuum state, a special signal-idler entangled state. The obtained wide bandwidth makes the JTWPA an ideal candidate for generating quantum radiation in quantum metrology and information processing applications
First Results from the TOTEM Experiment
The first physics results from the TOTEM experiment are here reported,
concerning the measurements of the total, differential elastic, elastic and
inelastic pp cross-section at the LHC energy of = 7 TeV, obtained
using the luminosity measurement from CMS. A preliminary measurement of the
forward charged particle distribution is also shown.Comment: Conference Proceeding. MPI@LHC 2010: 2nd International Workshop on
Multiple Partonic Interactions at the LHC. Glasgow (UK), 29th of November to
the 3rd of December 201
Double diffractive cross-section measurement in the forward region at LHC
The first double diffractive cross-section measurement in the very forward
region has been carried out by the TOTEM experiment at the LHC with
center-of-mass energy of sqrt(s)=7 TeV. By utilizing the very forward TOTEM
tracking detectors T1 and T2, which extend up to |eta|=6.5, a clean sample of
double diffractive pp events was extracted. From these events, we measured the
cross-section sigma_DD =(116 +- 25) mub for events where both diffractive
systems have 4.7 <|eta|_min < 6.5 .Comment: 5 pages, 1 figure, submitted for publicatio
Performance of the TOTEM Detectors at the LHC
The TOTEM Experiment is designed to measure the total proton-proton
cross-section with the luminosity-independent method and to study elastic and
diffractive pp scattering at the LHC. To achieve optimum forward coverage for
charged particles emitted by the pp collisions in the interaction point IP5,
two tracking telescopes, T1 and T2, are installed on each side of the IP in the
pseudorapidity region 3.1 < = |eta | < = 6.5, and special movable beam-pipe
insertions - called Roman Pots (RP) - are placed at distances of +- 147 m and
+- 220 m from IP5. This article describes in detail the working of the TOTEM
detector to produce physics results in the first three years of operation and
data taking at the LHC.Comment: 40 pages, 31 figures, submitted to Int. J. Mod. Phys.
Elastic Scattering and Total Cross-Section in p+p reactions measured by the LHC Experiment TOTEM at sqrt(s) = 7 TeV
Proton-proton elastic scattering has been measured by the TOTEM experiment at
the CERN Large Hadron Collider at TeV in special runs with the
Roman Pot detectors placed as close to the outgoing beam as seven times the
transverse beam size. The differential cross-section measurements are reported
in the |t|-range of 0.36 to 2.5 GeV^2. Extending the range of data to low t
values from 0.02 to 0.33 GeV^2,and utilizing the luminosity measurements of
CMS, the total proton-proton cross section at sqrt(s) = 7 TeV is measured to be
(98.3 +- 0.2(stat) +- 2.8(syst)) mb.Comment: Proceedings of the XLI International Symposium on Multiparticle
Dynamics. Accepted for publication in Prog. Theor. Phy
Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study
Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep. The release of endogenous adenosine during the sleep-wake cycle has mainly been studied in vivo with microdialysis techniques. The biochemical changes that accompany sleep-wake status may be preserved in vitro. We have therefore used adenosine-sensitive biosensors in slices of the basal forebrain (BFB) to study both depolarization-evoked adenosine release and the steady state adenosine tone in rats, mice and hamsters. Adenosine release was evoked by high K+, AMPA, NMDA and mGlu receptor agonists, but not by other transmitters associated with wakefulness such as orexin, histamine or neurotensin. Evoked and basal adenosine release in the BFB in vitro exhibited three key features: the magnitude of each varied systematically with the diurnal time at which the animal was sacrificed; sleep deprivation prior to sacrifice greatly increased both evoked adenosine release and the basal tone; and the enhancement of evoked adenosine release and basal tone resulting from sleep deprivation was reversed by the inducible nitric oxide synthase (iNOS) inhibitor, 1400 W. These data indicate that characteristics of adenosine release recorded in the BFB in vitro reflect those that have been linked in vivo to the homeostatic control of sleep. Our results provide methodologically independent support for a key role for induction of iNOS as a trigger for enhanced adenosine release following sleep deprivation and suggest that this induction may constitute a biochemical memory of this state
Proton-proton elastic scattering at the LHC energy of {\surd} = 7 TeV
Proton-proton elastic scattering has been measured by the TOTEM experiment at
the CERN Large Hadron Collider at {\surd}s = 7 TeV in dedicated runs with the
Roman Pot detectors placed as close as seven times the transverse beam size
(sbeam) from the outgoing beams. After careful study of the accelerator optics
and the detector alignment, |t|, the square of four-momentum transferred in the
elastic scattering process, has been determined with an uncertainty of d t =
0.1GeV p|t|. In this letter, first results of the differential cross section
are presented covering a |t|-range from 0.36 to 2.5GeV2. The differential
cross-section in the range 0.36 < |t| < 0.47 GeV2 is described by an
exponential with a slope parameter B = (23.6{\pm}0.5stat {\pm}0.4syst)GeV-2,
followed by a significant diffractive minimum at |t| =
(0.53{\pm}0.01stat{\pm}0.01syst)GeV2. For |t|-values larger than ~ 1.5GeV2, the
cross-section exhibits a power law behaviour with an exponent of -7.8_\pm}
0.3stat{\pm}0.1syst. When compared to predictions based on the different
available models, the data show a strong discriminative power despite the small
t-range covered.Comment: 12pages, 5 figures, CERN preprin
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of
continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a
fully coherent search, based on matched filtering, which uses the position and rotational parameters
obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto-
noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch
between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have
been developed, allowing a fully coherent search for gravitational waves from known pulsars over a
fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of
11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial
outliers, further studies show no significant evidence for the presence of a gravitational wave signal.
Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of
the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for
the first time. For an additional 3 targets, the median upper limit across the search bands is below the
spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried
out so far
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