Evaluación del perfil inmunitario postrasplante autólogo de progenitores hematopoyéticos, en pacientes con mieloma múltiple en remisión completa de larga duración

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Bioquímica. Fecha de lectura: 18-01-201

Magnetic Resonance Imaging of Gliomas

Open Access.This work was supported in part by grants CTQ2010-20960-C02-02 to P.L.L. and grant SAF2008-01327 to S.C. A.M.M. held an Erasmus Fellowship from Coimbra University and E.C.C. a predoctoral CSIC contract.Peer Reviewe

Magnetic resonance imaging findings and clinical management of suspected intracranial hypovolemia following transfrontal craniotomy in a dog

Objective: To report the diagnosis and clinical management of a case of suspected intracranial hypovolemia (IH) in a dog after resection of a large fronto‐olfactory chordoid meningioma. Study design: Clinical case report. Animal: One 8‐year‐old border collie with forebrain neurological signs caused by a fronto‐olfactory extra‐axial mass diagnosed by using MRI. Methods: The dog underwent bilateral transfrontal craniotomy for excision of the mass by using ultrasonic aspiration. Immediate postsurgical MRI revealed complete gross resection with no evidence of early‐onset complications such as edema, hemorrhage, mass effect, or pneumoencephalus. However, diffuse symmetric meningeal thickening and contrast enhancement were noted. No complications were noted during surgery or while under anesthesia. Results: Neurological deterioration was observed postoperatively. No abnormalities were detected systemically. Thus, early MRI‐confirmed findings and neurological deterioration were suspected to be caused by IH. Conservative treatment consisting of bed rest, gabapentin, and intravenous theophylline was then initiated in addition to steroids, antiepileptic drugs, and antibiotics. A gradual neurological improvement was observed, and the dog was discharged completely ambulatory with moderate proprioceptive ataxia 15 days after surgery. Conclusion: The clinical and MRI‐confirmed findings reported here are consistent with IH, a well‐described syndrome in man. This is the first report of a dog with MRI‐confirmed findings consistent with IH describing subsequent response to medical management. Clinical significance: Intracranial hypovolemia after craniotomy should be considered when there is neurological deterioration and characteristic MRI‐confirmed findings

Knowledge-Based Economy in Argentina, Costa Rica and Mexico: A Comparative Analysis from the Bio-Economy Perspective

The objective of this article is to determine the necessary institutional characteristics of technology and human capital in Argentina, Costa Rica and Mexico in order to evolve towards a knowledge-based economy, addressing the importance of institutions for their development. In particular, the knowledge-based economy is analyzed from the perspective of bioeconomics. Based on the Knowledge Economy Index (KEI) which considers 148 indicators, in the following categories: a) economic performance and institutional regime; b) education and human resources, c) innovation, and d) information and communication technologies, we selected 13 indicators. We aim to identify the strengths and opportunities for these countries in order to meet the challenges that arise from the paradoxes of technological progress and globalization. In this sense, bioeconomy is approached as part of the economy. This analysis shows, among other things, that Argentina has greater potential to compete in an economy sustained in the creation and dissemination of knowledge, while Costa Rica has an institutional and regulatory environment that is more conducive to the development of business activities, and Mexico faces significant challenges regarding its institutional structure, economic performance and human resources

Comparative life cycle analysis between commercial porcelain stoneware and new ones designed by using volcanic scraps

: To achieve carbon neutrality by 2050, many companies have started implementing sustainability policies. The aim of this work, as result of collaboration between Universities and companies, is to assess the environmental impacts associated with the production of alternative formulations of porcelain stoneware. The proposed formulations contain extraction scraps and chamotte and have promising technological properties. A comparative analysis of the life cycle in three different scenarios was carried out to assess the environmental footprint of the final products. The analyzed scenarios were a glazed porcelain stoneware (which was taken as a reference and is commercially available), a porcelain stoneware containing pumice scraps, and one containing volcanic lapillus scraps. It was observed that the transportation of raw materials has the largest environmental impact, followed by the production and extraction of the raw materials themselves. From the performed analysis, it was possible to observe that by replacing the currently used materials by the ones hereby studied, environmental benefits can be obtained. In particular, depending on the considered pollutant, the environmental impact can be reduced between a minimum of about 8 % (Freshwater Aquatic Ecotoxicity category) to a maximum of 48 % (Acidification category). In a time when raw materials supply is difficult, the use of scraps, which would otherwise be disposed of, is particularly interesting and can lead to the production of an environmentally friendly product

Influence of Y2O3 on the structure of Y2O3-doped BaTiO3 powder and ceramics

Barium titanate (BaTiO3) doped with rare-earth elements (REE) is used as dielectric in the manufacture of multilayer ceramic capacitors (MLCCs). The most common REE oxide employed as dopant for this application is Y2O3. The behavior of the Y3+ in the BaTiO3 structure depends on its concentration and the sintering conditions, among other factors, which can induce the formation of secondary phases that are a potential cause a detriment to the electrical properties of BaTiO3. The purpose of this work is to perform a phase characterization of BaTiO3 doped with different concentrations of Y2O3, validating its possible contribution to the formation of secondary phases. The role of Y2O3 was evaluated on two kinds of raw materials. The first one is pure BaTiO3 (< 100 ppm Y) and the second kind is a commercial formulation designed for MLCCs known as X7R (-55°C and 125°C, 15% tolerance), which among other elements, already contained 1 wt% of Y2O3. High concentrations of Y2O3 (1% up to 20 wt%) were used aiming to promote structural changes, and even the formation of secondary phases in amounts suitable to be detected by X-ray diffraction. Heat treatment of powder and sintering of ceramics (powder compacted at 2 MPa) were conducted in air (1310°C in air for 3 h, two steps: 1350°C then 1150°C 15 h). A phase transition from tetragonal to a mixture of tetragonal and cubic was observed as Y2O3 concentration increases in the thermally treated powder and in the corresponding ceramics. Commercially formulated powder showed higher densification than pure BaTiO3, and produced cubic structure at higher Y2O3concentrations. The phase Ba6Ti17O40is detected in the 20 wt% Y2O3-doped sample