Deducing high pressure behavior for chemically fragile systems: the polymorphism of spironolactone

International audienc

Polymorphism of spironolactone: An unprecedented case of monotropy turning to enantiotropy with a huge difference in the melting temperatures

Postprint (author's final draft

Taphonomic Criteria for Identifying Iberian Lynx Dens in Quaternary Deposits

For decades, taphonomists have dedicated their efforts to assessing the nature of the massive leporid accumulations recovered at archaeological sites in the northwestern Mediterranean region. Their interest lying in the fact that the European rabbit constituted a critical part of human subsistence during the late Pleistocene and early Holocene. However, rabbits are also a key prey in the food webs of Mediterranean ecosystems and the base of the diet for several specialist predators, including the Iberian lynx (Lynx pardinus). For this reason, the origin of rabbit accumulations in northwestern Mediterranean sites has proved a veritable conundrum. Here, we present the zooarchaeological and taphonomic study of more than 3000 faunal and 140 coprolite remains recovered in layer IIIa of Cova del Gegant (Catalonia, Spain). Our analysis indicates that this layer served primarily as a den for the Iberian lynx. The lynxes modified and accumulated rabbit remains and also died at the site creating an accumulation dominated by the two taxa. However, other agents and processes, including human, intervened in the final configuration of the assemblage. Our study contributes to characterizing the Iberian lynx fossil accumulation differentiating between the faunal assemblages accumulated by lynxes and hominins

A microphysiological setup to mimic, test and analyze myocardial tissue for cardiovascular diseases

Creating cardiac tissue models for drug testing before clinical trials is still a major challenge in drug discovery. This is mainly because it is difficult to replicate the complex nature of cardiac tissue in a lab setting. One of the biggest challenges is accurately mimicking the functional features of the heart muscle. This is largely due to the immaturity of the cells used in these models, which makes it difficult to get reliable results that can be translated to human patients. Currently, in vivo models are the gold standard for evaluating new treatments. However, it is widely accepted that these animal models cannot fully reproduce human physiological responses. As a result, this mismatch often leads to failures in subsequent clinical trials. In this work, we designed two cardiac culture experiments, using GCampp6-infected cardiomyocytes, on a microfluidic chip. One of them is an aligned 2D model, and the other is a 3D tissue grown in a hydrogel of methacrylated gelatin (GelMa) and methacrylated hyaluronic acid (HaMa), the calcium traces of both were analysed at the network level, being able to obtain parameters that determine the degree of maturity and connectivity of the culture. In this way, we can ensure that we have a reproducible environment for future drug testing.We gratefully acknowledge the financial support from the Spanish Ministry of Science and Innovation (MICINN) and the Spanish State Research Agency (AEI) through grants PID2021-124575OB-I00 and PDC2022-133918- C22

Thermodynamic Structure of the Solar Corona: Tomographic Reconstructions and MHD Modeling

We carry out a study of the global three-dimensional (3D) structure of the electron density and temperature of the quiescent inner solar corona ($r<1.25 R_\odot$) by means of tomographic reconstructions and magnetohydrodynamic simulations. We use differential emission measure tomography (DEMT) and the Alfv\'en Wave Solar Model (AWSoM), in their latest versions. Two target rotations were selected from the solar minimum between solar cycles (SCs) 23 and 24 and the declining phase of SC 24. We report in quantitative detail on the 3D thermodynamic structure of the core and outer layers of the streamer belt, and of the high latitude coronal holes (CH), as revealed by the DEMT analysis. We report on the presence of two types of structures within the streamer belt, loops with temperature decreasing/increasing with height (dubbed down/up loops), as reported first in previous DEMT studies. We also estimate the heating energy flux required at the coronal base to keep these structures stable, found to be or order $10^5 erg\, cm^{-2} s^{-1}$, consistently with previous DEMT and spectroscopic studies. We discuss how these findings are consistent with coronal dissipation of Alfv\'en waves. We compare the 3D results of DEMT and AWSoM in distinct magnetic structures. We show that the agreement between the products of both techniques is the best so far, with an overall agreement $\lesssim 20\%$, depending on the target rotation and the specific coronal region. In its current implementation the ASWsoM model can not reproduce down loops though. Also, in the source region of the fast and slow components of the solar wind, the electron density of the AWSoM model increases with latitude, opposite to the trend observed in DEMT reconstructions

SP-0489: HPV-transformation in the cervix and at non-cervical sites

Pla general d'un dels panells horitzontals sobre espais verds de Barcelona a l'exposició Ciutat. Barcelona projecta a l'Edifici Fòrum. Exposició sobre la planificació urbanística i arquitectònica de Barcelon

Elastocaloric, barocaloric and magnetocaloric effects in spin crossover polymer composite films

Giant barocaloric effects were recently reported for spin-crossover materials. The volume change in these materials suggests that the transition can be influenced by uniaxial stress, and give rise to giant elastocaloric properties. However, no measurements of the elastocaloric properties in these compounds have been reported so far. Here, we demonstrated the existence of elastocaloric effects associated with the spin-crossover transition. We dissolved particles of ([Fe(L)2](BF4)2, [L=2,6di(pyrazol-1-yl)pyridine]) into a polymeric matrix. We showed that the application of tensile uniaxial stress to a composite film resulted in a significant elastocaloric effect. The elastocaloric effect in this compound required lower applied stress than for other prototype elastocaloric materials. Additionally, this phenomenon occurred for low values of strain, leading to coefficient of performance of the material being one order of magnitude larger than that of other elastocaloric materials. We believe that spin-crossover materials are a good alternative to be implemented in eco-friendly refrigerators based on elastocaloric effects

Barocaloric properties of quaternary Mn3(Zn,In)N for room-temperature refrigeration applications

The magnetically frustrated manganese nitride antiperovskite family displays significant changes of entropy under hydrostatic pressure that can be useful for the emerging field of barocaloric cooling. Here we show that barocaloric properties of metallic antiperovskite Mn nitrides can be tailored for room-temperature application through quaternary alloying. We find an enhanced entropy change of |¿St|=37JK-1kg-1 at the Tt=300K antiferromagnetic transition of quaternary Mn3Zn0.5In0.5N relative to the ternary end members. The pressure-driven barocaloric entropy change of Mn3Zn0.5In0.5N reaches |¿SBCE|=20JK-1kg-1 in 2.9 kbar. Our results open up a large phase space where compounds with improved barocaloric properties may be found.Peer ReviewedPostprint (author's final draft