1,060 research outputs found
Particulate matter exposure and attention-deficit/hyperactivity disorder in children: A systematic review of epidemiological studies
Surface magnetism in ZnO/Co3O4 mixtures
We recently reported the observation of room temperature ferromagnetism in
mixtures of ZnO and Co3O4 despite the diamagnetic and antiferromagnetic
character of these oxides respectively. Here we present a detailed study on the
electronic structure of this material in order to account for this unexpected
ferromagnetism. Electrostatic interactions between both oxides lead to a
dispersion of Co3O4 particles over the surface of ZnO larger ones. As a
consequence, the reduction of Co+3 to Co2+ at the particle surface takes place
as evidenced by XAS measurements and optical spectrocopy. This reduction allows
to xplain the observed ferromagnetic signal within the well established
theories of magnetism.Comment: Accepted in Journal of Applied Physic
Wide-Field Multi-Parameter FLIM: Long-Term Minimal Invasive Observation of Proteins in Living Cells.
Time-domain Fluorescence Lifetime Imaging Microscopy (FLIM) is a remarkable tool to monitor the dynamics of fluorophore-tagged protein domains inside living cells. We propose a Wide-Field Multi-Parameter FLIM method (WFMP-FLIM) aimed to monitor continuously living cells under minimum light intensity at a given illumination energy dose. A powerful data analysis technique applied to the WFMP-FLIM data sets allows to optimize the estimation accuracy of physical parameters at very low fluorescence signal levels approaching the lower bound theoretical limit. We demonstrate the efficiency of WFMP-FLIM by presenting two independent and relevant long-term experiments in cell biology: 1) FRET analysis of simultaneously recorded donor and acceptor fluorescence in living HeLa cells and 2) tracking of mitochondrial transport combined with fluorescence lifetime analysis in neuronal processes
When are active Brownian particles and run-and-tumble particles equivalent? Consequences for motility-induced phase separation
Active Brownian particles (ABPs, such as self-phoretic colloids) swim at
fixed speed along a body-axis that rotates by slow angular
diffusion. Run-and-tumble particles (RTPs, such as motile bacteria) swim with
constant \u until a random tumble event suddenly decorrelates the
orientation. We show that when the motility parameters depend on density
but not on , the coarse-grained fluctuating hydrodynamics of
interacting ABPs and RTPs can be mapped onto each other and are thus strictly
equivalent. In both cases, a steeply enough decreasing causes phase
separation in dimensions , even when no attractive forces act between
the particles. This points to a generic role for motility-induced phase
separation in active matter. However, we show that the ABP/RTP equivalence does
not automatically extend to the more general case of \u-dependent motilities
Room-temperature ferromagnetism in the mixtures of the TiO₂ and Co₃O₄ powders
We report here the observation of ferromagnetism (FM) at 300 K in mixtures of TiO₂ and Co₃O₄ powders despite the antiferromagnetic and diamagnetic characters of both oxides, respectively. The ferromagnetic behavior is found in the early stages of reaction and only for TiO₂ in anatase structure; no FM is found for identical samples prepared with rutile-TiO². Optical spectroscopy and x-ray absorption spectra confirm a surface reduction of octahedral Co^(+3) -> Co^(+2) in the mixtures which is in the origin of the observed magnetism
Material-driven fibronectin assembly for high-efficiency presentation of growth factors
Growth factors (GFs) are powerful signaling molecules with the potential to drive regenerative strategies, including bone repair and vascularization. However, GFs are typically delivered in soluble format at supraphysiological doses because of rapid clearance and limited therapeutic impact. These high doses have serious side effects and are expensive. Although it is well established that GF interactions with extracellular matrix proteins such as fibronectin control GF presentation and activity, a translation-ready approach to unlocking GF potential has not been realized. We demonstrate a simple, robust, and controlled material-based approach to enhance the activity of GFs during tissue healing. The underlying mechanism is based on spontaneous fibrillar organization of fibronectin driven by adsorption onto the polymer poly(ethyl acrylate). Fibrillar fibronectin on this polymer, but not a globular conformation obtained on control polymers, promotes synergistic presentation of integrin-binding sites and bound bone morphogenetic protein 2 (BMP-2), which enhances mesenchymal stem cell osteogenesis in vitro and drives full regeneration of a nonhealing bone defect in vivo at low GF concentrations. This simple and translatable technology could unlock the full regenerative potential of GF therapies while improving safety and cost-effectiveness
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