22 research outputs found
TANF: The Past, the Present, and the Future of Ending Welfare As We Know It?
These slides are from our 2016 national conference, A Nation That Works: What's It Going to Take? The Temporary Assistance for Needy Families (TANF) program has been one of the most studied, evaluated, and debated pieces of American public policy of the last 20 years. TANF has raised important questions and concerns about the role of the safety net in the lives of poor, single female heads of household. On a national scale, and in localities across the country, program designers, implementers, advocates, researchers, and thought leaders have been at odds with the program's multiple—and often times conflicting—goals. Participants are invited to join a discussion session that takes a look back at the last twenty years of TANF implementation and what we have learned, what is happening now, and what advocates and others are thinking about the future of safety net policy and supporting pathways to work and opportunity for low-income female heads of household
Predictors for a dementia gene mutation based on gene-panel next-generation sequencing of a large dementia referral series
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Collins and Sivers asymmetries in muonproduction of pions and kaons off transversely polarised protons
Measurements of the Collins and Sivers asymmetries for charged pions and charged and neutral kaons produced in semi-inclusive deep-inelastic scattering of high energy muons off transversely polarised protons are presented. The results were obtained using all the available COMPASS proton data, which were taken in the years 2007 and 2010. The Collins asymmetries exhibit in the valence region a non-zero signal for pions and there are hints of non-zero signal also for kaons. The Sivers asymmetries are found to be positive for positive pions and kaons and compatible with zero otherwise. © 2015