Exile Vol. XXXIII No. 2

POETRY Seams by Jennie Dawes 7 The Milky Blue Water by Mark Livengood 8-9 Patchwork by Mark Livengood 10 Belle Epoque by Karen J. Hall 21 Ballad by Zachary Smith 22-23 My Grandmother\u27s House by Karen J. Hall 24 Ghost by Jennie Dawes 27 What\u27s for Dessert? by Jennifer H. Miller 28 Dreams by Kent Lambert 31 Postmarked Fort Hill by Jennifer H. Miller 32 FICTION A Fostoria Tale by Debra Benko 13-18 The Pile by Jeff Montgomery 35-40 ARTWORK untitled by Lauren Kronish (cover) Standing by Heidi Rubin 3 Home, Part I by Heidi Rubin 4 Untitled by Dan Kirk 19 Infra-red (untitled) by Woody Woodroof 26 Florence, Italy (untitled) by Eliza Brown 29 Mwanafunzi by David Bloch 33 Joshua Tree by Susan McLain 41 CONTRIBUTOR\u27S NOTES 43 Editors share equally all editorial decisions. -2 NOTE: the artwork Home, Part I by Heidi Rubin does not appear to have been published, although it is listed in the table of contents for this issue and so is included here

Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation.

BACKGROUND: Herd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population. METHODS: Carried meningococci in individuals aged 15-19 years attending education establishments were investigated before and for 2 years after vaccine introduction. Isolates were characterized by multilocus sequence typing, serogroup, and capsular region genotype and changes in phenotypes and genotypes assessed. RESULTS: A total of 8462 meningococci were isolated from 47 765 participants (17.7%). Serogroup prevalence was similar over the 3 years, except for decreases of 80% for serogroup C and 40% for serogroup 29E. Clonal complexes were associated with particular serogroups and their relative proportions fluctuated, with 12 statistically significant changes (6 up, 6 down). The reduction of ST-11 complex serogroup C meningococci was probably due to vaccine introduction. Reasons for a decrease in serogroup 29E ST-254 meningococci (from 1.8% to 0.7%) and an increase in serogroup B ST-213 complex meningococci (from 6.7% to 10.6%) were less clear. CONCLUSIONS: Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine introduction

Low Prevalence of Chlamydia trachomatis Infection in Non-Urban Pregnant Women in Vellore, S. India

Objective: To determine the prevalence and risk factors for Chlamydia trachomatis (CT) infection in pregnant women and the rate of transmission of CT to infants. Methods: Pregnant women ($28 weeks gestation) in Vellore, South India were approached for enrollment from April 2009 to January 2010. After informed consent was obtained, women completed a socio-demographic, prenatal, and sexual history questionnaire. Endocervical samples collected at delivery were examined for CT by a rapid enzyme test and nucleic acid amplification test (NAAT). Neonatal nasopharyngeal and conjunctival swabs were collected for NAAT testing. Results: Overall, 1198 women were enrolled and 799 (67%) endocervical samples were collected at birth. Analyses were completed on 784 participants with available rapid and NAAT results. The mean age of women was 25.8 years (range 18– 39 yrs) and 22 % (95 % CI: 19.7–24.4%) were primigravida. All women enrolled were married; one reported.one sexual partner; and six reported prior STI. We found 71 positive rapid CT tests and 1/784 (0.1%; 95 % CI: 0–0.38%) true positive CT infection using NAAT. Conclusions: To our knowledge, this is the largest study on CT prevalence amongst healthy pregnant mothers in southern India, and it documents a very low prevalence with NAAT. Many false positive results were noted using the rapid test. Thes

Role of fault attributions and desire/effort/outcome expectations in children’s anticipated responses to hypothetical peers with various undesirable characteristics

A total of 137 third- through eighth-grade students were asked to respond to a series of statements concerning six male peers described as having various undesirable characteristics (i.e., poor student, poor athlete, extremely overweight, extremely aggressive, extremely shy, or having the symptoms of ADHD). The aggressive peer and the overweight peer consistently elicited the least favorable reactions from the children. For all six peers included in the study, the more strongly the children agreed that a peer was at fault for his undesirable characteristic, the less favorably they anticipated responding to that peer. In contrast, the children’s expectations concerning a peer’s desire to change, effort to change, and success in changing an undesirable characteristic were generally unrelated to their anticipated responses to that peer. The children demonstrated the general belief that desire backed by effort leads to success in overcoming an undesirable characteristic, but lack of effort leads to failure regardless of the peer’s desire or lack of desire to change the characteristic

Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models

Chikungunya virus (CHIKV) is a reemerging arbovirus capable of causing explosive outbreaks of febrile illness, polyarthritis, and polyarthralgia, inflicting severe morbidity on affected populations. CHIKV can be genetically classified into 3 major lineages: West African (WA); East, Central, and South African (ECSA); Indian Ocean (IOL); and Asian. Additionally, the Indian Ocean (IOL) sublineage emerged within the ECSA clade and the Asian/American sublineage emerged within the Asian clade. While differences in epidemiological and pathological characteristics among outbreaks involving different CHIKV lineages and sublineages have been suggested, few targeted investigations comparing lineage virulence levels have been reported. We compared the virulence levels of CHIKV isolates representing all major lineages and sublineages in the type I interferon receptor-knockout A129 mouse model and found lineage-specific differences in virulence. We also evaluated the cross-protective efficacy of the IOL-derived, live-attenuated vaccine strain CHIKV/IRESv1 against the Asian/American CHIKV isolate YO123223 in both murine and nonhuman primate models, as well as the WA strain SH2830 in a murine model. The CHIKV/IRES vaccine provided protection both in mice and in nonhuman primate cohorts against Caribbean strain challenge and protected mice against WA challenge. Taken together, our data suggest that Asian/American CHIKV strains are less virulent than those in the Asian, ECSA, and WA lineages and that despite differences in virulence, IOL-based vaccine strains offer robust cross-protection against strains from other lineages. Further research is needed to elucidate the genetic basis for variation in CHIKV virulence in the A129 mouse model and to corroborate this variation with human pathogenicity