Theory of the Jamming Transition at Finite Temperature

A theory for the microscopic structure and the vibrational properties of soft sphere glass at finite temperature is presented. With an effective potential, derived here, the phase diagram and vibrational properties are worked out around the Maxwell critical point at zero temperature $T$ and pressure $p$. Variational arguments and effective medium theory identically predict a non-trivial temperature scale $T^*\sim p^{(2-a)/(1-a)}$ with $a \approx 0.17$ such that low-energy vibrational properties are hard-sphere like for $T \gtrsim T^*$, and zero-temperature soft-sphere like otherwise. However, due to crossovers in the equation of state relating $T$, $p$, and the packing fraction $\phi$, these two regimes lead to four regions where scaling behaviors differ when expressed in terms of $T$ and $\phi$. Scaling predictions are presented for the mean-squared displacement, characteristic frequency, shear modulus, and characteristic elastic length in all regions of the phase diagram.Comment: 8 pages + 3 pages S

Supercritical super-Brownian motion with a general branching mechanism and travelling waves

We consider the classical problem of existence, uniqueness and asymptotics of monotone solutions to the travelling wave equation associated to the parabolic semi-group equation of a super-Brownian motion with a general branching mechanism. Whilst we are strongly guided by the probabilistic reasoning of Kyprianou (2004) for branching Brownian motion, the current paper offers a number of new insights. Our analysis incorporates the role of Seneta-Heyde norming which, in the current setting, draws on classical work of Grey (1974). We give a pathwise explanation of Evans' immortal particle picture (the spine decomposition) which uses the Dynkin-Kuznetsov N-measure as a key ingredient. Moreover, in the spirit of Neveu's stopping lines we make repeated use of Dynkin's exit measures. Additional complications arise from the general nature of the branching mechanism. As a consequence of the analysis we also offer an exact X(log X)^2 moment dichotomy for the almost sure convergence of the so-called derivative martingale at its critical parameter to a non-trivial limit. This differs to the case of branching Brownian motion and branching random walk where a moment `gap' appears in the necessary and sufficient conditions.Comment: 34 page

Packet equalisation in PONs using adjustable gain-clamped semiconductor optical amplifiers (AGC-SOA)

The past ten years have witnessed a dramatic growth in the delivery of high bandwidth services through Passive Optical Networks (PONs), directly to the home or to the kerb. The bursty nature of upstream traffic in a PON (from the user to Optical Network Unit, ONU) combined with a wide dynamic range of signal strength (-15dB to -28dB the difference between a very close Optical Network Terminal (ONT) with a small split ratio and a distant ONT with a high split ratio), places severe demands on the burst mode receiver at the ONU. We report here on an adjustable gain-clamped semiconductor optical amplifier (AGC-SOA) designed to maximize the output saturated power while adjusting gain to regulate the power differences between packets without loss of linearity. This device is shown to be able to modulate gain at rates that are compatible with packet to packet equalisation. Through theoretical analysis coupled with experimental verification, this paper demonstrates for the first time that this is entirely feasible

Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression.

BackgroundNovel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models.MethodsLevels of total and phosphorylated MEK and extracellular signal-regulated kinase (ERK) were examined in primary neuroblastoma tumor samples and in neuroblastoma cell lines by Western blot. A panel of established neuroblastoma tumor cell lines was treated with increasing concentrations of binimetinib, and their viability was determined using MTT assays. Western blot analyses were performed to examine changes in total and phosphorylated MEK and ERK and to measure apoptosis in neuroblastoma tumor cells after binimetinib treatment. NF1 protein levels in neuroblastoma cell lines were determined using Western blot assays. Gene expression of NF1 and MEK1 was examined in relationship to neuroblastoma patient outcomes.ResultsBoth primary neuroblastoma tumor samples and cell lines showed detectable levels of total and phosphorylated MEK and ERK. IC50 values for cells sensitive to binimetinib ranged from 8 nM to 1.16 μM, while resistant cells did not demonstrate any significant reduction in cell viability with doses exceeding 15 μM. Sensitive cells showed higher endogenous expression of phosphorylated MEK and ERK. Gene expression of NF1, but not MEK1, correlated with patient outcomes in neuroblastoma, and NF1 protein expression also correlated with responses to binimetinib.ConclusionsNeuroblastoma tumor cells show a range of sensitivities to the novel MEK inhibitor binimetinib. In response to binimetinib, sensitive cells demonstrated complete loss of phosphorylated ERK, while resistant cells demonstrated either incomplete loss of ERK phosphorylation or minimal effects on MEK phosphorylation, suggesting alternative mechanisms of resistance. NF1 protein expression correlated with responses to binimetinib, supporting the use of NF1 as a biomarker to identify patients that may respond to MEK inhibition. MEK inhibition therefore represents a potential new therapeutic strategy for neuroblastoma

Thermal barrier coating life prediction model development

Thermal barrier coatings (TBCs) for turbine airfoils in high-performance engines represent an advanced materials technology with both performance and durability benefits. The foremost TBC benefit is the reduction of heat transferred into air-cooled components, which yields performance and durability benefits. This program focuses on predicting the lives of two types of strain-tolerant and oxidation-resistant TBC systems that are produced by commercial coating suppliers to the gas turbine industry. The plasma-sprayed TBC system, composed of a low-pressure plasma-spray (LPPS) or an argon shrouded plasma-spray (ASPS) applied oxidation resistant NiCrAlY (or CoNiCrAlY) bond coating and an air-plasma-sprayed yttria (8 percent) partially stabilized zirconia insulative layer, is applied by Chromalloy, Klock, and Union Carbide. The second type of TBC is applied by the electron beam-physical vapor deposition (EB-PVD) process by Temescal

Control of dissipation in superconducting films by magnetic stray fields

Hybrid superconducting/magnetic nanostructures on Si substrates have been built with identical physical dimensions but different magnetic configurations. By constructing arrays based on Co-dots with in-plane, out-of-plane, and vortex state magnetic configurations, the stray fields are systematically tuned. Dissipation in the mixed state of superconductors can be decreased (increased) by several orders of magnitude by decreasing (increasing) the stray magnetic fields. Furthermore, ordering of the stray fields over the entire array helps to suppress dissipation and enhance commensurability effects increasing the number of dissipation minima.Comment: 16 pages including 4 figures; accepted in Applied Physics Letter

Dielectric nonlinearity of relaxor ferroelectric ceramics at low ac drives

Dielectric nonlinear response of (PbMg$_{1/3}$Nb$_{2/3}$O$_3$)$_{0.9}$(PbTiO$_3$)$_{0.1}$ (0.9PMN-0.1PT) relaxor ceramics was investigated under different ac drive voltages. It was observed that: (i) the dielectric permittivity is independent on ac field amplitude at high temperatures; (ii) with increasing ac drive, the permittivity maximum increases, and the temperature of the maximum shifts to lower temperature; (iii) the nonlinear effect is weakened when the measurement frequency increases. The influences of increasing ac drive were found to be similar to that of decreasing frequency. It is believed that the dielectric nonlinearities of relaxors at low drives can be explained by the phase transition theory of ergodic space shrinking in succession. A Monte Carlo simulation was performed on the flips of micro polarizations at low ac drives to verify the theory.Comment: Submitted to J. Phys.: Cond. Matte

Food Safety Incidents, Collateral Damage and Trade Policy Responses: China-Canada Agri-Food Trade

As markets become globalized, food safety policy and international trade policy are increasingly intertwined. Globalization also means that food safety incidents are widely reported internationally. One result is that food safety incidents can negatively impact products where no food safety issue exists as consumers lose trust in both foreign and domestic food safety institutions. While the policy framework for dealing with directly effected imported foods is well understood, how to deal with the market failure associated with indirectly affected products within the existing trade policy rules has not been explored. Using the example of China’s 2007 problems with a spate of products safety incidents, a theoretical framework is developed and the response of both the Chinese and Canadian governments analyzed. A cooperative approach to the issues appears to have a number of advantages and does not contravene trade policy commitments.Canada, China, cooperation, food safety, market failure, trade policy, Agricultural and Food Policy, International Development, International Relations/Trade,