48,095 research outputs found
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Compositions and medical devices for controlled release of nitric oxide and methods of production thereof
The present disclosure describes compositions providing for controlled release of nitric oxide (NO) and methods for production of these compositions. In some embodiments, the compositions may include a biodegradable polymer and a nitric oxide-releasing material at least partially encapsulated by the biodegradable polymer. Nitric oxide-releasing materials may include, for example, diazeniumdiolates and nitric oxide contained within a zeolite, metal-organic framework or other porous material. In general, the compositions are spun into a porous fiber, which may be further annealed by heating in order to densify the fiber. Annealing may prolong the NO release profile. Medical devices containing the compositions described herein are also contemplated by the present disclosure. Medical devices include, for example, textiles, bandages and articles of clothing.Board of Regents, University of Texas Syste
Mid-infrared broadband modulation instability and 50 dB Raman assisted parametric gain in silicon photonic wires
Abstract: We demonstrate broadband modulation instability, > 40 dB parametric amplification with on-chip gain bandwidth > 580 nm, and narrowband Raman-assisted peak on-chip gain exceeding 50 dB, using mid-infrared dispersion-engineered silicon nanophotonic wires
Potential secondary transmission of SARS-CoV-2 via wastewater
The new coronavirus, SARS-CoV-2, has spread internationally and whilst the current focus of those dealing with the COVID-19 pandemic is understandably restricting its direct transmission, the potential for secondary transmission via wastewater should not be underestimated. The virus has been identified in human fecal and wastewater samples from different countries and potential cases of transmission via wastewater have been reported. Our recommendations for hospital wastewater treatment, municipal wastewater plants, sewage sludge, water reuse and aquatic environments are designed to reduce the risk of such transmission, and contribute to limiting the resurgence of COVID-19 as current restrictions are relaxed. A particular urgent recommendation focusses on supporting low-income countries in tackling the potential for secondary transmission via wastewater
Multi-Channel Stochastic Variational Inference for the Joint Analysis of Heterogeneous Biomedical Data in Alzheimer's Disease
The joint analysis of biomedical data in Alzheimer's Disease (AD) is
important for better clinical diagnosis and to understand the relationship
between biomarkers. However, jointly accounting for heterogeneous measures
poses important challenges related to the modeling of the variability and the
interpretability of the results. These issues are here addressed by proposing a
novel multi-channel stochastic generative model. We assume that a latent
variable generates the data observed through different channels (e.g., clinical
scores, imaging, ...) and describe an efficient way to estimate jointly the
distribution of both latent variable and data generative process. Experiments
on synthetic data show that the multi-channel formulation allows superior data
reconstruction as opposed to the single channel one. Moreover, the derived
lower bound of the model evidence represents a promising model selection
criterion. Experiments on AD data show that the model parameters can be used
for unsupervised patient stratification and for the joint interpretation of the
heterogeneous observations. Because of its general and flexible formulation, we
believe that the proposed method can find important applications as a general
data fusion technique.Comment: accepted for presentation at MLCN 2018 workshop, in Conjunction with
MICCAI 2018, September 20, Granada, Spai
Control of Josephson current by Aharonov-Casher Phase in a Rashba Ring
We study the interference effect induced by the Aharonov-Casher phase on the
Josephson current through a semiconducting ring attached to superconducting
leads. Using a 1D model that incorporates spin-orbit coupling in the
semiconducting ring, we calculate the Andreev levels analytically and
numerically, and predict oscillations of the Josephson current due to the AC
phase. This result is valid from the point contact limit to the long channel
length limit, as defined by the ratio of the junction length and the BCS
healing length. We show in the long channel length limit that the impurity
scattering has no effect on the oscillation of the Josephson current, in
contrast to the case of conductivity oscillations in a spin-orbit coupled ring
system attached to normal leads where impurity scattering reduces the amplitude
of oscillations. Our results suggest a new scheme to measure the AC phase with,
in principle, higher sensitivity. In addition, this effect allows for control
of the Josephson current through the gate voltage tuned AC phase.Comment: 12pages, 8 figure
The prediction of blood–tissue partitions, water–skin partitions and skin permeation for agrochemicals
YesBACKGROUND: There is considerable interest in the blood–tissue distribution of agrochemicals, and a number of researchershave developed experimental methods for in vitro distribution. These methods involve the determination of saline–blood andsaline–tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution.RESULTS: The authors set out equations for gas–tissue and blood–tissue distribution, for partition from water into skin andfor permeation from water through human skin. Together with Abraham descriptors for the agrochemicals, these equationscan be used to predict values for all of these processes. The present predictions compare favourably with experimental in vivoblood–tissue distribution where available. The predictions require no more than simple arithmetic.CONCLUSIONS: The present method represents a much easier and much more economic way of estimating blood–tissuepartitions than the method that uses saline–blood and saline–tissue partitions. It has the added advantages of yielding therequired in vivo partitions and being easily extended to the prediction of partition of agrochemicals from water into skin andpermeation from water through skin
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A simple method for estimating in vitro air-tissue and in vivo blood-tissue partition coefficients
YesA simple method is reported for the estimation of in vivo air-tissue partition coefficients of VOCs and of in vitro blood-tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-tissue and blood-tissue partitions
Scalar Decay in Chaotic Mixing
I review the local theory of mixing, which focuses on infinitesimal blobs of
scalar being advected and stretched by a random velocity field. An advantage of
this theory is that it provides elegant analytical results. A disadvantage is
that it is highly idealised. Nevertheless, it provides insight into the
mechanism of chaotic mixing and the effect of random fluctuations on the rate
of decay of the concentration field of a passive scalar.Comment: 35 pages, 15 figures. Springer-Verlag conference style svmult.cls
(included). Published in "Transport in Geophysical Flows: Ten Years After,"
Proceedings of the Grand Combin Summer School, 14-24 June 2004, Valle
d'Aosta, Italy. Fixed some typo
Holographic Penta and Hepta Quark State in Confining Gauge Theories
We study a new embedding solutions of D5 brane in an asymptotic
AdS space-time, which is dual to a confining gauge
theory. The D5 brane is wrapped on as in the case of the vertex of
holographic baryon. However, the solution given here is different from the
usual baryon vertex in the point that it couples to -anti-quarks and
quarks on the opposite two points of , the north and south poles,
respectively. The total quark number of this state is preserved as when
minus one is assigned to anti-quark, then it forms a color singlet like the
baryon. However, this includes anti-quarks and quarks, whose number is larger
than that of the baryon. When we set as , we find the so called penta
and hepta-quark states. We study the dynamical properties of these states by
solving the vertex and string configurations for such states. The mass spectra
of these states and the tension of the stretched vertex are estimated, and they
are compared with that of the baryon.Comment: 24 pages, 6 figure
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