Rigidity and a Riemann–Hilbert correspondence for p-adic local systems

We construct a functor from the category of p-adic étale local systems on a smooth rigid analytic variety X over a p-adic field to the category of vector bundles with an integrable connection on its “base change to B_(dR)”, which can be regarded as a first step towards the sought-after p-adic Riemann–Hilbert correspondence. As a consequence, we obtain the following rigidity theorem for p-adic local systems on a connected rigid analytic variety: if the stalk of such a local system at one point, regarded as a p-adic Galois representation, is de Rham in the sense of Fontaine, then the stalk at every point is de Rham. Along the way, we also establish some basic properties of the p-adic Simpson correspondence. Finally, we give an application of our results to Shimura varieties

Gypenosides protect against cardiac ischemia-reperfusion injury by inhibiting mitochondria-dependent apoptosis

Purpose: To investigate the effect of gypenoside (Gyp) on myocardial ischemia-reperfusion (I/R), focusing on mitochondrial function and oxidative stress.Methods: A 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide methylthiazolyldiphenyltetrazolium bromide (MTT) assay was employed to measure the protective effect of Gyp pre-treatment against I/R injury. Flow cytometry was used to detect cellular reactive oxygen species (ROS) content and mitochondrial membrane potential (MMP) levels. Additionally, cytochrome C release was observedby laser scanning confocal microscopy. Finally, Annexin V staining and western blot were applied to analyse cell apoptosis.Results: MTT assay results showed that Gyp pre-treatment protected H9C2 cells against I/R injury in a Gyp concentration-dependent manner. Moreover, Gyp treatment inhibited intracellular ROS production, repressed cytochrome C transposition induced by I/R treatment, and recovered MMP to almost normal levels. Furthermore, the expression of apoptosis-related proteins included cleaved caspase-3, -9 and Bax which were decreased by Gyp treatment after I/R injury.Conclusion: These results suggest that Gyp treatment prior to injury can help maintain normal mitochondrial function and inhibit ROS production during I/R injury, ultimately leading to the suppression of I/R-induced cell apoptosis. Thus, Gyp may be a promising drug for the treatment of myocardial I/R.Keywords: Gynostemma pentaphyllum, Ischemia-reperfusion, Mitochondria damage, Oxidative stress, Apoptosi

Coordination States and Catalytic Performance of Ti in Titanium Silicalite-1

In the past two decades, we studied the synthesis, modification, and application of titanium silicalite-1 (TS-1) systematically with the goal of exploring its role as a catalyst for industrial selective oxidation reactions. Three factors were primarily considered for catalytic performance: the coordination states of titanium ions, locations of titanium ions, and diffusion properties. The coordination state of Ti, which was the most important of all the three factors, was tuned by controlling the synthesis conditions and posttreating with organic bases. Spectroscopy was used to help establishing the relationship between catalytic activity and coordination state. More active titanium species were located on the external surface by posttreatment, so the catalytic performance for larger molecules was improved significantly. The diffusion properties can be enhanced by posttreatment with organic bases. Furthermore, meso−/microporous titanium silicalite was synthesized by one-pot synthesis with cetyltrimethyl ammonium bromide (CTAB) as a mesoporous porogen. The TS-1 plate with a short b-axis length was also provided

Learning boosted asymmetric classifiers for object detection

http://ieeexplore.ieee.orgObject detection can be posted as those classification tasks where the rare positive patterns are to be distinguished from the enormous negative patterns. To avoid the danger of missing positive patterns, more attention should be payed on them. Therefore there should be different requirements for False Reject Rate (FRR) and False Accept Rate (FAR) , and learning a classifier should use an asymmetric factor to balance between FRR and FAR. In this paper, a normalized asymmetric classification error is proposed for the task of rejecting negative patterns. Minimizing it not only controls the ratio of FRR and FAR, but more importantly limits the upper-bound of FRR. The latter characteristic is advantageous for those tasks where there is a requirement for low FRR. Based on this normalized asymmetric classification error, we develop an asymmetric AdaBoost algorithm with variable asymmetric factor and apply it to the learning of cascade classifiers for face detection. Experiments demonstrate that the proposed method achieves less complex classifiers and better performance than some previous AdaBoost methods

Recombinant adenovirus, a powerful vector to transfer gene

Recombinant adenovirus has been used extensively to express foreign genes because of its high infection efficiency and its ability to infect a broad spectrum of cell-types. In this review, we describe these advantages and how it works by using a recombinant adenovirus to study the NS2 of Hepatitis C virus (HCV) and focal adhesion kinase(FAK)- related non-kinase(FRNK). Taken the research we have done together recombinant adenovirus demonstrates a very useful vector for transferring genes of interest from the outside

Rigidity and a Riemann–Hilbert correspondence for p-adic local systems

We construct a functor from the category of p-adic étale local systems on a smooth rigid analytic variety X over a p-adic field to the category of vector bundles with an integrable connection on its “base change to B_(dR)”, which can be regarded as a first step towards the sought-after p-adic Riemann–Hilbert correspondence. As a consequence, we obtain the following rigidity theorem for p-adic local systems on a connected rigid analytic variety: if the stalk of such a local system at one point, regarded as a p-adic Galois representation, is de Rham in the sense of Fontaine, then the stalk at every point is de Rham. Along the way, we also establish some basic properties of the p-adic Simpson correspondence. Finally, we give an application of our results to Shimura varieties