Document-level sentiment analysis of email data

Sisi Liu investigated machine learning methods for Email document sentiment analysis. She developed a systematic framework that has been qualitatively and quantitatively proved to be effective and efficient in identifying sentiment from massive amount of Email data. Analytical results obtained from the document-level Email sentiment analysis framework are beneficial for better decision making in various business settings

Parallel Toolkit for Measuring the Quality of Network Community Structure

Many networks display community structure which identifies groups of nodes within which connections are denser than between them. Detecting and characterizing such community structure, which is known as community detection, is one of the fundamental issues in the study of network systems. It has received a considerable attention in the last years. Numerous techniques have been developed for both efficient and effective community detection. Among them, the most efficient algorithm is the label propagation algorithm whose computational complexity is O(|E|). Although it is linear in the number of edges, the running time is still too long for very large networks, creating the need for parallel community detection. Also, computing community quality metrics for community structure is computationally expensive both with and without ground truth. However, to date we are not aware of any effort to introduce parallelism for this problem. In this paper, we provide a parallel toolkit to calculate the values of such metrics. We evaluate the parallel algorithms on both distributed memory machine and shared memory machine. The experimental results show that they yield a significant performance gain over sequential execution in terms of total running time, speedup, and efficiency.Comment: 8 pages; in Network Intelligence Conference (ENIC), 2014 Europea

Quantum error correction meets continuous symmetries: fundamental trade-offs and case studies

We systematically study the fundamental competition between quantum error correction (QEC) and continuous symmetries, two key notions in quantum information and physics, in a quantitative manner. Three meaningful measures of approximate symmetries in quantum channels and in particular QEC codes, respectively based on the violation of covariance conditions over the entire symmetry group or at a local point, and the violation of charge conservation, are introduced and studied. Each measure induces a corresponding characterization of approximately covariant codes. We explicate a host of different ideas and techniques that enable us to derive various forms of trade-off relations between the QEC inaccuracy and all symmetry violation measures. More specifically, we introduce two frameworks for understanding and establishing the trade-offs respectively based on the notions of charge fluctuation and gate implementation error, and employ methods including the Knill--Laflamme conditions as well as quantum metrology and quantum resource theory for the derivation. From the perspective of fault-tolerant quantum computing, our bounds on symmetry violation indicate limitations on the precision or density of transversally implementable logical gates for general QEC codes, refining the Eastin--Knill theorem. To exemplify nontrivial approximately covariant codes and understand the achievability of the above fundamental limits, we analyze the behaviors of two explicit types of codes: a parametrized extension of the thermodynamic code (which gives a construction of a code family that continuously interpolates between exact QEC and exact symmetry), and the quantum Reed--Muller codes. We show that both codes can saturate the scaling of the bounds for group-global covariance and charge conservation asymptotically, indicating the near-optimality of these bounds and codes.Comment: 46 pages, 4 figures, long version of arXiv:2111.06355 published as supplementary informatio

Approximate symmetries and quantum error correction

Quantum error correction (QEC) is a key concept in quantum computation as well as many areas of physics. There are fundamental tensions between continuous symmetries and QEC. One vital situation is unfolded by the Eastin--Knill theorem, which forbids the existence of QEC codes that admit transversal continuous symmetry actions (transformations). Here, we systematically study the competition between continuous symmetries and QEC in a quantitative manner. We first define a series of meaningful measures of approximate symmetries motivated from different perspectives, and then establish a series of trade-off bounds between them and QEC accuracy utilizing multiple different methods. Remarkably, the results allow us to derive general quantitative limitations of transversally implementable logical gates, an important topic in fault-tolerant quantum computation. As concrete examples, we showcase two explicit types of quantum codes, obtained from quantum Reed--Muller codes and thermodynamic codes, respectively, that nearly saturate our bounds. Finally, we discuss several potential applications of our results in physics.Comment: 19 pages, 2 figures, published version, concise version of arXiv:2111.0636

Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response.

Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection. However, the involvement of type-I transmembrane glycoprotein CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) in the antiviral response to HCMV infection is still unknown. Here, we demonstrated the specific knockdown of CD147 significantly decreased HCMV-induced activation of NF-κB and Interferon-beta (IFN-β), which contribute to the cellular antiviral responses. Next, we confirmed that HCMV-encoded miR-US25-1-5p could target the 3 UTR (Untranslated Region) of CD147 mRNA, and thus facilitate HCMV lytic propagation at a low multiplicity of infection (MOI). The expression and secretion of Cyclophilin A (sCyPA), as a ligand for CD147 and a proinflammatory cytokine, were up-regulated in response to HCMV stimuli. Finally, we confirmed that CD147 mediated HCMV-triggered antiviral signaling via the sCyPA-CD147-ERK (extracellular regulated protein kinases)/NF-κB axis signaling pathway. These findings reveal an important HCMV mechanism for evading antiviral innate immunity through its encoded microRNA by targeting transmembrane glycoprotein CD147, and a potential cause of HCMV inflammatory disorders due to the secretion of proinflammatory cytokine CyPA

Antidiabetic effect of Tibetan medicine Tang-Kang-Fu-San in db/db mice via activation of PI3K/Akt and AMPK pathways

This study was to investigate the anti-diabetic effects and molecular mechanisms of Tang-Kang-Fu-San (TKFS), a traditional Tibetan medicine, in treating type 2 diabetes mellitus of spontaneous diabetic db/db mice. Firstly HPLC fingerprint analysis was performed to gain the features of the chemical compositions of TKFS. Next different doses of TKFS (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) were administrated via oral gavage to db/db mice and their controls for 4 weeks. TKFS significantly lowered hyperglycemia and ameliorated insulin resistance (IR) in db/db mice, indicated by results from multiple tests, including fasting blood glucose test, intraperitoneal insulin and glucose tolerance tests, fasting serum insulin levels and homeostasis model assessment of IR analysis as well as histology of pancreas islets. TKFS also decreased concentrations of serum triglyceride, total and low-density lipoprotein cholesterol, even though it did not change the mouse body weights. Results from western blot and immunohistochemistry analysis indicated that TKFS reversed the down-regulation of p-Akt and p-AMPK, and increased the translocation of Glucose transporter type 4 in skeletal muscles of db/db mice. In all, TKFS had promising benefits in maintaining the glucose homeostasis and reducing IR. The underlying molecular mechanisms are related to promote Akt and AMPK activation and Glucose transporter type 4 translocation in skeletal muscles. Our work showed that multicomponent Tibetan medicine TKFS acted synergistically on multiple molecular targets and signaling pathways to treat type 2 diabetes mellitus

p53 involvement in clonal hematopoiesis of indeterminate potential

Purpose of review Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and occurs when a single mutant hematopoietic stem cell (HSC) contributes to a significant clonal proportion of mature blood lineages. Somatic mutations in the TP53 gene, which encodes the tumor suppressor protein p53, rank in the top five among genes that were mutated in CHIP. This review focuses on mechanisms by which mutant p53 promotes CHIP progression and drives the pathogenesis of hematological malignancies, including myelodysplastic syndromes, and acute myeloid leukemia. Recent findings TP53 was frequently mutated in individuals with CHIP. Although clinical studies suggest that expansion of HSCs with TP53 mutations predisposes the elderly to hematological neoplasms, there is a significant gap in knowledge regarding the mechanisms by which TP53 mutations promote HSC expansion. Recent findings suggest that several cellular stressors, including hematopoietic transplantation, genotoxic stress, and inflammation, promote the expansion of HSCs with TP53 mutations. Further, TP53 mutations identified in CHIP cooperate with genetic and/or epigenetic changes in leukemogenesis. Summary TP53 mutations identified in CHIP are associated with increased risks of de novo and therapy-related hematological neoplasms. Thus, targeting mutant p53 and related pathways holds great potential in preventing CHIP progression and treating hematological malignancies