CULTURA, SOCIEDADE, IDÉIAS E INOVAÇÃO DA DISCIPLINA DE EDUCAÇÃO GERAL DOS ESTUDANTES NO AGORA NORMAL: UM CONCEITO E DESENVOLVIMENTO NO ENSINO

The study aims to examine the culture, society, ideas, and innovation (CSII) of General Education subjects of students in the now normal concept and development in teaching. It also identifies the core competency of culture, society, ideas, and innovation of general education subject of students in the now normal in the area of cognitive knowledge, soft skills, hard skills, and specific discipline knowledge and the concept and development of teaching as student-centred learning culture in terms of digital literacy, effective communication, and critical thinking framework, outcome-based learning, inquiry and collaborative learning, and authentic assessment learning. The study employs descriptive quantitative research design. It measures the educational phenomena of the study on the core competency of culture, society, ideas, and innovation of general education subjects of students in the now normal and concept development. Random sampling technique is utilised in the study. The study comprised Seven Hundred (700) respondents only from the selected students in the General Education Subject.              Results show that core competency on cognitive knowledge provides creative thinking, critical thinking, coordination, self-reflection, making references, and reasoning, show that soft skills are attributed to communication, collaboration, creative thinking, and time management in the core competency of learning, show that hard skills specify the role and task needed for the ability of skills and competency, show that specific discipline knowledge explores the defining core competency and discipline for ideas in various levels of outcome in learning, show that concept and development of teaching in terms of digital literacy, effective communication, and critical thinking framework develop a sustainable skills proficiency in digital technology literacy, effective communication, and framework of critical thinking, show that outcome-based learning promotes order of higher thinking skills and curriculum acquisition on conventional requirement information ability in learning, show that inquiry and collaborative learning involves inquiry based learning and collaborative student involvement through group learning for the collective task of students, and show that authentic assessment learning stimulates student ability and assessment effectively and efficiently in complex tasks, skills, and knowledge.             Findings show that there is no significant correlation between the core competency of culture, society, ideas, and innovation of general education subjects of students in the now normal and the concept and development of teaching as student-centred and learning culture among the respondents.  O estudo visa examinar a cultura, a sociedade, as idéias e a inovação (CSII) das disciplinas de Educação Geral dos estudantes no conceito agora normal e no desenvolvimento do ensino. Também identifica a competência central da cultura, sociedade, idéias e inovação da disciplina de educação geral dos estudantes no agora normal na área do conhecimento cognitivo, habilidades suaves, habilidades duras e conhecimentos específicos da disciplina e o conceito e desenvolvimento do ensino como cultura de aprendizagem centrada no estudante em termos de alfabetização digital, comunicação eficaz e estrutura de pensamento crítico, aprendizagem baseada em resultados, investigação e aprendizagem colaborativa, e aprendizagem autêntica de avaliação. O estudo emprega um desenho descritivo de pesquisa quantitativa. Ele mede os fenômenos educacionais do estudo sobre a competência central da cultura, sociedade, idéias e inovação das disciplinas de educação geral dos estudantes no agora normal e desenvolvimento de conceitos. A técnica de amostragem aleatória é utilizada no estudo. O estudo incluiu setecentos (700) respondentes apenas dos estudantes selecionados na disciplina de Educação Geral. Os resultados mostram que a competência central no conhecimento cognitivo fornece pensamento criativo, pensamento crítico, coordenação, auto-reflexão, fazendo referências e raciocínio, mostram que habilidades suaves são atribuídas à comunicação, colaboração, pensamento criativo e gerenciamento de tempo na competência central da aprendizagem, mostram que habilidades difíceis especificam o papel e a tarefa necessária para a capacidade de habilidades e competência, mostram que o conhecimento específico da disciplina explora a competência central definidora e a disciplina para idéias em vários níveis de resultados na aprendizagem, mostram que o conceito e o desenvolvimento do ensino em termos de alfabetização digital, comunicação eficaz, e a estrutura de pensamento crítico desenvolvem uma proficiência sustentável em habilidades de alfabetização em tecnologia digital, comunicação eficaz e estrutura de pensamento crítico, mostram que o aprendizado baseado em resultados promove a ordem de maior capacidade de pensamento e aquisição de currículo sobre a capacidade convencional de informação de requisitos no aprendizado, mostram que a investigação e o aprendizado colaborativo envolvem o aprendizado baseado em investigação e o envolvimento colaborativo do estudante através do aprendizado em grupo para a tarefa coletiva dos estudantes, e mostram que o aprendizado autêntico de avaliação estimula a capacidade e a avaliação do estudante de forma eficaz e eficiente em tarefas, habilidades e conhecimentos complexos. As descobertas mostram que não há correlação significativa entre a competência central da cultura, sociedade, idéias e inovação das disciplinas de educação geral dos estudantes no agora normal e o conceito e desenvolvimento do ensino como cultura centrada no estudante e cultura de aprendizagem entre os respondentes.

Brain Abcess due to Cladophialophora bantiana: first case in Portugal

Clinical case reporting a brain abscess caused by Cladophialophora bantiana in an male patient with 56 years old. This is a rare case of a brain abscess caused by this species. Few cases have been reported in the literature world-wide, being this one the first reported in Portugal. The fungal isoltate was identified by morphological and molecular methods. After 16 months of the first brain abscess excision and after 5 months under therapy with voriconazol, the patient improved clinical and imagiologicaly, maintaining only minimal neurological deficits

A Phylogenomic Approach for the Analysis of Colistin Resistance-Associated Genes in Klebsiella Pneumoniae, its Mutational Diversity and Implications for Phenotypic Resistance

The emergence of carbapenemase-producing Klebsiella pneumoniae strains has triggered the use of old antibiotics such as colistin. This is driving the emergence of colistin resistance in multidrug-resistant strains that underlie life-threatening infections. This study analyses the mutational diversity of 22 genes associated with colistin resistance in 140 K. pneumoniae clinical isolates integrated in a high-resolution phylogenetic scenario. Colistin susceptibility was accessed by broth microdilution. A total of 98 isolates were susceptible and 16 were resistant, 10 of which were carbapenemase producers. Across the 22 genes examined, 171 non-synonymous mutations and 9 mutations associated with promoter regions were found. Eighty-five isolates had a truncation and/or deletion in at least one of the 22 genes. However, only seven mutations, the complete deletion of mgrB or insertion sequence (IS)-mediated disruption, were exclusively observed in resistant isolates. Four of these (mgrBIle13fs, pmrBGly207Asp, phoQHis339Asp and ramAIle28Met) comprised novel mutations that are potentially involved in colistin resistance. One strain bore a ISEcp1-blaCTX-M-15::mgrB disruption, underlying co-resistance to third-generation cephalosporins and colistin. Moreover, the high-resolution phylogenetic context shows that most of the mutational diversity spans multiple phylogenetic clades, and most of the mutations previously associated with colistin resistance are clade-associated and present in susceptible isolates, showing no correlation with colistin resistance. In conclusion, the present study provides relevant data on the genetic background of genes involved with colistin resistance deeply rooted across monophyletic groups and provides a better understanding of the genes and mutations involved in colistin resistance.info:eu-repo/semantics/publishedVersio

Um Caso Clínico de Lepra Multibacilar com Vários Surtos de Eritema Nodoso Leproso

Leprosy is a chronic granulomatous disease with a long incubation period caused by Mycobacterium leprae that mainly affects the skin, mucous membranes and the peripheral nervous system. It carries the risk of per-manent sequels with a significant impact on the patient’s quality of life. It has a considerable clinically diver-sity and possible atypical presentations. We present a case of a 31-year-old, skin phototype V woman with multibacillary leprosy characterized by multiple outbreaks of erythema nodosum leprosum, as an inaugural manifestation of the disease. The disease was acquired within a group of children and adolescents from an endemic region of Africa, evolved untreated for 3 years, and presented with unusual features and remarkable lymphatic involvement. We highlight the importance of building and maintaining collaboration between expert centers and institutional partnerships in order to provide the adequate diagnostic resources and appropriate care to the affected populations.A lepra é uma doença granulomatosa crónica com longo período de incubação causada pelo bacilo Mycobacte- -rium leprae que afeta principalmente a pele, mucosas e sistema nervoso periférico. Tem risco de sequelas permanentes e impacto significativo na qualidade de vida do paciente. É clinicamente heterogénea com possíveis apresentações atípicas. Descrevemos o caso de uma mulher de 31 anos, fototipo V, com lepra multibacilar caracterizada por múltiplos surtos de eritema nodoso leproso como manifestação inaugural. A doença foi adquirida num grupo de crianças e adolescentes de uma região endémica de África, evoluiu sem tratamento durante 3 anos, e manifestou-se com algumas características clínicas incomuns e notável envolvimento linfático. Destacamos a importância da colaboração entre centros especializados e parcerias institucionais, a fim de fornecer os recursos de diagnósti-co e os cuidados adequados às populações afetadas

Gonorrhea in a tertiary care Portuguese hospital : a 10-year retrospective study of the evolution of cases and drug resistance of the isolates

© 2020 AEDV. Published by Elsevier España, S.L.U. Este es un artículo OpenAccess bajo la licencia CC BY-NC-ND(http://creativecommons.org/licenses/by-nc-nd/4.0/)Background: Sexually Transmitted Infections remain a major public health concern worldwide. Although traditionally considered treatable, the emergence of Neisseria gonorrhoeae resistance to antimicrobials is currently a serious problem. The goal of this study was to evaluate the incidence and trends of antimicrobial resistance over the last 10 years in N. gonorrhoeae isolates from a Portuguese Centre. Methods: Laboratorial confirmed N. gonorrhoeae infections diagnosed between 2009 and 2018 were evaluated. Susceptibilities to penicillin, tetracycline, ciprofloxacin, azithromycin and cefotaxime were studied, along with demographic and clinical characteristics. Results: From 2009 to 2018, 440 cases of N. gonorrhoeae infection were diagnosed in our center, with a significant yearly increase (p<0.05). Most cases occurred in males (97.9%), with a median age of 25 years. In 88.7% of the cases, treatment with ceftriaxone plus azithromycin was used. Resistances to penicillin, tetracycline and ciprofloxacin remained high throughout the study period. Conclusions: Antimicrobial resistance of N. gonorrhoeae appeared shortly after the introduction of antimicrobials. To combat this problem, improved surveillance and more studies combining susceptibility and epidemiological data are needed. In our population, N. gonorrhoeae remains highly susceptible to the antibiotics currently recommended for its treatment, whereas ciprofloxacin, azithromycin (in monotherapy) and penicillin should be avoided as empirical treatment.info:eu-repo/semantics/publishedVersio

Prevention and contrast of child abuse and neglect in the practice of European paediatricians: a multi-national pilot study

Background: Child abuse and neglect, or maltreatment, is a serious public health problem, which may cause long-term effects on children's health and wellbeing and expose them to further adulthood vulnerabilities. Studies on child maltreatment performed in Europe are scarce, and the number of participants enrolled relatively small. The aim of this multi-national European pilot study, was to evaluate the level of understanding and perception of the concepts of child abuse and neglect by European paediatricians working in different medical settings, and the attitude toward these forms of maltreatment in their practice. Methods: The study was performed by a cross-sectional, descriptive, online survey, made available online to European paediatricians members of 50 national paediatric, who belonged to four different medical settings: hospital, family care, university centres and private practice. The questionnaire, designed as a multiple choice questions survey, with a single answer option consisted of 22 questions/statements. Frequency analyses were applied. Most of the data were described using univariate analysis and Chi-squared tests were used to compare the respondents and answers and a significance level of p ≤ 0.05 applied. Results: Findings show that European paediatricians consider the training on child maltreatment currently provided by medical school curricula and paediatric residency courses to be largely insufficient and continuing education courses were considered of great importance to cover educational gaps. Physical violence was recognized by paediatricians mostly during occasional visits with a significant correlation between detecting abuse during an occasional visit and being a primary care paediatrician. Results also showed a reluctance by paediatricians to report cases of maltreatment to the competent judicial authorities. Conclusions: Data of this study may provide useful contribution to the current limited knowledge about the familiarity of European paediatricians with child maltreatment and their skills to recognize, manage and contrast abusive childhood experiences in their practice. Finally, they could provide local legislators and health authorities with information useful to further improve public health approaches and rules able to effectively address shared risk and protective factors, which could prevent child abuse and neglect from ever occurring

Lower prevalence of congenital cytomegalovirus infection in Portugal: possible impact of COVID-19 lockdown?

Cytomegalovirus (CMV) is the most frequent cause of congenital infection all over the world. Its prevalence ranges from 0.2 to 2.2%. Transmission from children to their pregnant mothers is a well-known risk factor, particularly if they attend a childcare centre. This study aims to compare the prevalence of CMV congenital infection (CMV_CI) in Portugal (Lisbon) between two studies, performed respectively in 2019 and 2020. In the 2019 study, performed in two hospitals, we found a 0.67% CMV_CI prevalence, using a pool strategy previously tested with saliva samples. In the 2020 study, using the same pool approach in four hospitals (the previous and two additional), and based on 1277 samples, the prevalence was 0.078%.Conclusion: The close temporal coincidence with COVID-19 lockdown suggests that these measures may have had a significant impact on this reduction, although other explanations cannot be ruled-out. What is Known: • Cytomegalovirus is the leading cause of congenital infection. • Behavioural measures decrease cytomegalovirus seroconversion in pregnant women. What is New: • From 2019 to 2020 there was a significant reduction in the prevalence of congenital CMV infection.info:eu-repo/semantics/publishedVersio