214 research outputs found

    Shoreline Monitoring Toolbox: Development and Goals for Implementation

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    Shoreline monitoring is often a desired or required goal by volunteer groups and local entities, but protocols and guidelines can be hard to find and misleading if not used appropriately. We will present the initial developments of a Shoreline Monitoring Toolbox, an idea that progressed from its original concept at the Shoreline Restoration Monitoring Consortium in June 2013. Among the issues are the needs of local entities for a standardized approach for monitoring and a “toolbox” of protocols and information. Emphasis is placed on methods that are simple and affordable, and that can be used for monitoring restoration sites, establishing baseline conditions, and evaluating status and trends and preservation efforts. The toolbox is coordinated with the PSEMP Nearshore Work Group in order to establish a foundation of technical expertise. Most of the effort so far has been to (1) organize a decision tree that will help guide monitoring choices, and (2) organize protocols that are not well known or might be lost if not in digital form. The goal is to provide the toolbox as a web-based platform that will build upon other resources to fill gaps of monitoring needs. In this process, science will help inform decisions to catalyze action by (1) providing effective guidance for how to monitor, (2) informing groups on how to move forward in their goals, and (3) providing a feedback loop of completed projects that can inform future projects. An example will be given of how completed restoration monitoring at the Olympic Sculpture Park (Seattle, WA) was useful to guide local shoreline planning, but the technical methods were difficult to apply when taken out of context to other efforts such as at Carpenter Creek Estuary (Kingston, WA). Invited comment from the Stillwaters Environmental Center will discuss how volunteer monitoring efforts were established, and how a toolbox would have and hopefully will better organize monitoring efforts in the future

    Interview with Thomas J. Litle

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    On Seminar Day—Caltech’s annual reunion event—May 19, 2012, for the first time the Caltech Archives and Library offered alumni/ae the opportunity to record mini-interviews with Archives’ staff. Nine people participated, including one alumni spouse and one daughter. These alums held bachelor’s, master’s and doctoral degrees across several divisions, with engineering marginally in the lead. One former student who transferred out of Caltech came back to relate how well his Caltech years had served him in his later studies and career in psychology. Ranging from 10 to 15 minutes in length, the interviews typically relate stories or episodes from student years. Favorite topics include pranks and traditions, some of which have died out. Alumni also reflect on professors and classes which were memorable and on the unique intellectual stimulus that a Caltech education provides. Readers will find that the transcripts of the short interviews reflect the personal and colloquial tone at which the event aimed

    Surgical Treatment of Carotid Body Paragangliomas: Outcomes and Complications According to the Shamblin Classification

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    OBJECTIVES: The objective of this study was to review our experience in the surgical management of carotid body paragangliomas and evaluate the outcomes and complications according to the Shamblin classification. METHODS: Thirteen patients who had been diagnosed and surgically treated for carotid body tumors (CBTs) were enrolled in this study. We reviewed patient demographics, radiographic findings, and surgical outcomes collected from medical records. RESULTS: Fifteen CBTs were found in 13 patients and 13 tumors were resected. Selective preoperative tumor embolization was performed on six patients. The median blood loss, operation time, and hospital stay for these patients were not significantly reduced compared to those without embolization. The median tumor size was 2.3 cm in Shamblin I and II and 4 cm in Shamblin III. The median intraoperative blood loss was 280 mL and 700 mL, respectively (P<0.05). Internal carotid artery ligation with reconstruction was accomplished on three patients (23%), and they all belonged to Shamblin III (38%). One Shamblin III patient (8%) developed transient cerebral ischemia, and postoperative stroke with death occurred in another Shamblin III patient. Postoperative permanent cranial nerve deficit occurred in three patients (23%) who were all in Shamblin III (P=0.03). There were no recurrences or delayed complications at the median follow up of 29 months. CONCLUSION: Shamblin III had a high risk of postoperative neurovascular complications. Therefore, early detection and prompt surgical resection of CBTs will decrease surgical morbidity.ope

    Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients

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    The clinical significance of detecting supposed tumour cell-derived mRNA transcripts in blood using the polymerase chain reaction (PCR) remains unclear. We have used a fully quantitative 5′-nuclease RT-PCR assay to screen for the expression of cytokeratins (ck) 19 and 20 and guanylyl cyclase C (GCC) in the peripheral blood of 21 healthy controls and 27 colorectal cancer patients. Expression of cytokeratin 19 and 20 mRNA was detected in 30% and 100% of samples, respectively, taken from healthy volunteers. There was no apparent difference in ck19 and ck20 mRNA transcription levels between controls and patients, or between patients with different Dukes' stages. While GCC mRNA was detected in only 1/21 control samples, it was expressed in approximately 80% of patients, although again there was no correlation between GCC levels and disease stage. Transcription levels of all three markers varied considerably between samples, even between samples taken from the same person at different times. We conclude that neither ck19 nor ck20 are reliable markers for the detection of colon epithelial cells in peripheral blood and that an evaluation of the usefulness of GCC awaits further longitudinal studies. © 1999 Cancer Research Campaig
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