2,318 research outputs found
Solid state television camera system Patent
Solid state television camera system consisting of monolithic semiconductor mosaic sensor and molecular digital readout system
CP and Lepton-Number Violation in GUT Neutrino Models with Abelian Flavour Symmetries
We study the possible magnitudes of CP and lepton-number-violating quantities
in specific GUT models of massive neutrinos with different Abelian flavour
groups, taking into account experimental constraints and requiring successful
leptogenesis. We discuss SU(5) and flipped SU(5) models that are consistent
with the present data on neutrino mixing and upper limits on the violations of
charged-lepton flavours and explore their predictions for the CP-violating
oscillation and Majorana phases. In particular, we discuss string-derived
flipped SU(5) models with selection rules that modify the GUT structure and
provide additional constraints on the operators, which are able to account for
the magnitudes of some of the coefficients that are often set as arbitrary
parameters in generic Abelian models.Comment: 30 pages, 6 figure
Dapagliflozin Monotherapy in Type 2 Diabetic Patients With Inadequate Glycemic Control by Diet and Exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
OBJECTIVE - Dapagliflozin, a highly selective inhibitor of the renal sodium-glucose co-transporter-2, increases urinary excretion of glucose and lowers plasma glucose levels in an insulin-independent manner. We evaluated the efficacy and safety of dapagliflozin in treatment-naive patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - This was a 24-week parallel-group, double-blind, placebo-controlled phase 3 trial. Patients with A1C 7.0-10% (n = 485) were randomly assigned to one of seven arms to receive once-daily placebo or 2.5, 5, or 10 mg dapagliflozin once daily in the morning (main cohort) or evening (exploratory cohort). Patients with A1C 10.1-12% (high-A1C exploratory cohort, it n=73) were randomly assigned 1:1 to receive blinded treatment with a morning close of 5 or 10 mg/day dapagliflozin. The primary end point was change from baseline in A1C in the main cohort, statistically tested using an ANCOVA. RESULTS - In the main cohort, mean A1C changes from baseline at week 24 were -0.23% with placebo and -0.58, -0.77 (P = 0.0005 vs. placebo), and -0.89% (P < 0.0001, vs. placebo) with 2.5, 5, and 10 mg dapagliflozin, respectively. Signs, symptoms, and other reports suggestive of urinary tract infections and genital infection were more frequently noted in the dapagliflozin arms. There were no major episodes of hypoglycemia. Data from exploratory cohorts were consistent with these results. CONCLUSIONS - Dapagliflozin lowered hyperglycemia in treatment-naive patients with newly diagnosed type 2 diabetes. The near absence of hypoglycemia and an insulin-independent mechanism of action make dapagliflozin a unique addition to existing treatment options for type 2 diabetes
Split or Steal? Cooperative Behavior When the Stakes Are Large
We examine cooperative behavior when large sums of money are at stake, using data from the television game show Golden Balls. At the end of each episode, contestants play a variant on the classic prisoner's dilemma for large and widely ranging stakes averaging over $20,000. Cooperation is surprisingly high for amounts that would normally be considered consequential but look tiny in their current context, what we call a “big peanuts” phenomenon. Utilizing the prior interaction among contestants, we find evidence that people have reciprocal preferences. Surprisingly, there is little support for conditional cooperation in our sample. That is, players do not seem to be more likely to cooperate if their opponent might be expected to cooperate. Further, we replicate earlier findings that males are less cooperative than females, but this gender effect reverses for older contestants because men become increasingly cooperative as their age increases
Static flow on complete noncompact manifolds I: short-time existence and asymptotic expansions at conformal infinity
In this paper, we study short-time existence of static flow on complete
noncompact asymptotically static manifolds from the point of view that the
stationary points of the evolution equations can be interpreted as static
solutions of the Einstein vacuum equations with negative cosmological constant.
For a static vacuum we also compute the asymptotic expansions of
and at conformal infinity.Comment: 25 page
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