36,119 research outputs found
The effects of after-school physical activity and adult encouragement on adolescents
Includes bibliographical references
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Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets.
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells. How mitotic recombination is prevented-and how genetic stability is maintained across daughter cells-is a fundamental, unanswered question. Here, we report that both human and mouse cells impede homologous chromosome pairing by keeping two haploid chromosome sets apart throughout mitosis. Four-dimensional analysis of chromosomes during cell division revealed that a haploid chromosome set resides on either side of a meridional plane, crossing two centrosomes. Simultaneous tracking of chromosome oscillation and the spindle axis, using fluorescent CENP-A and centrin1, respectively, demonstrates collective genome behavior/segregation of two haploid sets throughout mitosis. Using 3D chromosome imaging of a translocation mouse with a supernumerary chromosome, we found that this maternally derived chromosome is positioned by parental origin. These data, taken together, support the identity of haploid sets by parental origin. This haploid set-based antipairing motif is shared by multiple cell types, doubles in tetraploid cells, and is lost in a carcinoma cell line. The data support a mechanism of nuclear polarity that sequesters two haploid sets along a subcellular axis. This topological segregation of haploid sets revisits an old model/paradigm and provides implications for maintaining mitotic fidelity
Child protection procedures in emergency departments
Background: Emergency departments (EDs) may be the first point at which children who have been subject to abuse or neglect come into contact with professionals who are able to act for their protection. In order to ascertain current procedures for identifying and managing child abuse, we conducted a survey of EDs in England and Northern Ireland.
Methods: Questionnaires were sent to the lead professionals in a random sample of 81 EDs in England and 20 in Northern Ireland. Departments were asked to provide copies of their procedures for child protection. These were analysed qualitatively using a structured template.
Results: A total of 74 questionnaires were returned. 91.3% of departments had written protocols for child protection. Of these, 27 provided copies of their protocols for analysis. Factors judged to improve the practical usefulness of protocols included: those that were brief; were specific to the department; incorporated both medical and nursing management; included relevant contact details; included a single page flow chart which could be accessed separately. 25/71 (35.2%) departments reported that they used a checklist to highlight concerns. The most common factors on the checklists included an inconsistent history or one which did not match the examination; frequent attendances; delay in presentation; or concerns about the child’s appearance or behaviour, or the parent–child interaction.
Conclusions: There is a lack of consistency in the approach to identifying and responding to child abuse in EDs. Drawing on the results of this survey, we are able to suggest good practice guidelines for the management of suspected child abuse in EDs. Minimum standards could improve management and facilitate clinical audit and relevant training
WAG Shares the DOPE: Tools for Effective Writing of Course Assignments International Writing Across the Curriculum Conference
We facilitated a three-hour workshop the afternoon of June 6, 2018. This workshop was an extension of work we have been doing in the College of Health and Human Services for the last 2 ½ years. This work was originally supported by an Assessment Fellows Grant and focused on addressing assessment at the college level. To do that, we needed to focus on an area of competence that was relevant to all programs in the college. After reviewing the key goals that the college set back in 2005, and listening to colleagues on the college assessment committee, we decided to focus on the assessment of writing in the College of Health and Human Services. From there, we led focus groups with faculty in the college, to discern what exactly they were looking for when it came to writing assignments in their courses. After all, we could not assess something if we did not first describe it
The Importance of Acknowledgement as a High Class Society for Teenager in Alyson Noël's Faking 19
This paper discusses the Alex's desire to be acknowledged as a high class person. Alex comes from a middle class background. When she enters high school, she started to change. In this paper I analyze the changes that happened to Alex. In the analysis, I use Georg Simmel's theory about fashion and metropolitan lifestyle. I divided this analysis into three parts. The first part, it discusses what Alex does to get the acknowledgement. Second, it discusses the reasons and result behind her desire to be acknowledged as a high class. Finally, it discusses what Alex learns from her encounter with the high class. Through the analysis I find that Faking 19 shows an important moral lesson. Being acknowledged as a high class is not the most important thing in life. The most important thing in life is when someone can be themselves
Perceptions of sport science students on the potential applications and limitations of blended learning in their education: A qualitative study
This study sought to gain insight into blended learning-naive sports science students’ understanding and perceptions of the potential benefits and limitations of blended (hybrid) learning, which has been defined as the thoughtful integration of face-to-face and online instructional approaches. Five focus groups, each comprising 3–4 students from either the undergraduate or postgraduate sports science programmes were conducted. The focus groups were facilitated by a researcher who was not involved in sports science. Audio recordings of the focus groups were transcribed verbatim. NVivo software was used to code the transcripts to identify the themes and subthemes. Students generally had little initial understanding of blended learning. When provided with a definition, they believed that blended learning could improve educational outcomes and assist those who were legitimately unable to attend a session. Their reservations about blended learning mainly related to some students not being sufficiently autonomous to undertake independent study, timetabling considerations and access to reliable Internet services. For blended learning to be effective, students felt the online material had to be interactive, engaging and complement the face-to-face sessions. Better understanding the perceptions of the students in the current study may assist educators who are considering implementing blended learning in their teaching. © 2017 Informa UK Limited, trading as Taylor & Francis Grou
Classification of Coastal Communities Reporting Commercial Fish Landings in the U.S. Northeast Region: Developing and Testing a Methodology
The National Marine Fisheries Service is required by law to conduct social impact assessments of communities impacted by fishery management plans. To facilitate this process, we developed a technique for grouping communities based on common sociocultural attributes. Multivariate data reduction techniques (e.g. principal component analyses, cluster analyses) were used to classify Northeast U.S. fishing communities based on census and fisheries data. The comparisons indicate that the clusters represent real groupings that can be verified with the profiles. We then selected communities representative of different values on these multivariate dimensions for in-depth analysis. The derived clusters are then compared based on more detailed data from fishing community profiles. Ground-truthing (e.g. visiting the communities and collecting primary information) a sample of communities from three clusters (two overlapping geographically) indicates that the more remote techniques are sufficient for typing the communities for further in-depth analyses. The in-depth analyses provide additional important information which we contend is representative of all communities within the cluster
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