Growth promoting effects of growth hormone and IGF-I are additive in experimental uremia.

Exogenous growth hormone (GH) stimulates the endogenous production of IGF-I and improves growth in uremia. We investigated whether exogenous IGF-I is also able to improve uremic growth failure in rats and whether the growth promoting effects of GH and IGF-I are additive. In female 150 g uremic (subtotal nephrectomy, NX) Sprague-Dawley rats, both rhGH in doses from 2 X 1.25 to 2 X 10 IU/kg bid s.c. and rhIGF-I in doses from 2 X 0.5 to 2 X 4.0 mg/kg bid s.c. caused a dose-dependent increase in weight gain and length gain. However, endogenous production of GH was suppressed by both agents. Peptide hormone treatment did not affect cumulative food intake, but significantly increased food efficiency ratio (weight gain/food intake). Concomitant s.c. treatment with maximally effective doses of rhGH (12 X 5 IU/kg bid) and of rhIGF-I (2 X 2 mg/kg bid) resulted in additive growth promoting effects in NX and pair-fed control (CO) animals during the observation period of 12 days. Cumulative length gain was 3.2 +/- 0.5 cm in solvent-treated NX-animals, 4.1 +/- 0.5 cm with rhGH (+ 28% above solvent), 4.2 +/- 0.6 cm with rhIGF-I (+ 31%) and 4.9 +/- 0.5 cm with both peptides (+ 53%). The food efficiency ratio was 0.16 +/- 0.05 in solvent NX, 0.33 +/- 0.04 with rhGH (+ 106% above solvent), 0.23 +/- 0.02 with rhIGF-I (+ 44%), and 0.38 +/- 0.02 with both peptides (+ 138%). Histomorphometric analysis and measurements of length gain by fluorescence microscopy in the upper tibial metaphysis confirmed the growth promoting effects of both peptide hormones. The serum concentrations of IGF binding protein (BP)-4 (Western ligand blotting analysis) and of IGFBP-2 (immunoblot) were increased in uremic animals whereas IGFBP-3 was unchanged. Treatment with IGF-I and/or rhGH increased serum concentration of IGF-I but did not change the IGFBP pattern. rhIGF-I lowered blood glucose levels within one to two hours after injection. The effect was most pronounced during the first treatment day and declined thereafter. Concomitant treatment with rhGH attenuated the glucose lowering effect of rhIGF-I (glucose serum concentration at day one: 120 +/- 11 mg% in solvent NX, 50 +/- 21 mg% with rhIGF-I, 80 +/- 24 mg% with both peptides). It is concluded that: (i) IGF-I is able to stimulate growth in NX animals but suppresses endogenous GH production in the long run; (ii) the concomitant treatment with IGF-I and GH has additive effects on growth; and (iii) concomitant treatment with rhGH prevents hypoglycemia that is noted with rhIGF-I alone

Cafer Bater'den suluboya sergi

Taha Toros Arşivi, Dosya No: 97-Cafer Bate

Bey der höchst beglückten hohen Vermählung des Hochgebohrnen Grafen und Herrn, Herrn Heinrich des XXIII. Jüngern Reussen des H. Röm. Reichs Grafen und Herrn von Plauen, Greitz, ... Mit der auch Hochgebohrnen Gräfin Ernestinen Henrietten Sophien des H. R. R. Gräfin zu Schönburg-Wechselburg ... welche den 13. Febr. des ietztlaufenden 1754sten Jahres ... vollzogen wurde, setzten dieses ... Denkmahl ... Deroselben ... Vettern Carl Ernst Casimir und Friedrich Wilhelm, Grafen zur Lippe

Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Halle, mit Schneiderschen Schriften

Die Wercke und Wege Gottes in ihrer Grösse Bey dem Vermählungsfest Des ... Herrn Seyfried ... Grafen von Promnitz, ... Mit der ... Gräfin Wilhelminen Louisen Constantien ... zur Lippe ... Als solches am 15 August 1754. zu Wernigerode frölich gefeiret wurde, glückwünschend erwogen von zweyen der Gräfin Braut zärtlichst ergebensten Brüdern Carl Ernst Casimir Grafen zur Lippe. Friedrich Wilhelm Grafen zur Lippe

Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Halle, mit Schneiderschen Schriften

Die rationelle ernährung des volkes. Mit besonderer berücksichtigung der beköstigung in schulen, seminarien, arbeitshäusern und armenhäusern.

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