269 research outputs found
FILLING THE GAPS: SHAPING LIGHTING EDUCATION FOR THE FUTURE:LIGHTING METROPOLIS WP6.1
Training and knowledge of lighting is an increasingly sought-after professional quality in Denmark and Sweden. However, technological development in the lighting field has been in recent years extremely rapid, not least in Scandinavia. This has led to a situation, where users, designers, specifiers, buyers and installers are often neither in possession, nor have access to, the knowledge about lighting that they need. The aim of the study is to map and analyze the existing offer and demand for competencies within lighting related fields. That is to say, the study has looked at the existing educational programs within a broad field of lighting and compared this ‘supply’ to the current ‘demand’ by local employers. The paper presents the results from a statistical analysis of data collected from a series of surveys, expert interviews and focus groups, involving more than 250 participants in Sweden and Denmark. Based on the findings, the paper presents recommendations for the design of educational curricula
Treatment of Zygomatic Complex Fractures with Surgical or Nonsurgical Intervention:A Retrospective Study
Objective:Evaluate the 1-year treatment outcome of zygomatic complex fractures with surgical or nonsurgical intervention.Materials and Methods:One hundred and forty-two consecutive patients with a zygomatic complex fracture were enrolled. Sixty-eight patients underwent surgical intervention and 74 patients nonsurgical intervention. The 1-year examination evaluated cosmetic and functional outcome including malar symmetry, ocular motility, occlusion, mouth opening, neurosensory disturbances, and complications.Results:Forty-six patients allocated to surgical intervention responded to the 1-year follow-up examination. Satisfying facial contour and malar alignment was observed in 45 patients. All patients presented with identical position of the eye globe without enophthalmos and normal ocular movement. A habitual occlusion was seen in all patients with a mean interincisal mouth opening without pain of 49 mm. One patient presented with minor ectropion. Wound infection occurred in five patients. Persistent infraorbital neurosensory disturbance was described by 19 patients. The 1-year radiographic examination showed adequate fracture alignment in all patients with satisfying facial contour. However, dissimilar position of the orbital floor was seen in three patients having orbital reconstruction. None of the patients were re-operated or needed secondary correction of the zygomatic complex or orbital floor.Conclusion:Surgical intervention is an effective treatment modality of depressed zygomatic complex fractures, whereas a nonsurgical approach is often used for nondisplaced fractures. Most zygomatic complex fractures can be treated solely by an intraoral approach and rigid fixation at the zygomaticomaxillary buttress. Further exposure of the zygomaticofrontal junction or inferior orbital rim is necessary for severely displaced fractures, which require additional fixation.</jats:sec
Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial
BACKGROUND: Consistent with its effect on gastric emptying, exenatide, an injectable treatment for type 2 diabetes, may slow the absorption rate of concomitantly administered oral drugs resulting in a decrease in maximum concentration (C(max)). This study evaluated the drug interaction potential of exenatide when administered adjunctively with oral contraceptives, given their potential concomitant use. METHODS: This trial evaluated the effect of exenatide co-administration on single- and multiple-dose pharmacokinetics of a combination oral contraceptive (ethinyl estradiol [EE] 30 μg, levonorgestrel [LV] 150 μg [Microgynon 30(®)]). Thirty-two healthy female subjects participated in an open-label, randomised, crossover trial with 3 treatment periods (oral contraceptive alone, 1 hour before exenatide, 30 minutes after exenatide). Subjects received a single dose of oral contraceptive on Day 8 of each period and QD doses on Days 10 through 28. During treatment periods of concomitant usage, exenatide was administered subcutaneously prior to morning and evening meals at 5 μg BID from Days 1 through 4 and at 10 μg BID from Days 5 through 22. Single- (Day 8) and multiple-dose (Day 22) pharmacokinetic profiles were assessed for each treatment period. RESULTS: Exenatide did not alter the bioavailability nor decrease daily trough concentrations for either oral contraceptive component. No substantive changes in oral contraceptive pharmacokinetics occurred when oral contraceptive was administered 1 hour before exenatide. Single-dose oral contraceptive administration 30 minutes after exenatide resulted in mean (90% CI) C(max )reductions of 46% (42-51%) and 41% (35-47%) for EE and LV, respectively. Repeated daily oral contraceptive administration 30 minutes after exenatide resulted in C(max )reductions of 45% (40-50%) and 27% (21-33%) for EE and LV, respectively. Peak oral contraceptive concentrations were delayed approximately 3 to 4 hours. Mild-to-moderate nausea and vomiting were the most common adverse events observed during the trial. CONCLUSIONS: The observed reduction in C(max )is likely of limited importance given the unaltered oral contraceptive bioavailability and trough concentrations; however, for oral medications that are dependent on threshold concentrations for efficacy, such as contraceptives and antibiotics, patients should be advised to take those drugs at least 1 hour before exenatide injection. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00254800
Thick‑billed Murres in breeding pairs migrate and overwinter far apart but in similar photic environments
Scheduling between mates in species with long-term pair bonds can be essential for positive fitness. The annual cycle in photoperiod is the primary environmental cue used by many animals to synchronize behavior and physiology among members of a population, and animals that migrate must have similar annual schedules to ensure successful breeding. However, we know little about whether members of mated pairs in migratory species experience similar photic environments across the year, which could allow for synchronization in annual phenology. Here, we used light-based geolocation to estimate positions of mated pairs of Thick-billed Murres (Uria lomvia, a seabird a.k.a. Brünnich’s Guillemot) which bred above the northern polar circle in Greenland. We tested the hypothesis that individuals in mated pairs occur in more similar locations and photic environments than randomly matched females and males. We found no difference in the amount of spatial separation or in the photic environment between mates and randomized heterosexual pairings. In general, the distance between females and males ranged from 1,198.5 km during August to 737.4 km during January. The sexes remained in photic environments with highly correlated photoperiods and moderately correlated times of solar noon in UTC. The spatial separation of, but similar photic environments experienced by, female and male murres regardless of pair status is probably adaptive by facilitating the synchronization of annual schedules between sexes, while allowing individuals in mated pairs the freedom to pursue the best foraging opportunities during migration and overwintering independent of their mate. Greenland · Pair migration · Photoperiod · Seabird · Thick-billed Murre · Uria lomviaThick‑billed Murres in breeding pairs migrate and overwinter far apart but in similar photic environmentspublishedVersio
Effect of renal impairment on the pharmacokinetics of exenatide
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Effects of oil and oil burn residues on seabird feathers
It is well known, that in case of oil spill, seabirds are among the groups of animals most vulnerable. Even small amounts of oil can have lethal effects by destroying the waterproofing of their plumage, leading to loss of insulation and buoyancy. In the Arctic these impacts are intensified. To protect seabirds, a rapid removal of oil is crucial and in situ burning could be an efficient method. In the present work exposure effects of oil and burn residue in different doses was studied on seabird feathers from legally hunted Common eider (Somateria mollissima) by examining changes in total weight of the feather and damages on the microstructure (Amalgamation Index) of the feathers before and after exposure. The results of the experiments indicate that burn residues from in situ burning of an oil spill have similar or larger fouling and damaging effects on seabird feathers, as compared to fresh oil
PREFERENCE FOR TOP- VS. SIDE-BINDING IN FLUORINATED ETHYLENE· · · CO2 COMPLEXES
The weakly bound complexes between 1-fluoroethylene (FE), 1,1-difluoroethylene (DFE), and 1,1,2-trifluoroethylene (TFE) and carbon dioxide have been investigated using reduced bandwidth chirped-pulse (CP) and resonant-cavity Fourier-transform microwave (FTMW) spectroscopy. In FECO, two distinct planar isomers are observed, corresponding to the CO interacting with the CHF end of the FE (side-binding) or roughly parallel to the C=C bond (top-binding). Both structures contain a C--HO contact between one FE hydrogen atom and CO. In DFECO, only a top-binding configuration is possible, consistent with the observed structure. Finally, although both top- and side-binding orientations are possible for TFECO, only the side-binding conformation has been observed. The C--HO distances in the four species vary from \AA\ to \AA, while the observed FC distances are much more consistent, varying by only about \AA\ across the series. Ab initio calculations at the MP2/6-311++G(2d,2p) level have provided exceptionally accurate estimates of the rotational constants of these CO complexes, although the energy ordering is, in several cases, inconsistent with the observed geometries
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