Exploiting gender-based biomarkers and drug targets: advancing personalized therapeutic strategies in hepatocellular carcinoma

This review systematically examines gender differences in hepatocellular carcinoma (HCC), identifying the influence of sex hormones, genetic variance, and environmental factors on the disease’s epidemiology and treatment outcomes. Recognizing the liver as a sexually dimorphic organ, we highlight how gender-specific risk factors, such as alcohol consumption and obesity, contribute differently to hepatocarcinogenesis in men and women. We explore molecular mechanisms, including the differential expression of androgen and estrogen receptors, which mediate diverse pathways in tumor biology such as cell proliferation, apoptosis, and DNA repair. Our analysis underscores the critical need for gender-specific research in liver cancer, from molecular studies to clinical trials, to improve diagnostic accuracy and therapeutic effectiveness. By incorporating a gender perspective into all facets of liver cancer research, we advocate for a more precise and personalized approach to cancer treatment that acknowledges gender as a significant factor in both the progression of HCC and its response to treatment. This review aims to foster a deeper understanding of the biological and molecular bases of gender differences in HCC and to promote the development of tailored interventions that enhance outcomes for all patients

Soil Water Dynamics Under Different Land Uses in Loess Hilly Region in China by Stable Isotopic Tracing

Exploring soil water dynamics under different land use types is important for water resource management and vegetation restoration in the Loess Plateau. In this study, we investigated the hydrogen and oxygen isotopic compositions of soil water from four different land use types to explore the mechanism of soil water movement and transformation and analyse the influence of land use. The results show that the range of stable isotopes (δD and δ18O) in soil water was smaller than that in precipitation. Values for δD and δ18O in soil water showed relatively similar temporal variation, heavy isotopes were enriched in the soil water in July and depleted in October. Stable isotope values in shallow (200 cm depth) soil water were low. The δD and δ18O values in woodlands decreased gradually with increasing depth. Across the four land use types, the maximum variation in δD and δ18O was in the shallow depth of the soil profile. Groundwater was recharged mainly from precipitation and then from soil water. The ratio of groundwater recharge by soil water under different land use types followed this rank order: woodland (35.70%) > grassland (31.14%) > shrubland (29.47%) > cropland (29.18%). Matrix flow and preferential flow coexisted during infiltration, and the occurrence of preferential flow was related to the land use type. The main reason for the variation in isotopic composition in soil water is the difference in soil evaporation, which is influenced by different vegetation cover. Owing to the difference in soil evaporation and fractionation, precipitation on cropland, shrubland, and grassland can recharge more soil water than on woodland

Exploring the Attractiveness of Residential Areas for Human Activities Based on Shared E-Bike Trajectory Data

Human activities generate diverse and sophisticated functional areas and may impact the existing planning of functional areas. Understanding the relationship between human activities and functional areas is key to identifying the real-time urban functional areas based on trajectories. Few previous studies have analyzed the interactive information on humans and regions for functional area identification. The relationship between human activities and residential areas is the most representative for urban functional areas because residential areas cover a wide range and are closely connected with human life. The aim of this paper is to propose the CARA (Commuting Activity and Residential Area) model to quantify the correlation between human activities and urban residential areas. In this model, human activities are represented by hot spots extracted by the Gaussian Mixture Model algorithm while residential areas are represented by POI (point of interest) data. The model shows that human activities and residential areas present a logarithmic relationship. The CARA model is further assessed by retrieving urban residential areas in Tengzhou City from shared e-bike trajectories. Compared with the actual map, the accuracy reaches 83.3%, thus demonstrating the model’s reliability and feasibility. This study provides a new method for functional areas identification based on trajectory data, which is helpful for formulating the urban people-oriented policies

Characterization of an immunologically active pectin from the fruits of Lycium ruthenicum

An immunologically active pectin, named LRGP5, was firstly isolated from the fruits of Lycium ruthenicum Murr. It contained rhamnose, arabinose, xylose, galactose and galacturonic acid in the molar ratio of 1.0:2.2:0.5:1.2:4.7. Its molecular weight was estimated to be approximately 1.37 x 10(5) Da by high performance gel permeation chromatography. The structure was elucidated using methylation analysis, partial acid hydrolysis, NMR and ESI-MS analysis. Results showed that LRGP5 consisted of a (1 -> 4)-linked galacturonic acid backbone occasionally interrupted by (1 -> 2)-linked rhamnose. The side chains were attached to position 4 of the rhamnosyl units, including (1 -> 3)-linked arabinose, (1 -> 3)-linked galactose, (1 -> 3,6)-linked galactose, (1 -> 4)-linked galacturonic acid, (1 -> 2)-linked rhamnose and (1 -> 2,4)-linked rhamnose, and the termini were arabinose and rhamnose. Immunological assay results demonstrated that LRGP5 could significantly promote macrophage proliferation and enhance the secretion of nitrogen monoxide in vitro. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved

Improving the solubility of Mn and suppressing the oxygen vacancy density in Zn0.98Mn0.02O nanocrystals via octylamine treatment

Zn0.98Mn0.02O nanocrystals were synthesized by the wet chemical route and were treated with different content of octylamine. The environment around Mn and the defect type and concentration were characterized by photoluminescence, Raman, X-ray photoelectron spectroscopy, and X-ray absorption fine structure. It is found that N codoping effectively enhances the solubility of Mn substituting Zn via reducing donor binding energy of impurity by the orbital hybridization between the N-acceptor and Mn-donor. On the other hand, the O atoms released from MnO6 and the N ions from octylamine occupy the site of oxygen vacancies and result in reduction of the concentration of oxygen vacancies in Zn0.98Mn0.02O nanocrystals

Improving the Solubility of Mn and Suppressing the Oxygen Vacancy Density in Zn_0.98Mn_0.02O Nanocrystals via Octylamine Treatment

Zn_0.98Mn_0.02O nanocrystals were synthesized by the wet chemical route and were treated with different content of octylamine. The environment around Mn and the defect type and concentration were characterized by photoluminescence, Raman, X-ray photoelectron spectroscopy, and X-ray absorption fine structure. It is found that N codoping effectively enhances the solubility of Mn substituting Zn via reducing donor binding energy of impurity by the orbital hybridization between the N-acceptor and Mn-donor. On the other hand, the O atoms released from MnO₆ and the N ions from octylamine occupy the site of oxygen vacancies and result in reduction of the concentration of oxygen vacancies in Zn_0.98Mn_0.02O nanocrystals