1,091 research outputs found
Symbol Synchronization for SDR Using a Polyphase Filterbank Based on an FPGA
This paper is devoted to the proposal of a highly efficient symbol synchronization subsystem for Software Defined Radio. The proposed feedback phase-locked loop timing synchronizer is suitable for parallel implementation on an FPGA. The polyphase FIR filter simultaneously performs matched-filtering and arbitrary interpolation between acquired samples. Determination of the proper sampling instant is achieved by selecting a suitable polyphase filterbank using a derived index. This index is determined based on the output either the Zero-Crossing or Gardner Timing Error Detector. The paper will extensively focus on simulation of the proposed synchronization system. On the basis of this simulation, a complete, fully pipelined VHDL description model is created. This model is composed of a fully parallel polyphase filterbank based on distributed arithmetic, timing error detector and interpolation control block. Finally, RTL synthesis on an Altera Cyclone IV FPGA is presented and resource utilization in comparison with a conventional model is analyzed
Formation of singularities for equivariant 2+1 dimensional wave maps into the two-sphere
In this paper we report on numerical studies of the Cauchy problem for
equivariant wave maps from 2+1 dimensional Minkowski spacetime into the
two-sphere. Our results provide strong evidence for the conjecture that large
energy initial data develop singularities in finite time and that singularity
formation has the universal form of adiabatic shrinking of the degree-one
harmonic map from into .Comment: 14 pages, 5 figures, final version to be published in Nonlinearit
Phenotypic characteristics of the p.Asn215Ser (p.N215S) GLA mutation in male and female patients with Fabry disease: A multicenter Fabry Registry study.
BackgroundThe p.Asn215Ser or p.N215S GLA variant has been associated with late-onset cardiac variant of Fabry disease.MethodsTo expand on the scarce phenotype data, we analyzed natural history data from 125 p.N215S patients (66 females, 59 males) enrolled in the Fabry Registry (NCT00196742) and compared it with data from 401 patients (237 females, 164 males) harboring mutations associated with classic Fabry disease. We evaluated interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), estimated glomerular filtration rate and severe clinical events.ResultsIn p.N215S males, mildly abnormal mean IVST and LVPWT values were observed in patients aged 25-34Â years, and values gradually increased with advancing age. Mean values were similar to those of classic males. In p.N215S females, these abnormalities occurred primarily in patients aged 55-64Â years. Severe clinical events in p.N215S patients were mainly cardiac (males 31%, females 8%) while renal and cerebrovascular events were rare. Renal impairment occurred in 17% of p.N215S males (mostly in patients aged 65-74Â years), and rarely in females (3%).Conclusionp.N215S is a disease-causing mutation with severe clinical manifestations found primarily in the heart. Cardiac involvement may become as severe as in classic Fabry patients, especially in males
Pegunigalsidase alfa: a novel, pegylated recombinant alpha-galactosidase enzyme for the treatment of Fabry disease
Fabry disease, a rare X-linked genetic disorder, results from pathogenic variants in GLA, leading to deficient lysosomal Îą-galactosidase A enzyme activity and multi-organ manifestations. Since 2001, enzyme replacement therapy (ERT), using agalsidase alfa or agalsidase beta, has been the mainstay treatment, albeit with limitations such as rapid clearance and immunogenicity. Pegunigalsidase alfa, a novel PEGylated recombinant alpha-galactosidase, offers promise as an alternative. Produced in plant cells, pegunigalsidase alfa exhibits enhanced stability, prolonged half-life, and reduced immunogenicity due to pegylation. A phase 1/2 clinical trial demonstrated Gb3 clearance from renal capillary endothelial cells and its 48-month extension study revealed notable outcomes in renal function preservation. Three phase 3 clinical trials (BRIDGE, BRIGHT, and BALANCE) have shown favorable efficacy and safety profile, although caution is warranted in interpreting the results of BRIDGE and BRIGHT which lacked control groups. In BALANCE, the pivotal phase 3 trial comparing pegunigalsidase alfa with agalsidase beta, an intention-to-treat analysis of the eGFR decline over 2Â years showed that the intergroup difference [95%confidence interval] in the median slope was â0.36Â mL/min/1.73 m2/year [â2.44; 1.73]. The confidence interval had a lower limit above the prespecified value of â3Â mL/min/1.73 m2/year and included zero. Despite challenges such as occasional hypersensitivity reactions and immune-complex-mediated glomerulonephritis, pegunigalsidase alfa approval by the European Medicines Agency and the Food and Drug Administration represents a significant addition to Fabry disease therapeutic landscape providing an option for patients in whom enzyme replacement therapy with current formulations is poorly tolerated or poorly effective
Collapse of an Instanton
We construct a two parameter family of collapsing solutions to the 4+1
Yang-Mills equations and derive the dynamical law of the collapse. Our
arguments indicate that this family of solutions is stable. The latter fact is
also supported by numerical simulations.Comment: 17 pages, 1 figur
Quantum lump dynamics on the two-sphere
It is well known that the low-energy classical dynamics of solitons of
Bogomol'nyi type is well approximated by geodesic motion in M_n, the moduli
space of static n-solitons. There is an obvious quantization of this dynamics
wherein the wavefunction evolves according to the Hamiltonian H_0 equal to
(half) the Laplacian on M_n. Born-Oppenheimer reduction of analogous mechanical
systems suggests, however, that this simple Hamiltonian should receive
corrections including k, the scalar curvature of M_n, and C, the n-soliton
Casimir energy, which are usually difficult to compute, and whose effect on the
energy spectrum is unknown. This paper analyzes the spectra of H_0 and two
corrections to it suggested by work of Moss and Shiiki, namely H_1=H_0+k/4 and
H_2=H_1+C, in the simple but nontrivial case of a single CP^1 lump moving on
the two-sphere. Here M_1=TSO(3), a noncompact kaehler 6-manifold invariant
under an SO(3)xSO(3) action, whose geometry is well understood. The symmetry
gives rise to two conserved angular momenta, spin and isospin. A hidden
isometry of M_1 is found which implies that all three energy spectra are
symmetric under spin-isospin interchange. The Casimir energy is found exactly
on the zero section of TSO(3), and approximated numerically on the rest of M_1.
The lowest 19 eigenvalues of H_i are found for i=0,1,2, and their spin-isospin
and parity compared. The curvature corrections in H_1 lead to a qualitatively
unchanged low-level spectrum while the Casimir energy in H_2 leads to
significant changes. The scaling behaviour of the spectra under changes in the
radii of the domain and target spheres is analyzed, and it is found that the
disparity between the spectra of H_1 and H_2 is reduced when the target sphere
is made smaller.Comment: 35 pages, 3 figure
The geodesic approximation for lump dynamics and coercivity of the Hessian for harmonic maps
The most fruitful approach to studying low energy soliton dynamics in field
theories of Bogomol'nyi type is the geodesic approximation of Manton. In the
case of vortices and monopoles, Stuart has obtained rigorous estimates of the
errors in this approximation, and hence proved that it is valid in the low
speed regime. His method employs energy estimates which rely on a key
coercivity property of the Hessian of the energy functional of the theory under
consideration. In this paper we prove an analogous coercivity property for the
Hessian of the energy functional of a general sigma model with compact K\"ahler
domain and target. We go on to prove a continuity property for our result, and
show that, for the CP^1 model on S^2, the Hessian fails to be globally coercive
in the degree 1 sector. We present numerical evidence which suggests that the
Hessian is globally coercive in a certain equivariance class of the degree n
sector for n>1. We also prove that, within the geodesic approximation, a single
CP^1 lump moving on S^2 does not generically travel on a great circle.Comment: 29 pages, 1 figure; typos corrected, references added, expanded
discussion of the main function spac
Patients affected with Fabry disease have an increased incidence of progressive hearing loss and sudden deafness: an investigation of twenty-two hemizygous male patients
BACKGROUND: Fabry disease (FD, OMIM 301500) is an X-linked inborn error of glycosphingolipid metabolism due to the deficient activity of alpha-galactosidase A, a lysosomal enzyme. While the progressive systemic deposition of uncleaved glycosphingolipids throughout the body is known to have protean clinical manifestations, few data are available regarding the cochlear involvement. METHODS: We non-invasively investigated cochlear functions in 22 consecutive hemizygous males (age 19â64 years, mean 39) affected with classic FD. Conventional audiometry, tympanometry, ABR audiometry, otoacoustic emissions were performed in all patients, together with medical history record and physical examination as part of an exhaustive baseline evaluation prior to enzyme replacement therapy. RESULTS: A total of 12 patients (54.5%) with classic FD were found to have abnormal audition. Five patients had progressive hearing loss and seven patients (32%) experienced sudden deafness. In addition, a hearing loss on high-tone frequencies was found in 7 out of the 10 remaining patients without clinical impairment, despite their young age at time of examination. The incidence of hearing loss appeared significantly increased in FD patients with kidney failure (P < 0.01) or cerebrovascular lesions (P < 0.01), whereas there was no correlation with left ventricular hypertrophy. In addition, tinnitus aurium was also found in six patients (27%). CONCLUSION: This is the first evidence of a high incidence of both progressive hearing loss and sudden deafness in a cohort of male patients affected with classic Fabry disease. The exact pathophysiologic mechanism(s) of the cochlear involvement deserves further studies
Optical markers of magnetic phase transition in CrSBr
Here, we investigate the role of the interlayer magnetic ordering of CrSBr in
the framework of calculations and by using optical
spectroscopy techniques. These combined studies allow us to unambiguously
determine the nature of the optical transitions. In particular,
photoreflectance measurements, sensitive to the direct transitions, have been
carried out for the first time. We have demonstrated that optically induced
band-to-band transitions visible in optical measurement are remarkably well
assigned to the band structure by the momentum matrix elements and energy
differences for the magnetic ground state (A-AFM). In addition, our study
reveals significant differences in electronic properties for two different
interlayer magnetic phases. When the magnetic ordering of A-AFM to FM is
changed, the crucial modification of the band structure reflected in the
direct-to-indirect band gap transition and the significant splitting of the
conduction bands along the direction are obtained. In addition,
Raman measurements demonstrate a splitting between the in-plane modes
/, which is temperature dependent and can be assigned to
different interlayer magnetic states, corroborated by the DFT+U study.
Moreover, the mode has not been experimentally observed before.
Finally, our results point out the origin of interlayer magnetism, which can be
attributed to electronic rather than structural properties. Our results reveal
a new approach for tuning the optical and electronic properties of van der
Waals magnets by controlling the interlayer magnetic ordering in adjacent
layers.Comment: 33 pages, 15 figure
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