3,226 research outputs found
Traveling waves in lattice differential equations with distributed maturation delay
In this paper we derive a lattice model with infinite distributed delay to describe the growth of a single-species population in a 2D patchy environment with infinite number of patches connected locally by diffusion and global interaction. We consider the existence of traveling wave solutions when the birth rate is large enough that each patch can sustain a positive equilibrium. When the birth function is monotone, we prove that there exists a traveling wave solution connecting two equilibria with wave speed by using the monotone iterative method and super and subsolution technique, where is any fixed direction of propagation. When the birth function is non-monotone, we prove the existence of non-trivial traveling wave solutions by constructing two auxiliary systems satisfying quasi-monotonicity
Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs
Ferroptosis is a newly identified form of regulated cell death that is associated with iron metabolism and oxidative stress. As a physiological mechanism, ferroptosis selectively removes cancer cells by regulating the expression of vital chemical molecules. Current findings on regulation of ferroptosis have largely focused on the function of non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), in mediating ferroptotic cell death, while the sponging effect of circular RNAs (circRNAs) has not been widely studied. In this review, we discuss the molecular regulation of ferroptosis and highlight the value of circRNAs in controlling ferroptosis and carcinogenesis. Herein, we deliberate future role of this emerging form of regulated cell death in cancer therapeutics and predict the progression and prognosis of oncogenesis in future clinical therapy.publishedVersio
Ethyl 4-[(4-chlorophenoxy)methyl]-2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate
The title compound, C19H15ClN2O5S, contains two molecules (A and B) in the asymmetric unit. In molecule A, the dihedral angles between the thiazole ring and the pendant chlorobenzene and nitrobenzene rings are 72.14 (15) and 3.03 (15)°, respectively. The corresponding angles for molecule B are 45.56 (16) and 1.51 (14)°, respectively. In the crystal, both molecules form inversion dimers linked by pairs of weak C—H⋯O interactions
3,3′-Di-tert-butyl-5,5′-dimethoxybiphenyl-2,2′-diol
The title compound, C22H30O4, displays twofold rotational symmetry. The two benzene rings are almost perpendicular to each other, forming a dihedral angle of 89.8 (6)°. In the crystal, molecules are linked into an extended one-dimensional chain structure via intermolecular O—H⋯O hydrogen bonds
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