Deploying quantum light sources on nanosatellites II: lessons and perspectives on CubeSat spacecraft

To enable space-based quantum key distribution proposals the Centre for Quantum Technologies is developing a source of entangled photons ruggedized to survive deployment in space and greatly miniaturised so that it conforms to the strict form factor and power requirements of a 1U CubeSat. The Small Photon Entangling Quantum System is an integrated instrument where the pump, photon pair source and detectors are combined within a single optical tray and electronics package that is no larger than 10 cm x 10 cm x 3 cm. This footprint enables the instrument to be placed onboard nanosatellites or the CubeLab structure aboard the International Space Station. We will discuss the challenges and future prospects of CubeSat-based missions.Comment: Submitted to SPIE Quantum Information Science and Technology. Paper number 9648-4

Enhancing Landslide Susceptibility Modelling Through a Novel Non-landslide Sampling Method and Ensemble Learning Technique

In recent years, several catastrophic landslide events have been observed throughout the globe, threatening to lives and infrastructures. To minimize the impact of landslides, the need of landslide susceptibility map is important. The study aims to extract high-quality non-landslide samples and improve the accuracy of landslide susceptibility modelling (LSM) outcomes by applying a coupled method of ensemble learning and Machine Learning (ML). The Zigui-Badong section of the Three Gorges Reservoir area (TGRA) in China was considered in the present study. Twelve influencing factors were selected as inputs for LSM, and the relationship between each causal factor and landslide spatial development was quantitatively analyzed. A total of 179 landslides have been used in the present study. About 70% of the landslide pixels were randomly considered for training, and the remaining 30% were used for validation. Logistic Regression (LR) model was applied to produce an initial susceptibility map, and the non-landslide samples were selected within the classified low-susceptibility zone. Subsequently, two ML classifiers – the Classification and Regression Tree (CART), and the Multi-Layer Perceptron (MLP), and four coupling models – the CART-Bagging, CART-Boosting, MLP-Bagging, and MLP-Boosting, were utilized for LSM. Finally, the receiver operating characteristics (ROC) curve and statistical analysis were applied for accuracy assessment. The results show that altitude and distance to rivers were the main causal factors of landslides in the study area. The LR-MLP-Boosting performed the best with an accuracy of 0.986 followed by the LR-CART-Bagging, LR-CART-Boosting, and LR-MLP-Bagging. Accuracy comparisons demonstrate that ensemble learning algorithm can notably enhance the LSM performance of ML classifiers, and the Boosting algorithm marginally outperforms the Bagging algorithm. Moreover, the LR model can effectively constrain the selection range of non-landslide samples. The non-landslide sampling method constrained by LR yields higher quality samples compared to raditional random sampling method with no constraints, which develops a more excellent LSM

Nanosatellite experiments to enable future space-based QKD missions

We present a programme for establishing the space worthiness of highly-miniaturised, polarisation-entangled, photon pair sources using CubeSat nanosatellites. Once demonstrated, the photon pair sources can be deployed on more advanced satellites that are equipped with optical links to establish a global space-based quantum key distribution network. In doing so, this work will also bring experimental tests of the overlap between quantum and relativistic regimes closer to realisation

Orexin Receptor-1 in the Rostral Ventrolateral Medulla Mediates the Antihypertensive Effects of Electroacupuncture

Electroacupuncture (EA) has been used to treat numerous diseases, including hypertension. This study aimed to investigate the long-term effect and underlying mechanisms of EA stimulation at the LI11 point on the hypertension and sympathetic nerve activity in two-kidney, one-clip (2K1C) hypertensive rats. EA (0.1–0.4 mA, 2 and 15 Hz) was applied to the acupoints LI11 overlying the deep radial nerve once a day for 6 weeks. The mean arterial pressure (MAP) and heart rate (HR) were determined by radiotelemetry, and the sympathetic nerve activity was evaluated by telemetric analyses of the low-frequency component of blood pressure (BP) and by plasma epinephrine and norepinephrine levels. The results showed 6 weeks of EA significantly lowered the increased BP effectively, inhibited the enhanced sympathetic nerve activities and attenuated cardiac hypertrophy in 2K1C hypertensive rats. The level of orexin receptor-1 (OX1R) in the rostral ventrolateral medulla (RVLM) after EA treatment was markedly reduced in 2K1C rats, while there was no difference in the RVLM expression of orexin receptor-2 (OX2R) in 2K1C and 2K1C+EA rats. Moreover, the increased pressor and depressor responses to microinjection of orexin A or OX1R antagonist SB408124 into the RVLM of 2K1C rats were significantly blunted by the EA treatment. These findings suggest that BP-lowering effect of EA on renovascular hypertension may be through inhibition of central sympathetic activities and modulation of functional orexin receptors in the RVLM

Enhancing the efficacy of stem cell therapy with glycosaminoglycans

Human mesenchymal stem cell (hMSC) therapy offers significant potential for osteochondral regeneration. Such applications require their ex vivo expansion in media frequently supplemented with fibroblast growth factor 2 (FGF2). Particular heparan sulfate (HS) fractions stabilize FGF2-FGF receptor complexes. We show that an FGF2-binding HS variant (HS8) accelerates the expansion of freshly isolated bone marrow hMSCs without compromising their naivety. Importantly, the repair of osteochondral defects in both rats and pigs is improved after treatment with HS8-supplemented hMSCs (MSCHS8), when assessed histologically, biomechanically, or by MRI. Thus, supplementing hMSC culture media with an HS variant that targets endogenously produced FGF2 allows the elimination of exogenous growth factors that may adversely affect their therapeutic potency

Genome-wide regulation of innate immunity by juvenile hormone and 20-hydroxyecdysone in the Bombyx fat body

<p>Abstract</p> <p>Background</p> <p>Insect innate immunity can be affected by juvenile hormone (JH) and 20-hydroxyecdysone (20E), but how innate immunity is developmentally regulated by these two hormones in insects has not yet been elucidated. In the silkworm, <it>Bombyx mori</it>, JH and 20E levels are high during the final larval molt (4 M) but absent during the feeding stage of 5^thinstar (5 F), while JH level is low and 20E level is high during the prepupal stage (PP). Fat body produces humoral response molecules and hence is considered as the major organ involved in innate immunity.</p> <p>Results</p> <p>A genome-wide microarray analysis of <it>Bombyx </it>fat body isolated from 4 M, 5 F and PP uncovered a large number of differentially-expressed genes. Most notably, 6 antimicrobial peptide (AMP) genes were up-regulated at 4 M versus PP suggesting that <it>Bombyx </it>innate immunity is developmentally regulated by the two hormones. First, JH treatment dramatically increased AMP mRNA levels and activities. Furthermore, 20E treatment exhibited inhibitory effects on AMP mRNA levels and activities, and RNA interference of the 20E receptor <it>EcR</it>-<it>USP </it>had the opposite effects to 20E treatment.</p> <p>Conclusion</p> <p>Taken together, we demonstrate that JH acts as an immune-activator while 20E inhibits innate immunity in the fat body during <it>Bombyx </it>postembryonic development.</p

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

The slow-releasing hydrogen sulfide (H2S) donor, GYY4137, caused concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38) as determined by trypan blue exclusion. Sodium hydrosulfide (NaHS) was less potent and not active in all cell lines. A structural analogue of GYY4137 (ZYJ1122) lacking sulfur and thence not able to release H2S was inactive. Similar results were obtained using a clonogenic assay. Incubation of GYY4137 (400 µM) in culture medium led to the generation of low (<20 µM) concentrations of H2S sustained over 7 days. In contrast, incubation of NaHS (400 µM) in the same way led to much higher (up to 400 µM) concentrations of H2S which persisted for only 1 hour. Mechanistic studies revealed that GYY4137 (400 µM) incubated for 5 days with MCF-7 but not IMR90 cells caused the generation of cleaved PARP and cleaved caspase 9, indicative of a pro-apoptotic effect. GYY4137 (but not ZYJ1122) also caused partial G2/M arrest of these cells. Mice xenograft studies using HL-60 and MV4-11 cells showed that GYY4137 (100–300 mg/kg/day for 14 days) significantly reduced tumor growth. We conclude that GYY4137 exhibits anti-cancer activity by releasing H2S over a period of days. We also propose that a combination of apoptosis and cell cycle arrest contributes to this effect and that H2S donors should be investigated further as potential anti-cancer agents