Helioseismic analysis of the solar flare-induced sunquake of 2005 January 15

We report the discovery of one of the most powerful sunquakes detected to date, produced by an X1.2-class solar flare in active region 10720 on 2005 January 15. We used helioseismic holography to image the source of seismic waves emitted into the solar interior from the site of the flare. Acoustic egression power maps at 3 and 6 mHz with a 2 mHz bandpass reveal a compact acoustic source strongly correlated with impulsive hard X-ray and visible-continuum emission along the penumbral neutral line separating the two major opposing umbrae in the $\delta$-configuration sunspot that predominates AR10720. The acoustic emission signatures were directly aligned with both hard X-ray and visible continuum emission that emanated during the flare. The visible continuum emission is estimated at $2.0 \times 10^{23}$ J, approximately 500 times the seismic emission of $\sim 4 \times 10^{20}$ J. The flare of 2005 January 15 exhibits the same close spatial alignment between the sources of the seismic emission and impulsive visible continuum emission as previous flares, reinforcing the hypothesis that the acoustic emission may be driven by heating of the low photosphere. However, it is a major exception in that there was no signature to indicate the inclusion of protons in the particle beams thought to supply the energy radiated by the flare. The continued strong coincidence between the sources of seismic emission and impulsive visible continuum emission in the case of a proton-deficient white-light flare lends substantial support to the ``back -- warming'' hypothesis, that the low photosphere is significantly heated by intense Balmer and Paschen continuum-edge radiation from the overlying chromosphere in white-light flares.Comment: 12 pages, 7 figures, published in MNRA

Maternal fluoxetine exposure alters cortical hemodynamic and calcium response of offspring to somatosensory stimuli

Epidemiological studies have found an increased incidence of neurodevelopmental disorders in populations prenatally exposed to selective serotonin reuptake inhibitors (SSRIs). Optical imaging provides a minimally invasive way to determine if perinatal SSRI exposure has long-term effects on cortical function. Herein we probed the functional neuroimaging effects of perinatal SSRI exposure in a fluoxetine (FLX)-exposed mouse model. While resting-state homotopic contralateral functional connectivity was unperturbed, the evoked cortical response to forepaw stimulation was altered in FLX mice. The stimulated cortex showed decreased activity for FLX versus controls, by both hemodynamic responses [oxyhemoglobin (Hb

A simplified protocol for detecting two systemic bait markers (Rhodamine B and iophenoxic acid) in small mammals

We developed a method of quantifying levels of fluorescence in the whiskers of wild stoats (Mustela erminea) using fluorescence microscopy and Axiovision 3.0.6.1 software. The method allows for discrimination between natural fluorescence present in or on a whisker, and the fluorescence resulting from the ingestion of the systemic marker Rhodamine B (RB), although some visual judgement is still required. We also developed a new high performance liquid chromatography (HPLC) protocol for detecting the systemic marker iophenoxic acid (IPA) in the blood of laboratory rats (Rattus norvegicus) and wild stoats. With this method, the blood of an animal that has consumed IPA can be tested for the presence of the foreign IPA compound itself. This is a more reliable test than the previous method, which measured the raised level of natural blood protein-bound iodine correlated with IPA absorption. The quantity of blood required from animal subjects is very small (10 μl), so the testing is less intrusive and the method can be extended to smaller species. The extraction technique uses methanol, rather than acids and heavy metal salts, thereby simplifying the procedure. Recovery of IPA is quantitative, giving a highly reliable reading. In experiments on captive rats the IPA method proved successful. Of 12 positively marked carcasses, two that had not been frozen for the 24 h before blood samples were taken showed relatively lower IPA levels. The same IPA detection method, as well as the whisker analysis for RB, was applied successfully to a population of wild stoats to which both Rhodamine B and IPA were made available at bait stations. The presence of both bait markers was detectable in rats for at least 21 days and in stoats for at least 27 days

Measurement of mutual inductance from frequency dependence of impedance of AC coupled circuit using digital dual-phase lock-in amplifier

We present a simple method to determine the mutual inductance $M$ between two coils in a coupled AC circuit by using a digital dual-phase lock-in amplifier. The frequency dependence of the real and imaginary parts is measured as the coupling constant is changed. The mutual inductance $M$ decreases as the distance $d$ between the centers of coils is increased. We show that the coupling constant is proportional to $d^{-n}$ with an exponent $n$ ($\approx$ 3). This coupling is similar to that of two magnetic moments coupled through a dipole-dipole interaction.Comment: 9 pages, 10 figures, Fig.1 is corrected, figures in png files, short version is published in Am. J. Phys. 76, (2008) 12

Diffusion Enhancement in a Periodic Potential under High-Frequency Space-Dependent Forcing

We study the long-time behavior of underdamped Brownian particle moving through a viscous medium and in a systematic potential, when it is subjected to a space-dependent high-frequency periodic force. When the frequency is very large, much larger than all other relevant system-frequencies, there is a Kapitsa time-window wherein the effect of frequency dependent forcing can be replaced by a static effective potential. Our new analysis includes the case when the forcing, in addition to being frequency-dependent, is space-dependent as well. The results of the Kapitsa analysis then lead to additional contributions to the effective potential. These are applied to the numerical calculation of the diffusion coefficient (D) for a Brownian particle moving in a periodic potential. Presented are numerical results, which are in excellent agreement with theoretical predictions and which indicate a significant enhancement of D due to the space-dependent forcing terms. In addition we study the transport property (current) of underdamped Brownian particles in a ratchet potential.Comment: RevTex 6 pages, 5 figure

Mind-Body Skills Groups for Adolescents with Depression in Primary Care: A Pilot Study

Objective: To determine acceptability and preliminary effectiveness of Mind-Body Skills Groups (MBSGs) as a treatment for depressed adolescents in primary care. Methods: A single arm clinical trial was conducted. A 10-week MBSG program was implemented in primary care. Participants completed self-report measures at baseline, post-intervention, and 3-months following the MBSGs. Measures included the Children’s Depression Inventory-2, Suicidal Ideation Questionnaire, Mindful Attention Awareness Scale, Self-Efficacy for Depressed Adolescents, rumination subscale of the Children’s Response Style Questionnaire, and a short acceptability questionnaire. Results: Participants included 43 adolescents. The total depression scores significantly improved following the MBSG intervention and continued to improve significantly from post-treatment to follow-up. Mindfulness, self-efficacy, rumination, and suicidal ideation all had significant improvement following the intervention. Acceptability of the program was strong, and attendance was excellent. Discussion: Preliminary evidence suggests that MBSGs are an acceptable treatment for primary care settings and lead to improved depression symptoms in adolescents.Sandra Eskenazi Mental Health Center and the Herbert Simon Family Foundation (070241-00002B

Strength in diversity: enhancing learning in vocationally-orientated, master's level courses

Postgraduate education in geography, especially at the Master’s level, is undergoing significant changes in the developed world. There is an expansion of vocationally-oriented degree programmes, increasing recruitment of international students, integration of work place skills, and the engagement of non-traditional postgraduate students as departments respond to policies for a more ‘inclusive’ higher education. This paper sets the context by outlining some programmatic changes in selected countries (Australia, the UK, and the USA). We briefly reflect on how postgraduate ‘bars’ or ‘levels’ are defined and explore in detail what ‘diversity’ or ‘heterogeneity’ means in these new postgraduate settings. The paper then explores some examples of practice drawn from our own experiences, whilst recognising that relevance will vary in other contexts. Finally we consider how diversity can be harnessed as a strength that has potential to enhance taught elements of contemporary postgraduate education in and beyond the discipline

The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)

Mouse double minute 2 (Mdm2) and MdmX dimerize in response to low levels of genotoxic stress to function in a ubiquitinating complex, which signals for destabilization of p53. Under growth conditions, Mdm2 functions as a neddylating ligase, but the importance and extent of MdmX involvement in this process are largely unknown. Here we show that when Mdm2 functions as a neddylating enzyme, MdmX is stabilized. Furthermore, we demonstrate that under growth conditions, MdmX enhances the neddylation activity of Mdm2 on p53 and is a substrate for neddylation itself. Importantly, MdmX knockdown in MCF-7 breast cancer cells resulted in diminished neddylated p53, suggesting that MdmX is important for Mdm2-mediated neddylation. Supporting this finding, the lack of MdmX in transient assays or in p53/MdmX-/- MEFs results in decreased or altered neddylation of p53 respectively; therefore, MdmX is a critical component of the Mdm2-mediated neddylating complex. c-Src is the upstream activator of this Mdm2-MdmX neddylating pathway and loss of Src signaling leads to the destabilization of MdmX that is dependent on the RING (Really Interesting New Gene) domain of MdmX. Treatment with a small molecule inhibitor of neddylation, MLN4924, results in the activation of Ataxia Telangiectasia Mutated (ATM). ATM phosphorylates Mdm2, converting Mdm2 to a ubiquitinating enzyme which leads to the destabilization of MdmX. These data show how distinct signaling pathways engage neddylating or ubiquitinating activities and impact the Mdm2-MdmX axis