Gestational diabetes mellitus- right person, right treatment, right time?

Background: Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases. For type 2 diabetes, the importance of the underlying clinical heterogeneity of the condition is emphasised and a range of treatments are now available, with personalised approaches being developed. While a close connection between risk factors for type 2 diabetes and gestational diabetes has long been acknowledged, stratification of screening, treatment and obstetric intervention remains in its infancy. Conclusions: Although there have been major advances in our understanding of glucose tolerance in pregnancy and of the benefits of treatment of gestational diabetes, we argue that far more vigorous approaches are needed to enable development of companion diagnostics, and to ensure the efficacious and safe use of novel therapeutic agents and strategies to improve outcomes in this common condition

The Devil is in the Detail: Hints for Practical Optimisation

Finding the minimum of an objective function, such as a least squares or negative log-likelihood function, with respect to the unknown model parameters is a problem often encountered in econometrics. Consequently, students of econometrics and applied econometricians are usually well-grounded in the broad differences between the numerical procedures employed to solve these problems. Often, however, relatively little time is given to understanding the practical subtleties of implementing these schemes when faced with illbehaved problems. This paper addresses some of the details involved in practical optimisation, such as dealing with constraints on the parameters, specifying starting values, termination criteria and analytical gradients, and illustrates some of the general ideas with several instructive examples.gradient algorithms, unconstrained optimisation, generalised method of moments.

Discrete time-series models when counts are unobservable

Count data in economics have traditionally been modeled by means of integer-valued autoregressive models. Consequently, the estimation of the parameters of these models and their asymptotic properties have been well documented in the literature. The models comprise a description of the survival of counts generally in terms of a binomial thinning process and an independent arrivals process usually specified in terms of a Poisson distribution. This paper extends the existing class of models to encompass situations in which counts are latent and all that is observed is the presence or absence of counts. This is a potentially important modification as many interesting economic phenomena may have a natural interpretation as a series of 'events' that are driven by an underlying count process which is unobserved. Arrivals of the latent counts are modeled either in terms of the Poisson distribution, where multiple counts may arrive in the sampling interval, or in terms of the Bernoulli distribution, where only one new arrival is allowed in the same sampling interval. The models with latent counts are then applied in two practical illustrations, namely, modeling volatility in financial markets as a function of unobservable 'news' and abnormal price spikes in electricity markets being driven by latent 'stress'.Integer-valued autoregression, Poisson distribution, Bernoulli distribution, latent factors, maximum likelihood estimation

Why is CDMA the solution for mobile satellite communication

It is demonstrated that spread spectrum Code Division Multiple Access (CDMA) systems provide an economically superior solution to satellite mobile communications by increasing the system maximum capacity with respect to single channel per carrier Frequency Division Multiple Access (FDMA) systems. Following the comparative analysis of CDMA and FDMA systems, the design of a model that was developed to test the feasibility of the approach and the performance of a spread spectrum system in a mobile environment. Results of extensive computer simulations as well as laboratory and field tests results are presented

Lubricant degradation, transport and the effect of extended oil drain intervals on piston assembly tribology

There are ever increasing demands on lubricant manufacturers to meet governmental legislation and customer needs by improving fuel economy, engine durability and exhaust system compatibility as shown by the introduction of GF4 and move towards GF5 specification oils. This has created an ever increasing need to understand how oil degrades in an engine and how this degraded oil affects piston assembly tribology. This review conference paper will give an overview of a collaborative project that has been undertaken to further enhance the understanding of how lubricant degrades in an operating engine, its transport through the engine and effect upon piston assembly tribology

Extraction and tribological investigation of top piston ring zone oil from a gasoline engine

With tightening emission regulations, increased expected fuel economy, and longer drain intervals impacting on lubricant formulation, greater understanding of how oil degrades in an automotive engine is becoming ever more important. Equally significant is the effect that this degraded lubricant has on the tribological operation of the engine, particularly its overall internal friction and component wear. In a previous paper, four tests to degrade oil in a single cylinder engine were reported [1]. These tests were set up such that the lubricating oil was degraded in the ring pack before returning to the sump, where it was sampled and chemical and rheological analysis undertaken. This paper reports the extension of this work using the same Hydra engine and describes how oil has additionally been extracted from the rear of the top piston ring during engine operation. This extracted oil has then been subjected to similar analysis as the sump oil samples in the previous tests, along with additional analysis to look at the tribological properties of the oil using tribometers. The results clearly show significant differences in the rheological, tribological, and chemical properties of the fresh oil and used sump oil samples when compared with the top ring zone (TRZ) oil samples, particularly the effect of load on the levels of volatiles present in the TRZ samples and their effect on traction and friction coefficient values during tribological testing

Melting-freezing cycles in a relatively sheared pair of crystalline monolayers

The nonequilibrium dynamical behaviour that arises when two ordered two-dimensional monolayers of particles are sheared over each other is studied in Brownian dynamics simulations. A curious sequence of nonequilibrium states is observed as the driving rate is increased, the most striking of which is a sliding state with irregular alternation between disordered and ordered states. We comment on possible mechanisms underlying these cycles, and experiments that could observe them.Comment: 7 pages, 8 figures, minor changes in text and figures, references adde

The Contribution of Expert Coaches’ Experiential Knowledge in Understanding Punching Performance in Boxers

Traditionally, the field of sports science has been interested in conducting research that is predominately quantitative in nature. Although this approach has provided significant findings, this has led to expert coaches’ experiential knowledge being neglected in favour of empirical knowledge. By investigating punching in boxing, we are interested in developing an understanding of whether elite coaches, through their experiential knowledge, intuitively identify key characteristics of effective punching as identified in controlled experimental research. For this purpose, five interviews were conducted with professional and amateur boxing coaches. From this qualitative approach it was evident that coaches’ knowledge was consistent with that of the empirical research on effective punching performance with four principal components emerging from the interview data. These included: 1) whole body movement, 2) footwork, 3) hip and shoulder rotation, and 4) hand and arm position. The data illuminated how coaches’ knowledge can be used to strengthen empirical findings in sports performance, in this case punching in boxing. Additionally, characteristics of performance that were discussed by coaches that were not identified in the empirical literature highlight directions for further research regarding effective punching technique, an area that requires further investigation before conclusive structures of good practice can be applied

Common themes and missing pieces: the educational value of postgraduate teaching development programmes

The purpose of this article is to present and discuss the findings of a literature review undertaken by three members of staff based at City University London, who are also members of a programme team that runs a professional development programme for higher education teachers. The original purpose of the literature review was to provide a deeper and more research-informed mechanism for evaluating and developing the aforementioned programme. Whilst focused in its intentions, the results of the review suggest that the existing research terrain about such programmes might be characterised in terms of common themes (areas for which there is already a range of published research) and missing pieces (areas for which there appears to be a paucity of published material). The authors are now using these results to continue developing their own programme, and as a starting point for follow-up research. However, it is hoped that the review will be of relevance to a wider audience, encouraging others to undertake research to address the missing pieces and as a source for others to enhance their own teaching development programmes