14 research outputs found
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
- Clark Sue
- Clarke Adrian
- Clarke Betty
- Clarke Eddie
- Clarke Kay
- Clarke Laura
- Clawson Hiram
- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
- Cordray Rebecca
- Cornell Christine
- Cornell Earl
- Cornell Linda
- Cornell Ruth
- Corum Ben
- Cottage Amanda
- Cotton Sara
- Coulson Alan
- Couronne Olivier
- Courtney Laura P.
- Coville Gez
- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
- Crespeau Hervé
- Crew Victor
- Critchlow Terrance
- Critz Paul
- Cruaud Corinne
- Cuff James
- Cui Hongjuan
- Cui Jinhui
- Cui Peng
- Cui Peng
- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
- Danganan Linda
- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
- Davies Joy
- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
- Dean Peter
- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
- Dhongsar Chemey
- Dias Jennifer
- Dias Victoria
- Dibartolo Genevieve
- Dibling Catherine
- Dickson Mark
- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
- Ding Keyue
- Ding Li
- Ding Yan
- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
- Dorris Lester
- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
- Draper Heather
- Du Feiyu
- Du Hui
- Du Yutao
- Duarte Suzanne
- Dubchak Inna
- Duffy Noah
- Dugan-Rocha Shannon
- Dunham Andrew
- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
- Edwards Carol
- Edwards Jennifer
- Edwards Karen
- Egan Amy
- Eichler Evan
- Eichler Evan
- Ejima Fumio
- Elkin Chris
- Ellington Andrew
- Elliot David
- Elliot Glendoria
- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
- Endrizzi Matthew
- Engh Ger van den
- Engle David
- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
- Escobar Julio
- Escotto Michael
- Eugene Craig S.
- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
- Feng Jie
- Feng Xiaoli
- Fennell Stephen
- Ferguson Alicia
- Fernandez Sonia
- Fernandez-Suarez Xose
- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
- Fey Jim
- Fidel Patrick
- Fields Elizabeth
- Fink Marie
- Finley Maria C.
- Finn Robert
- Fischer Heather
- Fischer Laurice
- Fisher Shelia
- Fitch Pat
- Fitzgerald Mike
- Flack Tina
- Flagg Nicole
- Flanagan J.
- Fleming Kerry
- Flint Jonathan
- Flint Mark
- Flowers Dave
- Floyd Yvonne
- Foley Karen
- Folta Peg
- Fong Jonathan
- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
- Fourcade Matthew
- Fowler John
- Fox Jessica
- Frame Deborah
- Francis Matthew
- Francis Stephen
- Frankel Ken
- Frankish Adam
- Frankland John
- Fraser Audrey
- Fraser David
- Frazier Marvin
- French Lisa
- Fricker David
- Fridlyand Jane
- Fronick Catrina
- Frost Carole
- Frost Daniel
- Frost Jackie
- Frost Lorna
- Fu Gang
- Fu Gang
- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
- Galgoczy Petra
- Gallegos Celsa
- Galvez Michael
- Gammon Stuart
- Gao Anwu
- Gao Jimei
- Gao Quan
- Gao Yang
- Gao Yimei
- Garcia Carmen
- Garcia Emilio
- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
- Gatewood Joseph M.
- Gatland Leigh
- Gatland Lindsay
- Gattung Stacie
- Gay Laura
- Gearin Gary
- Gebreyesus Binyam
- Gelein Cynthia
- Gelpke Maartin
- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
- Ghori Jilur
- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
- Gifford Mary
- Gil Isaias
- Gilbert James
- Gilby Lisa
- Gill Rachel
- Gillet Will
- Gillson Christopher
- Gilna Paul
- Gimmel Verena
- Gingrich Jeff
- Giovanelli Kira
- Glavina Tijana
- Glithero Rebecca
- Glöckner Gernot
- Gnerre Sante
- Gnirke Andreas
- Gold Darren
- Golinveaux Kristen
- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
- Groza Matthew
- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
- Guo Jane
- Guo Lili
- Gustafson Erik
- Guthrie Ian
- Guyer Mark
- Gwilliam Rhian
- Gyaltsen Kunsang
- Gyapay Gábor
- Görlich Yvonne
- Ha Chi
- Hafez Nabil
- Haglund Krista
- Hagopian Daniel
- Hagos Birhane
- Haim Allen
- Hajek Patrick
- Hall Brett Lynn
- Hall Brittany
- Hall Jennifer
- Hall Rebekah
- Hall-Tamly Gretta
- Halls Karen
- Hallsworth-Pepin Kym
- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
- Harper Georgina
- Harper Patrik
- Harradence Grant
- Harris Anthony
- Harrison Charlene-Lou
- Harrison Elliot
- Harrison Ruth
- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
- Hayes Kerry
- He Fengying
- He Jiaying
- He Lin
- Heaford Andrew
- Heath Paul
- Heathcott Rosemary
- Heilig Roland
- Heiner Cheryl
- Heinze Ivonne
- Heitmann Katja
- Helfenbein Keven
- Heller Andrew
- Hellsten Uffe
- Hembry Cathy
- Henderson Carl
- Henderson Nicholas
- Henderson Nina
- Hendrix David
- Hennig Steffen
- Henning Karla
- Hepa Victor
- Herd Tim
- Herman Charles
- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
- Holdgate Janet
- Hollaway Mara
- Hollins Barbara
- Holloway Ele
- Holmes Andrea
- Holmes Ian
- Holmes Sarah
- Holroyd Simon
- Holtz Ann
- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
- Hooper Alison
- Hopewell Lucy
- Hopkins Ben
- Horne Jennifer
- Hornett Gary
- Hornischer Klaus
- Hornsby Amber
- Hornsby Geoff
- Hornsby Tony
- Horsley Sharon
- Horton Roger
- Hosage-Norman Catherine
- Hosoda Kei
- Hosono Katsuhiro
- Hosseini Roya
- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
- Howell Gareth
- Howell Latoya Lynette
- Howells Sally Lucinda
- Hsu Fan
- Hu George
- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
- Huang Wayne
- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
- Hughes Lee
- Hughes-Hull Hillary
- Hull Louisa
- Hulme Bill
- Hulyk Steven
- Hume Jennifer
- Hummeric Holger
- Humphray Sean
- Humphries David
- Humphries Matthew
- Hunt Adrienne
- Hunt Michael
- Hunt Paul
- Hunt Sarah
- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
- Jin Yetao
- Jin Yongsan
- Johansen Tina
- Johnson Bennie
- Johnson Cheryl
- Johnson Christopher
- Johnson David
- Johnson Douglas
- Johnson Genevieve
- Johnson Lori
- Johnson Mark
- Johnson Philip
- Johnson Rudy
- Johnson Stephanie
- Jolivet Angela
- Jolley Keith
- Jones Abigail
- Jones Charlien
- Jones Claire
- Jones Juliet
- Jones Matthew
- Jones Michael
- Jones Micheil
- Jones Myrna D.
- Jones Steven
- Jong Pieter De
- Jordan Yun
- Joseph Shirin
- Joy Ann
- Joy Linsey
- Joy Victoria
- Joyce Gillian
- Jubb Mark
- Jung Eugine
- Järke Doris
- Kadner Kristen
- Kagan Ryan
- Kahsai Orsalem
- Kaida Kaoru
- Kale Pat
- Kalicki-Veizer Joelle
- Kamal Michael
- Kamat Asha
- Kamholz Sandra
- Kana Arnold
- Kang Hui
- Kang Kelie
- Kang Ning
- Kapur Hitesh
- Karolchik Donna
- Karunaratne Kanchi
- Kasprzyk Arek
- Katayama Takujiro
- Kato Takako
- Kauer Gerhard
- Kaul Rajinder
- Kaur Amardeep
- Kawagoe Chiharu
- Kawasaki Kazuhiko
- Kay Michael
- Kaye Danielle
- Kearney Lyndal
- Keefe Damian
- Keen Gifford
- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
- Kelley Simon
- Kells Cristyn
- Kelly Shayna P.
- Kelly Susan H.
- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
- Kierstan Peter
- Kieu Alix
- Kim Jennifer
- Kim Joomyeong
- Kim Kyung
- Kimball Heather
- Kimberley Andrew
- Kimura Moe
- King Andrew
- King Laquisha Monique
- King Mary-Clare
- Kingsley Simon
- Kingswood Colin
- Kisamo Haika
- Kisner Peter
- Kitts Paul
- Kiyooka Miho
- Klages Sven
- Klingle Gillian
- Knights Andrew
- Kobayashi Mai
- Kodira Chinnappa
- Kohlberg Sara
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- Kolbe William
- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
- Krogh Anders
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- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
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- Lucier Raymond L.
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- Madabhushi Ramki
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- Sun Yu
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- Sutherland Robert D.
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- Tatum Owatha I.
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- Tian Chaoguang
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- Tin-Wollam Aye M.
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- Togashi Naoko
- Tomizawa Iori
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- Tong Jingli
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- Ukegbu Ogechi Nkemdirim
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- Un Chun
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- Upson Darren
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- Viknaraja Ramya
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- Vine Wendy
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- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations
- Author
- Ackroyd Sam
- Addada Juanah (Jo)
- Ademokun Debo
- Ahmed Alhassani Thubeena M.
- Ahmed Khalil
- Aitchison Robin
- Al-Ani Maryam
- Aldouri Maadh
- Alfred Arun
- Allford Sarah
- Alvares Caroline
- Andrews Vivienne
- Anjum Farahn
- Ardeshna Kirit
- Arnold Claire
- Arnold Claire
- Austen Belinda
- Bake Bart
- Barker Helen
- Basu Supratik
- Batten Leona M.
- Beier Ommen Hans
- Berkhan Leanne
- Betteridge Sophie
- Blombery Piers
- Bokhari Syed
- Bond Lee
- Borg Anton
- Borregaard Niels
- Bowen Angela
- Bowen David
- Bowett Peter
- Brearton Gillian
- Burgess Jordan
- Burns Sarah
- Butler Andrew
- Byrne Jenny
- Cahalin Paul
- Canham Joanna
- Carr Robert
- Cavenagh Jamie
- Chacko Joseph
- Chalmers Isobel
- Chandra Deepak
- Chapman Oliver
- Chapple Mary
- Chatterjee Poulami
- Chodhouri Senthil S.
- Chvuka Shingi
- Copplestone Adrian
- Corbett Gillian
- Corbett Timothy
- Corser Robert
- Craddock Charles
- Craig Jenny
- Craig Joanne
- Cranfield Tanya
- Crawley Charles
- Creach Desmond
- Crowe Josephine
- Culligan Dominic
- Cullis Jonathan
- Cuthbert Robert
- Cutting Robert
- Cutting Robert
- Dalley Chris
- Dang Ray
- Dasgupta Emma
- Dasgupta Ranjit
- David Marianna
- Davidson Kerri
- Davies Simon
- Dennis Mike
- Devanny Ian
- DeVos Johannes
- Dignum Helen
- Dillon Richard
- Doocey Richard
- Dungarwalla Moez
- Dyer Peter
- Eagleton Helen
- Eden Ayed
- Edwards David
- Edwards Hugh
- Ellis Lauren
- Emmett Shannon
- Eve Heather
- Evely Roger
- Everington Tamara
- Fail Tom
- Farrell Katrina
- Fenella Willis Neoh
- Ferguson Paul
- Fernandes Savio
- Fernyhough Liam
- Finnegan Damian
- Fletcher Andrew
- Fletcher Andrew
- Forsyth Peter
- Francis McMullin Mary
- Freeman Sylvie D.
- Friis Lone
- Ganczakowski Mary
- Gandhi Anna Cowley S.
- Ganly Peter
- Gelly Keith
- Gharib Maged
- Gibbons Steve
- Gibbs Simon
- Gilkes Amanda
- Gilles Julie
- Gomez Cesar
- Goodman Hugh
- Goodrick Margaret
- Grand Effie
- Grey-Davies Elisabeth
- Groch Henri
- Hada Sunil
- Hall Rachel
- Hamilton Malcolm
- Hanlon Katharine
- Harrison Beth
- Hasan Yasmin
- Haskins Lea
- Hatcliffe Faye
- Hawkins Timothy
- Heartin Earnest
- Hemmaway Claire
- Hemmaway Claire
- Hendry Louise
- Hervey Victoria
- Hinson Emily L.
- Hodson Andrew
- Holm Mette
- Horne Gillian
- Horne Gillian
- Houghton John
- Hoyle Christine
- Hunter Ann
- Hunter Hannah
- Islam Shahid
- Ismail Saad
- Jack Fergus
- Jackson Nicholas
- Jacob Abraham
- Janes Sarah
- Janmohamed Riaz
- Jenner Matthew
- Jobanputra Shailesh
- Johnson Peter
- Jones Christopher
- Joseph Joe
- Jowitt Simon
- Juul Nielsen Ove
- Kaczmarski Richard
- Kakalamudi Sudhakar
- Kallenbach Maria
- Kampmann Peter
- Kaul Stuti
- Kaur Harpreet
- Keat Sally
- Kell Jonathan
- Kelsey P.
- Kerr Paul
- Kerr Ron
- Khwaja Asim
- Kjeldsen Lars
- Knapper Steve
- Knapper Steven
- Knechtli Christopher
- Kottaridis Panagiotis
- Krishnamurthy Pramila
- Krishnamurthy Suchitra
- Krogh Jensen Morten
- Kwan Mark
- Laing Alison
- Laird Jane
- Lawes Matthew
- Linch David
- Lindsay Kathrine
- Lindsay-Holmes Srividhya Sarah
- Longmuir Karyn
- Lovell Richard
- Lush Chris
- Lush Richard
- Lykke Petersen Soeren
- Lyons Simon
- Maclean Peter
- MacWhonell Alan
- Maddams Rebecca
- Maddox Jamie
- Mamat Mohd
- Mangos Hilda
- Mannari Deepak
- Marcher Claus
- Marks David
- Marshall Scott
- Martin Murray
- Maughan Elizabeth
- Maxwell Norgaard Jan
- McCaig Alison
- McCloskey Kayleigh
- McIntyre Victoria
- McLintock Lorna
- Medd Patrick
- Mehta Priyanka
- Mehta Priyanka
- Meiklejohn David
- Micallef-Eynaud Paul
- Milligan Donald
- Mills Juliet
- Milne Alison
- Mitchell Lindsey
- Mohite Unmesh
- Moreton Paul
- Moss Paula
- Mucklow Stuart
- Munro Laura
- Murphy John
- Murray Jim
- Murrin Richard
- Narat Santosh
- Narayanan Mekkali
- Neilson Jeff
- Neylon Annette
- Ngu Loretta
- Nicholson Emma
- Nicholson Toby
- Nicolle Annette
- Niemann Carsten
- Nokes Tim
- O'Hea Anne-Marie
- Omran Asad
- Orchard Kim
- Othman Jad
- Oun Hajer
- Overgaard Ulrik Malthe
- Paneesha Shankara
- Patel Amit
- Paterson Pamela
- Patil Kavita
- Pattinson Jonathan
- Pattinson Jonathan
- Patton Nigel
- Pechey Victoria
- Pemberton Lucy
- Peniket Andy
- Peters Jayne
- Plews Diane
- Popat Rakesh
- Potter Mike
- Potter Nicola
- Pottinger Bryson
- Powell Matthew
- Pullon Humphrey
- Raafat Alaeddin
- Raj Kavita
- Reilly John
- Richardson Deborah
- Roberts Patrick
- Roddie P.H.
- Rogers Stephen
- Rose Peter
- Roy Ashok
- Rudin Claudius
- Ruell Jackie
- Rule Simon
- Russell Nigel
- Russell Nigel H.
- Rye Adam
- Rye Adam
- Rymes Nicholas
- Sadik Walid
- Sadullah Shala
- Salesh Sana
- Sampson Rebecca
- Saravanamuttu Kandeepan
- Sati Hamdi
- Severinsen Marianne
- Shafeek Salim
- Sidra Gamal
- Simpson Sylwia
- Smith Jeffery
- Smith Mark
- Smith Steve
- Snowden John
- Somerfield Sven
- Somervaille Tim
- Sorour Youssef
- Spearing Ruth
- Stanchev Atanas
- Stokley Simone
- Sud Amit
- Sugai Taku
- Tauro Sudhir
- Tholouli Eleni
- Thomas Wayne
- Thomas-Dewing Rowena
- Tighe Jane
- Tomlins Jo
- Tuegar Salah
- Udby Peter Møller Lene
- Vavyla Maria
- Virchis Andres
- Walewska Renata
- Wandoo Farooq
- Wei Bjerrum Ole
- Welch Emma
- Went Richard
- Wexler Sarah
- White Denise
- Wilhelm-Benartzi Charlotte
- Wiliams Adrian
- Williams Mark
- Williamson Peter
- Wilson-Morkeh Isaac
- Wodzinski Mark
- Wright David
- Xu Chin Kate
- Yong Kwee
- Zaman Sonya
- Zhao New Oo Rui
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 30/04/2024
- Field of study
Purpose
To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics.
Patients and Methods
One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS).
Results
There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO.
Conclusion
Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-Hélène
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
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- Goralski Patricia
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- Gosbell Iain
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- Hall Alistair S
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- Huang David T.
- Hughes Debbie
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- Kremling Julius
- Kreß Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
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- Lavana Jayshree
- Laver Russell D.
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- Lawler Patrick R.
- Le Basnier Elliot
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- McAuley Daniel F.
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- McCarthy Aine
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
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- Yamashita Chizuru
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- Yarad Elizabeth
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- Yates David
- Yealy Donald
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- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
- Archer Simon
- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
- Aslam Natasha
- Atkinson Jane
- Atkinson Lorraine
- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
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- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Peter
- Chung Peter W.M.
- Churn Mark
- Churn Mark
- Clancy Joanna
- Clapp Felicity
- Clark Alison
- Clark Diane
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- Clark Su
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- Clarke Jude
- Clarke Maria
- Clarke Noel
- Clarke Noel W.
- Clarke Peter
- Clarke Rachael
- Clarke Samantha
- Cleary Kristy
- Clements Colette
- Clements Mia AnnaMaria
- Clitheroe Pat
- Cobos-Arrivabene Marta
- Cocks Tracie
- Coe Marc
- Coffin Teresa
- Cogley Lyn
- Cogley Lyn
- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
- Collins Gerald
- Collins Lucy
- Commisso Angela
- Conibear John
- Connolly nee McKenna Sarah
- Connor Marie
- Conroy Ruth
- Conroy Ruth
- Conway Lisa-Jane
- Conway Rachel
- Cook Adrian
- Cook Adrian D.
- Cook Audrey
- Cook Audrey
- Cook Wendy
- Cooke Jill
- Cooke Juniebel
- Cooke Peter
- Coomber Kristy
- Coombs Sarah
- Cooper Adele
- Cooper Sophie
- Coppins Helen
- Corbett Thomas B
- Corcoran Sam
- Corderoy Helen
- Cordwell Amanda
- Corkery Danylle
- Corless Rebecca
- Cormack Margaret
- Cornaby Andrew
- Corner Victoria
- Cornthwaite Stephanie
- Corwin Charlotte
- Cossette Danielle
- Cote Genevieve
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- Cotts Shannon
- Coubrough Claudia
- Couch Ellie
- Coughlan Tricia
- Cousins Jane
- Cousins Rebecca
- Coutts Tim
- Coventry Thomas
- Cowan Chloe
- Cowan Chloe
- Cowan Richard
- Cowan Richard
- Cowley Sue
- Cox Adam
- Cox Christine
- Coyle Catherine
- Coyle Catherine
- Crawford Melanie
- Crawford Sister Denise
- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R.
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
- Cusan Leonello
- Custins Laura
- Cyriac Abby
- Dabbs Marianne
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- Dallas Nicola
- Dalton-Short Ross
- Dalton-Short Ross
- Daly Deirdre
- Danaswamy Patricia
- Danaswamy Patricia
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- Davies Flor
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- Davison Alison
- Davison Sue
- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
- Dekaj Fatjon
- Dell Gillian
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- Dodds David
- Dodge Sister Jan
- Doherty A
- Donaghey Sally
- Donaldson David
- Donnison Michelle
- Douch Emma
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- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
- Driscoll Celine
- DSouza David
- Dubey Arbind
- Dubey Arbind
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- E Choan
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- Ferreira Miguel
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- Fielding Bethany
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- Flaherty Jan
- Flanagan Laura
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- Gao Annie
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- Gardiner Fiona
- Garner Victoria
- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
- GeorgeChayka Danielle
- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
- Gibbs Stephanie
- Gibson Sian
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- Gilbert Duncan
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- Gillatt David
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- Ginnelly Helen
- Giovannini Julia
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- Gladwell Louise
- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
- Glen Tracy
- Glick Daniel
- Goel Roshni
- Goh Chee
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- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
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- Goss Vanessa
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- Goulding James
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- Grau Isabel
- Gray Emma
- Gray Emma
- Grayland Sarah
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- Green James
- Green Sara
- Green Sarah
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- Greenland Jonathan
- Gregg Jane
- Gregorcic Emily
- Gregory Debbie
- Grieve Sylvia
- Griffen Ailsa
- Griffin Hannah
- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
- Gunn Melanie
- Gupta Kamalnayan
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- Gurzanski Christina
- Guy Peter
- Gwilt Julie
- Gwilt Julie
- Gwilt Julie
- Haddad Alain
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- Haldeos Anne
- Hale Jennifer
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- Hall Julia
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- Hamilton Ronald
- Hammonds John Christopher
- Hanna Emma
- Hannaford Zeta
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- Hardie Maryon
- Harding Claudia
- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
- Harney Jackie
- Harnwell Juliette
- Harpell Rhonda
- Harris (n. Marchant) Emily
- Harris Catherine
- Harris Sarah
- Harris-Burland Angie
- Harrison Alison
- Harrow Sister Kath
- Hart Amber
- Hart Andrew
- Harter Leah
- Hartley Jasmine
- Hartman Carrie
- Hartt Nancy
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- Haskell Annelise
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- Hassan Nebah
- Hathout Lara
- Hatimy Umi
- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heckford Louise
- Hedges Andy
- Heeley Janine
- Hefferon Billy
- Hegarty Gemma
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- Henry Ann
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Joanne
- Henry Joanne
- Henson (nee Savidge) Verity
- Henson Helen
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- Herbert Chris
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- Hicks Kimberly
- Higgins Linda
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- Hillman Paul
- Hillman Paul
- Hilman Serena
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- Hindle Margaret
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- Hocking Christopher
- Hodder June
- Hodge Simon
- Hodges Samantha
- Hodgkinson Sheila
- Hodson Hayley
- Hodson Hayley
- Hogan Holly
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- Hogbin Emma
- Holbrook Andy
- Holbrook Becky
- Holden Simon
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- Hollenhorst Helmut
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- Hollingdale Abigail
- Hollis Keri
- Hollister Robert
- Holloway Caroline
- Holmes Evelyn
- Holwerda Eleanor
- Homer David
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- Horne Rhian
- Hornzee Gillian
- Hornzee Gillian
- Horton Sarah
- Horwich Alan
- Hoskin Peter
- Hoskin Peter
- Hoskins Ashley
- Hoskins Chloe
- Hotine Jodie
- Hough Adele
- Hough Chris
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- Howard Joanna
- Howard Lucy
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- Howitt Pamela
- Hsien John
- Hubley Lynn
- Huddart Robert
- Huddart Robert
- Hudson Zoe
- Hughes Claire
- Hughes Faye
- Hughes Hayley
- Hughes Joanne
- Hughes Kathryn
- Hughes Owen
- Hughes Robert
- Hughes Simon
- Hughes-Davies Luke
- Hugill Angela
- Hugill Angela
- Humber Caroline
- Humpreys Louise
- Hunt Allison
- Hunter Catherine
- Hunter William
- Hunting Liz
- Hutchinson Camille
- Hyde Katherine
- Hyde Katherine
- Hyde Katherine
- Hynds Sharon
- Ibrahim Azman
- Ingham Jo
- Ingle Charlotte
- Inman Hayley
- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
- Islam Zaheer
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- Jackman Dee
- Jackson Cathy
- Jackson Kim
- Jackson Sister Ann
- Jain Suneil
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- James Naomi
- James Nicholas
- Jamieson Ceri
- Jampana Raj
- Janke Susan
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- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
- Jeffrey David
- Jelski Joseph
- Jenkins Peter
- Jenkins Suzanne
- Jenner Abigail
- Jennings Marian
- Jepson Debbie
- Jevons Cody
- Jewers Karen
- Jewers Karen
- Jeyasanger Ganesan
- Joe Howard
- John Babbin
- Johns Louise
- Johnson Arlissa
- Johnson Craig
- Johnson Joanne
- Johnson Lyndsey
- Johnson Nigel
- Johnson-Rollings Ashley
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- Johnston Ruth
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- Johnstone Maria
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- Jones (Birch) Janine
- Jones Andrea
- Jones Ania
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- Jones Gareth
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- Jones Kathryn
- Jones Katie
- Jones Lesley
- Jones Lewis
- Jones Richard
- Jones Rob
- Jones Stephanie
- Jones Stephanie
- Jones-Skipper Kay
- Jonnada Sai
- Jope Carmel
- Jose Sanal
- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
- Kalyvas Maria
- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
- Kanji Femina
- Kanyi Karen
- Kapur Guarav
- Karim Omer
- Karp Stephen
- Karsera Louise
- Karunakaran Subashini
- Karvat Anand
- Kaushal Malan
- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
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- Kelly Alison
- Kelly Kay
- Kemp Gail
- Kempel Mette Moe
- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
- Kenyon Lucille
- Kershaw Elizabeth
- Key Claire
- Keyes Mira
- Khaksar Sara
- Khan Omar
- Khan Yakhub
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- Khong Rachel
- Khoo Vincent
- Khoo Vincent
- Khoo Vincent
- Khoury Ghassan
- Kiff Janet
- Kift Shannon
- Kilmartin John
- Kilroy Stephen
- Kilroy Stephen
- Kiltie Anne
- Kiltie Anne
- Kim David
- Kim TuongVan
- KimSing Charmaine
- King Amy
- King Jennifer
- King Jennifer
- King Lisa
- Kinrade Yvonne
- KirbyBello Denise
- Kirk Christine
- Kirk Sister Sarah
- Kirkbride Peter
- Kirkbride Peter
- Kirkby Amy
- Kirkby Sarah
- Kirkpatrick Suriya
- Kisanga Mary
- Kitkowski Caitlin
- Klapp Kathi
- Klotz Laurence
- Klovgaard Karina
- Knackstedt Jochen
- Knapp Jeanette
- Knight (n. Sherburn) Victoria
- Knott Helen
- Knox WF
- Kockelbergh Roger
- Koehler Ingrid
- Kokholm Kathrine Friser
- Koll Wayne
- Kong Vickie
- Kotze Michelle
- Koul Rashmi
- Koulouris Zoe
- Koupparis Anthony
- Kowalczyk-Williams Wioletta
- Kowalewska Paulina
- Kronstal Flo
- Krysta Beata
- Kuenzig Greg
- Kujawa Magda
- Kuk Joda
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- Kumar Daniel
- Kumar Muthar
- Kumar Shiyam
- Kumar Vikaash
- Kurian-Downer Sunita
- Kurup Rahul
- Kuzyk Valerie
- Kwan Winkle
- Kyffin Phillippa
- Kynaston Howard
- Kynaston Howard
- Lacey Cathy
- Lachance Nicole
- Lactao Ranee
- Ladouceur Cynthia
- Laing Robert
- Lajoie MarieAndree
- Lake Sister Judith
- Lalani Nafisha
- Laliberte Benoit
- Lam Jacqueline
- Lambert Carole
- Lambert Katy
- Lamoureux Alexandra
- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
- Larouche Julie
- Larson Beverly
- Lassen Yasmin
- Last Debbie
- Lau Maurice
- Laubscher Angelique
- Laughlin Anne
- Laursen Vibeke
- Lavender Helene
- Laverick Rosaleen
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- Lawless Claire
- Lawless Theresa
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- Lawrence Steph
- Lawrey Sarah
- Lawson Daeria
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- Leach Deborah
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- Lewington Val
- Lewis Amanda
- Lewis Christina
- Lewis Joanne
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- Li Audrey
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- Liptrott Sarah
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- Little Erin
- Little Jessica
- Littler John
- Littler Stephen
- Liu Stanley
- Livsey Jacqueline
- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
- Locke Angela
- Lockwood Carol
- Logue John
- Logue John
- Logue John
- Logue John
- Lokes Rachel
- Lokes Rachel
- Lomas Alia
- Lomas Claire
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- Loughlin Kate
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- Love Clare
- Love Sally
- Lowe Amelia
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- Lunau Anne Sofie
- Lydon Anna
- Lydon Anne Marie
- Lynch Rory
- Lyons Ciara
- Mabelin Louies
- Macavoy Tina
- Macdonald Alison
- MacDonald Angela
- MacDonald Graham
- Macefield Rhiannon
- MacGregor Barbara
- Macgregor Carol
- MacIsaac Kathy
- MacIsaac Patricia
- Mackay Rachel
- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
- Madine John
- Magwaro Sophia
- Magwaro Sophia
- Magwaro Sophia
- Mahmood Rana
- Mahmood Rana
- Mahmood Sana
- Mahmud Aamer
- Mahoney Catriona
- Mahoney Sue
- Maitland Katrina
- Maize Christine
- Majumdar Arpita
- Makepeace Barbara
- Malde Rohit
- Malek Leila
- Malik Zafar
- Mallett Debbie
- Malone Shawn
- Malone Shawn C.
- Manetta Caroline
- Manganaro Aileen
- Mangar Stephen
- Maniatis Christos
- Manley Rachel
- Mannan Aliyah
- Manning Courtney
- Manning Kimberley
- Mansell Gemma
- Mansfield Carolyn
- Mantle Mark
- Manyangadze Sarah
- Marange Josephine
- Mardell Stephen
- Marek Kathleen
- Mariappan Param
- Marineau Line
- Mark Ian
- Markus Sarah
- Marley Hazel
- Marquis Tania
- Marriott Sue
- Marshall John
- Marshall Lynn
- MarshGray Kimberley
- Marston Kerrie
- Martin AndreGuy
- Martin Jackie
- Martin Joseph
- Martin Karen
- Martindale John
- Martindale John
- Martindale John
- Martinez Maria
- Martinou Maria
- Martins Sarah
- Marty Janet
- Mashegede Beverley
- Mason Jessica
- Mason Malcolm
- Masson Susan
- Masson Susan
- Masters Benjamin
- Masters Lindsey
- Masters Lindsey
- Matkins Ellen
- Matthews Laura
- Mattocks Lehentha
- Mayer Heather
- Mayne Barbara
- Mazhar Danish
- McAleese Jonathan
- McAlister Judy
- McAllister Jo
- McAuliffe Sarah
- McBain Hazel
- McBride Julia
- McCabe Alastair
- McCadden Angela
- McCarth Fiona
- McCartin Fiona
- McCaul Damian
- McClelland Marie
- McClements Jane
- McClurey Sister Patricia
- McCormack Anne
- McCormick Marian
- McCracken Jillian
- McCrisken Lauren
- McCrudden Sylvia
- McCully Ruby
- McCurrie Marilyn
- McFarlane Jonathan
- McFarlane Victoria
- McGarry Karen
- McGinley Shannon
- McGlynn Brian
- McGrath John
- McGrath Katherine
- McIndoe Sue
- McInerney Paul
- McInerney Sue
- McInerney Veronica
- Mcintosh Gregor
- McKee Dianne
- McKenna Karen
- McKenzie Michael
- McKernan Margaret
- McKinna Fiona
- McKinna Fiona
- McLain-Smith Susan
- McLaren Duncan
- McLarty Esther
- Mcleod Nick
- McMeekin Faith
- McMenemin Rhona
- McNally Morag
- McNish Jennifer
- McNulty Dawn
- McPhail Neil
- McWilliam Donna
- McWilliam Marie
- Meadows Lorna
- Medisetti Aruna
- Meidhal Petersen Peter
- Melcher Lucinda
- Melcher Lucinda
- Menard Cynthia
- Menard Cynthia
- Mendoza Edeliza
- Merante Pat
- Mercer Lily
- Mercier Barbara
- Merrick Richard
- Metcalf Karen
- Meyer Ralph
- Michael Elena
- Michaelidou Andriana
- Michels Jorg
- Middleton Sharon
- Mikropoulos Christos
- Mikropoulos Christos
- Millage Helen
- Miller Nikki
- Mills Jamie
- Mills Laurie
- Mills-Baldock Tina
- Milner Jessica
- Milosevic Michael
- Mirmooji Ramesh
- Mirza Arafat
- Mislang Albert
- Mistry Heena
- Mistry Leena
- Mitchell Darren
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- Mitchell Lesley
- Mithal Natasha
- Mitra Anita
- Moelker Yvonne
- Moffatt Emily
- Mohamed Fatima
- Mohan Rita
- Mohseeni Arizoo
- Moir Rachel
- Mojidra Chintan
- Mole Lisa
- Moller Christensen Trine
- Molony-Oates Barbara
- Money-Kyrle Julian
- Montebello Joseph
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- Moody Emma
- Mooney Matthew
- Moore Eleanor
- Moore Eleanor
- Moore Sally
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- Morales Maria
- Morales-Azofra Fabiola
- Morgan Rachel
- Morgan Scott
- Morris Stephen
- Morris Stephen L.
- Morris William James
- Morrison Andrew
- Morrison Jennifer
- Morrison MaryBeth
- Morrow Hugh
- Morton Gerard
- Morton Gerard
- Morton Susan
- Moss Sarah
- Mthethwa Thobekile
- Mui Jimmy
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- Mumin Anissa
- Mundy Carina
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- Murad Fatima
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- Murphy Ann
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- Murphy Claire
- Murphy Karen
- Murphy Louise
- Murray Jane
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- Murtha Albert
- Musunuru Hima Bindu
- Muthukumar Dakshinamoorthy
- Myatt Alison
- Myles Sophie
- Myrehaug Sten
- Nabid Abdenour
- Nabid Abdenour
- Nagar Yoodhvir
- Naim Farhan
- Nakashima Lynne
- Nallathambi Chandran
- Nam Robert K
- Narahari Krishna
- Naraine Nicky
- Nash Dominic
- Nash Maxine
- Nashed Maged
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- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
- Archer Simon
- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
- Aslam Natasha
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- Atkinson Lorraine
- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
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- Bahl Amit
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- Barnett Debra
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- Bashir Faheem
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- Batz Margaret
- Bauman Glenn
- Baumber Shelley
- Baxter Matt
- Bayley Andrew J
- Beamish Neal
- Beaney Katherine
- Beaney Ronald
- Beard Karen
- Beard Karen
- Beaton Heather
- Beaton Kirsty
- Beattie Louise
- Beauchemin MarieClaude
- Beaumont Erica
- Beausoleil Rachelle
- Beazer Sarah
- Bech-Nielsen Nanette
- Bech-Nielsen Nanette
- Bedoya Luis Diaz de
- Beech Darren
- Beer Nigel
- Beesley Kate
- Beesley Katherine
- Beesley Sharon
- Beety Jane
- Bekulart Sylwia
- Belcher Rebecca
- Bell Karen
- Bellenger Katharine
- Benjaminson Patricia
- Bennett Molly
- Bennett Sarah
- Bennion Carole
- Benson Richard
- Benson Richard
- Benth Silvine
- Benton Louise
- Benton Richard
- Bentzen Lise
- Beresford Mark
- Beresford Mark
- Beresford Mark
- Bergen Leah
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- Berlin Alejandro
- Bermingham Nicola
- Betts Chris
- Bhana Rajanee
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- Bhatnagar Gagan
- Bici Julia
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- Binks Colin
- Binns Louise
- Birch Richard
- Bird Stephanie
- Birtle Alison
- Bishop Emma
- Bissa Caterina
- Bissett Donald
- Bisson MarieEve
- Blackwood Geoffrey
- Blaney Hilary
- Blight Kathy
- Blood Paul A
- Bloomfield David
- Bloomfield David
- Bloomfield Mark
- Blundell Martyn
- Blythe Tracy
- Boam Samantha
- Boardman John
- Bohra Vikram
- Bois (nee Harris) Elizabeth
- Bolger Annette
- Bolton Olivia
- Bolton Olivia
- Bond Brittany
- Bone Linzi
- Bonner Scott
- Bonner-Shand Shelagh
- Bonsu Nicole
- Boon Ian
- Borgaonkar Sudhir
- Borre Michael
- Borynec Carol
- Bott Trevor
- Bottomley David
- Bottomley David
- Bottomley David M
- Bottomley Ian
- Bouchard Myriam
- Bourke Amie
- Bourque JeanMarc
- Boutflower Jane
- Bowen Jo
- Bowen Jo
- Bowen Katie
- Bower Lorna
- Bower Lorna C
- Bowers Dawn
- Bowers Richard
- Bowes-Cavanagh Jeanette
- Bowling Lorna
- Bowman Sue
- Bowmer Amanda
- Bownie-Mukumbu Godfrey
- Brady Joanne
- Brady Joanne
- Brain Carol
- Branagan Jenny
- Brander Mike
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- Brasso Klaus
- Brasso Klaus
- Braun Michael W
- Brawley Chris
- Brawley Chris
- Breakspear Sally
- Breckin Edmund
- Breen Vivienne
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- Brewster Simon
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- Brock Sue
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- Brogan (nee Roddie) Stephanie
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- Brough Richard
- Brough Richard
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- Brown Emmanuel
- Brown Grace
- Brown Joanne
- Brown Maggie
- Brown Rebecca
- Brown Richard B
- Brown Richard B
- Brown Sandra
- Brown Simon
- Brown Stephen CW
- Brown Teddy
- Brownless Caroline
- BrucePayne Kim
- Brulinski Patryk
- Brulinski Patryk
- Brundage Michael
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- Burlace Barbara
- Burlace Barbara
- Burns Rebecca
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- Butt Zainab
- Butterfield Anne
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- Buus Simon
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- Caballes Mark
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- Camilleri Philip
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- Campbell Allister
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- Capaldi Lisa
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- Cartwright Debbie
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- Casanova Nathalie
- Casanova Nathalie
- Casey Linda
- Casey Sue
- Catt Natalie
- Catton Charles
- Catton Charles N
- Caumont Tom
- Cavanagh Kerrie
- Chadwick David
- Chadwick Eliot
- Chahal Rohit
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- Chakraborti Prabir
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- Challipalli Amarnath
- Chamberlain Shelley
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- Chikkamuniyappa Bindu
- Chikkamuniyappa Bindu
- Chikopela Loveness
- Chilcott Helen
- Chipman Penny
- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Hans T
- Chung Peter
- Chung Peter W M
- Churn Mark
- Churn Mark
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- Clark Alison
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- Clarke Elizabeth
- Clarke Jude
- Clarke Maria
- Clarke Noel
- Clarke Noel W
- Clarke Peter
- Clarke Rachael
- Clarke Samantha
- Cleary Kristy
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- Clitheroe Pat
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- Cocks Tracie
- Coe Marc
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- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
- Collins Gerald
- Collins Lucy
- Commisso Angela
- Conibear John
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- Connor Marie
- Conroy Ruth
- Conroy Ruth
- Conroy Ruth
- Conway Lisa-Jane
- Conway Rachel
- Cook Adrian
- Cook Adrian D
- Cook Audrey
- Cook Audrey
- Cook Wendy
- Cooke Jill
- Cooke Juniebel
- Cooke Peter
- Coomber Kristy
- Coombs Sarah
- Cooper Adele
- Cooper Sophie
- Coppins Helen
- Corbett Thomas B
- Corcoran Sam
- Corderoy Helen
- Cordwell Amanda
- Corkery Danylle
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- Cormack Margaret
- Cornaby Andrew
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- Cornthwaite Stephanie
- Corwin Charlotte
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- Coubrough Claudia
- Couch Ellie
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- Cousins Jane
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- Coutts Tim
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- Cowan Chloe
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- Cowan Richard
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- Cox Christine
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- Coyle Catherine
- Crawford Melanie
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- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
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- Dabbs Marianne
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- Dallas Nicola
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- Dalton-Short Ross
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- Danaswamy Patricia
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- Davison Alison
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- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
- Dekaj Fatjon
- Dell Gillian
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- Desai Parth
- Desai Parth
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- Di Maria Fabio
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- Dion Helene
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- Dixit Sanjay
- Dlodlo Jessica
- Dobson Tracey
- Dodds David
- Dodge Sister Jan
- Doherty A
- Donaghey Sally
- Donaldson David
- Donnison Michelle
- Douch Emma
- Doughty Victoria
- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
- Driscoll Celine
- DSouza David
- Dubey Arbind
- Dubey Arbind
- Duckett Tracey
- Duclos Marie
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- Dugas Stevie
- Duley Emma
- DuMontier Joelle
- Duncan (nee Keatley) Claire
- Duncan Graeme
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- Dunne Emma
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- Durrant Lisa
- Dymond Harvey
- E Choan
- Eady Robin
- Eapen Libni
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- Edwards Abigail
- Edwards Albert
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- Edwards Steve
- Edwards Steve
- Egan Lisa
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- Elliott Mark
- Elliott Tony
- Elliott Tony
- ElSokhn Nidale
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- Elwell Christine
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- Embleton Andrew
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- Falconer Alison
- Falconer Alison
- Fallah Fereshteh
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- Farnworth Christine
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- Fearnley Mark
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- Ferguson Catherine
- Ferguson Catherine
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- Ferreira Miguel
- Fiddes Kathleen
- Fielding Bethany
- Fielding Bethany
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- Finnegan Niall
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- Firth Alexandra
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- Firth Elizabeth
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- Flaherty Jan
- Flanagan Laura
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- Forkes Janet
- Forkes Janet
- Forkes Janet
- Forman Susan
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- Frankland Helen
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- Frew John
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- Galloway Lucy
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- Gamble Tina
- Gamble Tina
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- Gao Annie
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- Gardiner Fiona
- Garner Victoria
- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
- GeorgeChayka Danielle
- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
- Gibbs Stephanie
- Gibson Sian
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- Gilbert Duncan
- Gilbert Duncan
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- Gilby Lisa
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- Gillatt David
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- Gillesen Annelies
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- Ginnelly Helen
- Ginnelly Helen
- Giovannini Julia
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- Girolametto Carla
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- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
- Glen Tracy
- Glick Daniel
- Goel Roshni
- Goh Chee
- Goh Chee L
- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
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- Goulden Kay
- Goulding James
- Goyena Ruby
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- Gratton Albert
- Grau Isabel
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- Green Sarah
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- Gregg Jane
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- Griffen Ailsa
- Griffin Hannah
- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
- Gunn Melanie
- Gupta Kamalnayan
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- Gurzanski Christina
- Guy Peter
- Gwilt Julie
- Gwilt Julie
- Gwilt Julie
- Haddad Alain
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- Haidar Imran
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- Hale Jennifer
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- Hall Julia
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- Hamilton Joanna
- Hamilton Ronald
- Hammonds John Christopher
- Hanna Emma
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- Happle Liz
- Hardie Maryon
- Harding Claudia
- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
- Harney Jackie
- Harnwell Juliette
- Harpell Rhonda
- Harris (n. Marchant) Emily
- Harris Catherine
- Harris Sarah
- Harris-Burland Angie
- Harrison Alison
- Harrow Sister Kath
- Hart Amber
- Hart Andrew
- Harter Leah
- Hartley Jasmine
- Hartman Carrie
- Hartt Nancy
- Hartwell Lyn
- Harvey Julie
- Harvey Sally
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- Haskell Annelise
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- Hassan Nebah
- Hathout Lara
- Hatimy Umi
- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heath Catherine M
- Heckford Louise
- Hedges Andy
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- Hefferon Billy
- Hegarty Gemma
- Hejlesen Finn
- Helou Joelle
- Hendel Debra
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Ann
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- Henry Joanne
- Henson (nee Savidge) Verity
- Henson Helen
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- Herbert Chris
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- Hicks Kimberly
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- Hillman Paul
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- Hindle Margaret
- Hines John
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- Hocking Christopher
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- Hodgkinson Sheila
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- Hodson Hayley
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- Holbrook Andy
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- Hollis Keri
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- Hornzee Gillian
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- Hoskins Chloe
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- Hughes Owen
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- Hugill Angela
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- Humber Caroline
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- Hyde Katherine
- Hyde Katherine
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- Hynds Sharon
- Ibrahim Azman
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- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
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- Jain Suneil
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- James Naomi
- James Nicholas
- James Nicholas D
- Jamieson Ceri
- Jampana Raj
- Janke Susan
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- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
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- Jewers Karen
- Jewers Karen
- Jeyasanger Ganesan
- Joe Howard
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- Johnson Lyndsey
- Johnson Nigel
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- Johnstone Maria
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- Jones (Birch) Janine
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- Jonnada Sai
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- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
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- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
- Kanji Femina
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- Kapur Guarav
- Karim Omer
- Karp Stephen
- Karsera Louise
- Karunakaran Subashini
- Karvat Anand
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- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
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- Kelly Alison
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- Kemp Gail
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- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
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- Keyes Mira
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- Khoo Vincent
- Khoo Vincent
- Khoury Ghassan
- Kiff Janet
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- Kilmartin John
- Kilroy Stephen
- Kilroy Stephen
- Kiltie Anne
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- Kim David
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- Kim-Sing Charmaine
- KimSing Charmaine
- King Amy
- King Jennifer
- King Jennifer
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- KirbyBello Denise
- Kirk Christine
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- Kirkbride Peter
- Kirkbride Peter
- Kirkby Amy
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- Kirkpatrick Suriya
- Kisanga Mary
- Kitkowski Caitlin
- Klapp Kathi
- Klotz Laurence
- Klovgaard Karina
- Knackstedt Jochen
- Knapp Jeanette
- Knight (n. Sherburn) Victoria
- Knott Helen
- Knox WF
- Kockelbergh Roger
- Kodavatiganti Ravi
- Koehler Ingrid
- Kokholm Kathrine Friser
- Koll Wayne
- Kong Vickie
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- Koul Rashmi
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- Koupparis Anthony
- Kowalczyk-Williams Wioletta
- Kowalewska Paulina
- Kronstal Flo
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- Kuenzig Greg
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- Kumar Daniel
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- Kurup Rahul
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- Kwan Winkle
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- Kynaston Howard
- Kynaston Howard
- Lacey Cathy
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- Laing Robert
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- Lake Sister Judith
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- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
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- Larson Beverly
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- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
- Locke Angela
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- Logue John
- Logue John
- Logue John
- Logue John
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- Loughlin Kate
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- Love Sally
- Lowe Amelia
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- Parker Chris
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- Peters John
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- Rodda Sree
- Rodda Sree
- Rodda Sree
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- Rogers Brian
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- Saad Fred
- Saad Fred
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- Sayers Ian
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- Sharif Shahid
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- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smith Beccy
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- Smith Susan
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- So Alan I
- Sohanpal Sundip
- Sohanpal Sundip
- Somasiri Ashane
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- Stacey Wendy
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- Stringer (pr. Davis) Sally
- Strong-Sheldrake Sophia
- Stuart Robert
- Subramaniam Ramachandran
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- Sundar Santhanam
- Sundaram Subramanian Kanaga
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- Swann Michelle
- Sydes Matthew
- Sydes Matthew R
- Sylvestre Alma
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- Syndikus Isabel
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- Teahan Seamus
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- Thomas Carys
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- Thomasson Georgia
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- Thompson Catherine
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- Thomson Alastair H
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- Thornton Lorraine
- Thorogood Lucy
- Tickle Vivienne
- Tickle Vivienne
- Tiessen Kyoko
- Tighe (nee Bussey) Rachel
- Tighe Helen
- Tighe Mary
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- Totten Grace
- Toussi H
- Townley Barbara
- Townley Luke
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- Towse Jo
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- Tran Anna
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- Tree Alison
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- Vasanthan Subramanian
- Vaughn Jamie
- Vavassis Peter
- Velec Erin
- Vengalil Salil
- Venkatesan Varagur M
- Venkitaraman Ramachandran
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- Vermette Tracy
- Vesprini Danny
- Vickery Kathryn
- Vigneault Eric
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- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
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- Webb Claire
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- Wilke Derek
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- Williams (Née Allen) Sister Tania
- Williams Amanda
- Williams Bethan
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- Williams Jo
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- Woloshyn Rose
- Wong Jason W T
- Wood Allison
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- Wood Sister Kim
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- Woodhouse Iain
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- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
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- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Primaquine Dosing Errors: The Human Cost of a Pharmaceutical Anachronism
- Author
- Publication venue
- 'American Society of Tropical Medicine and Hygiene'
- Publication date
- Field of study
Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations.
- Author
- Alkelai Anna
- Antonarakis Stylianos E.
- Atallah Isis
- Au Ping Yee Billie
- Bar-Yosef Omer
- Bilan Frédéric
- Bjorgo Kathrine
- Blanc Xavier
- Bolkier Yoav
- Burrage Lindsay C.
- Christ Björn U.
- Dickson Patricia
- Donald Kirsten A.
- Dubourg Christèle
- Eliyahu Aviva
- Emrick Lisa
- Engleman Kendra
- Gonfiantini Michaela Veronika
- Good Jean-Marc
- Granadillo Jorge L.
- Jamra Rami Abou
- Kalser Judith
- Kloeckner Chiara
- Kurata Harley T.
- Lachmeijer Guus
- Lamothe Shawn M.
- Macchiaiolo Marina
- Maghera Jasmine
- Nicita Francesco
- Odent Sylvie
- Ortiz-Gonzalez Xilma
- O’Heir Emily
- Pacio-Miguez Marta
- Palomares-Bralo María
- Pena Loren
- Pitt Geoffrey
- Platzer Konrad
- Pode-Shakked Ben
- Quinodoz Mathieu
- Ranza Emmanuelle
- Rodan Lance H.
- Rosenfeld Jill A.
- Roulet-Perez Eliane
- Rush Eric
- Santani Avni
- Santos-Simarro Fernando
- Shashi Vandana
- Skraban Cara
- Slaugh Rachel
- Spillmann Rebecca C.
- Superti-Furga Andrea
- Thiffault Isabelle
- Van Bogaert Patrick
- van Jaabrsveld Richard H.
- Vincent Marie
- Wang Hong-Gang
- Zacher Pia
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2021
- Field of study
CACNA1C encodes the alpha-1-subunit of a voltage-dependent L-type calcium channel expressed in human heart and brain. Heterozygous variants in CACNA1C have previously been reported in association with Timothy syndrome and long QT syndrome. Several case reports have suggested that CACNA1C variation may also be associated with a primarily neurological phenotype.
We describe 25 individuals from 22 families with heterozygous variants in CACNA1C, who present with predominantly neurological manifestations.
Fourteen individuals have de novo, nontruncating variants and present variably with developmental delays, intellectual disability, autism, hypotonia, ataxia, and epilepsy. Functional studies of a subgroup of missense variants via patch clamp experiments demonstrated differential effects on channel function in vitro, including loss of function (p.Leu1408Val), neutral effect (p.Leu614Arg), and gain of function (p.Leu657Phe, p.Leu614Pro). The remaining 11 individuals from eight families have truncating variants in CACNA1C. The majority of these individuals have expressive language deficits, and half have autism.
We expand the phenotype associated with CACNA1C variants to include neurodevelopmental abnormalities and epilepsy, in the absence of classic features of Timothy syndrome or long QT syndrome
Phylogeography of the Koala, (Phascolarctos cinereus), and Harmonising Data to Inform Conservation
- Author
- A Melzer
- A Polkinghorne
- A Ramírez-Soriano
- AC Robinson
- AC Taylor
- AC Taylor
- AJ Drummond
- AJ Drummond
- AL Bazinet
- Alex D. Greenwood
- AM Seymour
- Amber Gillett
- AR Templeton
- BA Houlden
- BA Houlden
- BA Houlden
- C Adams-Hosking
- C Adams-Hosking
- C McAlpine
- C Moritz
- Cheyne Flannagan
- CT Ruiz-Rodriguez
- D Lunney
- D Posada
- DA Whisson
- DG Chapple
- DJ Colgan
- DL Edwards
- DR Middleton
- DS Dique
- DS Dique
- E V Fowler
- EF Hynes
- Emily Hynes
- F Lewis
- F Rousset
- F Tajima
- G Gordon
- G Hewitt
- GA de Groot
- GJ Frankham
- Greta J. Frankham
- GS Simmons
- HA Lindsay
- I Dupanloup
- JCZ Woinarski
- JL Jensen
- JLS Patterson
- JM Seddon
- K McGuigan
- K Tamura
- K Tsangaras
- K Tsangaras
- Kathrine Handasyde
- KE Lee
- KE Lee
- KMC Rowe
- Kristofer M. Helgen
- Kyriakos Tsangaras
- L Excoffier
- L Fumagalli
- L Pereira
- L Seabrook
- LE Neaves
- Linda E. Neaves
- LM Bryant
- LM Bryant
- LM McInnes
- M Byrne
- M Byrne
- M Byrne
- M Hasegawa
- M Kearse
- Mark D. B. Eldridge
- MG Rix
- NJ Briscoe
- P Masters
- P Menkhorst
- P Sunnucks
- R Cristescu
- R Cristescu
- Rebecca N. Johnson
- RM Andrews
- RW Martin
- RW Martin
- S Dennison
- S Guindon
- S Schneider
- S Van Dyck
- Sam C Banks
- Sean FitzGibbon
- Siobhan Dennison
- SJ Keogh
- SL Hazlitt
- SR Kjeldsen
- T Lee
- T Lee
- WAH Ellis
- WB Sherwin
- WS Grant
- YX Fu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations
- Author
- Acosta Maria T
- Adam Margaret
- Adams David R
- Agrawal Pankaj B
- Alejandro Mercedes E
- Alkelai Anna
- Alvey Justin
- Amendola Laura
- Andrews Ashley
- Antonarakis Stylianos E
- Ashley Euan A
- Atallah Isis
- Au Ping Yee Billie
- Azamian Mahshid S
- Bacino Carlos A
- Bademci Guney
- Baker Eva
- Balasubramanyam Ashok
- Baldridge Dustin
- Bale Jim
- Bamshad Michael
- Bar-Yosef Omer
- Barbouth Deborah
- Bayrak-Toydemir Pinar
- Beck Anita
- Beggs Alan H
- Behrens Edward
- Bejerano Gill
- Bennett Jimmy
- Berg-Rood Beverly
- Bernstein Jonathan A
- Berry Gerard T
- Bican Anna
- Bilan Frédéric
- Bivona Stephanie
- Bjorgo Kathrine
- Blanc Xavier
- Blue Elizabeth
- Bohnsack John
- Bolkier Yoav
- Bonnenmann Carsten
- Bonner Devon
- Botto Lorenzo
- Boyd Brenna
- Briere Lauren C
- Brokamp Elly
- Brown Gabrielle
- Burke Elizabeth A
- Burrage Lindsay C
- Burrage Lindsay C
- Butte Manish J
- Byers Peter
- Byrd William E
- Carey John
- Carrasquillo Olveen
- Chang Ta Chen Peter
- Chanprasert Sirisak
- Chao Hsiao-Tuan
- Christ Björn U
- Clark Gary D
- Coakley Terra R
- Cobban Laurel A
- Cogan Joy D
- Coggins Matthew
- Cole F. Sessions
- Colley Heather A
- Cooper Cynthia M
- Cope Heidi
- Craigen William J
- Crouse Andrew B
- Cunningham Michael
- Dai Hongzheng
- Dasari Surendra
- Davis Joie
- Dayal Jyoti G
- Deardorff Matthew
- Dell’Angelica Esteban C
- Dhar Shweta U
- Dickson Patricia
- Dipple Katrina
- Doherty Daniel
- Donald Kirsten A
- Dorrani Naghmeh
- Doss Argenia L
- Douine Emilie D
- Draper David D
- Dubourg Christèle
- Duncan Laura
- D’Souza Precilla
- Earl Dawn
- Eckstein David J
- Eliyahu Aviva
- Emrick Lisa
- Emrick Lisa T
- Eng Christine M
- Engleman Kendra
- Esteves Cecilia
- Falk Marni
- Fernandez Liliana
- Ferreira Carlos
- Fieg Elizabeth L
- Findley Laurie C
- Fisher Paul G
- Fogel Brent L
- Forghani Irman
- Fresard Laure
- Gahl William A
- Glass Ian
- Gochuico Bernadette
- Godfrey Rena A
- Golden-Grant Katie
- Goldman Alica M
- Goldrich Madison P
- Goldstein David B
- Gonfiantini Michaela Veronika
- Good Jean-Marc
- Grajewski Alana
- Granadillo Jorge L
- Groden Catherine A
- Gutierrez Irma
- Hahn Sihoun
- Hamid Rizwan
- Hanchard Neil A
- Hassey Kelly
- Hayes Nichole
- High Frances
- Hing Anne
- Hisama Fuki M
- Holm Ingrid A
- Hom Jason
- Horike-Pyne Martha
- Huang Alden
- Huang Yong
- Huryn Laryssa
- Isasi Rosario
- Jamal Fariha
- Jamra Rami Abou
- Jarvik Gail P
- Jarvik Jeffrey
- Jayadev Suman
- Kalser Judith
- Karaviti Lefkothea
- Kelley Emily G
- Kennedy Jennifer
- Kiley Dana
- Kloeckner Chiara
- Kohane Isaac S
- Kohler Jennefer N
- Korrick Susan
- Kozuira Mary
- Krakow Deborah
- Krasnewich Donna M
- Kravets Elijah
- Krier Joel B
- Kurata Harley T
- Lachmeijer Guus
- Lalani Seema R
- Lam Byron
- Lam Christina
- Lamothe Shawn M
- LaMoure Grace L
- Lanpher Brendan C
- Lanza Ian R
- Latham Lea
- LeBlanc Kimberly
- Lee Brendan H
- Lee Hane
- Levitt Roy
- Lewis Richard A
- Lincoln Sharyn A
- Liu Pengfei
- Liu Xue Zhong
- Longo Nicola
- Loo Sandra K
- Loscalzo Joseph
- Maas Richard L
- Macchiaiolo Marina
- MacDowall John
- Macnamara Ellen F
- MacRae Calum A
- Maduro Valerie V
- Maghera Jasmine
- Majcherska Marta M
- Mak Bryan C
- Malicdan May Christine V
- Mamounas Laura A
- Manolio Teri A
- Mao Rong
- Maravilla Kenneth
- Markello Thomas C
- Marom Ronit
- Marth Gabor
- Martin Beth A
- Martin Martin G
- Martínez-Agosto Julian A
- Marwaha Shruti
- McCauley Jacob
- McConkie-Rosell Allyn
- McCormack Colleen E
- McCray Alexa T
- McGee Elisabeth
- Mefford Heather
- Merritt J. Lawrence
- Might Matthew
- Mirzaa Ghayda
- Morava Eva
- Moretti Paolo
- Moretti Paolo M
- Mosbrook-Davis Deborah
- Mulvihill John J
- Murdock David R
- Nagy Anna
- Nakano-Okuno Mariko
- Nath Avi
- Nelson Stanley F
- Newman John H
- Nicholas Sarah K
- Nicita Francesco
- Nickerson Deborah
- Nieves-Rodriguez Shirley
- Novacic Donna
- Odent Sylvie
- Oglesbee Devin
- Orengo James P
- Ortiz-Gonzalez Xilma
- O’Heir Emily
- Pace Laura
- Pacio-Miguez Marta
- Pak Stephen
- Pallais J. Carl
- Palmer Christina G.S
- Palomares-Bralo María
- Papp Jeanette C
- Parker Neil H
- Pena Loren
- Perry Katherine Wesseling
- PhillipsIII John A
- Pitt Geoffrey S
- Platzer Konrad
- Pode-Shakked Ben
- Posey Jennifer E
- Potocki Lorraine
- Power Bradley
- Pusey Barbara N
- Quinlan Aaron
- Quinodoz Mathieu
- Raja Archana N
- Ranza Emmanuelle
- Rao Deepak A
- Raskind Wendy
- Renteria Genecee
- Reuter Chloe M
- Rives Lynette
- Robertson Amy K
- Rodan Lance H
- Rodan Lance H
- Rosenfeld Jill A
- Rosenfeld Jill A
- Rosenwasser Natalie
- Rossignol Francis
- Roulet-Perez Eliane
- Rush Eric
- Ruzhnikov Maura
- Sacco Ralph
- Sampson Jacinda B
- Samson Susan L
- Santani Avni
- Santos-Simarro Fernando
- Saporta Mario
- Schaechter Judy
- Schedl Timothy
- Schoch Kelly
- Scott C. Ron
- Scott Daryl A
- Shashi Vandana
- Shashi Vandana
- Shin Jimann
- Signer Rebecca H
- Silverman Edwin K
- Sinsheimer Janet S
- Sisco Kathy
- Skraban Cara
- Slaugh Rachel
- Smith Edward C
- Smith Kevin S
- Solem Emily
- Solnica-Krezel Lilianna
- Solomon Ben
- Spillmann Rebecca C
- Spillmann Rebecca C
- Stoler Joan M
- Sullivan Jennifer A
- Sullivan Kathleen
- Sun Angela
- Superti-Furga Andrea
- Sutton Shirley
- Sweetser David A
- Sybert Virginia
- Tabor Holly K
- Tan Queenie K.-G
- Tekin Mustafa
- Telischi Fred
- Thiffault Isabelle
- Thorson Willa
- Thurm Audrey
- Tifft Cynthia J
- Toro Camilo
- Tran Alyssa A
- Tucker Brianna M
- Undiagnosed Diseases Network
- Urv Tiina K
- Van Bogaert Patrick
- van Jaabrsveld Richard H
- Vanderver Adeline
- Velinder Matt
- Vincent Marie
- Viskochil Dave
- Vogel Tiphanie P
- Wahl Colleen E
- Walker Melissa
- Wallace Stephanie
- Walley Nicole M
- Walsh Chris A
- Wambach Jennifer
- Wan Jijun
- Wang Hong-Gang
- Wang Lee-kai
- Wangler Michael F
- Ward Patricia A
- Wegner Daniel
- Wener Mark
- Wenger Tara
- Westerfield Monte
- Wheeler Matthew T
- Whitlock Jordan
- Wolfe Lynne A
- Woods Jeremy D
- Yamamoto Shinya
- Yang John
- Yousef Muhammad
- Zacher Pia
- Zastrow Diane B
- Zein Wadih
- Zhao Chunli
- Zuchner Stephan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2021
- Field of study
International audiencePurpose:CACNA1C encodes the alpha-1-subunit of a voltage-dependent L-type calcium channel expressed in human heart and brain. Heterozygous variants in CACNA1C have previously been reported in association with Timothy syndrome and long QT syndrome. Several case reports have suggested that CACNA1C variation may also be associated with a primarily neurological phenotype.Methods:We describe 25 individuals from 22 families with heterozygous variants in CACNA1C, who present with predominantly neurological manifestations.Results:Fourteen individuals have de novo, nontruncating variants and present variably with developmental delays, intellectual disability, autism, hypotonia, ataxia, and epilepsy. Functional studies of a subgroup of missense variants via patch clamp experiments demonstrated differential effects on channel function in vitro, including loss of function (p.Leu1408Val), neutral effect (p.Leu614Arg), and gain of function (p.Leu657Phe, p.Leu614Pro). The remaining 11 individuals from eight families have truncating variants in CACNA1C. The majority of these individuals have expressive language deficits, and half have autism.Conclusion:We expand the phenotype associated with CACNA1C variants to include neurodevelopmental abnormalities and epilepsy, in the absence of classic features of Timothy syndrome or long QT syndrome
Recommended from our members
Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations
- Author
- Acosta Maria T
- Adam Margaret
- Adams David R
- Agrawal Pankaj B
- Alejandro Mercedes E
- Alkelai Anna
- Alvey Justin
- Amendola Laura
- Andrews Ashley
- Antonarakis Stylianos E
- Ashley Euan A
- Atallah Isis
- Au Ping Yee Billie
- Azamian Mahshid S
- Bacino Carlos A
- Bademci Guney
- Baker Eva
- Balasubramanyam Ashok
- Baldridge Dustin
- Bale Jim
- Bamshad Michael
- Bar-Yosef Omer
- Barbouth Deborah
- Bayrak-Toydemir Pinar
- Beck Anita
- Beggs Alan H
- Behrens Edward
- Bejerano Gill
- Bennett Jimmy
- Berg-Rood Beverly
- Bernstein Jonathan A
- Berry Gerard T
- Bican Anna
- Bilan Frédéric
- Bivona Stephanie
- Bjorgo Kathrine
- Blanc Xavier
- Blue Elizabeth
- Bohnsack John
- Bolkier Yoav
- Bonnenmann Carsten
- Bonner Devon
- Botto Lorenzo
- Boyd Brenna
- Briere Lauren C
- Brokamp Elly
- Brown Gabrielle
- Burke Elizabeth A
- Burrage Lindsay C
- Butte Manish J
- Byers Peter
- Byrd William E
- Carey John
- Carrasquillo Olveen
- Chang Ta Chen Peter
- Chanprasert Sirisak
- Chao Hsiao-Tuan
- Christ Björn U
- Clark Gary D
- Coakley Terra R
- Cobban Laurel A
- Cogan Joy D
- Coggins Matthew
- Cole F. Sessions
- Colley Heather A
- Cooper Cynthia M
- Cope Heidi
- Craigen William J
- Crouse Andrew B
- Cunningham Michael
- Dai Hongzheng
- Dasari Surendra
- Davis Joie
- Dayal Jyoti G
- Deardorff Matthew
- Dell’Angelica Esteban C
- Dhar Shweta U
- Dickson Patricia
- Dipple Katrina
- Doherty Daniel
- Donald Kirsten A
- Dorrani Naghmeh
- Doss Argenia L
- Douine Emilie D
- Draper David D
- Dubourg Christèle
- Duncan Laura
- D’Souza Precilla
- Earl Dawn
- Eckstein David J
- Eliyahu Aviva
- Emrick Lisa
- Eng Christine M
- Engleman Kendra
- Esteves Cecilia
- Falk Marni
- Fernandez Liliana
- Ferreira Carlos
- Fieg Elizabeth L
- Findley Laurie C
- Fisher Paul G
- Fogel Brent L
- Forghani Irman
- Fresard Laure
- Gahl William A
- Glass Ian
- Gochuico Bernadette
- Godfrey Rena A
- Golden-Grant Katie
- Goldman Alica M
- Goldrich Madison P
- Goldstein David B
- Gonfiantini Michaela Veronika
- Good Jean-Marc
- Grajewski Alana
- Granadillo Jorge L
- Groden Catherine A
- Gutierrez Irma
- Hahn Sihoun
- Hamid Rizwan
- Hanchard Neil A
- Hassey Kelly
- Hayes Nichole
- High Frances
- Hing Anne
- Hisama Fuki M
- Holm Ingrid A
- Hom Jason
- Horike-Pyne Martha
- Huang Alden
- Huang Yong
- Huryn Laryssa
- Isasi Rosario
- Jamal Fariha
- Jarvik Gail P
- Jarvik Jeffrey
- Jayadev Suman
- Kalser Judith
- Karaviti Lefkothea
- Kelley Emily G
- Kennedy Jennifer
- Kiley Dana
- Kloeckner Chiara
- Kohane Isaac S
- Kohler Jennefer N
- Korrick Susan
- Kozuira Mary
- Krakow Deborah
- Krasnewich Donna M
- Kravets Elijah
- Krier Joel B
- Kurata Harley T
- Lachmeijer Guus
- Lalani Seema R
- Lam Byron
- Lam Christina
- Lamothe Shawn M
- LaMoure Grace L
- Lanpher Brendan C
- Lanza Ian R
- Latham Lea
- LeBlanc Kimberly
- Lee Brendan H
- Lee Hane
- Levitt Roy
- Lewis Richard A
- Lincoln Sharyn A
- Liu Pengfei
- Liu Xue Zhong
- Longo Nicola
- Loo Sandra K
- Loscalzo Joseph
- Maas Richard L
- Macchiaiolo Marina
- MacDowall John
- Macnamara Ellen F
- MacRae Calum A
- Maduro Valerie V
- Maghera Jasmine
- Majcherska Marta M
- Mak Bryan C
- Malicdan May Christine V
- Mamounas Laura A
- Manolio Teri A
- Mao Rong
- Maravilla Kenneth
- Markello Thomas C
- Marom Ronit
- Marth Gabor
- Martin Beth A
- Martin Martin G
- Martínez-Agosto Julian A
- Marwaha Shruti
- McCauley Jacob
- McConkie-Rosell Allyn
- McCormack Colleen E
- McCray Alexa T
- McGee Elisabeth
- Mefford Heather
- Merritt J. Lawrence
- Might Matthew
- Mirzaa Ghayda
- Morava Eva
- Moretti Paolo M
- Mosbrook-Davis Deborah
- Mulvihill John J
- Murdock David R
- Nagy Anna
- Nakano-Okuno Mariko
- Nath Avi
- Nelson Stanley F
- Nicholas Sarah K
- Nicita Francesco
- Nickerson Deborah
- Nieves-Rodriguez Shirley
- Novacic Donna
- Odent Sylvie
- Oglesbee Devin
- Orengo James P
- Ortiz-Gonzalez Xilma
- O’Heir Emily
- Pace Laura
- Pacio-Miguez Marta
- Pak Stephen
- Pallais J. Carl
- Palmer Christina G.S
- Palomares-Bralo María
- Papp Jeanette C
- Parker Neil H
- Pena Loren
- Perry Katherine Wesseling
- PhillipsIII John A
- Pitt Geoffrey S
- Platzer Konrad
- Pode-Shakked Ben
- Posey Jennifer E
- Potocki Lorraine
- Power Bradley
- Pusey Barbara N
- Quinlan Aaron
- Quinodoz Mathieu
- Raja Archana N
- Ranza Emmanuelle
- Rao Deepak A
- Raskind Wendy
- Renteria Genecee
- Reuter Chloe M
- Rives Lynette
- Robertson Amy K
- Rodan Lance H
- Rosenfeld Jill A
- Rosenwasser Natalie
- Rossignol Francis
- Roulet-Perez Eliane
- Rush Eric
- Ruzhnikov Maura
- Sacco Ralph
- Sampson Jacinda B
- Samson Susan L
- Santani Avni
- Santos-Simarro Fernando
- Saporta Mario
- Schaechter Judy
- Schedl Timothy
- Schoch Kelly
- Scott C. Ron
- Scott Daryl A
- Shashi Vandana
- Shin Jimann
- Signer Rebecca H
- Silverman Edwin K
- Sinsheimer Janet S
- Sisco Kathy
- Skraban Cara
- Slaugh Rachel
- Smith Edward C
- Smith Kevin S
- Solem Emily
- Solnica-Krezel Lilianna
- Solomon Ben
- Spillmann Rebecca C
- Stoler Joan M
- Sullivan Jennifer A
- Sullivan Kathleen
- Sun Angela
- Superti-Furga Andrea
- Sutton Shirley
- Sweetser David A
- Sybert Virginia
- Tabor Holly K
- Tan Queenie K.-G
- Tekin Mustafa
- Telischi Fred
- Thiffault Isabelle
- Thorson Willa
- Thurm Audrey
- Tifft Cynthia J
- Toro Camilo
- Tran Alyssa A
- Tucker Brianna M
- Urv Tiina K
- Van Bogaert Patrick
- van Jaabrsveld Richard H
- Vanderver Adeline
- Velinder Matt
- Vincent Marie
- Viskochil Dave
- Vogel Tiphanie P
- Wahl Colleen E
- Walker Melissa
- Wallace Stephanie
- Walley Nicole M
- Walsh Chris A
- Wambach Jennifer
- Wan Jijun
- Wang Hong-Gang
- Wang Lee-kai
- Wangler Michael F
- Ward Patricia A
- Wegner Daniel
- Wener Mark
- Wenger Tara
- Westerfield Monte
- Wheeler Matthew T
- Whitlock Jordan
- Wolfe Lynne A
- Woods Jeremy D
- Yamamoto Shinya
- Yang John
- Yousef Muhammad
- Zacher Pia
- Zastrow Diane B
- Zein Wadih
- Zhao Chunli
- Zuchner Stephan
- Publication venue
- Elsevier Inc
- Publication date
- 01/10/2021
- Field of study