3,851 research outputs found
Traversable Wormholes in Geometries of Charged Shells
We construct a static axisymmetric wormhole from the gravitational field of
two charged shells which are kept in equilibrium by their electromagnetic
repulsion. For large separations the exterior tends to the Majumdar-Papapetrou
spacetime of two charged particles. The interior of the wormhole is a
Reissner-Nordstr\"om black hole matching to the two shells. The wormhole is
traversable and connects to the same asymptotics without violation of energy
conditions. However, every point in the Majumdar-Papapetrou region lies on a
closed timelike curve.Comment: 9 pages, LaTeX, 1 figur
The neural correlates of emotion regulation by implementation intentions
Several studies have investigated the neural basis of effortful emotion regulation (ER) but the neural basis of automatic ER has been less comprehensively explored. The present study investigated the neural basis of automatic ER supported by ‘implementation intentions’. 40 healthy participants underwent fMRI while viewing emotion-eliciting images and used either a previously-taught effortful ER strategy, in the form of a goal intention (e.g., try to take a detached perspective), or a more automatic ER strategy, in the form of an implementation intention (e.g., “If I see something disgusting, then I will think these are just pixels on the screen!”), to regulate their emotional response. Whereas goal intention ER strategies were associated with activation of brain areas previously reported to be involved in effortful ER (including dorsolateral prefrontal cortex), ER strategies based on an implementation intention strategy were associated with activation of right inferior frontal gyrus and ventro-parietal cortex, which may reflect the attentional control processes automatically captured by the cue for action contained within the implementation intention. Goal intentions were also associated with less effective modulation of left amygdala, supporting the increased efficacy of ER under implementation intention instructions, which showed coupling of orbitofrontal cortex and amygdala. The findings support previous behavioural studies in suggesting that forming an implementation intention enables people to enact goal-directed responses with less effort and more efficiency
Capture Velocity for a Magneto-Optical Trap in a Broad Range of Light Intensity
In a recent paper, we have used the dark-spot Zeeman tuned slowing technique
[Phys. Rev. A 62, 013404-1, (2000)] to measure the capture velocity as a
function of laser intensity for a sodium magneto optical trap. Due to technical
limitation we explored only the low light intensity regime, from 0 to 27
mW/cm^2. Now we complement that work measuring the capture velocity in a
broader range of light intensities (from 0 to 400 mW/cm^2). New features,
observed in this range, are important to understant the escape velocity
behavior, which has been intensively used in the interpretation of cold
collisions. In particular, we show in this brief report that the capture
velocity has a maximum as function of the trap laser intensity, which would
imply a minimum in the trap loss rates.Comment: 2 pages, 2 figure
Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish
In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ultimately yielding a reduced-eye phenotype even in the presence of full HSP90 activity. Raising surface fish under conditions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as does direct inhibition of HSP90. These results suggest that cryptic variation played a role in the evolution of eye loss in cavefish and provide the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting
Thermodynamics of Heat Shock Response
Production of heat shock proteins are induced when a living cell is exposed
to a rise in temperature. The heat shock response of protein DnaK synthesis in
E.coli for temperature shifts from temperature T to T plus 7 degrees,
respectively to T minus 7 degrees is measured as function of the initial
temperature T. We observe a reversed heat shock at low T. The magnitude of the
shock increases when one increase the distance to the temperature , thereby mimicking the non monotous stability of proteins at low
temperature. Further we found that the variation of the heat shock with T
quantitatively follows the thermodynamic stability of proteins with
temperature. This suggest that stability related to hot as well as cold
unfolding of proteins is directly implemented in the biological control of
protein folding. We demonstrate that such an implementation is possible in a
minimalistic chemical network.Comment: To be published in Physical Review Letter
Cosmology of a brane radiating gravitons into the extra dimension
We study in a self-consistent way the impact of the emission of bulk
gravitons on the (homogeneous) cosmology of a three-brane embedded in a
five-dimensional spacetime. In the low energy regime, we recover the well known
result that the bulk affects the Friedmann equation only via a radiation-like
term \C/a^4, called dark or Weyl radiation. By contrast, in the high energy
regime, we find that the Weyl parameter \C is no longer constant but instead
grows very rapidly as \C\propto a^4. As a consequence, the value of \C
today is not a free parameter as usually considered but is a fixed number,
which, generically, depends only on the number of relativistic degrees of
freedom at the high/low energy transition. Our estimated amount of Weyl
radiation satisfies the present nucleosynthesis bounds.Comment: 12 page
Gravitational collapse to toroidal, cylindrical and planar black holes
Gravitational collapse of non-spherical symmetric matter leads inevitably to
non-static external spacetimes. It is shown here that gravitational collapse of
matter with toroidal topology in a toroidal anti-de Sitter background proceeds
to form a toroidal black hole. According to the analytical model presented, the
collapsing matter absorbs energy in the form of radiation (be it scalar,
neutrinos, electromagnetic, or gravitational) from the exterior spacetime. Upon
decompactification of one or two coordinates of the torus one gets collapsing
solutions of cylindrical or planar matter onto black strings or black
membranes, respectively. The results have implications on the hoop conjecture.Comment: 6 pages, Revtex, modifications in the title and in the interpretation
of some results, to appear in Physical Review
Prion Protein is Expressed on Long-term Repopulating Hematopoietic Stem Cells and is Necessary for their Self-renewal
We show that the prion protein (PrP) is expressed on the surface of bone marrow cell populations enriched in long-term repopulating hematopoietic stem cells. Affinity purification of the PrP-positive and PrP-negative fractions from these populations, followed by competitive reconstitution assays, show that all long-term repopulating hematopoietic stem cells express PrP. Hematopoietic stem cells from PrP null bone marrow exhibit impaired self-renewal in serial competitive transplantation experiments, and premature exhaustion when exposed to cell cycle-specific myelotoxic injury. Therefore, PrP is a novel marker for hematopoietic stem cells and regulates their self-renewal.Singapore-MIT Alliance (SMA
Edge-Based Compartmental Modeling for Infectious Disease Spread Part III: Disease and Population Structure
We consider the edge-based compartmental models for infectious disease spread
introduced in Part I. These models allow us to consider standard SIR diseases
spreading in random populations. In this paper we show how to handle deviations
of the disease or population from the simplistic assumptions of Part I. We
allow the population to have structure due to effects such as demographic
detail or multiple types of risk behavior the disease to have more complicated
natural history. We introduce these modifications in the static network
context, though it is straightforward to incorporate them into dynamic
networks. We also consider serosorting, which requires using the dynamic
network models. The basic methods we use to derive these generalizations are
widely applicable, and so it is straightforward to introduce many other
generalizations not considered here
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