Traversable Wormholes in Geometries of Charged Shells

We construct a static axisymmetric wormhole from the gravitational field of two charged shells which are kept in equilibrium by their electromagnetic repulsion. For large separations the exterior tends to the Majumdar-Papapetrou spacetime of two charged particles. The interior of the wormhole is a Reissner-Nordstr\"om black hole matching to the two shells. The wormhole is traversable and connects to the same asymptotics without violation of energy conditions. However, every point in the Majumdar-Papapetrou region lies on a closed timelike curve.Comment: 9 pages, LaTeX, 1 figur

The neural correlates of emotion regulation by implementation intentions

Several studies have investigated the neural basis of effortful emotion regulation (ER) but the neural basis of automatic ER has been less comprehensively explored. The present study investigated the neural basis of automatic ER supported by ‘implementation intentions’. 40 healthy participants underwent fMRI while viewing emotion-eliciting images and used either a previously-taught effortful ER strategy, in the form of a goal intention (e.g., try to take a detached perspective), or a more automatic ER strategy, in the form of an implementation intention (e.g., “If I see something disgusting, then I will think these are just pixels on the screen!”), to regulate their emotional response. Whereas goal intention ER strategies were associated with activation of brain areas previously reported to be involved in effortful ER (including dorsolateral prefrontal cortex), ER strategies based on an implementation intention strategy were associated with activation of right inferior frontal gyrus and ventro-parietal cortex, which may reflect the attentional control processes automatically captured by the cue for action contained within the implementation intention. Goal intentions were also associated with less effective modulation of left amygdala, supporting the increased efficacy of ER under implementation intention instructions, which showed coupling of orbitofrontal cortex and amygdala. The findings support previous behavioural studies in suggesting that forming an implementation intention enables people to enact goal-directed responses with less effort and more efficiency

Capture Velocity for a Magneto-Optical Trap in a Broad Range of Light Intensity

In a recent paper, we have used the dark-spot Zeeman tuned slowing technique [Phys. Rev. A 62, 013404-1, (2000)] to measure the capture velocity as a function of laser intensity for a sodium magneto optical trap. Due to technical limitation we explored only the low light intensity regime, from 0 to 27 mW/cm^2. Now we complement that work measuring the capture velocity in a broader range of light intensities (from 0 to 400 mW/cm^2). New features, observed in this range, are important to understant the escape velocity behavior, which has been intensively used in the interpretation of cold collisions. In particular, we show in this brief report that the capture velocity has a maximum as function of the trap laser intensity, which would imply a minimum in the trap loss rates.Comment: 2 pages, 2 figure

Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish

In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ultimately yielding a reduced-eye phenotype even in the presence of full HSP90 activity. Raising surface fish under conditions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as does direct inhibition of HSP90. These results suggest that cryptic variation played a role in the evolution of eye loss in cavefish and provide the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting

Thermodynamics of Heat Shock Response

Production of heat shock proteins are induced when a living cell is exposed to a rise in temperature. The heat shock response of protein DnaK synthesis in E.coli for temperature shifts from temperature T to T plus 7 degrees, respectively to T minus 7 degrees is measured as function of the initial temperature T. We observe a reversed heat shock at low T. The magnitude of the shock increases when one increase the distance to the temperature $T_0 \approx 23^o$, thereby mimicking the non monotous stability of proteins at low temperature. Further we found that the variation of the heat shock with T quantitatively follows the thermodynamic stability of proteins with temperature. This suggest that stability related to hot as well as cold unfolding of proteins is directly implemented in the biological control of protein folding. We demonstrate that such an implementation is possible in a minimalistic chemical network.Comment: To be published in Physical Review Letter

Cosmology of a brane radiating gravitons into the extra dimension

We study in a self-consistent way the impact of the emission of bulk gravitons on the (homogeneous) cosmology of a three-brane embedded in a five-dimensional spacetime. In the low energy regime, we recover the well known result that the bulk affects the Friedmann equation only via a radiation-like term \C/a^4, called dark or Weyl radiation. By contrast, in the high energy regime, we find that the Weyl parameter \C is no longer constant but instead grows very rapidly as \C\propto a^4. As a consequence, the value of \C today is not a free parameter as usually considered but is a fixed number, which, generically, depends only on the number of relativistic degrees of freedom at the high/low energy transition. Our estimated amount of Weyl radiation satisfies the present nucleosynthesis bounds.Comment: 12 page

Gravitational collapse to toroidal, cylindrical and planar black holes

Gravitational collapse of non-spherical symmetric matter leads inevitably to non-static external spacetimes. It is shown here that gravitational collapse of matter with toroidal topology in a toroidal anti-de Sitter background proceeds to form a toroidal black hole. According to the analytical model presented, the collapsing matter absorbs energy in the form of radiation (be it scalar, neutrinos, electromagnetic, or gravitational) from the exterior spacetime. Upon decompactification of one or two coordinates of the torus one gets collapsing solutions of cylindrical or planar matter onto black strings or black membranes, respectively. The results have implications on the hoop conjecture.Comment: 6 pages, Revtex, modifications in the title and in the interpretation of some results, to appear in Physical Review

Prion Protein is Expressed on Long-term Repopulating Hematopoietic Stem Cells and is Necessary for their Self-renewal

We show that the prion protein (PrP) is expressed on the surface of bone marrow cell populations enriched in long-term repopulating hematopoietic stem cells. Affinity purification of the PrP-positive and PrP-negative fractions from these populations, followed by competitive reconstitution assays, show that all long-term repopulating hematopoietic stem cells express PrP. Hematopoietic stem cells from PrP null bone marrow exhibit impaired self-renewal in serial competitive transplantation experiments, and premature exhaustion when exposed to cell cycle-specific myelotoxic injury. Therefore, PrP is a novel marker for hematopoietic stem cells and regulates their self-renewal.Singapore-MIT Alliance (SMA

Edge-Based Compartmental Modeling for Infectious Disease Spread Part III: Disease and Population Structure

We consider the edge-based compartmental models for infectious disease spread introduced in Part I. These models allow us to consider standard SIR diseases spreading in random populations. In this paper we show how to handle deviations of the disease or population from the simplistic assumptions of Part I. We allow the population to have structure due to effects such as demographic detail or multiple types of risk behavior the disease to have more complicated natural history. We introduce these modifications in the static network context, though it is straightforward to incorporate them into dynamic networks. We also consider serosorting, which requires using the dynamic network models. The basic methods we use to derive these generalizations are widely applicable, and so it is straightforward to introduce many other generalizations not considered here