Anharmonicity and self-similarity of the free energy landscape of protein G

The near-native free energy landscape of protein G is investigated through 0.4 microseconds-long atomistic molecular dynamics simulations in explicit solvent. A theoretical and computational framework is used to assess the time-dependence of salient thermodynamical features. While the quasi-harmonic character of the free energy is found to degrade in a few ns, the slow modes display a very mild dependence on the trajectory duration. This property originates from a striking self-similarity of the free energy landscape embodied by the consistency of the principal directions of the local minima, where the system dwells for several ns, and of the virtual jumps connecting them.Comment: revtex, 6 pages, 5 figure

Sensory Design in the Birth Environment: Learning from Existing Case Studies

Studies have shown how built environments for hospitals can influence psychological and physiological conditions and status for childbearing women. Sensory attributes of birth spaces can enhance comfort, feelings of wellbeing, and, to some extent, clinical outcomes. Recently, some case studies of multisensory rooms for the birth environment have been developed based on, e.g., Snoezelen room examples. The aim of this research is to develop an overview of how sensory aspects for birth environments are designed, used, and tested in current and recent studies. Case studies were selected according to sensory aspect significance, observing space factors, and relationship with the experience and comfort of users (women, partners, midwives). All case studies were analysed to collect information about the design and validation process. The collected data were organised in categories and compared for the selected case studies. Main findings were summarised in tables with the aim of underlining how sensory design processes and projects can positively influence comfort for birthing. Conclusions about how to bring forward the issue of sensory design so that it can be used and applied to support childbearing women is discussed

Claiming and Reclaiming Settings, Objects, and Situations: A Microethnographic Study of the Sociomaterial Practices of Everyday Life at Swedish Youth Homes

The aim of this study is to explore social interactions in the spatial and material environment within everyday life at special youth homes in Sweden, where youths with psychosocial problems, or criminal behavior are cared for involuntary. A microethnographic approach was chosen, and data was collected through participant observation. A theory integrating analysis, using Burke’s (1969) dramatistic pentad as a tool for structuring the data and Goffman’s (1956; 1961) dramaturgical perspective was undertaken. The findings demonstrate that the staff’s control over settings and objects also means control over the definition of what kind of place the special youth home is, and what takes place there. This is shown through a decorous behavior of sociomaterial control practices, rather than care practices, by the staff. This study contributes to knowledge on spaces and objects as crucial parts of care practices highlighting the intentions inscribed in institutional design and objects

Distributional Preferences in Adolescent Peer Networks

We study distributional ("social") preferences in adolescent peer networks. Using incentivized choices between allocations for themselves and a passive agent, children are classified into efficiency-loving, inequality-loving, inequality-averse, and spiteful types. We find that pairs of students who report a friendship link are more likely to exhibit the same preference type than other students that attend the same school. The relation between types is almost completely driven by inequality-loving and spiteful types. Further analyses suggest that preference peer networks are mainly formed by selection into the network and, to a smaller degree, by preference transmission. The role of peer networks in explaining distributional preferences goes beyond network composition effects. A low rank in academic performance and a central position within the network relate positively to a higher likelihood of being classified as spiteful. Hence, social hierarchies seem to be correlated with distributional preference types

Be prepared and do the best you can: a focus group study with staff on the care environment at Swedish secure youth homes

PURPOSE: This study examined staff members\u27 experiences of the institutional care environment within secure youth homes. METHODS: Data were collected through three focus group discussions with 17 staff members at two secure youth homes. Subsequently, a thematic analysis was conducted. RESULTS: The analysis indicated two main themes: risk management and damage control in a restricted environment and compensating and reconstructing ordinariness-trying to make the best of it; each theme had three subthemes. The care environment seems to be experienced by staff as characterized by conflicting demands, thus constituting a gap between needs and what is possible to achieve-a balancing act that constitutes a constant struggle. CONCLUSIONS: The staff members\u27 constant struggle could be interpreted as conflicting moral and instrumental demands; they know what the youths need, but the environment of the secure youth homes demands the decorous behaviour of sociomaterial control practices-rather than care practices

Genetic steps to organ laterality in zebrafish.

All internal organs are asymmetric along the left-right axis. Here we report a genetic screen to discover mutations which perturb organ laterality. Our particular focus is upon whether, and how, organs are linked to each other as they achieve their laterally asymmetric positions. We generated mutations by ENU mutagenesis and examined F3 progeny using a cocktail of probes that reveal early primordia of heart, gut, liver and pancreas. From the 750 genomes examined, we isolated seven recessive mutations which affect the earliest left-right positioning of one or all of the organs. None of these mutations caused discernable defects elsewhere in the embryo at the stages examined. This is in contrast to those mutations we reported previously (Chen et al., 1997) which, along with left-right abnormalities, cause marked perturbation in gastrulation, body form or midline structures. We find that the mutations can be classified on the basis of whether they perturb relationships among organ laterality. In Class 1 mutations, none of the organs manifest any left-right asymmetry. The heart does not jog to the left and normally leftpredominant BMP4 in the early heart tube remains symmetric. The gut tends to remain midline. There frequently is a remarkable bilateral duplication of liver and pancreas. Embryos with Class 2 mutations have organotypic asymmetry but, in any given embryo, organ positions can be normal, reversed or randomized. Class 3 reveals a hitherto unsuspected gene that selectively affects laterality of heart. We find that visceral organ positions are predicted by the direction of the preceding cardiac jog. We interpret this as suggesting that normally there is linkage between cardiac and visceral organ laterality. Class 1 mutations, we suggest, effectively remove the global laterality signals, with the consequence that organ positions are effectively symmetrical. Embryos with Class 2 mutations do manifest linkage among organs, but it may be reversed, suggesting that the global signals may be present but incorrectly orientated in some of the embryos. That laterality decisions of organs may be independently perturbed, as in the Class 3 mutation, indicates that there are distinctive pathways for reception and organotypic interpretation of the global signals

How Virtual Reality is used when involving healthcare staff in the design process

The design process of a new hospital is often recognized as a complex task involving a diverse group of actors. The most common information media used today are project related documents and drawings. Hospital users\ub4 ability to interpret information through these varies. This affects the design feedback from users. However, an increasing use of Virtual Reality (VR) support possibilities to facilitate better understanding. This paper presents six case studies of hospital design projects, where VR has been used with the purpose of involving end-users, investigating how and when VR has been implemented and which effects and experiences that could be noted.The findings show different levels of involvement, engagement, collaboration, and interactivity. Using VR contributes throughout the design process but is dependent on purpose and setup. Furthermore, there is a strong connection between engagement and the interactivity of the VR model