Nitrous Oxide: Mechanism of Its Antinociceptive Action

Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated. The mechanism of this analgesic effect was long thought to be nonspecific in nature, but a landmark study by Berkowitz and others in 1976 first implicated an opioid mechanism of action, possibly via N2O-stimulated neuronal release of endogenous opioid peptides to activate opioid receptors. N2O-induced release of opioid peptide has been demonstrated in both in vivo and in vitro preparations. Reversal of N2O-induced antinociception in animals by narcotic antagonists has been reported by a number of laboratories. Subsequent studies have utilized more selective opioid antagonists to identify the opioid receptor subtypes involved in the antinociceptive effect of N2O. Extensive pharmacological testing in the mouse abdominal constriction and rat hot plate paradigms have established that N2O-induced antinociception is mediated by κ-opioid receptors in the former and by µ- and -opioid receptors in the latter. Current studies focus on two recent developments. The poor responsiveness of the DBA/2J mouse strain to N2O has led to pharmacogenetic studies that hope to identify the underlying genetic basis for antinociceptive responsiveness to N2O. Other research suggests an involvement of nitric oxide (NO) in mediating the antinociceptive effects of N2O in both rats and mice

Results of the 2007-2008 Illinois Hunter Harvest Survey

Grant/Contract No: W-112-R-17A random sample of 3,000 potential hunters was selected from among 2007 Illinois Habitat Stamp and hunting license purchasers. An 8-page questionnaire was successfully mailed to 2,906 of the 3,000 individuals. We received 1,625 returned questionnaires, 1,620 of which were usable, for a 56% response rate. Comparisons of harvest estimates from the 2006-2007 season to the 2007-2008 season suggest harvest decreased for 10 game animal categories (rabbit, quail, pheasant, dove, gray partridge, fox squirrel, gray squirrel, red fox, gray fox, and opossum), and increased for 3 categories (woodcock, raccoon, and coyote). License sales increased 0.4% from 282,000 sold for the 2006 season to 283,000 sold in the 2007 season. This represents a recovery in license sales of less than 1% since the lowest level on record (since 1938) in 2005. Low license sales may be related to increasing difficulty in finding land to hunt. Resident hunters pursuing deer (61%) and small game species (51%) reported little difficulty in gaining access to hunting lands. However, all other seasons were associated with more difficulty in accessing land. Efforts should be undertaken to ensure that hunters are aware of the locations of public hunting lands associated with these seasons. Few residents reported leasing land (4%) or hiring outfitters (1%) to access land.INHS Technical Report Prepared for Illinois Department of Natural Resources; Illinois Natural History Surve

Influence of store attributes on shopping intentions in factory outlet malls

This paper examines the effect of eight types of consumer decision-making styles and shopping behaviour on future shopping intentions at factory outlet malls. Results indicate that six out of eight decision-making styles are positively related of future shopping intentions. Conclusions drawn from the current study's findings and their implications for consumer decision-making and shopping behaviour are discussed

Worker Morale in Russia: An Exploratory Study

Despite unanimous agreement in the existing literature that morale influences employee performance, no well-defined measure of morale exists. Our study develops a robust measure of morale and focuses on the factors that influence morale among Russian workers. Survey data were collected from Russian employees at two different points in time, 1995 and 2002, in five Russian cities. Among the workers participating in our study, expectation of receiving a desired reward contributes to high morale, with expected monetary rewards having a larger influence than expected non-monetary rewards, but praise for a job well done and a feeling of accomplishment also contribute positively to employee morale. There is a significant correlation between positive attitudes toward work and morale, and a positive correlation between performance assessment and morale. Demographic characteristics (age and gender) have no discernable influence on morale when controls are included for work experience.http://deepblue.lib.umich.edu/bitstream/2027.42/57196/1/wp816 .pd

LARCMACS: A TEX macro set for typesetting NASA reports

This LARCMACS user's manual describes the February 1988 version of LARCMACS, the TEX macro set used by the Technical Editing Branch (TEB) at NASA Langley Research Center. These macros were developed by the authors to facilitate the typesetting of NASA formal reports. They are also useful, however, for informal NASA reports and other technical documents such as meeting papers. LARCMACS are distributed by TEB for the convenience of the Langley TEX user community. LARCMACS contain macros for obtaining the standard double-column format for NASA reports, for typesetting tables in the ruled format traditional in NASA reports, and for typesetting difficult mathematical expressions. Each macro is described and numerous examples are included. Definitions of the LARCMACS macros are also included

Increased Metabolic Rate in X-linked Hypophosphatemic Mice

Hyp mice are a model for human X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets. It has previously been observed that Hyp mice have a greater food consumption per gram body weight than do normal mice. This led to the search for some alteration in metabolism in Hyp mice. We found that oxygen consumption was significantly higher in Hyp mice than in normal C57BL/6J mice and this was accompanied by an increased percentage of cardiac output being delivered to organs of heat production (liver and skeletal muscle), to the skin, and to bone and a decreased percentage to the gastrointestinal tract of Hyp mice. The increased oxygen consumption in Hyp mice was not associated with increased plasma free T4 levels and was not affected by alterations in plasma phosphate produced by a low phosphate diet. The cause of the increased oxygen consumption is not known, and the role that this change and reported changes in distribution of cardiac output may play in the development of X-linked hypophosphatemia is also unknown. Study of the cardiovascular and thermoregulatory systems in Hyp mice should help increase understanding of the underlying mechanisms of this disease

Aloe vera: A Multipurpose Healer and Bacterial Eradicator

The Aloe vera plant is a succulent known for its rich content in vitamins and minerals, thus gaining popularity over the years in healthcare products. With advancements in alternative medicine, it has been recently found useful in dentistry due to properties such as anti-inflammatory, antioxidant and antimicrobial actions that contribute to wound healing. The purpose of this study was to examine and discover how Aloe vera can be used as an alternative therapy in the dental field. The PubMed, Google Scholar and Dentistry & Oral Sciences (DOSS) databases were utilized to find current scientific evidence on the effects of Aloe vera. Relevant articles were summarized to write a review of findings. In this study, 21 articles published from 2015 to present were reviewed. From the studies, there is strong evidence to support that Aloe vera exhibits beneficial effects in prevention of carious lesions, non-surgical scaling and root planing in patients with chronic periodontitis, and oral wounds. Furthermore, it is cost effective and easily accessible. This review’s findings indicate that dental health care providers could recommend Aloe vera as a preventive and an alternative treatment option to improve patients’ oral health status.https://scholarscompass.vcu.edu/denh_student/1005/thumbnail.jp

Misreporting Fundraising: How do Nonprofit Organizations Account for Telemarketing Campaigns?

The purpose of this study is to examine the frequency, determinants and implications of misreporting fundraising activities. We compare state telemarketing campaign reports with the associated information from nonprofits annual Form 990 filings to directly test nonprofits revenue and expense recognition policies. Our study indicates that smaller nonprofits, and those with less accounting sophistication, are more likely to inappropriately report telemarketing costs as a component of net revenues rather than as expenses. In addition, less monitored firms are more likely to report telemarketing campaign revenues net of expenses. Additionally, among those firms that do report telemarketing costs as expenses, we find that smaller firms, and those with relatively less officer compensation, are more likely to allocate telemarketing expenses to non-fundraising expense categories.This publication is Hauser Center Working Paper No. 37. The Hauser Center Working Paper Series was launched during the summer of 2000. The Series enables the Hauser Center to share with a broad audience important works-in-progress written by Hauser Center scholars and researchers