Charm meson scattering cross sections by pion and rho meson

Using the local flavor SU(4) gauge invariance in the limit of vanishing vector meson masses, we extend our previous study of charm meson scattering cross sections by pion and rho meson, which is based only on the pseudoscalar-pseudoscalar-vector meson couplings, to include also contributions from the couplings among three vector mesons and among four particles. We find that diagrams with light meson exchanges usually dominate the cross sections. For the processes considered previously, the additional interactions lead only to diagrams involving charm meson exchanges and contact interactions, and the cross sections for these processes are thus not much affected. Nevertheless, these additional interactions introduce new processes with light meson exchanges and increase significantly the total scattering cross sections of charm mesons by pion and rho meson.Comment: 14 pages, revtex, 6 figures, added a figure on the effects of on-shell divergence, final version to appear in Nucl. Phys.

Preferences for cancer investigation:a vignette-based study of primary-care attendees

SummaryBackgroundThe UK lags behind many European countries in terms of cancer survival. Initiatives to address this disparity have focused on barriers to presentation, symptom recognition, and referral for specialist investigation. Selection of patients for further investigation has come under particular scrutiny, although preferences for referral thresholds in the UK population have not been studied. We investigated preferences for diagnostic testing for colorectal, lung, and pancreatic cancers in primary-care attendees.MethodsIn a vignette-based study, researchers recruited individuals aged at least 40 years attending 26 general practices in three areas of England between Dec 6, 2011, and Aug 1, 2012. Participants completed up to three of 12 vignettes (four for each of lung, pancreatic, and colorectal cancers), which were randomly assigned. The vignettes outlined a set of symptoms, the risk that these symptoms might indicate cancer (1%, 2%, 5%, or 10%), the relevant testing process, probable treatment, possible alternative diagnoses, and prognosis if cancer were identified. Participants were asked whether they would opt for diagnostic testing on the basis of the information in the vignette.Findings3469 participants completed 6930 vignettes. 3052 individuals (88%) opted for investigation in their first vignette. We recorded no strong evidence that participants were more likely to opt for investigation with a 1% increase in risk of cancer (odds ratio [OR] 1·02, 95% CI 0·99–1·06; p=0·189), although the association between risk and opting for investigation was strong when colorectal cancer was analysed alone (1·08, 1·03–1·13; p=0·0001). In multivariable analysis, age had an effect in all three cancer models: participants aged 60–69 years were significantly more likely to opt for investigation than were those aged 40–59 years, and those aged 70 years or older were less likely. Other variables associated with increased likelihood of opting for investigation were shorter travel times to testing centre (colorectal and lung cancers), a family history of cancer (colorectal and lung cancers), and higher household income (colorectal and pancreatic cancers).InterpretationParticipants in our sample expressed a clear preference for diagnostic testing at all risk levels, and individuals want to be tested at risk levels well below those stipulated by UK guidelines. This willingness should be considered during design of cancer pathways, particularly in primary care. The public engagement with our study should encourage general practitioners to involve patients in referral decision making.FundingThe National Institute for Health Research Programme Grants for Applied Research programme

On the complementarity of pulsar timing and space laser interferometry for the individual detection of supermassive black hole binaries

Gravitational waves coming from Super Massive Black Hole Binaries (SMBHBs) are targeted by both Pulsar Timing Array (PTA) and Space Laser Interferometry (SLI). The possibility of a single SMBHB being tracked first by PTA, through inspiral, and later by SLI, up to merger and ring down, has been previously suggested. Although the bounding parameters are drawn by the current PTA or the upcoming Square Kilometer Array (SKA), and by the New Gravitational Observatory (NGO), derived from the Laser Interferometer Space Antenna (LISA), this paper also addresses sequential detection beyond specific project constraints. We consider PTA-SKA, which is sensitive from 10^(-9) to p x 10^(-7) Hz (p=4, 8), and SLI, which operates from s x 10^(-5) up to 1 Hz (s = 1, 3). A SMBHB in the range 2x 10^(8) - 2 x 10^(9) solar masses (the masses are normalised to a (1+z) factor, the red shift lying between z = 0.2 and z=1.5) moves from the PTA-SKA to the SLI band over a period ranging from two months to fifty years. By combining three Super Massive Black Hole (SMBH)-host relations with three accretion prescriptions, nine astrophysical scenarios are formed. They are then related to three levels of pulsar timing residuals (50, 5, 1 ns), generating twenty-seven cases. For residuals of 1 ns, sequential detection probability will never be better than 4.7 x 10^(-4) y^(-2) or 3.3 x 10^(-6) y^(-2) (per year to merger and per year of survey), according to the best and worst astrophysical scenarios, respectively; put differently this means one sequential detection every 46 or 550 years for an equivalent maximum time to merger and duration of the survey. The chances of sequential detection are further reduced by increasing values of the s parameter (they vanish for s = 10) and of the SLI noise, and by decreasing values of the remnant spin. REST OF THE ABSTRACT IN THE PDF FILE.Comment: To appear in the Astrophysical Journa

Do Demographic Profiles of Listed and Unlisted Households Differ? Results of a Nationwide Telephone Survey

A growing number of households are not reachable through traditional directory-based samples, which can have important implications for the representativeness of telephone surveys. The current study aims to investigate the demographic differences between households which have their telephone numbers listed or not listed in the Australian White Pages telephone directory. A total of 5,023 eligible Australian residents who were currently in paid employment participated in this study. Each respondent’s telephone number was individually matched to the residential White Pages to determine its listed status, and demographic variables were compared between those with a listed and unlisted telephone number. Those with an unlisted number were significantly more likely to be younger, to have been born in a country outside of Australia, and to live in a lower socioeconomic area than those who were listed in the White Pages. These demographic differences should be considered when undertaking telephone surveys using a White Pages sample

Rule-Based Exposure Assessment Versus Case-By-Case Expert Assessment Using the Same Information in a Community-Based Study

Background: Retrospective exposure assessment in community-based studies is largely reliant on questionnaire information. Expert assessment is often used to assess lifetime occupational exposures, but these assessments generally lack transparency and are very time-consuming. We explored the agreement between a rule-based assessment approach and case-by-case expert assessment of occupational exposures in a community-based study. Methods: We used data from a case-control study of childhood acute lymphoblastic leukaemia in which parental occupational exposures were originally assigned by expert assessment. Key questions were identified from the completed parent questionnaires and, based on these, rules were written to assign exposure levels to diesel exhaust, pesticides, and solvents. We estimated exposure prevalence separately for fathers and mothers, and used Kappa statistics to assess the agreement between the two exposure assessment methods.Results: Exposures were assigned to 5829 jobs among 1079 men and 6189 jobs among 1234 women. For both sexes, agreement was good for the two assessment methods of exposure to diesel exhaust at a job level (κ=0.70 for men and κ=0.71 for women) and at a person level (κ=0.74 and κ=0.75). The agreement was good to excellent for pesticide exposure among men (κ=0.74 for jobs and κ=0.84 at a person level) and women (κ=0.68 and κ=0.71 at a job and person level, respectively). Moderate to good agreement was observed for assessment of solvent exposure, which was better for women than men. Conclusion: The rule-based assessment approach appeared to be an efficient alternative for assigning occupational exposures in a community-based study for a selection of occupational exposures

Stationary Light Pulses in Cold Atomic Media

Stationary light pulses (SLPs), i.e., light pulses without motion, are formed via the retrieval of stored probe pulses with two counter-propagating coupling fields. We show that there exist non-negligible hybrid Raman excitations in media of cold atoms that prohibit the SLP formation. We experimentally demonstrate a method to suppress these Raman excitations and realize SLPs in laser-cooled atoms. Our work opens the way to SLP studies in cold as well as in stationary atoms and provides a new avenue to low-light-level nonlinear optics.Comment: 4 pages, 4 figure

Diagnostic quality assessment of compressed sensing accelerated magnetic resonance neuroimaging.

PURPOSE: To determine the efficacy of compressed sensing (CS) reconstructions for specific clinical magnetic resonance neuroimaging applications beyond more conventional acceleration techniques such as parallel imaging (PI) and low-resolution acquisitions. MATERIALS AND METHODS: Raw k-space data were acquired from five healthy volunteers on a 3T scanner using a 32-channel head coil using T2 -FLAIR, FIESTA-C, time of flight (TOF), and spoiled gradient echo (SPGR) sequences. In a series of blinded studies, three radiologists independently evaluated CS, PI (GRAPPA), and low-resolution images at up to 5× accelerations. Synthetic T2 -FLAIR images with artificial lesions were used to assess diagnostic accuracy for CS reconstructions. RESULTS: CS reconstructions were of diagnostically acceptable quality at up to 4× acceleration for T2 -FLAIR and FIESTA-C (average qualitative scores 3.7 and 4.3, respectively, on a 5-point scale at 4× acceleration), and at up to 3× acceleration for TOF and SPGR (average scores 4.0 and 3.7, respectively, at 3× acceleration). The qualitative scores for CS reconstructions were significantly better than low-resolution images for T2 -FLAIR, FIESTA-C, and TOF and significantly better than GRAPPA for TOF and SPGR (Wilcoxon signed rank test, P \u3c 0.05) with no significant difference found otherwise. Diagnostic accuracy was acceptable for both CS and low-resolution images at up to 3× acceleration (area under the ROC curve 0.97 and 0.96, respectively.) CONCLUSION: Mild to moderate accelerations are possible for those sequences by a combined CS and PI reconstruction. Nevertheless, for certain sequences/applications one might mildly reduce the acquisition time by appropriately reducing the imaging resolution rather than the more complicated CS reconstruction. J. Magn. Reson. Imaging 2016;44:433-444

Assessment of Exposure to Shiftwork Mechanisms in the General Population: the Development of a New Job-Exposure Matrix

Objective. To develop a job-exposure matrix (JEM) that estimates exposure to eight variables representing different aspects of shiftwork among female workers. Methods. Occupational history and shiftwork exposure data were obtained from a population-based breast cancer case–control study. Exposure to light at night, phase shift, sleep disturbances, poor diet, lack of physical activity, lack of vitamin D, and graveyard and early morning shifts, was calculated by occupational code. Three threshold values based on the frequency of exposure were considered (10%, 30% and 50%) for use as cut-offs in determining exposure for each occupational code. JEM-based exposure classification was compared with that from the OccIDEAS application (job-specific questionnaires and assessment by rules) by assessing the effect on the OR for phase shift and breast cancer. Using data from the Australian Workplace Exposure Study, the specificity and sensitivity of the threshold values were calculated for each exposure variable. Results. 127 of 413 occupational codes involved exposure to one or more shiftwork variables. Occupations with the highest probability of exposure shiftwork included nurses and midwives. Using the 30% threshold, the OR for the association between phase shift exposure and breast cancer was decreased and no longer statistically significant (OR=1.14, 95% CI 0.92 to 1.42). The 30% cut-off point demonstrated best specificity and sensitivity, although results varied between exposure variables. Conclusions This JEM provides a set of indicators reflecting biologically plausible mechanisms for the potential impact of shiftwork on health and may provide an alternative method of exposure assessment in the absence of detailed job history and exposure data

The evolution of a supermassive binary caused by an accretion disc

The interaction of a massive binary and a non-self-gravitating circumbinary accretion disc is considered. The shape of the stationary twisted disc produced by the binary is calculated. It is shown that the inner part of the disc must lie in the binary orbital plane for any value of viscosity. When the inner disc midplane is aligned with the binary orbital plane on the scales of interest and it rotates in the same sense as the binary, the modification of the disc structure and the rate of decay of the binary orbit, assumed circular, due to tidal exchange of angular momentum with the disc, are calculated. It is shown that the modified disc structure is well described by a self-similar solution of the non-linear diffusion equation governing the evolution of the disc surface density. The calculated time scale for decay of the binary orbit is always smaller than the "accretion" time $t_{acc}=m/{\dot M}$ ($m$ is the mass of the secondary component, and $\dot M$ is the disc accretion rate), and is determined by ratio of secondary mass $m$, assumed to be much smaller than the primary mass, the disc mass inside the initial binary orbit, and the form of viscosity in the disc.Comment: to be published in MNRA