Wildfire Alters Spatial Patterns of Available Soil Nitrogen and Understory Environments in a Valley Boreal Larch Forest

Wildfire, a primary natural disturbance in many forests, affects soil nutrient availability and spatial distributions of forest plants. However, post-fire changes in soil nutrients and spatial patterns of understory environments at fine scales are poorly understood. Here, we characterized spatial patterns of soil nitrogen availability and site characteristics at a 3-year-post-fire and an unburned site in a valley boreal larch forest. We also examined the relationship between soil nitrogen availability and site characteristics. The results showed that the burned site had higher NO3− and lower NH4+ than the control. The herb, litter and coarse wood debris cover was greater at the burned site than at the control site with higher soil pH, depth of the organic horizon (DOH) and shrub cover. Relative variability (coefficient of variation) in soil nitrogen and site characteristic variables at the control site was greater than at the burned site except for shrub and regeneration tree seedling cover. Spatial structure (quantified by semi-variograms) was lacking for soil nitrogen and site characteristic variables except for DOH, herb and shrub cover at the control site, but wildfire created a strong spatial structure for all variables. Shorter spatial autocorrelation ranges of soil nitrogen (1.6–3.5 m) and site characteristic variables (2.6–6.0 m) were detected at the burned site, indicating higher heterogeneity. The spatial scale of soil NH4+ was congruent with those of herb, shrub and regeneration tree seedling cover, indicating local coupling, while that of soil NO3− was not. The number of correlations between soil nitrogen and site characteristic variables in the burned site was greater than in the control. These results indicate that fire could not only create higher heterogeneity patches of soil resources, but also strengthen the local coupling between soil resources and understory vegetation, which may impact the establishment and growth of new individual plants

Simultaneous inference on treatment effects in survival studies with factorial designs: Simultaneous Inference on Treatment Effects in Survival Studies with Factorial Designs

A clinical trial with a 2 × 2 factorial design involves randomization of subjects to treatment A or A¯ and, within each group, further randomization to treatment B or B¯. Under this design, one can assess the effects of treatments A and B on a clinical endpoint using all patients. One may additionally compare treatment A, treatment B, or combination therapy AB to A¯B¯. With multiple comparisons, however, it may be desirable to control the overall type I error, especially for regulatory purposes. Because the subjects overlap in the comparisons, the test statistics are generally correlated. By accounting for the correlations, one can achieve higher statistical power compared to the conventional Bonferroni correction. Herein, we derive the correlation between any two (stratified or unstratified) log-rank statistics for a 2 × 2 factorial design with a survival time endpoint, such that the overall type I error for multiple treatment comparisons can be properly controlled. In addition, we allow for adjustment of prognostic factors in the treatment comparisons and conduct simultaneous inference on the effect sizes. We use simulation studies to show that the proposed methods perform well in realistic situations. We then provide an application to a recently completed randomized controlled clinical trial on alcohol dependence. Finally, we discuss extensions of our approach to other factorial designs and multiple endpoints

Optimal design and performance analysis of a hybrid system combing a floating wind platform and wave energy converters

Combined floating offshore wind platform and Wave Energy Converters (WECs) systems have the potential to provide a cost-effective solution to offshore power supply and platform protection. The objective of this paper is to optimize the size and layout of WECs within the hybrid system under a given sea state with a numerical study. The numerical model was developed based on potential flow theory with viscous correction in frequency domain to investigate the hydrodynamic performance of a hybrid system consisting of a floating platform and multiple heaving WECs. A non-dimensional method was presented to determine a series of variables, including radius, draft, and layout of the cylindrical WEC at a typical wave frequency as the initial design. WECs with larger diameter to draft ratio were found to experience relatively smaller viscous effects, and achieve more wave power, larger effective frequency range and similar wave power per unit weight compared with those with the smaller diameter to draft ratio in the same sea state. The addition of WECs reduced the maximum horizontal force and pitch moment on the platform, whereas the maximum vertical force increased due to the increasing power take-off force, especially at low frequencies. The results presented in this paper provide guidance for the optimized design of WECs and indicate the potential for synergies between wave and wind energy utilization on floating platforms

Chemical Constituents and Digestion-Promoting Effect of Maojian Green Tea

In this study, the digestion-promoting function of an aqueous extract from Maojian green tea extract (MJ-GTE) was evaluated by small intestinal motility in mice as well as body mass, body mass gain, food intake, food utilization rate, gastric pepsin activity, and gastric pepsin excretion in rats. The chemical composition of MJ-GTE was then systematically analyzed using metabolomics based on ultra-high performance liquid chromatography-quadrupole electrostatic orbitrap mass spectrometry (UPLC-Q-Exactive/MS). The results of animal experiments showed that the intestinal propulsion ratio of ink in the high-dose MJ-GTE group (0.83 g/(kg·d)) was significantly increased compared with the model group (P < 0.05), and gastric pepsin excretion in the medium-dose MJ-GTE group (0.21 g/(kg·d)) was significantly increased compared with the negative control group (deionized water) (P < 0.05), which collectively indicated that MJ-GTE has a digestion-promoting effect. The metabolomics analysis identified 98 compounds, among which, flavones (apigenin and luteolin, 0.14–0.77 mg/g), flavanones (naringenin and eriodictyol, 0.49–1.49 mg/g), flavone-7-O-glycosides (0.57–9.07 mg/g), and flavanone-7-O-glycosides (4.49–38.98 mg/g) were the major components in MJ-GTE. This study will provide a theoretical basis for the promotion and development of Maojian green tea and related products in the future

Xiaoqinglong granules as add-on therapy for asthma: latent class analysis of symptom predictors of response.

Xiaoqinglong granules (XQLG) has been shown to be an effective therapy in asthma animal models. We reviewed the literature and conducted this study to assess the impact of XQLG as an add-on therapy to treatment with fluticasone/salmeterol (seretide) in adult patients with mild-to-moderate, persistent asthma. A total of 178 patients were randomly assigned to receive XQLG and seretide or seretide plus placebo for 90 days. Asthma control was assessed by asthma control test (ACT), symptoms scores, FEV(1), and PEF. Baseline patient-reported Chinese medicine (CM)-specific symptoms were analyzed to determine whether the symptoms may be possible indicators of treatment response by conducting latent class analysis (LCA). There was no statistically significant difference in ACT score between two groups. In the subset of 70 patients with symptoms defined by CM criteria, XQLG add-on therapy was found to significantly increase the levels of asthma control according to global initiative for asthma (GINA) guidelines (P = 0.0329). There was no significant difference in another subset of 100 patients with relatively low levels of the above-mentioned symptoms (P = 0.1291). Results of LCA suggest that patients with the six typical symptoms defined in CM may benefit from XQLG

Rnd3/RhoE Modulates HIF1α/VEGF Signaling by Stabilizing HIF1α and Regulates Responsive Cardiac Angiogenesis

The insufficiency of compensatory angiogenesis in the heart of patients with hypertension contributes to heart failure transition. The hypoxia-inducible factor 1α-vascular endothelial growth factor (HIF1α-VEGF) signaling cascade controls responsive angiogenesis. One of the challenges in reprograming the insufficient angiogenesis is to achieve a sustainable tissue exposure to the proangiogenic factors, such as HIF1α stabilization. In this study, we identified Rnd3, a small Rho GTPase, as a proangiogenic factor participating in the regulation of the HIF1α-VEGF signaling cascade. Rnd3 physically interacted with and stabilized HIF1α, and consequently promoted VEGFA expression and endothelial cell tube formation. To demonstrate this proangiogenic role of Rnd3 in vivo, we generated Rnd3 knockout mice. Rnd3 haploinsufficient (Rnd3(+/-)) mice were viable, yet developed dilated cardiomyopathy with heart failure after transverse aortic constriction stress. The poststress Rnd3(+/-) hearts showed significantly impaired angiogenesis and decreased HIF1α and VEGFA expression. The angiogenesis defect and heart failure phenotype were partially rescued by cobalt chloride treatment, a HIF1α stabilizer, confirming a critical role of Rnd3 in stress-responsive angiogenesis. Furthermore, we generated Rnd3 transgenic mice and demonstrated that Rnd3 overexpression in heart had a cardioprotective effect through reserved cardiac function and preserved responsive angiogenesis after pressure overload. Finally, we assessed the expression levels of Rnd3 in the human heart and detected significant downregulation of Rnd3 in patients with end-stage heart failure. We concluded that Rnd3 acted as a novel proangiogenic factor involved in cardiac responsive angiogenesis through HIF1α-VEGFA signaling promotion. Rnd3 downregulation observed in patients with heart failure may explain the insufficient compensatory angiogenesis involved in the transition to heart failure

Soft-templated synthesis of mesoporous nickel oxide using poly(styrene-block-acrylic acid-block-ethylene glycol) block copolymers

In this work, we report the soft-templated preparation of mesoporous nickel oxide using an asymmetric poly(styrene-block-acrylic acid-block-ethylene glycol) (PS-b-PAA-b-PEG) triblock copolymer. This block copolymer forms a micelle consisting of a PS core, a PAA shell and a PEG corona in aqueous solutions, which can serve as a soft template. Specifically, the PS block forms the core of the micelles on the basis of its lower solubility in water. The anionic PAA block interacts with the cationic Ni ions present in the solution to generate the shell. The PEG block forms the corona of the micelles and stabilizes the micelles by preventing secondary aggregation through steric repulsion between the PEG chains. In terms of textural characteristics, the as-synthesized mesoporous NiO exhibits a large average pore size of 35 nm with large specific surface area and pore volume of 97.0 m g and 0.411 cm g, respectively. It is expected that the proposed soft-templated strategy can be expanded to other metal oxides/sulfides in the future for potential applications in gas sensors, catalysis, energy storage and conversion, optoelectronics, and biomedical applications

Jute-derived microporous/mesoporous carbon with ultra-high surface area using a chemical activation process

Here, we report the synthesis of nanoporous carbons (NCs) derived from a low-cost and renewable biomass, jute, by a chemical activation process using KOH. Jute is one of the least expensive and most abundant crops, with a staggering 2.8 million metric tons of jute produced each year. In this study, we synthesize NCs from three different parts of jute fibers through a chemical activation technique using KOH. The NCs prepared from the bottom portion of the fiber show a high surface area (2682 m g) with the presence of both micropores and mesopores. The ultra-high surface area of jute makes it an economically viable, environmentally friendly precursor for NCs, with a wide variety of applications from energy storage to environmental and biomedical applications

Rational design of TiO2 architectures as photoanodes for efficient dye-sensitized solar cells

Solar energy is the largest source of carbon-free energy that can be converted into heat and electricity. Since the early 1990s, dye-sensitized solar cells (DSCs) have received a great deal of attention as a promising alternative photovoltaic technology on account of their projected low costs and reduced energy input in manufacture. Considerable efforts have been made to improve the energy conversion efficiency, by developing or modifying DSC components, such as sensitizers, photoanodes, electrolytes, and counter electrodes. However, a number of challenging issues remain, such as new optimised structures are required as DSCs evolve. The aims of this thesis are to design, develop and investigate new semiconductor TiO2 architectures for use as photoanodes in different types of DSC (such as flexible DSCs, cobalt-based DSCs, rutile TiO2-based DSCs) applications. Among the novel materials developed as part of this thesis, a new type of highly connected hierarchical textured TiO2 spheres (HCHT) was rationally designed for DSCs. An overall energy conversion efficiency of up to 9.0 % can be achieved by using these HCHT as the photoelectrode with N719 dye, a considerable improvement over state-of-the-art commercial available TiO2 particles (Dyesol TiO2 paste) (8.2 %) under the same conditions. A new photoanode architecture for cold isostatic pressing (CIP), with a new mesoporous hierarchical anatase TiO2 (MHAT) architecture deposited onto P25, was rationally designed for efficient charge transport and better light management in flexible dye-sensitized solar cells, with a 5.6 % conversion efficiency realized. Mesoporous anatase single crystals (MASCs) with special polyhedral pores (~ 7 nm) is employed to construct MK-2–sensitized solar cells using a cobalt redox shuttle, with a maximum efficiency of 8.7 % achieved, which is significantly higher than for analogous devices based on commercial Dyesol TiO2 (6.3 %). A DSC combining a well-defined 3D hierarchical rutile TiO2 architecture (HRT) is reported in conjunction with a high-extinction-coefficient metal-free organic sensitizer (D149), achieving a conversion efficiency of 5.5 %, which is superior to ones employing P25 (4.5 %), comparable to state-of-the-art commercial transparent titania anatase paste (5.8 %). Further to this, an overall conversion efficiency 8.6 % was achieved when HRT was used as the light scattering layer, a considerable improvement over the commercial transparent/reflector titania anatase paste (7.6 %), a significantly smaller gap in performance than has been seen previously. In addition, two dyes, N719 and D149, were used as sensitizers of the modified HRT-based DSCs, with maximum η of 5.6 % and 5.8 % achieved, respectively

A radial basis function based ghost cell method with improved mass conservation for complex moving boundary flows

A sharp interface immersed boundary method is presented for simulating flows around moving boundaries with arbitrary complex geometries. A time semi-implicit finite difference method is used to solve the incompressible Navier–Stokes equations on a fixed, staggered Cartesian grid. The boundary conditions at the immersed interface are enforced by a ghost cell method. Tracking complex moving boundaries and suppressing pressure oscillations are two major challenges in the sharp interface method. In this work, a polynomial radial basis function (PRBF) is introduced to the ghost cell method to implicitly represent and reconstruct the arbitrary immersed boundaries. In addition, a simple and robust signed identification strategy is used to determine the phase state of the grid cells. To suppress violent pressure oscillations on the moving boundaries, a fractional area representation (FAR) method, together with a mass force term, is introduced to the pressure Poisson equation. This FAR method not only retains the desirable property of consistent discretization in the ghost cell method but also takes advantage of the mass conservation property of the cut cell method. The proposed method is validated using five test cases, including the flow around a hydrofoil, in-line oscillation of a cylinder in a static fluid, uniform flows around a transversely oscillating cylinder, twin oscillating cylinders, and a pitching hydrofoil. The present results are in good agreement with the reference results, which validates the accuracy and capability of the proposed method.</p