Calcified Carcinoma of the Gallbladder with Calcified Nodal Metastasis Presenting as a Porcelain Gallbladder: A Case Report

Porcelain gallbladder is regarded as a risk factor of gallbladder cancer. A porcelain gallbladder with calcified regional lymph nodes was found using computed tomography (CT) and magnetic resonance imaging (MRI) in a 43-year-old man who presented with nausea, vomiting, and abdominal pain. His cholecystectomy specimen showed diffuse wall thickening and contained small gallstones. Histological examination revealed diffuse infiltrative adenocarcinoma with extensive intratumoral calcification (calcified carcinoma). The majority of the calcified material was located within or replaced the tumor glands, and was not found in the stroma. A lymph node was totally replaced with a calcified metastatic adenocarcinoma. To the best of our knowledge, only one case of calcified lymph node metastasis from a calcified carcinoma of the gallbladder has been previously reported in the literature. We herein add a case of calcified carcinoma of the gallbladder with calcified lymph node metastasis, presenting as a porcelain gallbladder on CT and MRI

<i>Neisseria</i> species as pathobionts in bronchiectasis

Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group.Published versio

Regionalisation of food & beverage industry to Southeast Asia

114 p.This study discusses the reasons for Singapore food and beverage companies expanding overseas, commonly faced obstacles, factors that contribute to success, key sources in financing the expansion and the extent of government aid used by the companies.ACCOUNTANC

Cyberbullying Detection Based on Emotion

Due to the detrimental consequences caused by cyberbullying, a great deal of research has been undertaken to propose effective techniques to resolve this reoccurring problem. The research presented in this paper is motivated by the fact that negative emotions can be caused by cyberbullying. This paper proposes cyberbullying detection models that are trained based on contextual, emotions and sentiment features. An Emotion Detection Model (EDM) was constructed using Twitter datasets that have been improved in terms of its annotations. Emotions and sentiment were extracted from cyberbullying datasets using EDM and lexicons based. Two cyberbullying datasets from Wikipedia and Twitter respectively were further improved by comprehensive annotation of emotion and sentiment features. The results show that anger, fear and guilt were the major emotions associated with cyberbullying. Subsequently, the extracted emotions were used as features in addition to contextual and sentiment features to train models for cyberbullying detection. The results demonstrate that using emotion features and sentiment has improved the performance of detecting cyberbullying by 0.5 to 0.6 recall. The proposed models also outperformed the state-of-the-art models by a 0.7 f1-score. The main contribution of this work is two-fold, which includes a comprehensive emotion-annotated dataset for cyberbullying detection, and an empirical proof of emotions as effective features for cyberbullying detection

Antiviral activity of seaweed extracts against feline calicivirus

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Additional file 1: of Patient with multiple acyl-CoA dehydrogenase deficiency disease and ETFDH mutations benefits from riboflavin therapy: a case report

Table S1. Primers sequences used to amplify and sequence candidate genes. Table S2. Number of candidate variants filtered against dbSNP and 1000 Genome public databases. (DOCX 45 kb

Enhanced thermoelectric cooling properties of Bi2Te3−xSex alloys fabricated by combining casting, milling and spark plasma sintering

Bi2Te3−xSex alloys are extensively used for thermoelectric cooling around room temperature, but, previous studies have reported peak thermoelectric efficiency of the material at higher temperature around 450 K. This study presents the casting followed by high energy ball milling and spark plasma sintering as a thriving methodology to produce efficient and well-built Bi2Te3−xSex material for the thermoelectric cooling around room temperature. In addition, changes in electrical and thermal transport properties brought up by amount of Se in the Bi2Te3−xSex material for this methodology are measured and discussed. Although Seebeck coefficient and electrical conductivity showed irregular trend, power factor, thermal conductivity and figure of merit ZT gradually decreased with the increase in amount of Se. A maximum ZT value of 0.875 at 323 K was obtained for x = 0.15 sample owing to its higher power factor. This value is 17% and 38% greater than for x = 0.3 and x = 0.6 samples respectively. At 323 K, herein reported ZT value of 0.875 is higher than the state of art n-type Bi2Te3 based thermoelectric materials produced by the time consuming and expensive methodologies