A Young Researcher’s Guide to Creating an Online Presence

Academic and social networks can help define your online presence, increase your academic visibility, as well as draw attention to your research. Creating a cohesive presence across platforms allows the public and fellow scholars better understand your digital identity and facilitates access to your research outputs and ideas. Find out how to make use of online sites and networks like LinkedIn, Twitter, WeChat and ResearchGate to improve your online visibility, create great first impressions and highlight the information about your research that you want others to see

Modeling the dynamics of bivalent histone modifications

Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that bivalent domains play an important role in stem cell differentiation, but the underlying mechanisms remain unclear. Here we formulate a mathematical model to investigate the dynamic properties of histone modification patterns. We then illustrate that our modeling framework can be used to capture key features of experimentally observed combinatorial chromatin states.Comment: 23 pages, 10 figure

Complete response of skull base inverted papilloma to chemotherapy: Case report.

BackgroundInverted papilloma (IP) is the most common benign sinonasal neoplasm. Endoscopic techniques, improved understanding of pathophysiology, and novel surgical approaches have allowed rhinologists to treat IPs more effectively, with surgery being the mainstay of therapy. Frontal sinus IP poses a challenge for surgical therapy due to complex anatomy and potentially difficult surgical access.ObjectivesWe reported a unique case of a massive frontal sinus IP that presented with intracranial and orbital extension, with near resolution after chemotherapy.MethodsA retrospective case review of a patient with a frontal sinus IP treated at a tertiary academic medical center.ResultsA 75-year-old male patient presented with nasal obstruction, purulent nasal discharge, and a growing left supraorbital mass. Endoscopy demonstrated a mass that filled both frontal and ethmoid sinuses, with orbital invasion. There also was substantial erosion of the posterior table, which measured 1.73 × 1.40 cm. A biopsy specimen demonstrated IP with carcinoma in situ. The patient was deemed unresectable on initial evaluation and, subsequently, underwent chemotherapy (carboplatin and paclitaxel). The tumor had a dramatic response to chemotherapy, and the patient elected for definitive surgery to remove any residual disease. During surgery, only a small focus of IP was found along the superior wall of the frontal sinus. No tumor was found elsewhere, including at the site of skull base erosion. The final pathology was IP without carcinoma in situ or dysplasia.ConclusionThis was the first reported case of chemotherapeutic "debulking" of IP, which facilitated surgical resection, despite substantial intracranial and orbital involvement. Although nearly all IPs can be treated surgically, rare cases, such as unresectable tumors, may benefit from systemic chemotherapy

Are More Frequent Releases Always Better? Dynamics of Pivoting, Scaling, and the Minimum Viable Product

Using the system dynamics methodology, we model the minimum viable product (MVP) approach to product development and examine the impact of release frequency, planning practices and committed reengineering capacity on software development outcomes. We leverage the organizational learning, Lean Startup, and Agile methodology literature to form the underpinnings of the model and measure outcomes using cumulative market cost of failing to meet market wants and cumulative engineering cost. While shorter release cycles are better in general for achieving market fit, the relationship is moderated by planning delays and committed reengineering capacity. We show that reducing the extent of pivot in each iteration may be better for firms. Firms instead should iterate moderately and not radically during any particular release. Counter intuitively, planning delays are beneficial by reducing overreaction to spurious market signals. Finally, we discuss implications of our findings for future research on learning and planning amongst entrepreneurial firms

Three Non-U.S. Perspectives on the COVID-19 Experience in Libraries

This was an interactive panel presented at the Critical Pedagogy Symposium. Our presenters’ theme was their atypical work experiences across different cities. Jennifer shared her perspective as a privileged economic migrant (White American woman in Shanghai). Colleges and graduate schools have been online–successfully–for over a decade. Our students are not alone. This is the new normal and it is cool. Sarah shared her perspective both as a library student doing her fieldwork on a controversial topic during the lockdown in Singapore, as well as a library staff managing on-site student workers who live on campus while she worked from home. Edward shared his perspective as a parent working entirely from home, and with a twist: connecting with colleagues in an entirely different timezone while prevented from entering the U.S. due to a President’s executive order. These presenters then facilitated several breakout rooms. Their pedagogical goal was to show what a good, interactive session can be

Discovering states and transformations in image collections

Objects in visual scenes come in a rich variety of transformed states. A few classes of transformation have been heavily studied in computer vision: mostly simple, parametric changes in color and geometry. However, transformations in the physical world occur in many more flavors, and they come with semantic meaning: e.g., bending, folding, aging, etc. The transformations an object can undergo tell us about its physical and functional properties. In this paper, we introduce a dataset of objects, scenes, and materials, each of which is found in a variety of transformed states. Given a novel collection of images, we show how to explain the collection in terms of the states and transformations it depicts. Our system works by generalizing across object classes: states and transformations learned on one set of objects are used to interpret the image collection for an entirely new object class

A Dynamic Model of Platform Versioning and Its Impact on Third-Party Developers

Using the system dynamics methodology, we leverage extant research on digital platforms and Agile development from the information systems and strategic management literatures to create a dynamic framework for considering the effect of digital platform versioning under different levels of market dynamism. We find that the impact of platform versioning release cycle time (RCT) and the scope of platform updates on platform outcomes (number of packages available and number of downloads) depends on market dynamism, sensitivity of users’ utility to app breakage, and value of the platform’s core functionality to the developers. Among other results, we show that smaller, incremental updates of functionality are generally preferable to larger, radical updates, even in dynamic markets. In contrast, longer RCTs are preferred in less dynamic markets, while small to moderate RCTs are preferred in more dynamic markets. We conclude with an agenda for future research