Physiological Resolution of Periodic Breath Holding During Heavy Intensity Fartlek Exercise

The purpose was to compare the physiological responses to periodic 5 s breath holds (CBH), increased power output (FLK), and both (FBH) every 30 s followed by 25 s of continuous heavy intensity cycling exercise with free-breathing (CON). Minute ventilation (V̇ E) was greater (p \u3c 0.05) in CBH (97.58 + 16 L·min-1) and FBH (100.9 + 19 L·min-1), pulmonary oxygen uptake (V̇ O2p) was similar in CBH (2.73 + 0.14 L·min-1) and FBH (2.73 + 0.14 L·min-1) and greater in FLK (2.85 + 0.12 L·min-1), compared to CON (2.71 + 0.12 L·min-1). FBH also resulted in slower V̇ O2p kinetics (62.2 + 19 s) and greater blood lactate concentrations (11.5 + 2.7 mM), compared to CON (48.8 + 12 s; 9.0 + 2.3 mM). Together, we demonstrated that breath hold-induced hypoxemia and hypercapnia were resolved when not combined with additional work

Formation of Relativistic Axion Stars

Axions and axion-like particles are compelling candidates for the missing dark matter of the universe. As they undergo gravitational collapse, they can form compact objects such as axion stars or even black holes. In this paper, we study the formation and distribution of such objects. First, we simulate the formation of compact axion stars using numerical relativity with aspherical initial conditions that could represent the final stages of axion dark matter structure formation. We show that the final states of such collapse closely follow the known relationship of initial mass and axion decay constant $f_a$. Second, we demonstrate with a toy model how this information can be used to scan a model density field to predict the number densities and masses of such compact objects. In addition to being detectable by the LIGO/VIRGO gravitational wave interferometer network for axion mass of $10^{-9} < m_a < 10^{-11}$ eV, we show using peak statistics that for $f_a < 0.2M_{pl}$, there exists a "mass gap" between the masses of axion stars and black holes formed from collapse

Complete genome sequence of Torque teno indri virus 1, a novel anellovirus in blood from a free-living lemur

ABSTRACT We identified Torque teno indri virus 1 (TTIV1), the first anellovirus in a free-living lemur ( Indri indri ). The complete circular 2,572-nucleotide (nt) TTIV1 genome is distantly related to torque teno sus virus. Phylogenetic and sequence analyses support TTIV1 as a putative member of a new genus within the Anelloviridae family. </jats:p

Power conversion architecture for grid interface at high switching frequency

This paper presents a new power conversion architecture for single-phase grid interface. The proposed architecture is suitable for realizing miniaturized ac-dc converters operating at high frequencies (HF, above 3 MHz) and high power factor, without the need for electrolytic capacitors. It comprises of a line-frequency rectifier, a stack of capacitors, a set of regulating converters, and a power combining converter (or set of power combining converters). The regulating converters have inputs connected to capacitors on the capacitor stack, and provide regulated outputs while also achieving high power factor, with twice-line-frequency energy buffered on the capacitor stack. The power combining converter combines power from the individual regulated outputs to a single output, and may also provide isolation. While this architecture can be utilized with a variety of circuit topologies, it is especially suited for systems operating at HF (above 3 MHz), and we introduce circuit implementations that enable efficient operation in this range. The proposed approach is demonstrated for an LED driver operating from 120 V[subscript ac], and supplying a 35 V, 30 W output. The prototype converter operates at a (variable) switching frequency of 5-10 MHz and an efficiency of > 93%. The converter achieves a displacement power density of 130 W/in[superscript 3], while providing a 0.89 power factor, without the use of electrolytic capacitors

Advanced nickel-cadmium batteries for geosynchronous spacecraft

A nickel cadmium battery was developed that can be operated at 80 percent depth of discharge in excess of 10 years in a geosynchronous orbit application, and has about a 30 percent weight savings per spacecraft over present nickel cadmium batteries when used with a 1000 watts eclipse load. The approach used in the development was to replace nylon separators with inert polymer impregnated zirconia, use electrochemically deposited plates in place of conventional chemically precipitated ones, and use an additive to extend negative plate lifetime. The design has undergone extensive testing using both engineering and protoflight cell configurations

Cotunneling drag effect in Coulomb-coupled quantum dots

In Coulomb drag, a current flowing in one conductor can induce a voltage across an adjacent conductor via the Coulomb interaction. The mechanisms yielding drag effects are not always understood, even though drag effects are sufficiently general to be seen in many low-dimensional systems. In this Letter, we observe Coulomb drag in a Coulomb-coupled double quantum dot (CC-DQD) and, through both experimental and theoretical arguments, identify cotunneling as essential to obtaining a correct qualitative understanding of the drag behavior.Comment: Main text: 5 pages, 5 figures; SM: 11 pages, 5 figures, 1 tabl

Two-Stage Power Conversion Architecture Suitable for Wide Range Input Voltage

This paper presents a merged-two-stage circuit topology suitable for either wide-range dc input voltage or ac line voltage at low-to-moderate power levels (e.g., up to 30 W). This two-stage topology is based on a soft-charged switched-capacitor preregulator/transformation stage and a high-frequency magnetic regulator stage. Soft charging of the switched capacitor circuit, zero voltage switching of the high-frequency regulator circuit, and time-based indirect current control are used to maintain high efficiency, high power density, and high power factor. The proposed architecture is applied to an LED driver circuit, and two implementations are demonstrated: a wide input voltage range dc-dc converter and a line interfaced ac-dc converter. The dc-dc converter shows 88%-96% efficiency at 30-W power across 25-200-V input voltage range, and the ac-dc converter achieves 88% efficiency with 0.93 power factor at 8.4-W average power. Contributions of this paper include: 1) demonstrating the value of a merged two-stage architecture to provide substantial design benefits in high-input voltage, low-power step down conversion applications, including both wide-range-input dc-dc and line-input ac-dc systems; 2) introduction of a multimode soft-charged SC stage for the merged architecture that enables compression of an 8:1 input voltage range into a 2:1 intermediate range, along with its implementation, loss considerations, and driving methods; and 3) merging of this topology with an resonant transition discontinuous-mode inverted buck stage and pseudocurrent control to enable step-down power conversion (e.g., for LED lighting) operating at greatly increased frequencies and reduced magnetics size than with more conventional approaches

NOD2/RICK-dependent β-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection.

Middle ear infection, otitis media (OM), is clinically important due to the high incidence in children and its impact on the development of language and motor coordination. Previously, we have demonstrated that the human middle ear epithelial cells up-regulate β-defensin 2, a model innate immune molecule, in response to nontypeable Haemophilus influenzae (NTHi), the most common OM pathogen, via TLR2 signaling. NTHi does internalize into the epithelial cells, but its intracellular trafficking and host responses to the internalized NTHi are poorly understood. Here we aimed to determine a role of cytoplasmic pathogen recognition receptors in NTHi-induced β-defensin 2 regulation and NTHi clearance from the middle ear. Notably, we observed that the internalized NTHi is able to exist freely in the cytoplasm of the human epithelial cells after rupturing the surrounding membrane. The human middle ear epithelial cells inhibited NTHi-induced β-defensin 2 production by NOD2 silencing but augmented it by NOD2 over-expression. NTHi-induced β-defensin 2 up-regulation was attenuated by cytochalasin D, an inhibitor of actin polymerization and was enhanced by α-hemolysin, a pore-forming toxin. NOD2 silencing was found to block α-hemolysin-mediated enhancement of NTHi-induced β-defensin 2 up-regulation. NOD2 deficiency appeared to reduce inflammatory reactions in response to intratympanic inoculation of NTHi and inhibit NTHi clearance from the middle ear. Taken together, our findings suggest that a cytoplasmic release of internalized NTHi is involved in the pathogenesis of NTHi infections, and NOD2-mediated β-defensin 2 regulation contributes to the protection against NTHi-induced otitis media

Two-stage power conversion architecture for an LED driver circuit

This paper presents a merged-two-stage circuit topology suitable for efficient LED drivers operating from either wide-range dc input voltage or ac line voltage. This two-stage topology is based on a soft-charged switched-capacitor pre-regulator/transformation stage and a high-frequency magnetic regulator stage. Soft charging of the switched capacitor circuit, zero voltage switching of the high-frequency regulator circuit, and time-based indirect scale current control are used to maintain high efficiency, high power density, and high power factor. Two implementations of the proposed architecture are demonstrated: a wide input voltage range dc-dc converter and a line interfaced ac-dc converter. The dc-dc converter shows 85–95% efficiency at 20 W power across 25–200 V input voltage range, and the ac-dc converter achieves 88% efficiency with 0.93 power factor at 8.4 W average power