25 research outputs found
Toxicological Profile of Ultrapure 2,2 ',3,4,4 ',5,5 '-Heptachlorbiphenyl (PCB 180) in Adult Rats
Peer reviewe
The importance of gender of patients and general practitioners in relation to treatment practices for overweight.
BACKGROUND: Several studies suggest that men and women are treated differently for similar disease including diabetes and cardiovascular disease. Differences in attitudes and treatment practices towards men and women with obesity are not well recognized. OBJECTIVE: To investigate the attitudes and treatment practices among Danish general practitioners (GPs), in relation to treatment of overweight, while taking gender of both the patients and practitioners into account. DESIGN: Questionnaire inventory covertly examining attitudes and practices among Danish general practitioners towards treatment of overweight. All 3.637 general practitioners from the Danish Medical Association register were invited to participate in the survey. In total 1.136 participated. RESULTS: The GPs found weight loss to be more important for overweight male than overweight female patients. They also treated complications to overweight more rigorously among male than female patients, and recommended lipid lowering medicine more often to male than female overweight patients. In addition, the younger female GPs and older male GPs more often said that they would treat an overweight patient with lipid lowering medicine. CONCLUSION: Among general practitioners in Denmark, treatment for weight loss is more often practiced for overweight male than overweight female patients presenting with same symptoms. In addition, hyperlipidemia among overweight males is also more often treated with lipid lowering medicine than hyperlipidemia among overweight females
Distribution of GPs gender, age, practice type, region and size of practice by patients gender.
<p>The total number GPs may not be 1136 in all categories because of missing data.</p
Case report: Odds and CI’s for GPs advising weight loss to overweight patients.
<p>Note: Reference category: Male patients, Male GP’s. Values shown: Odds Ratio, CI and P-value.</p
Case report: Fraction of overweight female and male patients for whom it was thought to be important/not important to use lipid lowering medicine by age and gender of GPs.
<p>Case report: Fraction of overweight female and male patients for whom it was thought to be important/not important to use lipid lowering medicine by age and gender of GPs.</p
Case report: Fraction of overweight female and male patients for whom weight loss was thought to be important/not important by age and gender of GPs.
<p>Case report: Fraction of overweight female and male patients for whom weight loss was thought to be important/not important by age and gender of GPs.</p
Case report: Odds and CI’s for GP’s advising weight loss or treatment with lipid lowering medicine to overweight patients.
<p>Note: Reference category: Male patients, Male GP’s. Values shown: Odds Ratio, CI and P-value.</p
Case report: Distribution of GP’s finding a specific treatment important/not important for male and female patients.
<p>Case report: Distribution of GP’s finding a specific treatment important/not important for male and female patients.</p
Case report: Odds and CI’s for GPs advising treatment with lipid lowering medicine to overweight patients.
<p>Note: Reference category: Male patients, Male GP’s. Values shown: Odds Ratio, CI and P-value.</p
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An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.
Variants in the gene myosin-binding protein C3 (MYBPC3) account for approximately 50% of familial hypertrophic cardiomyopathy (HCM), leading to reduced levels of myosin-binding protein C3 (MyBP-C), the protein product made by gene MYBPC3. Elucidation of the pathways that regulate MyBP-C protein homeostasis could uncover new therapeutic strategies. Toward this goal, we screened a library of 2,426 bioactive compounds and identified JG98, an allosteric modulator of heat shock protein 70 that inhibits interaction with Bcl-2-associated athanogene (BAG) domain co-chaperones. JG98 reduces MyBP-C protein levels. Furthermore, genetic reduction of BAG3 phenocopies treatment with JG-98 by reducing MYBP-C protein levels.. Thus, an unbiased compound screen identified the heat shock protein 70-BAG3 complex as a regulator of MyBP-C stability