NÃO-LUGAR LITERÁRIO: O ESPAÇO PROVISÓRIO DA LITERATURA NA BNCC

Com o objetivo de identificar o tratamento dedicado à literatura na Base Nacional Comum Curricular (BNCC), este estudo propõe um debate sobre o espaço limitado que o documento reserva para a área. Para tanto, guiamo-nos pelo conceito de “não-lugar” que, em Augé (2005), corresponde a um ambiente em que prevalecem o utilitarismo e a transitoriedade, ou seja, um espaço, ao mesmo tempo, lotado e vazio, que como estrutura física realmente existe, mas sem construção identitária, nem valor relacional e histórico, portanto, banal. Circunscrevendo a literatura ao “não-lugar literário”, ao fazer recomendações vazias, antagônicas, inconsistentes e, por vezes, impraticáveis ​​ao campo artístico-literário, a BNCC atua tanto no sentido de esgotar o acesso à literatura no contexto educacional – já que colabora para o apagamento desta arte neste espaço –, mas também contribui para, veladamente, direcioná-la para o caminho da utilidade mercadológica e de outros ideais neoliberais, cujo principal efeito é a anulação dos poderes desta arte plural. Imbuída de perspectivas intrincadas e esvaziada de sentidos em um texto insignificante, na nova BNCC a literatura não apenas não consegue alcançar o status de arte, mas também é (in)oportunamente fragilizada, levada ao esquecimento e/ou mesmo a um propósito muito distante do isto.Con el objetivo de identificar el tratamiento dedicado a la literatura en la Base Curricular Común Nacional (BNCC, en Portugués), este estudio propone un debate sobre el espacio limitado que el documento reserva para el área. Para ello nos guiamos por el concepto de “no lugar” que, en Augé (2005), corresponde a un entorno en el que prevalecen el utilitarismo y la fugacidad, es decir, un espacio, al mismo tiempo, poblado y vacío, que como estructura física existe realmente, pero sin construcción identitaria, ni valor relacional e histórico, por tanto, banal. Circunscribiendo la literatura al “no lugar literario”, haciendo recomendaciones vacías, antagónicas, inconsistentes y, a veces, poco prácticas al campo artístico-literario, el BNCC actúa tanto para agotar el acceso a la literatura en el contexto educativo – ya que colabora durante la borradura de este arte en este espacio–, pero también contribuye a, encubiertamente, encaminarlo hacia el camino del marketing utilitario y otros ideales neoliberales, cuyo principal efecto es la anulación de los poderes de este arte plural. Imbuida de perspectivas intrincadas y vaciada de significados en un texto insignificante, en el nuevo BNCC, la literatura no sólo no logra alcanzar el estatus de arte sino que también es (in)oportunamente debilitada, conducida al olvido y/o incluso a un propósito muy alejado del él.Com o mote de identificar o tratamento dedicado à literatura na Base Nacional Comum Curricular - Ensino Médio, o presente estudo propõe um debate sobre o espaço minguado que o documento reserva à área. Para tanto, nos norteamos pelo conceito de “não-lugar” que, em Augé (2005), corresponde a um ambiente no qual imperam o utilitarismo e a transitoriedade, isto é, um espaço, ao mesmo tempo, lotado e vazio, que enquanto estrutura física existe de fato, mas sem construção identitária, nem valor relacional e histórico, por isso, banal. Circunscrevendo a literatura ao “não-lugar literário”, ao fazer recomendações vazias, antagônicas, inconsistentes e, às vezes, impraticáveis ​​ao campo artístico-literário, a BNCC opera tanto no sentido de esgotar o acesso à literatura em âmbito educacional – já que colabora para o apagamento dessa arte nesse espaço –, como também contribui para, disfarçadamente, direcionar-la ao caminho da utilidade mercadológica e de outros ideais neoliberais, cujo efeito principal é a anulação das potências dessa arte plural. Imbuída de perspectivas intrincadas e vazias de sentidos em um texto insignificante, na nova BNCC, a literatura não somente não logra o relevo de arte como também é (in)oportunamente enfraquecida, impulsionada ao esquecimento e/ou até mesmo a um propósito afastado dela

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil

Soroprevalence for Hepatitis C virus is reported as 2.12% in Northern Brazil, with about 50% of the patients exhibiting a sustained virological response (SVR). Aiming to associate polymorphisms in Killer Cell Immunoglobulin-like Receptors (KIR) with chronic hepatitis C and therapy responses we investigated 125 chronic patients and 345 controls. Additionally, 48 ancestry markers were genotyped to control for population stratification. The frequency of the KIR2DL2 and KIR2DL2+HLA-C Asp80 gene and ligand was higher in chronic infected patients than in controls (p < 0.0009, OR = 3.4; p = 0.001, OR = 3.45). In fact, KIR2DL3 is a weaker inhibitor of NK activity than KIR2DL2, which could explain the association of KIR2DL2 with chronic infection. Moreover, KIR2DS2 and KIR2DS2+HLA-C Asp80 (p < 0.0001, OR = 2.51; p = 0.0084, OR = 2.62) and KIR2DS3 (p < 0.0001; OR = 2.57) were associated with chronic infection, independently from KIR2DL2. No differences in ancestry composition were observed between control and patients, even with respect to therapy response groups. The allelic profile KIR2DL2/KIR2DS2/KIR2DS3 was associated with the chronic hepatitis C (p < 0.0001; OR = 3). Furthermore, the patients also showed a higher mean number of activating genes and a lower frequency of the homozygous AA profile, which is likely secondary to the association with non-AA and/or activating genes. In addition, the KIR2DS5 allele was associated with SVR (p = 0.0261; OR = 0.184).The ancestry analysis of samples ruled out any effects of population substructuring and did not evidence interethnic differences in therapy response, as suggested in previous studies

Table_1_Retrospective cohort study to evaluate the continuous use of anticholesterolemics and diuretics in patients with COVID-19.DOCX

PurposeThe purpose of this study is to evaluate the interference of the continuous use of drug classes in the expression of biomarkers during the first week of hospitalization and in the prognosis of patients with COVID-19.MethodsThe patients diagnosed with COVID-19 and confirmed with SARS-CoV-2 by RT-qPCR assay underwent the collection of fasting whole blood samples for further analysis. Other data also extracted for this study included age, sex, clinical symptoms, related comorbidities, smoking status, and classes of continuous use. Routine serum biochemical parameters, including alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, N-terminal fragment of B-type natriuretic peptide, and cardiac troponin, were measured.ResultsIn this cross-sectional study, a total of 176 patients with COVID-19 hospitalizations were included. Among them, 155 patients were discharged (88.5%), and 21 patients died (12%). Among the drug classes evaluated, we verified that the continuous use of diuretic 4.800 (1.853–11.67) (p = 0.0007) and antihypercholesterolemic 3.188 (1.215–7.997) (p = 0.0171) drug classes presented a significant relative risk of death as an outcome when compared to the group of patients who were discharged. We evaluated biomarkers in patients who used continuous antihypercholesterolemic and diuretic drug classes in the first week of hospitalization. We observed significant positive correlations between the levels of CRP with cardiac troponin (r = 0.714), IL-6 (r = 0.600), and IL-10 (r = 0.900) in patients who used continuous anticholesterolemic and diuretic drug classes and were deceased. In these patients, we also evaluated the possible correlations between the biomarkers AST, NT-ProBNP, cardiac troponin, IL-6, IL-8, and IL-10. We observed a significantly negative correlations in AST levels with NT-ProBNP (r = −0.500), cardiac troponin (r = −1.00), IL-6 (r = −1.00), and IL-10 (r = −1.00) and a positive correlation with IL-8 (r = 0.500). We also observed significant negative correlation in the levels of NT-ProBNP with IL-10 (r = −0.800) and a positive correlation with cardiac troponin (r = 0.800). IL-6 levels exhibited positive correlations with cardiac troponin (r = 0.800) and IL-10 (r = 0.700).ConclusionIn this study, we observed that hospitalized COVID-19 patients who continued using anticholesterolemic and diuretic medications showed a higher number of correlations between biomarkers, indicating a poorer clinical prognosis. These correlations suggest an imbalanced immune response to injuries caused by SARS-CoV-2.</p

Image_1_Retrospective cohort study to evaluate the continuous use of anticholesterolemics and diuretics in patients with COVID-19.TIF

PurposeThe purpose of this study is to evaluate the interference of the continuous use of drug classes in the expression of biomarkers during the first week of hospitalization and in the prognosis of patients with COVID-19.MethodsThe patients diagnosed with COVID-19 and confirmed with SARS-CoV-2 by RT-qPCR assay underwent the collection of fasting whole blood samples for further analysis. Other data also extracted for this study included age, sex, clinical symptoms, related comorbidities, smoking status, and classes of continuous use. Routine serum biochemical parameters, including alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, N-terminal fragment of B-type natriuretic peptide, and cardiac troponin, were measured.ResultsIn this cross-sectional study, a total of 176 patients with COVID-19 hospitalizations were included. Among them, 155 patients were discharged (88.5%), and 21 patients died (12%). Among the drug classes evaluated, we verified that the continuous use of diuretic 4.800 (1.853–11.67) (p = 0.0007) and antihypercholesterolemic 3.188 (1.215–7.997) (p = 0.0171) drug classes presented a significant relative risk of death as an outcome when compared to the group of patients who were discharged. We evaluated biomarkers in patients who used continuous antihypercholesterolemic and diuretic drug classes in the first week of hospitalization. We observed significant positive correlations between the levels of CRP with cardiac troponin (r = 0.714), IL-6 (r = 0.600), and IL-10 (r = 0.900) in patients who used continuous anticholesterolemic and diuretic drug classes and were deceased. In these patients, we also evaluated the possible correlations between the biomarkers AST, NT-ProBNP, cardiac troponin, IL-6, IL-8, and IL-10. We observed a significantly negative correlations in AST levels with NT-ProBNP (r = −0.500), cardiac troponin (r = −1.00), IL-6 (r = −1.00), and IL-10 (r = −1.00) and a positive correlation with IL-8 (r = 0.500). We also observed significant negative correlation in the levels of NT-ProBNP with IL-10 (r = −0.800) and a positive correlation with cardiac troponin (r = 0.800). IL-6 levels exhibited positive correlations with cardiac troponin (r = 0.800) and IL-10 (r = 0.700).ConclusionIn this study, we observed that hospitalized COVID-19 patients who continued using anticholesterolemic and diuretic medications showed a higher number of correlations between biomarkers, indicating a poorer clinical prognosis. These correlations suggest an imbalanced immune response to injuries caused by SARS-CoV-2.</p

Table_2_Retrospective cohort study to evaluate the continuous use of anticholesterolemics and diuretics in patients with COVID-19.DOCX

PurposeThe purpose of this study is to evaluate the interference of the continuous use of drug classes in the expression of biomarkers during the first week of hospitalization and in the prognosis of patients with COVID-19.MethodsThe patients diagnosed with COVID-19 and confirmed with SARS-CoV-2 by RT-qPCR assay underwent the collection of fasting whole blood samples for further analysis. Other data also extracted for this study included age, sex, clinical symptoms, related comorbidities, smoking status, and classes of continuous use. Routine serum biochemical parameters, including alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, N-terminal fragment of B-type natriuretic peptide, and cardiac troponin, were measured.ResultsIn this cross-sectional study, a total of 176 patients with COVID-19 hospitalizations were included. Among them, 155 patients were discharged (88.5%), and 21 patients died (12%). Among the drug classes evaluated, we verified that the continuous use of diuretic 4.800 (1.853–11.67) (p = 0.0007) and antihypercholesterolemic 3.188 (1.215–7.997) (p = 0.0171) drug classes presented a significant relative risk of death as an outcome when compared to the group of patients who were discharged. We evaluated biomarkers in patients who used continuous antihypercholesterolemic and diuretic drug classes in the first week of hospitalization. We observed significant positive correlations between the levels of CRP with cardiac troponin (r = 0.714), IL-6 (r = 0.600), and IL-10 (r = 0.900) in patients who used continuous anticholesterolemic and diuretic drug classes and were deceased. In these patients, we also evaluated the possible correlations between the biomarkers AST, NT-ProBNP, cardiac troponin, IL-6, IL-8, and IL-10. We observed a significantly negative correlations in AST levels with NT-ProBNP (r = −0.500), cardiac troponin (r = −1.00), IL-6 (r = −1.00), and IL-10 (r = −1.00) and a positive correlation with IL-8 (r = 0.500). We also observed significant negative correlation in the levels of NT-ProBNP with IL-10 (r = −0.800) and a positive correlation with cardiac troponin (r = 0.800). IL-6 levels exhibited positive correlations with cardiac troponin (r = 0.800) and IL-10 (r = 0.700).ConclusionIn this study, we observed that hospitalized COVID-19 patients who continued using anticholesterolemic and diuretic medications showed a higher number of correlations between biomarkers, indicating a poorer clinical prognosis. These correlations suggest an imbalanced immune response to injuries caused by SARS-CoV-2.</p