COVID-19 pandemic as a socio-psychological influence on transformations in religion

This article aims to establish COVID-19’s sociopsychological influence on religion. This interdisciplinary study’s theoretical framework embraces the socialecological systems framework, the concept of deprivation, the theory of religious myth-making, religious individualism and bricolage, as well as the concept of quality of life. A sociological survey was conducted of 4,700 residents of Moscow and the Moscow region. The results revealed that the social sphere of society was relatively stable duringthe pandemic. Exploring COVID-19’s socio-psychological influence, this study examines transformations in religion that resulted from tactile deprivation.&nbsp

Geometric Shaping of 2-D Constellations in the Presence of Laser Phase Noise

In this article, we propose a geometric shaping (GS) strategy to design 8, 16, 32, and 64 -ary modulation formats for the optical fibre channel impaired by both additive white Gaussian (AWGN) and phase noise. The constellations were optimised to maximise generalised mutual information (GMI) using a mismatched channel model. The presented formats demonstrate an enhanced signal-to-noise ratio (SNR) tolerance in high phase noise regimes when compared with their quadrature amplitude modulation (QAM) or AWGN-optimised counterparts. By putting the optimisation results in the context of the 400ZR implementation agreement, we show that GS alone can either relax the laser linewidth (LW) or carrier phase estimation (CPE) requirements of 400 Gbit/s transmission links and beyond. Following the GMI validation, the performance of the presented formats was examined in terms of post forward error correction (FEC) bit-error-rate (BER) for a soft decision (SD) extended Hamming code (128, 120), implemented as per the 400ZR implementation agreement. We demonstrate gains of up to 1.2 dB when compared to the 64 -ary AWGN shaped formats

The Partially-Coherent AWGN Channel: Transceiver Strategies for Low-Complexity Fibre Links

Carrier phase estimation (CPE) is one of the key requirements to perform intradyne coherent detection in optical communication systems. Residual errors in the phase estimation at the receiver, also known as residual phase noise (RPN), follow the so-called Tikhonov distribution. In the digital domain, a channel where the phase has already been estimated by the CPE is generally known as a partially-coherent additive white Gaussian noise (PCAWGN) channel. Herein, we present a joint strategy to modulate and demodulate a 2-dimensional (2D) signal in a PCAWGN channel. Using a low-complexity demapper, we geometrically shape (GS) 8- to 64- ary modulation formats for a PCAWGN channel. Through numerical simulations, we then assess the bit-wise achievable information rates (AIRs) and post forward error correction (FEC) bit error rates (BER) of the presented constellations with the: theoretical optimum model, Euclidean model and the low-complexity PCAWGN model. The resulting constellations are shown to be tolerant to a significant amount of RPN and are therefore applicable to coherent optical communication systems using high linewidth lasers (e.g., >500 kHz) and/or lower symbol rates. Moreover, we demonstrate that shaped PCAWGN constellations combined with a low-complexity demapper can either significantly relax laser linewidth (LW) or carrier phase estimation (CPE) requirements. Assuming a rate-9/10 LDPC scheme, we demonstrate post-FEC BER shaping gains of up to 2.59 dB and 2.19 dB versus uniform 64QAM and 64-ary constellations shaped for the purely AWGN channel, respectively

Physico-chemical characterization and in vitro biological evaluation of a bionic hydrogel based on hyaluronic acid and l-lysine for medical applications

Hyaluronic acid (HA) is an endogenous polysaccharide, whose hydrogels have been used in medical applications for decades. Here, we present a technology platform for stabilizing HA with a biocrosslinker, the amino acid L-Lysine, to manufacture bionic hydrogels for regenerative medicine. We synthetized bionic hydrogels with tailored composition with respect to HA concentration and degree of stabilization depending on the envisaged medical use. The structure of the hydrogels was assessed by microscopy and rheology, and the resorption behavior through enzymatic degradation with hyaluronidase. The biological compatibility was evaluated in vitro with human dermal fibroblast cell lines. HA bionic hydrogels stabilized with lysine show a 3D network structure, with a rheological profile that mimics biological matrixes, as a harmless biodegradable substrate for cell proliferation and regeneration and a promising candidate for wound healing and other medical applications

Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation

The central melanocortinergic system plays an important role in regulating different aspects of energy homeostasis and the immunomodulatory response. In the present study, we evaluated the in vivo activities of food intake suppression and anti-inflammatory activity of THIQ, which has been proposed to possess high and selective melanocortin-4 receptor agonistic activity in vitro. The results showed that THIQ (0.1, 0.3 and 1 nmol/rat, intracerebroventricularly) is less effective in reducing food intake and body weights of rats than the non-selective melanocortin receptor agonist melanotan II. Electron paramagnetic resonance measurements in mice brain tissue showed that THIQ at doses of 0.001 and 0.01 nmol/mouse (intracisternally) increased the concentration of nitric oxide, which is not typical for melanocortin receptor agonists. In an experimental brain inflammation model, THIQ only weakly antagonized lipopolysaccharide-induced nitric oxide overproduction in brain tissue at a dose of 0.01 nmol/mouse. Our findings provide new insight into the in vivo pharmacological profile of the in vitro selective melanocortin-4 receptor agonist THIQ and give grounds for caution when interpreting and predicting melanocortin receptor selective agonist activity in vivo.publishersversionPeer reviewe

P1367Effects of levosimendan therapy in patients with severe functional mitral regurgitation and chronic heart failure undergoing mitraclip implantation: a single-centre experience

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Evaluation of anti-photoaging effects of a novel cosmeceutical containing a retinoids mixture using in vitro cell models

11noopenPhysiological ageing due to the passing of time and prolonged exposure to harmful sun rays generate wrinkles and reduce skin elasticity. These visible and clinical signs can be prevented or reversed by known strategies, such as the daily use of cosmetic products with antioxidant combina-tions or retinoids. A new dermocosmetic formulation enriched with a complex of retinoids, called RETINOIDS SERUM, was investigated through in vitro assays using human skin cells. The experiments were carried out to assess the anti-ageing activity in normal human dermal fibroblasts (NHDF) and epidermal keratinocytes (HaCaT). After the preliminary MTT assay, the proliferation together with the synthesis of collagen and elastin fibers was performed on NHDF cells after 24 h treatment with the two non-cytotoxic concentrations. Using UVB-irradiated HaCaT cells, the measurement of matrix metalloproteinase-1 (MMP-1) levels was also investigated. In vitro studies show that the dermocosmetic product improves collagen and elastin synthesis and the renewal of dermal fibrob-lasts. Moreover, a reduction in the MMP-1 secretion was also highlighted in UVB-irradiated HaCaT cells. These results suggest that the cosmetic formulation containing functional compounds such as retinoids can be useful to prevent the natural sign of ageing.openZerbinati N.; Sommatis S.; Maccario C.; Capillo M.C.; Di Francesco S.; Liga E.; Rauso R.; D'este E.; Dalla Gasperina D.; Guida S.; Mocchi R.Zerbinati, N.; Sommatis, S.; Maccario, C.; Capillo, M. C.; Di Francesco, S.; Liga, E.; Rauso, R.; D'Este, E.; Dalla Gasperina, D.; Guida, S.; Mocchi, R

Optical and digital phase conjugation techniques for fiber nonlinearity compensation

We discuss recent progress on the use of optical and digital phase conjugation techniques for nonlinearity compensation in optical fiber links. We compare the achievable performance gain of phase conjugated twin wave applied in two polarization states and time segments with mid-link optical phase conjugation and digital back propagation. For multicarrier transmission scheme such as orthogonal frequency division multiplexing, two recently proposed schemes, namely phase-conjugated pilots and phase-conjugated subcarrier coding are reviewed

Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin

(1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the \u201cMaskne\u201d, caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity\u2014skin and eye irritation\u2014antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment

Structural abnormalities of the coronary arterial wall - in addition to luminal narrowing - Affect myocardial blood flow reserve

Multislice CT provides information on coronary luminal narrowing and on the structural abnormalities of the coronary arterial wall using densitometric analysis. We sought to investigate the effects of coronary luminal narrowing, structural abnormalities of the coronary arterial wall, and cardiovascular risk factors on regional and global myocardial blood flow (MBF) reserve. Methods: We studied 68 patients (mean age ± SD, 61 ± 10 y; 41 men, 27 women) with an intermediate probability of coronary artery disease. We measured the severity of coronary stenoses and the fibroadipose, fibromuscular, and calcium components of the coronary arterial wall by 64-row multislice CT coronary angiography. We also measured regional and global MBF reserve by PET using 13N-ammonia as a flow tracer at rest and after dipyridamole. Results: One or more significant coronary stenoses (≥50% luminal narrowing) was present in 32 patients (47%), and nonsignificant stenoses were present in 15 patients (22%). Regional MBF reserve was significantly different in the territories perfused by normal coronary arteries, nonsignificant coronary stenoses, and significant coronary stenoses (P < 0.001). Calcium content was higher in the coronary arteries with significant or nonsignificant stenoses (0.95% ± 1.08% and 0.73% ± 0.93%, respectively) than in those without stenoses (0.11% ± 0.38%, P < 0.001). Significant coronary stenosis (P = 0.047) and calcium content (P = 0.017) were the only independent determinants of impaired regional MBF reserve using multivariate analysis. At multiple logistic regression analysis, the Framingham risk score, an index of global cardiovascular risk burden, was the only significant determinant of global MBF reserve (P = 0.028). Conclusion: Coronary stenoses and coronary calcium content independently affect regional MBF reserve. Framingham risk score is the only significant determinant of global MBF reserve. Copyright © 2011 by the Society of Nuclear Medicine, Inc