58 research outputs found

    Intimate partner violence in South Asian communities:Exploring the notion of 'shame' to promote understandings of migrant women's experiences

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    The notion of 'shame' is increasingly being recognized as a tool with some explanatory power to help promote understandings about a range of social problems. Through an exploration of migrant South Asian women's experiences of domestic violence and help-seeking practices, this article considers the relevance of the notion of shame as a unit of analysis to help contribute to the growing theoretical and empirical literature. This article sheds light on the meanings, events, processes and structures in the lives of migrant South Asian women respondents living in Hong Kong. Within the framework of the discussion on shame and intimate partner violence(IPV), the article also identifies the implications for social work practice

    Cold Case Reviews of Serious Sexual Offenders: An Exploration of Pre- and Post-Index Offending Patterns

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    This exploratory study investigates offending patterns of perpetrators of serious sexual assaults (SSA) who were not initially identified at the time of the offense. Thirty-eight adult male offenders were identified through Operation Advance, a phased approach program that forensically reviewed historical sexual offense cases submitted to the UK Forensic Science Service during 1989 to 1999. Results indicated that approximately one-third of the SSA offenders received a post-offense conviction for a sexual‐contact offense. Results showed greater chronicity and versatility of the subsequent offenses for those younger index offenders. Explanations for the findings are discussed with implications for suspect prioritization

    Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in Italian Lesch-Nyhan patients: identification of nine novel mutations.

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    Lesch-Nyhan syndrome (LSN, McKusick 300322) is an X-linked genetic disease due, in its typical form, to the complete absence of hypoxanthine-guanine phosphoribosyltransferase (HPRT, EC 2.4.2.8) enzyme activity. It is characterized by hyperuricaemia, leading to gout and kidney stones, accompanied by severe neurological dysfunction with self-injurious behaviour, choreoathetosis and spasticity. Based on a worldwide birth incidence estimate of about 1:380000, one or two new cases are expected every year in Italy. We performed biochemical and molecular genetic studies on 28 Italian patients from 25 families who are likely to represent most living individuals with the syndrome in the country. They all had absent HPRT activity and a typical LNS phenotype. Genetic analysis identified 24 HPRT mutations, 9 of which had not been previously reported: 74C>G (P25R), IVS2+1G>C, 194-195delTC, 329-332delCAAC insTCTs, IVS9-1G>A, 506insC, IVS8-1G>C, 606G>T (L202F), 418G>C (G140R). No mutation hotspots were identified. Only two mutations were found in more than one family, indicating the lack of any major mutation causing LNS in Italy. Three mutations arose de novo ,two in the proband's mother, one in the maternal grandmother. The virtual complete absence of HPRT activity was related to deletions, nonsense, or missense mutations leading to nonconservative amino acid changes.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe
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