Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats

BACKGROUND: Previous experiments have shown that a decoction of Bauhinia forficata leaves reduces the changes in carbohydrate and protein metabolism that occur in rats with streptozotocin-induced diabetes. In the present investigation, the serum activities of enzymes known to be reliable toxicity markers were monitored in normal and streptozotocin-diabetic rats to discover whether the use of B. forficata decoction has toxic effects on liver, muscle or pancreas tissue or on renal microcirculation. METHODS: An experimental group of normal and streptozotocin-diabetic rats received an aqueous decoction of fresh B. forficata leaves (150 g/L) by mouth for 33 days while a control group of normal and diabetic rats received water for the same length of time. The serum activity of the toxicity markers lactate dehydrogenase, creatine kinase, amylase, angiotensin-converting enzyme and bilirubin were assayed before receiving B. forficata decoction and on day 19 and 33 of treatment. RESULTS: The toxicity markers in normal and diabetic rats were not altered by the diabetes itself nor by treatment with decoction. Whether or not they received B. forficata decoction the normal rats showed a significant increase in serum amylase activity during the experimental period while there was a tendency for the diabetic rats, both treated and untreated with decoction, to have lower serum amylase activities than the normal rats. CONCLUSIONS: Administration of an aqueous decoction of B. forficata is a potential treatment for diabetes and does not produce toxic effects measurable with the enzyme markers used in our study

Christianity and the State in Showa Japan

Master of ArtsCenter for Japanese StudiesUniversity of Michiganhttps://deepblue.lib.umich.edu/bitstream/2027.42/145027/1/cjsmat_033.pdf45

Teori dan Praktek Farmasi Industri Jilid 2

xv,643-1146 hal,;ill,;21 c

Teori dan Praktek Farmasi Industri Jilid 3

xv,1147-1762 hal,;ill,;21 c

Best Practices for Mediation Training and Regulation: Preliminary Findings

This article makes recommendations as to “Best Practices” for the training of mediators in court-connected settings. The authors’ findings cover issues including the design of training programs, the importance of experiential learning through role-plays, teaching methods for adult learners, class size and length, training ethical mediators, suggested trainer qualifications, and recommended regulatory practices for administrators. Data comes primarily from an assessment of mediation training and regulation in Florida, but the findings hold insights for court-connected mediation programs throughout the United States. Additionally, the authors highlight the benefits of a collaborative assessment approach involving all stakeholder groups and facilitating smooth implementation of any needed change

Elevational gradients of species diversity, breeding system and floral traits of orchid species on Reunion Island

Aim: This research investigates changes in orchid species composition and diversity, plant breeding system and floral traits along an elevational gradient spanning 2300 m (200-2500 m). Location: The study was conducted on Réunion Island (Mascarene Islands, Indian Ocean). Methods: Data on the distribution of 135 orchid species from 35 genera were gathered from 121 localities situated between 200 and 2500 m a.s.l. For each locality, 500-m transects were walked and each orchid species was recorded. Measures of species diversity (species richness, a modified Shannon diversity index and the modified Shannon equitability index) were related to altitude using ordinary least-squares regression. Species turnover and elevational gradients in species composition were determined by: (1) relating scores of detrended correspondence analysis to altitude using ordinary least-squares regression, and (2) relating Sørensen similarity indices to differences in altitude using Mantel tests. Finally, the average proportion of species displaying similar floral traits or showing the same breeding system were compared among altitudinal zones. Results: Species richness per transect ranged from 1 to 36 species (mean 14.3) and decreased significantly with increasing altitude. Similarly, species evenness decreased significantly with increasing altitude. Around 50% of all orchid species were rare (occurred in fewer than 5% of all localities), and only a few occurred in more than 50% of all localities. Orchid species composition changed continuously with altitude, indicating turnover of species with increasing altitude. Analogously, orchid breeding systems and floral traits also changed with altitude. Relatively more auto-pollinating species were found at high altitudes compared with mid- and low-altitude sites where animal-pollinated species were most abundant. Species characterized by a cleistogamous pollination system were found almost exclusively in high-altitude sites, whereas the proportion of species displaying floral traits related to pollination by long-tongued moths (sphinx) and flies sharply decreased with increasing altitude. Main conclusions: Environmental conditions associated with altitude exert a large influence on orchid species composition and the distribution of orchid breeding systems. Our results revealed a high proportion of auto-pollinating species, and confirm earlier findings that auto-pollinating species are more frequent in high-altitude sites. © Blackwell Publishing Ltd