Turner/Down mosaicism: A case report

A 45,X/47,XX, +21 mosaicism (80%:20%) in a young girl with clinical features of Down syndrome is reported. The proportion of 45,X:47,XX, +21 cells present in peripheral lymphocytes does not necessarily have a profound effect on the phenotype. A possible explanation for the occurrence of double aneuploidy is given

The recovery of copper from a pregnant sulphuric acid bioleach solution with developmental resin Dow XUS43605

This paper focuses on the application of ion exchange technology for the recovery of copper from a leach solution originating from a heap bioleach in which base metals are leached from a low-grade ore that bears platinum group metals. Screening tests indicated that Dow XUS43605 has high selectivity for copper over the other metals in the solution, namely nickel, iron, cobalt, zinc, manganese, and aluminium. Batch adsorption kinetic experiments showed that copper adsorption equilibrium is attained at a fast rate. The kinetics of adsorption increased as the temperature was increased from 25°Cto 60°C due to the decrease in solution viscosity and the subsequent improved intra-particle mass diffusion. Single-component Langmuir and Freundlich isotherm models were fitted to the batch copper adsorption equilibrium data, and a maximum copper capacity of26 g/l was observed for Dow XUS43605. The effects of flow rate, temperature, pH, and initial metal concentration on the dynamic recovery of copper were investigated in fixed-bed columns, and it was determined that temperature and flow rate had the most significant impacts on the loading of copper on the resin at copper breakthrough. A 36% increase in copper loading at breakthrough was observed when the temperature was increased from 25°C to 60°C. Finally, it was determined that a split elution is possible by using different concentrations of H2SO4 to first elute co-loaded nickel from the resin, followed by the elution of copper

Preliminary investigation into the cause of acid mine water induced seismicity in Johannesburg

A preliminary investigation was done into the possible causes of the increased seismic activity in the Witwatersrand Basin. The paper focuses on approximated underground mining areas, groundwater mobility, rock types and the proximity of fault lines to seismic events. These parameters were mapped and correlated with observed seismicity in the area. There is some indication that the presence of underground mining areas has a positive relationship with the occurrence of seismic events. The other parameters exhibit a negative relationship with seismic activity. However, more detailed investigations are required before final conclusions can be drawn. An approach to risk assessment of possible earthquake scenarios in the City of Johannesburg (CoJ) is proposed. The approach aims to assess potential damage to infrastructure and loss of life in the case of an earthquake. The results of such an assessment may provide justification for more detailed investigations

Decomposing diversification effect: evidence from the U.S. property-liability insurance industry

Prior literature suggests that diversified property-liability (P/L) insurers underperform their focused counterparts. While most studies focus on insurers’ overall performance, there is an absence of evidence regarding whether the underperformance is driven by underwriting or investment profitability. The authors develop and test hypotheses of diversification’s separate effect on underwriting and investing in the U.S. property-liability (P/L) insurance industry. It is found that diversified insurers outperform their focused counterparts in terms of investment return, but that they underperform in terms of underwriting profitability. The results are robust to corrections for endogeneity bias and a matched sample analysis

Additive opportunistic capture explains group hunting benefits in African wild dogs

African wild dogs (Lycaon pictus) are described as highly collaborative endurance pursuit hunters based on observations derived primarily from the grass plains of East Africa. However, the remaining population of this endangered species mainly occupies mixed woodland savannah where hunting strategies appear to differ from those previously described. We used high-resolution GPS and inertial technology to record fine-scale movement of all members of a single pack of six adult African wild dogs in northern Botswana. The dogs used multiple short-distance hunting attempts with a low individual kill rate (15.5%), but high group feeding rate due to the sharing of prey. Use of high-level cooperative chase strategies (coordination and collaboration) was not recorded. In the mixed woodland habitats typical of their current range, simultaneous, opportunistic, short-distance chasing by dogs pursuing multiple prey (rather than long collaborative pursuits of single prey by multiple individuals) could be the key to their relative success in these habitats

A phase I trial of hypoxoside as an oral prodrug for cancer therapy - absence oftoxicity

No Abstract

Bugs, drugs, and HIV : the role of the vaginal microbiome in HIV risk and antiretroviral efficacy for HIV prevention.

CAPRISA, 2017.Abstract available in pdf

Energy cost and return for hunting in African wild dogs and Cheetahs

African wild dogs (Lycaon pictus) are reported to hunt with energetically costly long chase distances. We used high-resolution GPS and inertial technology to record 1,119 high-speed chases of all members of a pack of six adult African wild dogs in northern Botswana. Dogs performed multiple short, high-speed, mostly unsuccessful chases to capture prey, while cheetahs (Acinonyx jubatus) undertook even shorter, higher-speed hunts. We used an energy balance model to show that the energy return from group hunting and feeding substantially outweighs the cost of multiple short chases, which indicates that African wild dogs are more energetically robust than previously believed. Comparison with cheetah illustrates the trade-off between sheer athleticism and high individual kill rate characteristic of cheetahs, and the energetic robustness of frequent opportunistic group hunting and feeding by African wild dogs

Returns to food and agricultural R&D investments in Sub-Saharan Africa, 1975-2014

Research-enabled growth in agricultural productivity is pivotal to sub-Saharan Africa’s overall economic growth prospects. Yet, investments in research and development (R&D) targeted to many national food and agricultural economies throughout Africa are fragile and faltering. To gain insight into what could be driving this trend, this article updates, summarizes and reassesses the published evidence on the returns to African agricultural R&D. Based on a compilation of 113 studies published between 1975 and 2014 spanning 25 countries, the reported internal rates of return (IRRs) to food and agricultural research conducted in or of direct consequence for sub-Saharan Africa averaged 42.3%py. In addition to the 376 IRR estimates, the corresponding 129 benefit-cost ratios (BCRs) averaged 30.1. Most (96.5%) of the returns-to-research evaluations are of publicly performed R&D, and the majority (87.6%) of the studies were published in the period 1990–2009. The large dispersion in the reported IRRs and BCRs makes it difficult to discern meaningful patterns in the evidence. Moreover, the distribution of IRRs is heavily (positively) skewed, such that the median value (35.0%py) is well below the mean, like it is for research done elsewhere in the world (mean 62.4%py; median 38.0%py). Around 78.5% of the evaluations relate to the commodity-specific consequences of agricultural research, while 5.5% report on the returns to an ‘‘all agriculture” aggregate. The weight of commodity-specific evaluation evidence is not especially congruent with the composition of agricultural production throughout Africa, nor, to the best that can be determined, the commodity orientation of public African agricultural R&D.The CGIAR’s Standing Panel on Impact Assessment, with additional support from the University of Minnesota’s Agricultural Experiment Station (Project Nos. MIN-14-061 and MIN-14-034), the Centro Internacional de Agricultura Tropical (CIAT), and the Bill and Melinda Gates Foundation by way of the HarvestChoice project.http://www.elsevier.com/locate/foodpolhb2017Agricultural Economics, Extension and Rural Developmen