The Italian coal shortage: the price of import and distribution, 1861–1911

This paper estimates a measure of coal price for all NUTS3 Italian provinces between 1861 and 1911. Italy was a latecomer country and its late industrialization was characterized by the absence of coal in a time when the steam engine powered factory work. The new variable accounts for the main input factor of manufacturing production during that period in which the Italian economy registered a long-term growth of GDP and an increase in its industrial activity. The measure allows to speculate on the importance of coal for Italian industrialization and on the origins of the North–South divide

Parkinson's Disease DJ-1 L166P Alters rRNA Biogenesis by Exclusion of TTRAP from the Nucleolus and Sequestration into Cytoplasmic Aggregates via TRAF6

Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson's disease (PD). Although large gene deletions have been linked to a loss-of-function phenotype, the pathogenic mechanism of missense mutations is less clear. The L166P mutation causes misfolding of DJ-1 protein and its degradation. L166P protein may also accumulate into insoluble cytoplasmic aggregates with a mechanism facilitated by the E3 ligase TNF receptor associated factor 6 (TRAF6). Upon proteasome impairment L166P activates the JNK/p38 MAPK apoptotic pathway by its interaction with TRAF and TNF Receptor Associated Protein (TTRAP). When proteasome activity is blocked in the presence of wild-type DJ-1, TTRAP forms aggregates that are localized to the cytoplasm or associated to nucleolar cavities, where it is required for a correct rRNA biogenesis. In this study we show that in post-mortem brains of sporadic PD patients TTRAP is associated to the nucleolus and to Lewy Bodies, cytoplasmic aggregates considered the hallmark of the disease. In SH-SY5Y neuroblastoma cells, misfolded mutant DJ-1 L166P alters rRNA biogenesis inhibiting TTRAP localization to the nucleolus and enhancing its recruitment into cytoplasmic aggregates with a mechanism that depends in part on TRAF6 activity. This work suggests that TTRAP plays a role in the molecular mechanisms of both sporadic and familial PD. Furthermore, it unveils the existence of an interplay between cytoplasmic and nucleolar aggregates that impacts rRNA biogenesis and involves TRAF6

Mutant p53 as a guardian of the cancer cell

Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a complex framework of diverse effector pathways and processes that protect cellular homeostasis and genome stability. Missense mutations in the TP53 gene are extremely widespread in human cancers and give rise to mutant p53 proteins that lose tumor suppressive activities, and some of which exert trans-dominant repression over the wild-type counterpart. Cancer cells acquire selective advantages by retaining mutant forms of the protein, which radically subvert the nature of the p53 pathway by promoting invasion, metastasis and chemoresistance. In this review, we consider available evidence suggesting that mutant p53 proteins can favor cancer cell survival and tumor progression by acting as homeostatic factors that sense and protect cancer cells from transformation-related stress stimuli, including DNA lesions, oxidative and proteotoxic stress, metabolic inbalance, interaction with the tumor microenvironment, and the immune system. These activities of mutant p53 may explain cancer cell addiction to this particular oncogene, and their study may disclose tumor vulnerabilities and synthetic lethalities that could be exploited for hitting tumors bearing missense TP53 mutations

Bolsa Família: um survey sobre os efeitos do programa de transferência de renda condicionada do Brasil

Revisam-se pesquisas sobre efeitos do Programa Bolsa Família. Há quatro evidências frequentes. A primeira é que o programa tem focalização relativamente boa, mas que pode ainda ser melhorada. A segunda é o efeito positivo sobre a aquisição (consumo) de alimentos – sem conclusões sobre a qualidade da dieta. A terceira diz respeito ao estimulo às crianças a participarem da escola (matrícula, frequência e progressão), embora pouco se saiba sobre os efeitos na aprendizagem. A ausência de efeitos sobre a fecundidade das mulheres caracteriza a quarta conclusão robusta que se pode tirar da literatura, ainda que mais estudos devam ser realizados. Em outras dimensões, as evidências não formam consenso sobre direção dos efeitos.This paper surveys the literature about the effects of Bolsa Familia Program. We found four main results. The first is that the program is relatively well targeted, but it can still be improved.The second is the positive effect on the acquisition (consumption) of food, but there is no conclusions about the quality of the diet. The third is that the program encourages children to attend school (enrollment, attendance and progression). However, little is known about the effects on learning. The absence of effects on the fecundity of the women characterizes the fourth conclusion that can be drawn from the literature, although more studies must be carried out on this topic. In other dimensions, the evidence does not form consensus on the direction of effects

When history leaves a mark: a new measure of Roman roads

This paper introduces a new measure of Roman roads that has been constructed for the Italian territory. The measure computes the length in kilometers of Roman roads at different administrative and territorial levels (NUTS, Local Labor Systems, grid cells), and contributes to the literature on historical infrastructures, providing a new precise measure to use for empirical purposes and easy to extend in all those territories where Roman roads have been constructed. From a mere econometric point of view, the index allows to capture the intensity of the treatment, providing an alternative empirical strategy for all those cases where the simple binary treatment cannot be performed

The European firms' export activity to the neighbouring countries

The main goal of this paper is to study empirically the export decisions of the European firms and to explore their international activities to the European Neighbouring Countries (ENCs). We investigate what are the main characteristics, behaviour and strategies of European firms that export to and invest in one or more ENCs, in order to single out which are at the national level (data are not available at the regional level) the location determinants of European investments and trade patterns. We concentrate our analysis on exporting flows for which data are very detailed, and starting from this, we explore which are the main European exporting destinations and investigate on the intensive and the extensive margin; we control for several firms' characteristics and if exporting firms are active in foreign markets. To achieve our aims, we use the EFIGE dataset on firms from seven European countries and we isolate and compare exports to 16 neighbouring countries, with respect to all other possible world destinations

Measuring insularity as a state of nature

In this paper we construct a composite index that measures insularity for countries that are islands and for those that have islands. By collecting available physical data for all islands in the world, be they states or regions, we provide a novel data set of insularity along different dimensions. Three of these contribute to making insularity more or less severe: the degree of land dispersion, the remoteness and the average size of the island. We aggregate this information, weighting it by the share of insular land at the country level, and compute a measure of insularity that ranges between 0 and 100. We find that the greater burden linked to insularity is borne by islands with no territorial sovereignty