The impact of social disorganization and public school characteristics in explaining suspensions and expulsions

The purpose of this study is to examine if school or community characteristics correlate with suspensions and expulsions. The data examined in this study were drawn from Riverside County schools. The schools were examined to determine if school or social disorganization characteristics correlate with suspension and expulsion rates

Pla de Viabilitat d’una empresa de suport de vendes de vi

El present projecte presenta un pla de negoci d‟una empresa que té com a principal missió donar suport a productors de vi per incrementar les seves vendes. La proposta general de pla d‟empresa està formada per les següents elements: Estudi de la cadena de valor del sector Presentació de l‟empresa a través de l‟ idea de negoci, quin avantatge competitiu posa per las seva missió Anàlisi de l‟entorn político-legal, social i econòmic, així com de l‟entorn específic de l‟empresa i els seus competidors, tan verticals com horitzontals, tan directes com indirectes, tan reals com potencials Pla de màrqueting Pla de processos per a l‟activitat de l‟empresa Pla d‟estructura i RRHH Pla de viabilitat econòmica i financera Observant les conclusions del projecte, hi ha suficients elements i arguments que fan pensar que hi ha un lloc en el mercat per a que aquesta empresa pugui implantar la seva activitat i consolidar les seves característiques en el món empresarial barceloní

Pla de Viabilitat d’una empresa de suport de vendes de vi

El present projecte presenta un pla de negoci d‟una empresa que té com a principal missió donar suport a productors de vi per incrementar les seves vendes. La proposta general de pla d‟empresa està formada per les següents elements:  Estudi de la cadena de valor del sector Presentació de l‟empresa a través de l‟ idea de negoci, quin avantatge competitiu posa per las seva missió Anàlisi de l‟entorn político-legal, social i econòmic, així com de l‟entorn específic de l‟empresa i els seus competidors, tan verticals com horitzontals, tan directes com indirectes, tan reals com potencials Pla de màrqueting Pla de processos per a l‟activitat de l‟empresa Pla d‟estructura i RRHH Pla de viabilitat econòmica i financera Observant les conclusions del projecte, hi ha suficients elements i arguments que fan pensar que hi ha un lloc en el mercat per a que aquesta empresa pugui implantar la seva activitat i consolidar les seves característiques en el món empresarial barceloní

Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease

Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes (MW500Da). Materials and Methods: In 95 CKD-patients (CKD-stage 2-5 not on dialysis), associations between different eGFR-formulae (creatinine, CystatinC-based or both) and the natural logarithm of the concentration of several LMWP's were analyzed: i.e. parathyroid hormone (PTH), Cystatin C (CystC), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), leptin, retinol binding protein (RbP), immunoglobin light chains kappa and lambda (Ig-kappa and Ig-lambda), beta-2-microglobulin (beta M-2), myoglobin and fibroblast growth factor-23 (FGF-23)). Results: The regression coefficients (R-2) between eGFR, based on the CKD-EPI-Crea-CystC-formula as reference, and the examined LMWP's could be divided into three groups. Most of the LMWP's associated weakly (R-2 0.7). Almost identical R-2-values were found per LMWP for all eGFR-formulae, with exception of CystC and beta M-2 which showed weaker associations with creatinine-based than with CystC-based eGFR. Conclusion: The association between eGFR and the concentration of several LMWP's is inconsistent, with in general low R-2-values. Thus, the use of eGFR to evaluate kidney function does not reflect the concentration of several LMWP's with proven toxic impact in CKD

Decreased mitochondrial respiration associates with frailty in community-dwelling older adults

Aging population has led to an increased prevalence of chronic and degenerative pathologies. A manifestation of unhealthy aging is frailty, a geriatric syndrome that implies a non-specific state of greater vulnerability. Currently, methods for frailty diagnosis are based exclusively on clinical observation. The aim of this study is to determine whether the bioenergetic capacity defined as mitochondrial oxygen consumption rate (OCR) of peripheral circulation mononuclear cells (PBMC) associates with the frailty phenotype in older adults and with their nutritional status. This is a cross-sectional analytic study of 58 participants 70 years and older, 18 frail and 40 non-frail adults, from the ALEXANDROS cohort study, previously described. Participants were characterized through sociodemographic and anthropometric assessments. Frail individuals displayed a higher frequency of osteoporosis and depression. The mean age of the participants was 80.2 ± 5.2 years, similar in both groups of men and women. Regarding the nutritional status defined as the body mass index, most non-frail individuals were normal or overweight, while frail participants were mostly overweight or obese. We observed that OCR was significantly decreased in frail men (p < 0.01). Age was also associated with significant differences in oxygen consumption in frail patients, with lower oxygen consumption being observed in those over 80 years of age. Therefore, the use of PBMC can result in an accessible fingerprint that may identify initial stages of frailty in a minimally invasive way

Acute exposure to mobile phone and assessment of internal cerebral circulation in young healthy subjects : a transcranial Doppler study

International audienceThe rapid worldwide increase in the use of mobile phones raises questions about the possible adverse effects of RF fields emitted by these devices. The temporal lobe of brain is closest to the mobile phone. This may lead to relatively high energy deposition in these parts of human head during the use of mobile phone. The cerebral circulation may be potentially affected due to the exposure to RF emitted by mobile phone. Therefore the studies on cerebral blood flow are essential in order to evaluate the possible interaction exposure to RF with the central nervous system. Data in the literature related to the brain circulation are limited and controversial due to the different methods and protocols applied in these studie