Patch Is Not All You Need

Vision Transformers have achieved great success in computer visions, delivering exceptional performance across various tasks. However, their inherent reliance on sequential input enforces the manual partitioning of images into patch sequences, which disrupts the image's inherent structural and semantic continuity. To handle this, we propose a novel Pattern Transformer (Patternformer) to adaptively convert images to pattern sequences for Transformer input. Specifically, we employ the Convolutional Neural Network to extract various patterns from the input image, with each channel representing a unique pattern that is fed into the succeeding Transformer as a visual token. By enabling the network to optimize these patterns, each pattern concentrates on its local region of interest, thereby preserving its intrinsic structural and semantic information. Only employing the vanilla ResNet and Transformer, we have accomplished state-of-the-art performance on CIFAR-10 and CIFAR-100, and have achieved competitive results on ImageNet

Characterization of a multidrug-resistant porcine Klebsiella pneumoniae sequence type 11 strain coharboring blaKPC-2 and fosA3 on two novel hybrid plasmids

The occurrence of carbapenemase-producing Enterobacteriaceae (CPE) poses a considerable risk for public health. The gene for Klebsiella pneumoniae carbapenemase-2 (KPC-2) has been reported in many countries worldwide, and KPC-2-producing strains are mainly of human origin. In this study, we identified two novel hybrid plasmids that carry either blaKPC-2 or the fosfomycin resistance gene fosA3 in the multiresistant K. pneumoniae isolate K15 of swine origin in China. The blaKPC-2-bearing plasmid pK15-KPC was a fusion derivative of an IncF33:A−:B− incompatibility group (Inc) plasmid and chromosomal sequences of K. pneumoniae (CSKP). A 5-bp direct target sequence duplication (GACTA) was identified at the boundaries of the CSKP, suggesting that the integration might have been due to a transposition event. The blaKPC-2 gene on pK15-KPC was in a derivative of ΔTn6296-1. The multireplicon fosA3-carrying IncN-IncR plasmid pK15-FOS also showed a mosaic structure, possibly originating from a recombination between an epidemic fosA3-carrying pHN7A8-like plasmid and a pKPC-LK30-like IncR plasmid. Stability tests demonstrated that both novel hybrid plasmids were stably maintained in the original host without antibiotic selection but were lost from the transformants after approximately 200 generations. This is apparently the first description of a porcine sequence type 11 (ST11) K. pneumoniae isolate coproducing KPC-2 and FosA3 via pK15-KPC and pK15-FOS, respectively. The multidrug resistance (MDR) phenotype of this high-risk K. pneumoniae isolate may contribute to its spread and its persistence

Revealed Comparative Economies of Scope and Development Index

In this note, we attempt to construct some summary statistic to measure economic development and make comparisons across countries. A development index is defined in terms of both "scale" and "scope". "Scale" is measured by output per capita. "Scope" is measured by revealed comparative economies of scope, which in turn is measured by the ratio of the variety of exports over the variety of imports for a country. Using purchasing power parity and the Standard International Trade Classification, we have computed the development index for forty countries

Utility Analysis on Supply of Rural Public Policies in North Bay Economic Zone

From analysis on internal and external motive forces of development in North Bay Economic Zone, it indicates that public policies, as basic methods of government intervening against social and economic activities, are fundamental public goods produced by government. Effective supply of public policies brings rural economic growth, environmental protection and sustainable development, which greatly stimulates rural consumption, expands domestic demand and spurs economic growth, showing significant “multiplier effect”. In this situation, this paper studies conditions for rural economic development and social transformation of the North Bay Economic Zone. Results show that social and economic development of rural areas of the North Bay Economic Zone needs scientific, reasonable and effective “public policies”

Assessing the Role of Policies on Land-Use/Cover Change from 1965 to 2015 in the Mu Us Sandy Land, Northern China

Policy has long been considered one of the major driving forces for land-use/cover change. However, research on the interactions between land-use/cover change (LUCC) and relevant policies remains limited. The agropastoral ecotone is a typical area of policy implementation and LUCC. Therefore, this study integrates the use of multisource and multiresolution remote sensing and topographic and field-based datasets for the case of the Mu Us Sandy Land (MUSL) in northern China. The research aim was to quantify LUCC from 1965 to 2015 and describe the relationship between policy changes and land-use types during three stages: the stage of the Great Cultural Revolution, the stage of the modernization of the economy, and the stage of the Great Ecological Project. The results indicated that land use was affected by different national policies because of the national approach to land use during different periods. In the stage of the Great Cultural Revolution, the amount of cultivated land increased, and the environment deteriorated under the influence of leftists. In the stage of the modernization of the economy, vegetation coverage improved after the initial damage, and cultivated and artificial surfaces also increased. In the stage of the Great Ecological Project, cultivated land and unused land decreased, and woodland and sparse vegetation increased with the implementation of the Grain for Green Project (GGP). However, cultivated land increased but wood land and sparse vegetation decreased significantly by the end of the GGP. The coverage of artificial surfaces increased and grasslands decreased due to the encroachment of artificial surfaces into grasslands

Exploring a novel long-acting glucagon-like peptide-1 receptor agonist built on the albumin-binding domain and XTEN scaffolds

In recent years, glucagon-like peptide-1 (GLP-1) has demonstrated considerable potential in the treatment of type 2 diabetes (T2D) and obesity. However, the half-life of naturally occurring GLP-1 is quite short in vivo. Two common strategies employed for half-life extension are the use of the Albumin-binding domain (ABD) and XTEN polypeptide, which operate through different mechanisms. In this study, we designed an innovative GLP-1 receptor agonist with an extended duration of action. This new construct incorporated an albumin binding domain (ABD) and an XTEN sequence (either XTEN144 or XTEN288) as carriers. We referred to these fusion proteins as GLP-ABD-XTEN144 and GLP-ABD-XTEN288. In an E. coli system, the said constructs were efficaciously produced in substantial quantity. It was observed from in vitro studies that the fusion protein GLP-ABD-XTEN144 demonstrated a five times stronger affinity towards human serum albumin (HSA), boasting a binding affinity (Kd) of 5.50 nM. This was in contrast to GLP-ABD-XTEN288, whose Kd value was registered at 27.78 nM. Moreover, GLP-ABD-XTEN144 presented a half-life of 12.9 h in mice, thus exceeding the corresponding value for GLP-ABD-XTEN288, 7.32 h in mice. Both these fusion proteins significantly mitigated non-fasting blood sugar levels and overall food consumption for 48 h subsequent to a one-time injection in mice. Notably, GLP-ABD-XTEN144 exhibited more pronounced hypoglycemic activity and food inhibitory effects than GLP-ABD-XTEN288. The designed GLP-ABD-XTEN144 fusion protein shows promising prospects for clinical application in T2D treatment. Our findings also suggest that ABD and XTEN polypeptides synergistically contribute to half-life extension, further enhancing the pharmacokinetic characteristics of a payload

Synthesis of Helical Phenolic Resin Bundles through a Sol-Gel Transcription Method

Chiral and helical polymers possess special helical structures and optical property, and may find applications in chiral catalysis and optical devices. This work presents the preparation and formation process of helical phenolic resins through a sol-gel transcription method. A pair of bola-type chiral low-molecular-weight gelators (LMWGs) derived from valine are used as templates, while 2,4-dihydroxybenzoic acid and formaldehyde are used as precursors. The electron microscopy images show that the phenolic resins are single-handed helical bundles comprised of helical ultrafine nanofibers. The diffused reflection circular dichroism spectra indicate that the helical phenolic resins exhibit optical activity. A possible formation mechanism is proposed, which shows the co-assembly of the LMWGs and the precursors