Social Accounting Analysis: Can We Borrow and Improve?

Develops the position that measurable outcomes (e.g., goals and objectives, accountability, and performance) of not-for-profit organizations can be assessed. The article also reviews numerous measures that have been articulated in the last 20 yrs

Food Prices and Industrialisation: Some Questions from Indian Economic History

SUMMARY A recent study of the demand for British manufactures in Asia at the end of the last century suggests that demand increased when food prices rose, not when they fell. Because many people were below the threshold of income at which they bought factory goods, falling food prices did not enable them to buy these products. But when food prices rose, producers and dealers above that threshold became better off and increased their consumption of manufactures. If a similar situation exists today, planners seeking cheap food may be retarding the industrial development of their economies. RESUME Prix des produits alimentaires et industrialisation: Quelques questions du point de vue de I'histoire éeconomique Une étude récente de la demande qui existait en Asie à la fin du siècle dernier pour les produits manufacturés britanniques suggère que la demande s'accroissait lorsque les prix des produits alimentaires montaient, non lorsqu'ils baissaient. Parce que tant de gens étaient au?dessous du niveau de revenu auquel on achète des biens manufacturés, les baisses de prix dans les denrées alimentaires ne leur permettaient pas d'acheter davantage ces produits. Mais lorsque les prix des produits alimentaires montaient, les producteurs et les marchands au?dessus de ce niveau s'enrichissaient et augmentaient leur consommation de produits manufacturés. Si une telle situation existe aujourd'hui, les planificateurs qui cherchent à faire baisser les prix des denrées alimentaires contribuent peut?être à retarder le développement industriel de leurs économies. RESUMEN Precios de los comestibles y la Industrialización: algunas preguntas procedentes de la historia económics Un estudio llevado a cabo recientemente sobre la demanda en Asia de productos fabricados británicos a finales del siglo pasado, indica que la demanda aumentó cuando hubo un aumento en los precios de los comestibles, pero no cuando bajaron. Debido a que mucha gente no tenía ingresos que les permitiera comprar productos fabricados, la reducción en los precios de los comestibles no les permitía comprar estos productos. Sin embargo, con el aumento en dichos precios, los fabricantes y los comerciantes con ingresos por encima del límite inferior, prosperaron, aumentando en consecuencia sus consumos de los productos fabricados. Si hoy día existe una situación similar, se puede que los planificadores estén frenando el desarrollo industrial de sus economías

Neutropenia as an adverse event following vaccination : results from randomized clinical trials in healthy adults and systematic review

Background : In the context of early vaccine trials aimed at evaluating the safety profile of novel vaccines, abnormal haematological values, such as neutropenia, are often reported. It is therefore important to evaluate how these trials should be planned not to miss potentially important safety signals, but also to understand the implications and the clinical relevance. Methodology : We report and discuss the results from five clinical trials (two with a new Shigella vaccine in the early stage of clinical development and three with licensed vaccines) where the absolute neutrophil counts (ANC) were evaluated before and after vaccination. Additionally, we have performed a systematic review of the literature on cases of neutropenia reported during vaccine trials to discuss our results in a more general context. Principal Findings : Both in our clinical trials and in the literature review, several cases of neutropenia have been reported, in the first two weeks after vaccination. However, neutropenia was generally transient and had a benign clinical outcome, after vaccination with either multiple novel candidates or well-known licensed vaccines. Additionally, the vaccine recipients with neutropenia frequently had lower baseline ANC than non-neutropenic vaccinees. In many instances neutropenia occurred in subjects of African descent, known to have lower ANC compared to western populations. Conclusions : It is important to include ANC and other haematological tests in early vaccine trials to identify potential safety signals. Post-vaccination neutropenia is not uncommon, generally transient and clinically benign, but many vaccine trials do not have a sampling schedule that allows its detection. Given ethnic variability in the level of circulating neutrophils, normal ranges taking into account ethnicity should be used for determination of trial inclusion/exclusion criteria and classification of neutropenia related adverse events

Heavy-Baryon Spectroscopy from Lattice QCD

We use a four-dimensional lattice calculation of the full-QCD (quantum chromodynamics, the non-abliean gauge theory of the strong interactions of quarks and gluons) path integrals needed to determine the masses of the charmed and bottom baryons. In the charm sector, our results are in good agreement with experiment within our systematics, except for the spin-1/2 $\Xi_{cc}$, for which we found the isospin-averaged mass to be $\Xi_{cc}$ to be $3665\pm17\pm14^{+0}_{-78}$ MeV. We predict the mass of the (isospin-averaged) spin-1/2 $\Omega_{cc}$ to be $3763\pm19\pm26^{+13}_{-79}$ {MeV}. In the bottom sector, our results are also in agreement with experimental observations and other lattice calculations within our statistical and systematic errors. In particular, we find the mass of the $\Omega_b$ to be consistent with the recent CDF measurement. We also predict the mass for the as yet unobserved $\Xi^\prime_b$ to be 5955(27) MeV.Comment: Invited talk at Conference of Computational Physics 2009. 3 page

Cyanobacteria and microalgae in supporting human habitation on Mars

Establishing the first human presence on Mars will be the most technically challenging undertaking yet in the exploration beyond our planet. The remoteness of Mars from Earth, the inhospitable surface conditions including low atmospheric pressure and cold temperatures, and the need for basic resources including water, pose a formidable challenge to this endeavour. The intersection of multiple disciplines will be required to provide solutions for temporary and eventually permanent Martian habitation. This review considers the role cyanobacteria and eukaryotic microalgae (collectively referred to here as ‘microalgae’) may have in supporting missions to the red planet. The current research using these microorganisms in biological life support systems is discussed, with a systematic analysis of their usage in each system conducted. The potential of microalgae to provide astronauts with oxygen, food, bio-polymers and pharmaceuticals is considered. An overview of microalgal experiments in space missions across the last 60 years is presented, and the research exploring the technical challenges of cultivation on Mars is discussed. From these findings, an argument for culturing microalgae in subterranean bioreactors is proposed. Finally, future synthetic biology approaches for enhancing the cyanobacterial/microalgal role in supporting human deep-space exploration are presented. We show that microalgae hold significant promise for providing solutions to many problems faced by the first Martian settlers, however these can only be realised with significant infrastructure and a reliable power source

Truthmakers and modality

This paper attempts to locate, within an actualist ontology, truthmakers for modal truths: truths of the form or . In section 1 I motivate the demand for substantial truthmakers for modal truths. In section 2 I criticise Armstrong’s account of truthmakers for modal truths. In section 3 I examine essentialism and defend an account of what makes essentialist attributions true, but I argue that this does not solve the problem of modal truth in general. In section 4 I discuss, and dismiss, a theistic account of the source of modal truth proposed by Alexander Pruss. In section 5 I offer a means of (dis)solving the problem

Impact of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial

Background: Meningococcal conjugate vaccines protect individuals directly, but also confer herd protection by interrupting carriage transmission. This Phase III observer-blind, randomised, controlled study evaluated the effects of meningococcal quadrivalent (ACWY) glycoconjugate (MenACWY-CRM) or serogroup B (4CMenB) vaccination on meningococcal carriage rates in young adults. Methods: University students (aged 18–24 years) from ten sites in England were randomised to receive two vaccinations one month apart: two doses of Japanese Encephalitis vaccine (controls), two doses of 4CMenB (4CMenB), or one dose of MenACWY-CRM then placebo (MenACWY-CRM). Meningococci were isolated from oropharyngeal swabs collected before vaccination and at five scheduled intervals over one year. Primary analysis was cross-sectional carriage one month after the vaccine course; secondary analyses included comparison of carriage at any time point after primary analysis until study termination. Findings: 2954 subjects were randomised (control, n=987; 4CMenB, n=988; MenACWY-CRM, n=979); approximately one-third of each group was positive for meningococcal carriage at study entry. By one month, there was no significant difference in carriage between controls and 4CMenB (Odds Ratios (OR) [95% CI]; 1·2 [0·8−1·7]) or MenACWY-CRM (OR [95% CI], 0·9 [0·6–1·3]) groups. From three months after dose two, 4CMenB vaccination resulted in significantly lower carriage of any meningococcal strain (calculated efficacy 18·2% [95% CI: 3·4–30·8]) and capsular groups BCWY (calculated efficacy 26·6% [95% CI: 10·5–39·9]) compared to control vaccination. Significantly lower carriage rates were also observed in the MenACWY-CRM group compared with controls: calculated efficacies 39·0% [95%CI: 17·3-55·0] and 36.2% [95%CI: 15·6-51·7] for serogroups Y and CWY, respectively. Interpretation: MenACWY-CRM and 4CMenB vaccines reduced meningococcal carriage rates over 12 months post-vaccination and, therefore, may affect transmission where widely implemented