8,564 research outputs found
The search for Hesperian organic matter on Mars: Pyrolysis studies of sediments rich in sulfur and iron
Jarosite on Mars is of significant geological and astrobiological interest as it forms in acidic aqueous conditions that are potentially habitable for acidophilic organisms. Jarosite can provide environmental context and may host organic matter. The most common analytical technique used to search for organic molecules on the surface of Mars is pyrolysis. However, thermal decomposition of jarosite produces oxygen, which degrades organic signals. At pH values greater than 3 and high water to rock ratios jarosite has a close association with goethite. Hematite can form by dehydration of goethite or directly from jarosite under certain aqueous conditions. Goethite and hematite are significantly more amenable for pyrolysis experiments searching for organic matter than jarosite. Analysis of the mineralogy and organic chemistry of samples from a natural acidic stream revealed a diverse response for organic compounds during pyrolysis of goethite-rich layers but a poor response for jarosite-rich or mixed jarosite-goethite units. Goethite units that are associated with jarosite but do not contain jarosite themselves should be targeted for organic detection pyrolysis experiments on Mars. These findings are extremely timely as future exploration targets for Mars Science Laboratory include Hematite Ridge, which may have formed from goethite precursors
Influence of cultural factors in dynamic trust in automation
The use of autonomous systems has been rapidly increasing in recent decades. To improve human-automation interaction, trust has been closely studied. Research shows trust is critical in the development of appropriate reliance on automation. To examine how trust mediates the human-automation relationships across cultures, the present study investigated the influences of cultural factors on trust in automation. Theoretically guided empirical studies were conducted in the U.S., Taiwan and Turkey to examine how cultural dynamics affect various aspects of trust in automation. The results found significant cultural differences in human trust attitude in automation
A massive reservoir of low-excitation molecular gas at high redshift
Molecular hydrogen is an important component of galaxies because it fuels
star formation and accretion onto AGN, the two processes that generate the
large infrared luminosities of gas-rich galaxies. Observations of spectral-line
emission from the tracer molecule CO are used to probe the properties of this
gas. But the lines that have been studied in the local Universe, mostly the
lower rotational transitions of J = 1-0 and J = 2-1, have hitherto been
unobservable in high-redshift galaxies. Instead, higher transitions have been
used, although the densities and temperatures required to excite these higher
transitions may not be reached by much of the gas. As a result, past
observations may have underestimated the total amount of molecular gas by a
substantial amount. Here we report the discovery of large amounts of
low-excitation molecular gas around the infrared-luminous quasar, APM
08279+5255 at z = 3.91, using the two lowest excitation lines of 12CO (J = 1-0
and J = 2-1). The maps confirm the presence of hot and dense gas near the
nucleus, and reveal an extended reservoir of molecular gas with low excitation
that is 10 to 100 times more massive than the gas traced by higher-excitation
observations. This raises the possibility that significant amounts of
low-excitation molecular gas may lurk in the environments of high-redshift (z >
3) galaxies.Comment: To appear as a Letter to Nature, 4th January 200
Three-dimensional arrangement of elastic fibers in the human corneal stroma
This is the final version of the article. Available from the publisher via the DOI in this record.The cornea is the main refracting lens in the eye. As part of the outer tunic it has to be resilient, a property conferred by the organisation of the constituent collagen. It also has to be sufficiently elastic to regain its exact shape when deformed, in order not to distort the retinal image. The basis of this elasticity is not fully understood. The purpose of this study was to characterise in three dimensions the arrangement and distribution of elastic fibers in the human corneal stroma, using serial block face scanning electron microscopy. We have demonstrated that there exists a complex network of elastic fibers that appear to originate in the sclera or limbus. These appear as elastic sheets in the limbus and peripheral cornea immediately above the trabecular meshwork which itself appears to extend above Descemet's membrane in the peripheral stroma. From these sheets, elastic fibers extend into the cornea; moving centrally they bifurcate and trifurcate into narrower fibers and are concentrated in the posterior stroma immediately above Descemet's membrane. We contend that elastic sheets will play an important role in the biomechanical deformation and recovery of the peripheral cornea. The network may also have practical implications for understanding the structural basis behind a number of corneal surgeries.We would like to thank Dr Anthony Hayes and Mr Derek Scarborough
for help with the histology presented in this study and Dr
Sally Hayes for useful discussions concerning data interpretation.
This work was funded by a Programme Grant (503626) from the
Medical Research Council (to KMM) and an MRC studentship (to
TW). We thank the CTC Eye Bank at Bristol, UK and the HDBR at
Newcastle, UK, for supply of human corneas. The authors have no
conflicts of interest to declare
Outcomes After Total Ankle Replacement in Association With Ipsilateral Hindfoot Arthrodesis.
BACKGROUND: Ipsilateral hindfoot arthrodesis in combination with total ankle replacement (TAR) may diminish functional outcome and prosthesis survivorship compared to isolated TAR. We compared the outcome of isolated TAR to outcomes of TAR with ipsilateral hindfoot arthrodesis. METHODS: In a consecutive series of 404 primary TARs in 396 patients, 70 patients (17.3%) had a hindfoot fusion before, after, or at the time of TAR; the majority had either an isolated subtalar arthrodesis (n = 43, 62%) or triple arthrodesis (n = 15, 21%). The remaining 334 isolated TARs served as the control group. Mean patient follow-up was 3.2 years (range, 24-72 months). RESULTS: The SF-36 total, AOFAS Hindfoot-Ankle pain subscale, Foot and Ankle Disability Index, and Short Musculoskeletal Function Assessment scores were significantly improved from preoperative measures, with no significant differences between the hindfoot arthrodesis and control groups. The AOFAS Hindfoot-Ankle total, function, and alignment scores were significantly improved for both groups, albeit the control group demonstrated significantly higher scores in all 3 scales. Furthermore, the control group demonstrated a significantly greater improvement in VAS pain score compared to the hindfoot arthrodesis group. Walking speed, sit-to-stand time, and 4-square step test time were significantly improved for both groups at each postoperative time point; however, the hindfoot arthrodesis group completed these tests significantly slower than the control group. There was no significant difference in terms of talar component subsidence between the fusion (2.6 mm) and control groups (2.0 mm). The failure rate in the hindfoot fusion group (10.0%) was significantly higher than that in the control group (2.4%; p < 0.05). CONCLUSION: To our knowledge, this study represents the first series evaluating the clinical outcome of TARs performed with and without hindfoot fusion using implants available in the United States. At follow-up of 3.2 years, TAR performed with ipsilateral hindfoot arthrodesis resulted in significant improvements in pain and functional outcome; in contrast to prior studies, however, overall outcome was inferior to that of isolated TAR. LEVEL OF EVIDENCE: Level II, prospective comparative series
Learning outcomes for the education and training of laboratory animal caretakers in South Africa
Education and training is essential for laboratory animal caretakers (LACs), but there are no courses available in South Africa. A national workshop was thus held to collaboratively establish the learning outcomes (LOs) for the education and training (E&T) of LACs. Eighty-five stakeholders from 30 institutions took part in small group discussions interspersed with plenary sessions to draw up the consensus LOs.
One-hundred-and-twenty LOs were identified, grouped into the following three main themes and 15 topics: 1) Focus on animals (animal care and husbandry, animal ethics, animal welfare, basic biology, environment); 2) Focus on humans (administration, health and safety, lifelong learning, professionalism, psychological wellbeing); and 3) Focus on systems (biosecurity, equipment, jurisprudence, logistics, and quality management).
This E&T framework provides a foundation for a career path in the laboratory animal science field. The psychological (i.e. mental and emotional) wellbeing of LACs forms a noteworthy component of the focus on humans, since working with research animals is stressful and coping mechanisms are needed in order to promote compassion satisfaction and prevent compassion fatigue and burnout.
Approximately 75% of the LOs are knowledge-based, while 25% are competencies in practical skills. It is recommended that competencies should be assessed by direct observation of practical/procedural skills, where competence in a procedure or practical task is assessed against predetermined criteria.
These LOs are published with the intent that they will promote animal and human wellbeing, support ethical science, maintain public confidence, and in so doing, contribute to a just and civilised society
A gas-to-particle conversion mechanism helps to explain atmospheric particle formation through clustering of iodine oxides
Emitted from the oceans, iodine-bearing molecules are ubiquitous in the atmosphere and a source of new atmospheric aerosol particles of potentially global significance. However, its inclusion in atmospheric models is hindered by a lack of understanding of the first steps of the photochemical gas-to-particle conversion mechanism. Our laboratory results show that under a high humidity and low HOx regime, the recently proposed nucleating molecule (iodic acid, HOIO2) does not form rapidly enough, and gas-to-particle conversion proceeds by clustering of iodine oxides (IxOy), albeit at slower rates than under dryer conditions. Moreover, we show experimentally that gas-phase HOIO2 is not necessary for the formation of HOIO2-containing particles. These insights help to explain new particle formation in the relatively dry polar regions and, more generally, provide for the first time a thermochemically feasible molecular mechanism from ocean iodine emissions to atmospheric particles that is currently missing in model calculations of aerosol radiative forcing
The quality effects of agency staffing in residential aged care.
OBJECTIVES: In Australia, temporary agency workers are a relatively small but enduring component of the residential aged care workforce. However, evidence from other countries suggests reliance on agency workers has a detrimental effect on the quality of care (QoC). We examined whether QoC outcomes differ for Australian residential aged care facilities (RACFs) based on their reliance on agency care staff. METHODS: A retrospective observational study was conducted using de-identified datasets obtained under the legal authority of the Royal Commission into Aged Care Quality and Safety. Regression analysis was conducted using data comprising 6221 RACF-year observations, across 5âyears (2015-2019), from 1709 unique RACFs in Australia. RESULTS: After controlling for other determinants of QoC, RACFs with a greater reliance on agency care staff have poorer QoC outcomes, with significantly higher rates of complaints, missing persons, reportable assaults, hospitalisations, and accreditation flags. CONCLUSIONS: Consistent with international evidence, we found that the QoC of Australian RACFs is sensitive to the reliance on agency staff in delivering direct care to residents. These findings illustrate the importance of workers' employment conditions, alongside other workforce characteristics, in driving the quality of residential aged care
Household vacuum cleaners vs. the high-volume surface sampler for collection of carpet dust samples in epidemiologic studies of children
<p>Abstract</p> <p>Background</p> <p>Levels of pesticides and other compounds in carpet dust can be useful indicators of exposure in epidemiologic studies, particularly for young children who are in frequent contact with carpets. The high-volume surface sampler (HVS3) is often used to collect dust samples in the room in which the child had spent the most time. This method can be expensive and cumbersome, and it has been suggested that an easier method would be to remove dust that had already been collected with the household vacuum cleaner. However, the household vacuum integrates exposures over multiple rooms, some of which are not relevant to the child's exposure, and differences in vacuuming equipment and practices could affect the chemical concentration data. Here, we compare levels of pesticides and other compounds in dust from household vacuums to that collected using the HVS3.</p> <p>Methods</p> <p>Both methods were used in 45 homes in California. HVS3 samples were collected in one room, while the household vacuum had typically been used throughout the home. The samples were analyzed for 64 organic compounds, including pesticides, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls (PCBs), using GC/MS in multiple ion monitoring mode; and for nine metals using conventional microwave-assisted acid digestion combined with ICP/MS.</p> <p>Results</p> <p>The methods agreed in detecting the presence of the compounds 77% to 100% of the time (median 95%). For compounds with less than 100% agreement, neither method was consistently more sensitive than the other. Median concentrations were similar for most analytes, and Spearman correlation coefficients were 0.60 or higher except for allethrin (0.15) and malathion (0.24), which were detected infrequently, and benzo(k)fluoranthene (0.55), benzo(a)pyrene (0.55), PCB 105 (0.54), PCB 118 (0.54), and PCB 138 (0.58). Assuming that the HVS3 method is the "gold standard," the extent to which the household vacuum cleaner method yields relative risk estimates closer to unity by increasing random measurement error varies by compound and depends on the method used to calculate relative risk.</p> <p>Conclusion</p> <p>The household vacuum cleaner method appears to be a reasonable alternative to the HVS3 for detecting, ranking, and quantifying the concentrations of pesticides and other compounds in carpet dust.</p
âClinics arenât meant for menâ: Sexual health care access and seeking behaviours among men in Gauteng province, South Africa
Men may be key players in the transmission of sexually transmitted infections (STI), and it is important that STI/HIV health services reach men. The objective of this study was to explore sexual health care access and seeking behaviours in men. This study used focus groups to examine sexual health care access and seeking behaviours in men 5 years after implementation of free antiretroviral therapy (ART) in the South African public sector. Six focus groups (N=58) were conducted with men â„18 years in an urban area of Gauteng province. Men were recruited from various locations throughout the community. Men reported several barriers and facilitators to the use of public and private clinics for sexual health services including HIV testing, and many men reported seeking care from traditional healers. Men often viewed public clinics as a place for women and reported experiences with some female nurses who were rude or judgmental of the men. Additionally, some men reported that they sought sexual health care services at public clinics; however, they were not given physical examinations by health care providers to diagnose their STI syndrome. Most men lacked knowledge about ART and avoided HIV testing because of fear of death or being abandoned by their families or friends. Study findings suggest that men still require better access to high-quality, non-judgmental sexual health care services. Future research is needed to determine the most effective method to increase menâs access to sexual health care services.Keywords: sexual health care access, men.Les hommes peuvent ĂȘtre des responsables dans la transmission des infections sexuellement transmissibles (IST), et il est important que les services de santĂ© des IST/VIH les sensibilisent (les hommes). Les objectifs de cette Ă©tude Ă©taient dâexaminer lâaccĂšs aux soins de santĂ© et les comportements sexuels des hommes pendant 5 ans aprĂšs la mise en oeuvre de la thĂ©rapie antirĂ©trovirale (ART) gratuite dans le secteur public Sud-Africain. Six groups dâhommes ĂągĂ©s â„18 ans (N=58) ont menĂ©s des discussions dans la zone urbaine de la province de Gauteng. Ces hommes sont recrutĂ©s dans divers endroits dans toute la communautĂ©. Ils ont dĂ©clarĂ©s rencontrĂ©s des obstacles et facilitateurs Ă lâaccĂšs des cliniques publiques et privĂ©es des services de santĂ© sexuelle, y compris le test du VIH, et beaucoup dâhommes dĂ©clarent ĂȘtre Ă la recherche de soins vers des guĂ©risseurs traditionnels. Les hommes ont souvent vu les cliniques publiques comme des endroits pour les femmes et se sont souvent plaint des expĂ©riences quâils ont eues par rapport aux infirmiĂšres qui ont un mauvais jugement sur eux. Certains dâentre eux ont dĂ©clarĂ© quâils cherchaient des soins de santĂ© dans les cliniques publiques, mais quâils nâĂ©taient pas soumis Ă des examens physiques pour diagnostiquer leurs syndrome dâIST. La plupart dâentre eux nâavaient pas de connaissances de lâART et Ă©vitent le test du VIH parce quâils ont peur de la mort ou dâĂȘtre abandonnĂ© par leurs familles ou leurs amis. Cette Ă©tude suggĂšre que les hommes doivent exiger de meilleures qualitĂ©s de soins, un non-jugement des services de santĂ© sexuelle. Les recherches futures sont nĂ©cessaires pour dĂ©terminer la mĂ©thode la plus efficace dâaccroitre lâaccĂšs des hommes aux services de santĂ© sexuelle
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