Supporting the Academic Library Workforce: Updates from the Canadian Association of Research Libraries

The Canadian Association of Research Libraries (CARL) has invested significant energy over the last 20 years in building workforce capacity across the country’s academic libraries. The global pandemic has given this work a whole new intensity as directors find themselves seeking to fill large numbers of vacancies in a highly competitive market, to encourage more candidates from equity-deserving groups to apply, to prepare both new and long-serving staff members to take on new kinds of work, and to create workplace environments that encourage staff to stay. This paper will update the international community on a number of CARL initiatives that are collectively building the national understanding and approach to library workforce capacity. Most notably, the paper will introduce the new Competencies for Librarians in Canadian Research Libraries (September 2020) which aims to help with both personal and organizational goal setting, recruitment and professional development. The paper will also describe the national Diversity and Inclusion Survey conducted in partnership with the Canadian Centre for Diversity and Inclusion (CCDI) to better understand both the demographics of the CARL workforce and how individuals from various equity-deserving groups experience that workplace. The paper will document the dramatic increase in the number and engagement in professional learning and development opportunities for staff in Canadian research libraries, from webinars and symposiums to community calls and cross-Canada coffee chats. Finally, the paper will demonstrate the use of a logic model as envisioned by CARL’s Library Impact Framework Working Group, as a strategy for an individual library to visualize the impact of its various efforts on welcoming and retaining new staff

Preparing the Academic Library Workforce to Support 21st Century Learners: New Approaches from Canada

CARL has invested significant energy over the last 20 years in building workforce capacity across Canadian academic libraries. The Association has consistently focused its attention on areas where demand felt greatest and where collective, national action made sense. The “CARL approach” has been strategic, focused on community building and reflective of a peer-to-peer model. Much progress has been made in recent years to help the nation’s academic library workforce develop their professional expertise and, in doing so, better meet the expectations of 21st Century learners. Most notably, Canadian research libraries are drafting a contemporary slate of competencies for librarians; enhancing their focus on diversity, equity & inclusion; and shaping new leadership development opportunities for the most senior staff

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer.

BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood. This prospective trial evaluated the direct immune effects of systemically administered sipuleucel-T on prostatic cancer tissue in the preoperative setting.MethodsPatients with untreated localized prostate cancer were treated on an open-label Phase II study of sipuleucel-T prior to planned radical prostatectomy (RP). Immune infiltrates in RP specimens (posttreatment) and in paired pretreatment biopsies were evaluated by immunohistochemistry (IHC). Correlations between circulating immune response and IHC were assessed using Spearman rank order.ResultsOf the 42 enrolled patients, 37 were evaluable. Adverse events were primarily transient, mild-to-moderate and infusion related. Patients developed T cell proliferation and interferon-γ responses detectable in the blood following treatment. Furthermore, a greater-than-three-fold increase in infiltrating CD3(+), CD4(+) FOXP3(-), and CD8(+) T cells was observed in the RP tissues compared with the pretreatment biopsy (binomial proportions: all P < .001). This level of T cell infiltration was observed at the tumor interface, and was not seen in a control group consisting of 12 concurrent patients who did not receive any neoadjuvant treatment prior to RP. The majority of infiltrating T cells were PD-1(+) and Ki-67(+), consistent with activated T cells. Importantly, the magnitude of the circulating immune response did not directly correlate with T cell infiltration within the prostate based upon Spearman's rank order correlation.ConclusionsThis study is the first to demonstrate a local immune effect from the administration of sipuleucel-T. Neoadjuvant sipuleucel-T elicits both a systemic antigen-specific T cell response and the recruitment of activated effector T cells into the prostate tumor microenvironment

Effects of Auditory Cueing on Cadence and Gait Pattern

A large portion of the population participate in gait rehabilitation, especially those with conditions such as increased fall risk such as stroke, or Parkinson’s Disease. Some studies have shown that auditory cues help improve gait and reduce fall risk, but relationship with gait patterns is missing. In this study, eight participants walked at their preferred cadence and at increased and reduced cadence by 20%. We found that step length and step width were not significantly different in all walking conditions. Decreased cadence resulted in an increase of swing time, stance time, stride time, and stance to swing ratio, and a decrease in stride length. Increased cadence resulted in a decrease in stance time, stride time, swing time, and stance to swing ratio, and an increase in stride length. The results suggest there is a strong correlation between auditory cues and gait patterns that can improve rehabilitative processes in the future

Aerobiology over Antarctica – a new initiative for atmospheric ecology

The role of aerial dispersal in shaping patterns of biodiversity remains poorly understood, mainly due to a lack of coordinated efforts in gathering data at appropriate temporal and spatial scales. It has been long known that the rate of dispersal to an ecosystem can significantly influence ecosystem dynamics, and that aerial transport has been identified as an important source of biological input to remote locations. With the considerable effort devoted in recent decades to understanding atmospheric circulation in the south-polar region, a unique opportunity has emerged to investigate the atmospheric ecology of Antarctica, from regional to continental scales. This concept note identifies key questions in Antarctic microbial biogeography and the need for standardized sampling and analysis protocols to address such questions. A consortium of polar aerobiologists is established to bring together researchers with a common interest in the airborne dispersion of microbes and other propagules in the Antarctic, with opportunities for comparative studies in the Arctic

K 1-6: an asymmetric planetary nebula with a binary central star

We present new imaging data and archival multiwavelength observations of the little studied emission nebula K 1-6 and its central star. Narrow-band images in H-alpha (+ [NII]) and [OIII] taken with the Faulkes Telescope North reveal a stratified, asymmetric, elliptical nebula surrounding a central star which has the colours of a late G- or early K-type subgiant or giant. GALEX ultraviolet images reveal a very hot subdwarf or white dwarf coincident in position with this star. The cooler, optically dominant star is strongly variable with a period of 21.312 +/- 0.008 days, and is possibly a high amplitude member of the RS CVn class, although an FK Com classification is also possible. Archival ROSAT data provide good evidence that the cool star has an active corona. We conclude that K 1-6 is most likely an old bona fide planetary nebula at a distance of ~1.0 kpc, interacting with the interstellar medium, and containing a binary or ternary central star. The observations and data analyses reported in this paper were conducted in conjunction with Year 11 high school students as part of an Australian Research Council Linkage Grant science education project, denoted Space To Grow, conducted jointly by professional astronomers, educational researchers, teachers, and high-school students.Comment: 13 pages, 5 figures, accepted by the Publications of the Astronomical Society of Australia (PASA

Characterization of five members of the actin gene family in the sea urchin

Hybridization of an actin cDNA clone (pSA38) to restriction enzyme digests of Strongylocentrotus purpuratus DNA indicates that the sea urchin genome contains at least five different actin genes. A sea urchin genomic clone library was screened for recombinants which hydridize to pSA38 and four genomic clones were isolated. Restriction maps were generated which indicate that three of these recombinants contain different actin genes, and that the fourth may be an allele to one of these. The restriction maps suggest that one clone contains two linked actin genes. This fact, which was confirmed by heteroduplex analysis, indicates that the actin gene family may be clustered. The linked genes are oriented in the same direction and spaced about 8.0 kilobases apart. In heteroduplexes between genomic clones two intervening sequences were seen. Significant homology is confined to the actin coding region and does not include any flanking sequence. Southern blot analysis reveals that repetitive DNA sequences are found in the region of the actin genes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24164/1/0000422.pd

Columbus State University Honors College: Senior Theses, Fall 2020/Spring 2021

This is a collection of senior theses written by honors students at Columbus State University during the Fall 2020 and Spring 2021 semesters.https://csuepress.columbusstate.edu/honors_theses/1002/thumbnail.jp