PROPOSED LEGISLATION: It\u27s Time to Abolish Dower and Curtesy In Virginia

In its deliberations during 1966 and 1967 regarding estates of decedents, the Virginia Advisory Legislative Council gave particular consideration to the advisability of abolishing the contingent rights of dower and curtesy in Virginia. The VALC had to determine what interests, if any, should be reserved to the surviving consort, and whether the distinction between real and personal property in intestate succession should be abolished

Modulation of Natural Killer Cell Cytotoxicity in Human Cytomegalovirus Infection: The Role of Endogenous Class I Major Histocompatibility Complex and a Viral Class I Homolog

Natural killer (NK) cells have been implicated in early immune responses against certain viruses, including cytomegalovirus (CMV). CMV causes downregulation of class I major histocompatibility complex (MHC) expression in infected cells; however, it has been proposed that a class I MHC homolog encoded by CMV, UL18, may act as a surrogate ligand to prevent NK cell lysis of CMV-infected cells. In this study, we examined the role of UL18 in NK cell recognition and lysis using fibroblasts infected with either wild-type or UL18 knockout CMV virus, and by using cell lines transfected with the UL18 gene. In both systems, the expression of UL18 resulted in the enhanced killing of target cells. We also show that the enhanced killing is due to both UL18-dependent and -independent mechanisms, and that the killer cell inhibitory receptors (KIRs) and CD94/NKG2A inhibitory receptors for MHC class I do not play a role in affecting susceptibility of CMV-infected fibroblasts to NK cell–mediated cytotoxicity

A Phase 1b Study of Humanized Ks-Interleukin-2 (Huks-Il2) Immunocytokine with Cyclophosphamide in Patients with Epcam-Positive Advanced Solid Tumors

BackgroundHumanized KS-interleukin-2 (huKS-IL2), an immunocytokine with specificity for epithelial cell adhesion molecule (EpCAM), has demonstrated favorable tolerability and immunologic activity as a single agent.MethodsPhase 1b study in patients with EpCAM-positive advanced solid tumors to determine the maximum tolerated dose (MTD) and safety profile of huKS-IL2 in combination with low-dose cyclophosphamide. Treatment consisted of cyclophosphamide (300mg/m2 on day 1), and escalating doses of

The role of the two splice variants and extranuclear pathway on Ki-67 regulation in non-cancer and cancer cells

Ki-67 is a nuclear protein that has been used in cancer diagnostic because of its specific cell-cycle dependent expression profile. After quantifying and characterising the expression level of Ki-67, as a function of the cell cycle, we found out that the two main splice variants of the protein (i.e. α and β) are differently regulated in non-cancerous and cancerous cells both at mRNA and protein level. We were able to correlate the presence of the α variant of the protein with the progression through the interphase of cell cycle. We also observed that the different expression profiles correspond to different degradation pathways for non-cancerous and cancerous cells. Furthermore, Ki-67 is continuously regulated and degraded via proteasome system in both cell types, suggesting an active control of the protein. However we also observed a putative extranuclear elimination pathway of Ki-67 where it is transported to the Golgi apparatus. Our evidence in the different expression of the splice variants may represent a milestone for the development of new targets for cancer diagnostic and prognostic. Additionally, the unexpected extranuclear elimination of Ki-67 strongly suggests that this protein must be looked at also outside of the "nuclear box", as thought to date

Monsters and Heroes: The Ironies of Black Subjectivity in Stephen Crane’s The Monster and Richard Wright’s The Man Who Lived Underground

Cette analyse associe le concept d’africanismes américains élaboré par Toni Morrison à celui d’ironie discursive proposé par Clyde Taylor pour examiner comment la présence symbolique du monstre apparaît dans le roman court de Stephen Crane intitulé The Monster et comment il réapparait sous une forme différente dans celui de Richard Wright intitulé The Man Who Lived Underground. Crane et Wright ont le projet commun de proposer une construction des concepts de race, d'identité et de représentation à travers le personnage du monstre, mais leurs visions s'opposent en raison de leurs origines culturelles. Je pose alors la question suivante : dans quelle mesure les origines culturelles peuvent-elles orienter la réception des images littéraires et influencer la manière de présenter ces images dans la littérature américaine ? J'observe la tendance des écrivains noirs américains à critiquer et parodier les définitions de race, d'identité et de représentation des écrivains blancs américains en étudiant précisément cette interaction, par une lecture croisée des textes de Crane et de Wright. Le choix de sensibilités littéraires noire et blanche reflète également la diversité et le brassage culturels qui ont marqué et enrichi ce pays. Ce qui m'y intéresse, ce sont d'ailleurs les dichotomies raciales et la manière dont "L'Afrique" et le "peuple africain" vivant aux Etats-Unis sont associés à ces connotations raciales

Replacing the Social Security Tax with a Value-Added Tax: Policy Perspectives

On October 22, 1979, Representative Al Ullman (D-Ore.), then Chairman of the House Ways and Means Committee, introduced the Tax Restructuring Act of 1979, which would have lowered the rates of the individual income, corporate income and social security taxes along with certain other tax benefits and would have replaced the lost revenues from such reductions with the revenues from a 10% value-added tax (VAT). The introduction of the bill followed a speech delivered by Sen. Russell B. Long (D-La.), then Chairman of the Senate Finance Committee, at the 1978 Tulane Tax Institute, in which he advocated an overhaul of the tax system similar to the proposals contained in Ullman\u27s bill. Although there was nothing particularly novel in the proposals of Long and Ullman, the mere fact that the two members of Congress with the most influence over tax legislation were advocating a major overhaul of the entire tax system was enough to spark a lively debate on the merits of substituting a value-added tax for part or all of the components making up the present federal tax system in the United States

Phytoplankton, Zooplankton, Macrobenthos and lchthyoplankton Abundance, Biomass and Species Composition in Onondaga Lake, 1994

Once a pristine recreational center and a productive fishery that supplied New York City markets with fresh fish, Onondaga Lake is now considered one of the most badly degraded bodies of water in the entire world (Sage 1993). The Onondaga Lake Management Conference was established to develop a comprehensive restoration, conservation, and management plan for Onondaga Lake that recommends priority corrective actions and a compliance schedule for cleanup of the lake. Biological assessment of the lake has been infrequent and concentrated on a few biological groups. This study either updates or establishes baseline characteristics for the following biological components of the Onondaga Lake ecosystem: phytoplankton, zooplankton, ichthyoplankton and macrobenthos