Asynchronous Variational Integrators

We describe a new class of asynchronous variational integrators (AVI) for nonlinear elastodynamics. The AVIs are distinguished by the following attributes: (i) The algorithms permit the selection of independent time steps in each element, and the local time steps need not bear an integral relation to each other; (ii) the algorithms derive from a spacetime form of a discrete version of Hamilton’s variational principle. As a consequence of this variational structure, the algorithms conserve local momenta and a local discrete multisymplectic structure exactly. To guide the development of the discretizations, a spacetime multisymplectic formulation of elastodynamics is presented. The variational principle used incorporates both configuration and spacetime reference variations. This allows a unified treatment of all the conservation properties of the system.A discrete version of reference configuration is also considered, providing a natural definition of a discrete energy. The possibilities for discrete energy conservation are evaluated. Numerical tests reveal that, even when local energy balance is not enforced exactly, the global and local energy behavior of the AVIs is quite remarkable, a property which can probably be traced to the symplectic nature of the algorith

A Study of Gaussianity in CMB band maps

The detection of non-Gaussianity in the CMB data would rule out a number of inflationary models. A null detection of non-Gaussianity, instead, would exclude alternative models for the early universe. Thus, a detection or non-detection of primordial non-Gaussianity in the CMB data is crucial to discriminate among inflationary models, and to test alternative scenarios. However, there are various non-cosmological sources of non-Gaussianity. This makes important to employ different indicators in order to detect distinct forms of non-Gaussianity in CMB data. Recently, we proposed two new indicators to measure deviation from Gaussianity on large angular scales, and used them to study the Gaussianity of the raw band WMAP maps with and without the KQ75 mask. Here we extend this work by using these indicators to perform similar analyses of deviation from Gaussianity of the foreground-reduced Q, V, and W band maps. We show that there is a significant deviation from Gaussianity in the considered full-sky maps, which is reduced to a level consistent with Gaussianity when the KQ75 mask is employed.Comment: 5 pages, 2 PS figures, uses ws-ijmpd.cls ; to be published in the International Journal of Modern Physics

Non-Gaussianity in the HILC foreground-reduced three-year WMAP CMB map

A detection or nondetection of primordial non-Gaussianity in the CMB data is essential not only to test alternative models of the physics of the early universe but also to discriminate among classes of inflationary models. Given this far reaching consequences of such a non-Gaussianity detection for our understanding of the physics of the early universe, it is important to employ alternative indicators in order to have further information about the Gaussianity features of CMB that may be helpful for identifying their origins. In this way, a considerable effort has recently gone into the design of non-Gaussianity indicators, and in their application in the search for deviation from Gaussianity in the CMB data. Recently we have proposed two new large-angle non-Gaussianity indicators which provide measures of the departure from Gaussianity on large angular scales. We have used these indicators to carry out analyses of Gaussianity of the single frequency bands and of the available foreground-reduced {\it five-year} maps with and without the KQ75 mask. Here we extend and complement these studies by performing a new analysis of deviation from Gaussianity of the {\it three-year} harmonic ILC (HILC) foreground-reduced full-sky and KQ75 masked maps obtained from WMAP data. We show that this full-sky foreground-reduced maps presents a significant deviation from Gaussianity, which is brought down to a level of consistency with Gaussianity when the KQ75 mask is employed.Comment: 6 pages, 1 figure. To appear in IJMPD (2010). V2: Corrected ref.[8]

Effective cohesive behavior of layers of interatomic planes

A simple model of cleavage in brittle crystals consists of a layer of material containing N atomic planes separating in accordance with an interplanar potential under the action of an opening displacement delta prescribed on the boundary of the layer. The problem addressed in this work concerns the characterization of the constrained minima of the energy E-N of the layer as a function of delta as N becomes large. These minima determine the effective or macroscopic cohesive law of the crystal. The main results presented in this communication are: (i) the computation of the Gamma limit E-0 of E-N as N -> infinity; (ii) the characterization of the minimum values of E-0 as a function of the macroscopic opening displacement; (iii) a proof of uniform convergence of the minima of E-N for the case of nearest-neighbor interactions; and (iv) a proof of uniform convergence of the derivatives of E-N, or tractions, in the same case. The scaling on which the present Gamma-convergence analysis is based has the effect of separating the bulk and surface contributions to the energy. It differs crucially from other scalings employed in the past in that it renders both contributions of the same order

The Midpoint Rule as a Variational--Symplectic Integrator. I. Hamiltonian Systems

Numerical algorithms based on variational and symplectic integrators exhibit special features that make them promising candidates for application to general relativity and other constrained Hamiltonian systems. This paper lays part of the foundation for such applications. The midpoint rule for Hamilton's equations is examined from the perspectives of variational and symplectic integrators. It is shown that the midpoint rule preserves the symplectic form, conserves Noether charges, and exhibits excellent long--term energy behavior. The energy behavior is explained by the result, shown here, that the midpoint rule exactly conserves a phase space function that is close to the Hamiltonian. The presentation includes several examples.Comment: 11 pages, 8 figures, REVTe

Out of Place, Out of Mind: Schema-Driven False Memory Effects for Object-Location Bindings

Events consist of diverse elements, each processed in specialized neocortical networks, with temporal lobe memory systems binding these elements to form coherent event memories. We provide a novel theoretical analysis of an unexplored consequence of the independence of memory systems for elements and their bindings, 1 that raises the paradoxical prediction that schema-driven false memories can act solely on the binding of event elements despite the superior retrieval of individual elements. This is because if 2, or more, schema-relevant elements are bound together in unexpected conjunctions, the unexpected conjunction will increase attention during encoding to both the elements and their bindings, but only the bindings will receive competition with evoked schema-expected bindings. We test our model by examining memory for object-location bindings in recognition (Study 1) and recall (Studies 2 and 3) tasks. After studying schema-relevant objects in unexpected locations (e.g., pan on a stool in a kitchen scene), participants who then viewed these objects in expected locations (e.g., pan on stove) at test were more likely to falsely remember this object-location pairing as correct, compared with participants that viewed a different unexpected object-location pairing (e.g., pan on floor). In recall, participants were more likely to correctly remember individual schema-relevant objects originally viewed in unexpected, as opposed to expected locations, but were then more likely to misplace these items in the original room scene to expected places, relative to control schema-irrelevant objects. Our theoretical analysis and novel paradigm provide a tool for investigating memory distortions acting on binding processes

A new web-based genomics resource for bioinformatics analysis of Rhipicephalus (Boophilus) microplus: CattleTickBase

No abstract availabl

Radiation Testing and Evaluation Issues for Modern Integrated Circuits

Abstract. Changes in modern integrated circuit (IC) technologies have modified the way we approach and conduct radiation tolerance and testing of electronics. These changes include scaling of geometries, new materials, new packaging technologies, and overall speed and device complexity challenges. In this short course section, we will identify and discuss these issues as they impact radiation testing, modeling, and effects mitigation of modern integrated circuits. The focus will be on CMOS-based technologies, however, other high performance technologies will be discussed where appropriate. The effects of concern will be: Single-Event Effects (SEE) and steady state total ionizing dose (TID) IC response. However, due to the growing use of opto-electronics in space systems issues concerning displacement damage testing will also be considered. This short course section is not intended to provide detailed "how-to-test" information, but simply provide a snapshot of current challenges and some of the approaches being considered

Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

Photoimmunotherapy (PIT) of cancer utilizes tumor-specific monoclonal antibodies conjugated to a photosensitizer phthalocyanine dye IR700 which becomes cytotoxic upon irradiation with near infrared light. In this study, we aimed to evaluate the efficacy of PIT on human pancreatic cancer cells in vitro and in vivo in an orthotopic nude mouse model. The binding capacity of anti-CEA antibody to BxPC-3 human pancreatic cancer cells was determined by FACS analysis. An in vitro cytotoxicity assay was used to determine cell death following treatment with PIT. For in vivo determination of PIT efficacy, nude mice were orthotopically implanted with BxPC-3 pancreatic tumors expressing green fluorescent protein (GFP). After tumor engraftment, the mice were divided into two groups: (1) treatment with anti-CEA-IR700 + 690 nm laser and (2) treatment with 690 nm laser only. Anti-CEA-IR700 (100 μg) was administered to group (1) via tail vein injection 24 hours prior to therapy. Tumors were then surgically exposed and treated with phototherapy at an intensity of 150 mW/cm2 for 30 minutes. Whole body imaging was done subsequently for 5 weeks using an OV-100 small animal imaging system. Anti-CEA-IR700 antibody bound to the BxPC3 cells to a high degree as shown by FACS analysis. Anti-CEA-IR700 caused extensive cancer cell killing after light activation compared to control cells in cytotoxicity assays. In the orthotopic models of pancreatic cancer, the anti-CEA-IR700 group had significantly smaller tumors than the control after 5 weeks (p<0.001). There was no significant difference in the body weights of mice in the anti-CEA-IR700 and control groups indicating that PIT was well tolerated by the mice

Microarray evidence for off target effects in tick RNA interference experiments, and the lack of strong correlation between DSRNA and antibody phenotypes in tick In vitro treatments for vaccine candidate screening

No abstract availabl