671 research outputs found
A Bayesian approach to the estimation of maps between riemannian manifolds
Let \Theta be a smooth compact oriented manifold without boundary, embedded
in a euclidean space and let \gamma be a smooth map \Theta into a riemannian
manifold \Lambda. An unknown state \theta \in \Theta is observed via
X=\theta+\epsilon \xi where \epsilon>0 is a small parameter and \xi is a white
Gaussian noise. For a given smooth prior on \Theta and smooth estimator g of
the map \gamma we derive a second-order asymptotic expansion for the related
Bayesian risk. The calculation involves the geometry of the underlying spaces
\Theta and \Lambda, in particular, the integration-by-parts formula. Using this
result, a second-order minimax estimator of \gamma is found based on the modern
theory of harmonic maps and hypo-elliptic differential operators.Comment: 20 pages, no figures published version includes correction to eq.s
31, 41, 4
Semiclassical treatment of fusion processes in collisions of weakly bound nuclei
We describe a semiclassical treatment of nuclear fusion reactions involving
weakly bound nuclei. In this treatment, the complete fusion probabilities are
approximated by products of two factors: a tunneling probability and the
probability that the system is in its ground state at the strong absorption
radius. We investigate the validity of the method in a schematic two-channel
application, where the channels in the continuum are represented by a single
resonant state. Comparisons with full coupled-channels calculations are
performed. The agreement between semiclassical and quantal calculations isquite
good, suggesting that the procedure may be extended to more sophisticated
discretizations of the continuum.Comment: 11 pages, 5 figure
Recommended from our members
Mandatory Spending Since 1962
Mandatory spending includes federal government spending on entitlement programs as well as other budget outlays controlled by laws other than appropriation acts. Entitlement programs such as Social Security and Medicare make up the bulk of mandatory spending. This report looks at mandatory spending and how it has grown over time relative to total federal spending and the size of the U.S. economy. It also analyzes future mandatory spending levels and how they are projected to impact the federal budget
Coherent optical control of correlation waves of spins in semiconductors
We calculate the dynamical fluctuation spectrum of electronic spins in a
semiconductor under a steady-state illumination by light containing
polarization squeezing correlations. Taking into account quasi-particle
lifetime and spin relaxation for this non-equilibrium situation we consider up
to fourth order optical effects which are sensitive to the squeezing phases.
We demonstrate the possibility to control the spin fluctuations by optically
modulating these phases as a function of frequency, leading to a non-Lorentzian
spectrum which is very different from the thermal equilibrium fluctuations in
n-doped semiconductors. Specifically, in the time-domain spin-spin correlation
can exhibit time delays and sign flips originating from the phase modulations
and correlations of polarizations, respectively. For higher light intensity we
expect a regime where the squeezing correlations will dominate the spectrum.Comment: 17 pages, 8 figure
TEM Study of Precipitation in a NiAl-3Ti-0.5Hf Single-Crystal Alloy
Samples for transmission electron microscopy (TEM) were prepared from 3 mm diameter cylinders electro-discharge machined from the heat-treated ingots. Slices sectioned from the cylinders were mechanically ground and electrochemically thinned in a twinjet Tenupol-3 polisher. Microstructural and energy-dispersive X-ray spectroscopy (EDXS) studies were conducted in a Philips 400T TEM equipped with a double tilt goniometer and a KEVEX Si/Li X-ray detector
Limitation of energy deposition in classical N body dynamics
Energy transfers in collisions between classical clusters are studied with
Classical N Body Dynamics calculations for different entrance channels. It is
shown that the energy per particle transferred to thermalised classical
clusters does not exceed the energy of the least bound particle in the cluster
in its ``ground state''. This limitation is observed during the whole time of
the collision, except for the heaviest system.Comment: 13 pages, 15 figures, 1 tabl
Addition Spectra of Chaotic Quantum Dots: Interplay between Interactions and Geometry
We investigate the influence of interactions and geometry on ground states of
clean chaotic quantum dots using the self-consistent Hartree-Fock method. We
find two distinct regimes of interaction strength: While capacitive energy
fluctuations follow approximately a random matrix prediction for
weak interactions, there is a crossover to a regime where is
strongly enhanced and scales roughly with interaction strength. This
enhancement is related to the rearrangement of charges into ordered states near
the dot edge. This effect is non-universal depending on dot shape and size. It
may provide additional insight into recent experiments on statistics of Coulomb
blockade peak spacings.Comment: 4 pages, final version to appear in Phys. Rev. Let
Quality quantification model of basic raw materials
Basic raw materials belong to the key input sources in the production of pig iron. The properties of basic raw materials can be evaluated using a variety of criteria. The essential ones include the physical and chemical properties. Current competitive pressures, however, force the producers of iron more and more often to include cost and logistic criteria into the decision-making process. In this area, however, they are facing a problem of how to convert a variety of vastly different parameters into one evaluation indicator in order to compare the available raw materials. This article deals with the analysis of a model created to evaluate the basic raw materials, which was designed as part of the research
ΠΡΠΎΡΠ΅Π΄ΡΡΠ½Π°Ρ ΡΠ΅Π΄Π°ΡΠΈΡ ΠΈ/ΠΈΠ»ΠΈ Π°Π½Π°Π»ΡΠ³Π΅Π·ΠΈΡ: ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
ΠΠΠ’Π£ΠΠΠ¬ΠΠΠ‘Π’Π¬: ΠΠ° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ½Π°Ρ ΡΠ΅Π΄Π°ΡΠΈΡ ΠΈ/ΠΈΠ»ΠΈ Π°Π½Π°Π»ΡΠ³Π΅Π·ΠΈΡ (ΠΠ‘/ΠΠ‘Π) ΡΡΠ°Π»Π° ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΡΡ ΡΒ ΡΠ΅Π»ΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈΒ ΠΌΠ°Π»ΠΎΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ² Π²ΠΎ Π²Π½Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ Π²Β Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΏΠΎ ΠΠ‘/ΠΠ‘Π ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ²ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ Π²Β ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ, ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ, ΡΠΈΡΠΊΠΎΠ² ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ, Π±Π°Π·ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΠΈΒ ΡΠ΅Π»Π΅Π²ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ ΡΠ΅Π΄Π°ΡΠΈΠΈ (Π¦Π£Π‘). Π¦ΠΠΠ¬ ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ―: ΠΡΠΎΠ²Π΅ΡΡΠΈ Π°Π½Π°Π»ΠΈΠ· ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΡ
ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ, ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ (Π ΠΠ), ΠΎΠ±Π·ΠΎΡ Π΄Π°Π½Π½ΡΡ
Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈΒ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ Π΄Π°Π½Π½ΡΠ΅ ΠΎΒ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π΄Π°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈΒ Π½Π°ΡΠΊΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠΎΠ² Π²Β ΡΠ°ΠΌΠΊΠ°Ρ
ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ½ΠΎΠΉ ΡΠ΅Π΄Π°ΡΠΈΠΈ. ΠΠΠ’ΠΠ ΠΠΠΠ« Π ΠΠΠ’ΠΠΠ«: ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΏΠΎΠΈΡΠΊ Π²Β ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ
Π±Π°Π·Π°Ρ
PubMed, Medline, Embase, eLibrary ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΏΠΎ ΠΠ‘/ΠΠ‘Π, Π ΠΠ ΠΈΒ ΡΡΠ°ΡΠ΅ΠΉ. Π ΠΠΠ£ΠΠ¬Π’ΠΠ’Π«: ΠΒ ΠΎΠ±Π·ΠΎΡΠ΅ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΎΠΏΠΈΡΠ°Π½Ρ ΡΡΠΎΠ²Π½ΠΈ ΡΠ΅Π΄Π°ΡΠΈΠΈ Π²Β ΠΏΠΎΡΡΠ΄ΠΊΠ΅ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π½ΠΈΡ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΒ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½Π°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΏΠ΅ΡΠ²ΠΎΠΉ ΠΈΒ Π²ΡΠΎΡΠΎΠΉ Π»ΠΈΠ½ΠΈΠΈ Π΄Π»Ρ ΡΠ΅Π΄Π°ΡΠΈΠΈ ΠΈΒ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°Π½ΠΈΡ. Π‘ΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½Ρ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡ ΠΊΒ ΠΏΠ΅ΡΠΈΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌΡ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Ρ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎ Π²Π°ΠΆΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, ΡΡΠΎΠ²Π½Ρ ΡΠ΅Π΄Π°ΡΠΈΠΈ ΠΈΒ Π±ΠΎΠ»ΠΈ. ΠΠ«ΠΠΠΠ«: ΠΠ‘/ΠΠ‘Π Π²Β ΠΏΠ»Π°Π½ΠΎΠ²ΠΎΠΌ ΠΈΠ»ΠΈ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½ΠΎΠΌ ΠΏΠΎΡΡΠ΄ΠΊΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΠ΅, ΠΊΠΎΠΌΡΠΎΡΡΠ½ΠΎΠ΅ ΠΈΒ ΡΡΠΏΠ΅ΡΠ½ΠΎΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈΒ ΠΌΠ°Π»ΠΎΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ². ΠΡΠΈΠ½ΡΠΈΠΏΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈΒ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ΅Π΄Π°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΒ Π½Π°ΡΠΊΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠ°ΠΌΠΈ Π»Π΅ΠΆΠ°Ρ Π²Β ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡ
Π΅ΠΌ ΡΠ΅Π΄Π°ΡΠΈΠΈ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΊΠ°Π» ΠΈΠΌΠ΅Π΅Ρ Π²Π°ΠΆΠ½ΠΎΠ΅ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΡΠΎΠ²Π½Ρ ΡΠ΅Π΄Π°ΡΠΈΠΈ ΠΈΒ Π±ΠΎΠ»Π΅Π΅ ΡΠΎΠ½ΠΊΠΎΠ³ΠΎ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π΄ΠΎΠ·Π°ΠΌΠΈ ΡΠ΅Π΄Π°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ². ΠΠ±ΡΠΎΠ»ΡΡΠ½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ Π΄Π»Ρ ΠΠ‘/ΠΠ‘Π Π½Π΅Ρ. ΠΠ‘/ΠΠ‘Π ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΡΡΡΠ΅Π±ΠΎΠ²Π°Π½Π½ΡΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ Π²Β ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΎΠ»ΠΎΠ³Π°-ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΎΠ»ΠΎΠ³Π°. ΠΡΡΡΡΡΡΠ²ΠΈΠ΅ Π²Β Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ ΡΠ΅Π³Π»Π°ΠΌΠ΅Π½ΡΠΈΡΡΡΡΠΈΡ
Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠ² ΠΏΠΎ ΠΠ‘/ΠΠ‘Π Π΄ΠΈΠΊΡΡΠ΅Ρ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ
Aberrant Connexin26 Hemichannels Underlying KeratitisβIchthyosisβDeafness Syndrome Are Potently Inhibited by Mefloquine
Keratitisβichthyosisβdeafness (KID) syndrome is an ectodermal dysplasia caused by dominant mutations of connexin26 (Cx26). Loss of Cx26 function causes nonsyndromic sensorineural deafness, without consequence in the epidermis. Functional analyses have revealed that a majority of KID-causing mutations confer a novel expansion of hemichannel activity, mediated by connexin channels in a nonjunctional configuration. Inappropriate Cx26 hemichannel opening is hypothesized to compromise keratinocyte integrity and epidermal homeostasis. Pharmacological modulators of Cx26 are needed to assess the pathomechanistic involvement of hemichannels in the development of hyperkeratosis in KID syndrome. We have used electrophysiological assays to evaluate small-molecule analogs of quinine for suppressive effects on aberrant hemichannel currents elicited by KID mutations. Here, we show that mefloquine (MFQ) inhibits several mutant hemichannel forms implicated in KID syndrome when expressed in Xenopus laevis oocytes (IC50βΌ16βΞΌM), using an extracellular divalent cation, zinc (Zn++), as a nonspecific positive control for comparison (IC50βΌ3βΞΌM). Furthermore, we used freshly isolated transgenic keratinocytes to show that micromolar concentrations of MFQ attenuated increased macroscopic membrane currents in primary mouse keratinocytes expressing human Cx26-G45E, a mutation that causes a lethal form of KID syndrome
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